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Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice

Maxwell, Kara N., Soccio, Raymond E., Duncan, Elizabeth M., Sehayek, Ephraim, Breslow, Jan L.·2003·Journal of Lipid Research
DOI 10.1194/jlr.m300203-jlr200
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  • PCSK9 is a sterol-regulated gene mainly expressed in liver and to a lesser extent in kidney and intestine.

    “PCSK9 is a sterol-regulated gene mainly expressed in liver and to a lesser extent in kidney and intestine”

    From GRP94 Regulates Circulating Cholesterol Levels through Blockade of PCSK9-Induced LDLR Degradation (2015) · cites this paper as Maxwell et al., 2003

    The passage labeled Abstract reports that mouse Pcsk9 expression was strongly downregulated by dietary cholesterol and upregulated in SREBP transgenic mice, supporting sterol regulation in liver. The paper’s liver measurements do not establish that PCSK9 is expressed mainly in liver or at lower levels in kidney and intestine; searches for tissue expression and those organs found no supporting passage. No page number is available in our copy. (LLM, conf=0.84)

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Research works printed but not linked: 43

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Metadata

Authors
Maxwell, K. N., Soccio, R. E., Duncan, E. M., Sehayek, E., & Breslow, J. L.
Venue
Journal of Lipid Research
Publisher
Elsevier BV
Published
2003-11
Volume
44
Issue
11
Pages
2109-2119
ISSN
0022-2275
DOI
10.1194/jlr.m300203-jlr200
Cited by
329
References
2
Language
en
Licence

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