Specificity and Mechanism of Action of EHT 1864, a Novel Small Molecule Inhibitor of Rac Family Small GTPases

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Items 101–200 of 339

1. Ovarian Tumor Microenvironment Signaling: Convergence on the Rac1 GTPase
   Laurie G. Hudson, Jennifer M. Gillette, Huining Kang, Melanie R. Rivera, Angela Wandinger‐Ness · 2018 · Cancers
2. HIF-1α activation results in actin cytoskeleton reorganization and modulation of Rac-1 signaling in endothelial cells
   Alexander Weidemann, Johannes Breyer, Margot Rehm, Kai‐Uwe Eckardt, Christoph Daniel, Iwona Cicha, Klaudia Giehl, Margarete Goppelt‐Struebe · 2013 · Cell Communication and Signaling
3. Rac1 Is Required for Matrix Metalloproteinase 13 Production by Chondrocytes in Response to Fibronectin Fragments
   David L. Long, Jeffrey S. Willey, Richard F. Loeser · 2013 · Arthritis & Rheumatism
4. α9β1 Integrin in melanoma cells can signal different adhesion states for migration and anchorage
   Magnus Christian Lydolph, Marie Morgan-Fisher, Anette M. Høye, John Couchman, Ulla M. Wewer, Atsuko Yoneda · 2009 · Experimental Cell Research
5. Inhibition of prostate smooth muscle contraction and prostate stromal cell growth by the inhibitors of R ac, NSC 23766 and EHT 1864
   Yu Wang, Thomas Kunit, Anna Ciotkowska, Beata Rutz, Andrea Schreiber, Frank Strittmatter, Raphaela M. Waidelich, Chun Liu, Christian Georg Stief, Christian Gratzke et al. · 2015 · British Journal of Pharmacology
6. Actin regulators in cancer progression and metastases: From structure and function to cytoskeletal dynamics
   Guy Biber, Aviad Ben‐Shmuel, Batel Sabag, Mira Barda‐Saad · 2020 · International review of cytology
7. Lysophosphatidic acid and sphingosine-1-phosphate promote morphogenesis and block invasion of prostate cancer cells in three-dimensional organotypic models
   Ville Härmä, Matias Knuuttila, Johannes Virtanen, Tuomas K. Mirtti, Pekka J. Kohonen, Panu E. Kovanen, Antti P. Happonen, Suwisa Kaewphan, Ilmari Ahonen, Olli Kallioniemi et al. · 2011 · Oncogene
8. Research Resource: Progesterone Receptor Targetome Underlying Mammary Gland Branching Morphogenesis
   Ashlee R. Lain, Chad J. Creighton, Orla M. Conneely · 2013 · Molecular Endocrinology
9. Flow-induced endothelial cell alignment requires the RhoGEF Trio as a scaffold protein to polarize active Rac1 distribution
   Jeffrey Kroon, Niels Heemskerk, Martin J. T. Kalsbeek, Vivian de Waard, Jos van Rijssel, Jaap D. van Buul · 2017 · Molecular Biology of the Cell
10. Nuclear Factor of Activated T Cells c1 Mediates p21-activated Kinase 1 Activation in the Modulation of Chemokine-induced Human Aortic Smooth Muscle Cell F-actin Stress Fiber Formation, Migration, and Proliferation and Injury-induced Vascular Wall Remodeling
    Venkatesh Kundumani‐Sridharan, Nikhlesh Kumar Singh, Sanjay Kumar, Ravisekhar Gadepalli, Gadiparthi N. Rao · 2013 · Journal of Biological Chemistry
11. Genetic and functional characterization of putative Ras/Raf interaction inhibitors in C. elegans and mammalian cells
    Vanessa González‐Pérez, David J. Reiner, Jamie K. Alan, Cicely E. Mitchell, Lloyd J. Edwards, Vladimir Khazak, Channing J. Der, Adrienne D. Cox · 2010 · Journal of Molecular Signaling
12. How to Target Activated Ras Proteins: Direct Inhibition vs. Induced Mislocalization
    Ethan J. Brock, Kyungmin Ji, John J. Reiners, Raymond R. Mattingly · 2015 · Mini-Reviews in Medicinal Chemistry
13. Structural Mechanisms and Drug Discovery Prospects of Rho GTPases
    Cameron C. Smithers, Michael Overduin · 2016 · Cells
14. Wnt5a enhances proliferation of chronic lymphocytic leukemia and ERK1/2 phosphorylation via a ROR1/DOCK2-dependent mechanism
    Md Kamrul Hasan, Emanuela M. Ghia, Laura Z. Rassenti, George F. Widhopf, Thomas J. Kipps · 2020 · Leukemia
15. Neuronal Cytoskeleton in Intellectual Disability: From Systems Biology and Modeling to Therapeutic Opportunities
