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Effects of pH and Low Density Lipoprotein (LDL) on PCSK9-dependent LDL Receptor Regulation
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LDL particles are released from LDLR in the acidic environment of the sorting endosome, whereas the affinity of PCSK9 for LDLR increases 120-150-fold at low pH.
“Whereas LDL particles are released from the LDLR in the acidic environment of the sorting endosome, the affinity of PCSK9 for LDLR increases 120–150-fold at low pH121,122.”
From Pathways and Molecular Mechanisms Governing LDL Receptor Regulation (2025) · cites this paper as [121]
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The Evolving Future of PCSK9 Inhibitors
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The hypercholesterolemia-risk gene SORT1 facilitates PCSK9 secretion
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Pathways and Molecular Mechanisms Governing LDL Receptor Regulation
Schmidt, H. M., Jarrett, K. E., de Aguiar Vallim, T. Q., & Tarling, E. J. (2025) · Circulation Research · doi:10.1161/circresaha.124.323578 · Cited by 33
Metadata
- Authors
- Fisher, T. S., Surdo, P. L., Pandit, S., Mattu, M., Santoro, J. C., Wisniewski, D., Cummings, R. T., Calzetta, A., Cubbon, R. M., Fischer, P. A., Tarachandani, A., De Francesco, R., Wright, S. D., Sparrow, C. P., Carfi, A., & Sitlani, A.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2007-07
- Volume
- 282
- Issue
- 28
- Pages
- 20502-20512
- ISSN
- 0021-9258
- Cited by
- 181
- References
- 4
- Language
- en
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