    Carla Liaci, Mattia Camera, Giovanni Caslini, Simona Rando, Salvatore Contino, Valentino Romano, Giorgio Roberto Merlo · 2021 · International Journal of Molecular Sciences
16. Hyperstimulation of macropinocytosis leads to lysosomal dysfunction during exposure to methamphetamine in SH-SY5Y cells
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17. Deletion of Rac1GTPase in the Myeloid Lineage Protects against Inflammation-Mediated Kidney Injury in Mice
    Miki Nagase, Hidetake Kurihara, Atsu Aiba, Morag J. Young, Tatsuo Sakai · 2016 · PLoS ONE
18. Therapeutic sensitivity to Rac GTPase inhibition requires consequential suppression of mTORC1, AKT, and MEK signaling in breast cancer
    Riley A. Hampsch, Kevin Shee, Darcy J. P. Bates, Lionel D. Lewis, Laurent Désiré, Bertrand Leblond, Eugene Demidenko, Kurtis Stefan, Yina H. Huang, Todd W. Miller · 2017 · Oncotarget
19. Aptamer-Derived Peptides as Potent Inhibitors of the Oncogenic RhoGEF Tgat
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20. siRNA Screen Identifies Trafficking Host Factors that Modulate Alphavirus Infection
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21. RAC1 plays an essential role in estrogen receptor alpha function in breast cancer cells
    Jun Sun, Gabriel Gaidosh, Ye Xu, Adnan Kasim Mookhtiar, Na Man, Pradeep Reddy Cingaram, Ezra Blumenthal, Ramin Shiekhattar, Erik T. Goka, Stephen D. Nimer et al. · 2021 · Oncogene
22. Identification of Key Signaling Molecules Involved in the Activation of the Swelling-Activated Chloride Current in Human Glioblastoma Cells
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23. Tiam–Rac signaling mediates trans-endocytosis of ephrin receptor EphB2 and is important for cell repulsion
    Thomas N. Gaitanos, Jorg Koerner, Rüdiger Klein · 2016 · The Journal of Cell Biology
24. Modular and Distinct Plexin-A4/FARP2/Rac1 Signaling Controls Dendrite Morphogenesis
    Víctor Danelon, Ron Goldner, Edward A. Martinez, Irena Gokhman, Kimberly Wang, Avraham Yaron, Tracy S. Tran · 2020 · Journal of Neuroscience
25. Self-assembly of mesoscale collagen architectures and applications in 3D cell migration
    Chang Liu, Ryan Y. Nguyen, Gabriela A. Pizzurro, Xingjian Zhang, Xiangyu Gong, Alejandro Rossello‐Martinez, Michael Mak · 2022 · Acta Biomaterialia
26. Novel Role for p21-activated Kinase 2 in Thrombin-induced Monocyte Migration
    Ravisekhar Gadepalli, Sivareddy Kotla, Mark Heckle, Shailendra Kumar Verma, Nikhlesh Kumar Singh, Gadiparthi N. Rao · 2013 · Journal of Biological Chemistry · Retracted
27. The small GTPase Rac1 is required for smooth muscle contraction
    Awahan Rahman, Benjamin Davis, Cecilia Lövdahl, Veena T. Hanumaiah, Robert Feil, Cord Brakebusch, Anders Arner · 2013 · The Journal of Physiology
28. HGF-induced formation of the MET–AXL–ELMO2–DOCK180 complex promotes RAC1 activation, receptor clustering, and cancer cell migration and invasion
    Wenjing Li, Xiahui Xiong, Amro Abdalla, Salvador Alejo, Linyu Zhu, Fei Lu, Hong Sun · 2018 · Journal of Biological Chemistry
29. Function of small GTPases in Dictyostelium macropinocytosis
    Thomas D. Williams, Peggy Paschke, Robert R. Kay · 2018 · Philosophical Transactions of the Royal Society B Biological Sciences
30. Statin-mediated disruption of Rho GTPase prenylation and activity inhibits respiratory syncytial virus infection
    Manpreet Malhi, Michael J. Norris, Wenming Duan, Theo J. Moraes, Jason T. Maynes · 2021 · Communications Biology
31. Tiam1-deficiency impairs mammary tumor formation in MMTV-c-neu but not in MMTV-c-myc mice
    Kristin Strumane, Tomasz P. Rygiel, M. van der Valk, J.G. Collard · 2008 · Journal of Cancer Research and Clinical Oncology
32. PTPσ inhibitors promote hematopoietic stem cell regeneration
    Yurun Zhang, Martina M Roos, Heather Anne Himburg, Christina Marie Termini, Mamle Quarmyne, Michelle Li, Liman Zhao, Jenny Kan, Tiancheng Fang, Yan Xiao et al. · 2019 · Nature Communications
33. Role of Small GTPase Protein Rac1 in Cardiovascular Diseases
    Nicola Ferri, Alessandro Contini, Sergio Kevin Bernini, Alberto Corsini · 2013 · Journal of Cardiovascular Pharmacology
34. Activated Ras as a Therapeutic Target: Constraints on Directly Targeting Ras Isoforms and Wild-Type versus Mutated Proteins
    Raymond R. Mattingly · 2013 · ISRN Oncology
35. High-Throughput Flow Cytometry Bead-Based Multiplex Assay for Identification of Rho GTPase Inhibitors
    Zurab Surviladze, Susan M. Young, Larry A. Sklar · 2011 · Methods in molecular biology
36. The effect of Rho drugs on mast cell activation and degranulation
    Avinash Sheshachalam, Alicia Baier, Gary Eitzen · 2017 · Journal of Leukocyte Biology
37. Cognitive Enhancers (Nootropics). Part 2: Drugs Interacting with Enzymes
    Wolfgang Froestl, Andreas Muhs, Andrea Pfeifer · 2013 · Journal of Alzheimer s Disease
38. Combined Rational Design and a High Throughput Screening Platform for Identifying Chemical Inhibitors of a Ras-activating Enzyme
    Chris R. Evelyn, Jacek Biesiada, Xin Duan, Hong Ming Tang, Xun Shang, Ruben Papoian, William L. Seibel, Sandra L. Nelson, Jarek Meller, Yi Zheng · 2015 · Journal of Biological Chemistry
39. Rho inhibition by lovastatin affects apoptosis and DSB repair of primary human lung cells in vitro and lung tissue in vivo following fractionated irradiation
    Verena Ziegler, Christian Henninger, Ioannis Simiantonakis, Marcel Buchholzer, Mohammad Reza Ahmadian, Wilfried Budach, Gerhard Fritz · 2017 · Cell Death and Disease
40. Involvement of Tiam1, RhoG and ELMO2/ILK in Rac1-mediated phagocytosis in human trabecular meshwork cells
    Jennifer L. Peotter, Jenny Phillips, Tiegang Tong, Kaylee D. Dimeo, José M. González, Donna M. Pesciotta Peters · 2016 · Experimental Cell Research
41. Pharmacokinetics of Rac inhibitor EHop-016 in mice by ultra-performance liquid chromatography tandem mass spectrometry
    Tessa Humphries‐Bickley, Linette Castillo‐Pichardo, Francheska Corujo, Jorge Duconge-Soler, Eliud Hernandez O'Farril, Cornelis P. Vlaar, José F. Rodríguez‐Orengo, Luis A. Cubano, Suranganie Dharmawardhane · 2015 · Journal of Chromatography B
42. DNA damage response (DDR) induced by topoisomerase II poisons requires nuclear function of the small GTPase Rac
    Friedrich Wartlick, Anita Bopp, Christian Henninger, Gerhard Fritz · 2013 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
43. RHOA Therapeutic Targeting in Hematological Cancers
    Juliana Carvalho Santos, Núria Profitós-Pelejà, Salvador Sánchez-Vinces, Gaël Roué · 2023 · Cells
44. Discovery and characterization of small molecule Rac1 inhibitors
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45. Inhibition of Neutrophil Primary Granule Release during Yersinia pestis Pulmonary Infection
    Kara R. Eichelberger, Grant S. Jones, William E. Goldman · 2019 · mBio
46. Rho GTPases: Promising candidates for overcoming chemotherapeutic resistance
    Chunwen Zheng, Ruijie Zeng, Li‐Yan Xu, En‐Min Li · 2020 · Cancer Letters
47. Cell–substrate adhesion drives Scar/WAVE activation and phosphorylation by a Ste20-family kinase, which controls pseudopod lifetime
    Shashi Prakash Singh, Peter A. Thomason, Sérgio Lilla, Matthias Schaks, Qing Tang, Bruce L. Goode, Laura M. Machesky, Klemens Rottner, Robert H. Insall · 2020 · PLoS Biology
48. Phosphatidylinositol‐3,4,5‐triphosphate‐dependent Rac exchange factor 1 regulates epinephrine‐induced exocytosis of Weibel–Palade bodies
    Kathinka W. E. M. van Hooren, Dorothee van Breevoort, Mar Fernandez‐Borja, Alexander B. Meijer, Jeroen C.J. Eikenboom, Ruben Bierings, Jan Voorberg · 2013 · Journal of Thrombosis and Haemostasis
49. Tannerella forsythia invasion in oral epithelial cells requires phosphoinositide 3-kinase activation and clathrin-mediated endocytosis
    Elina Mishima, Ashu Sharma · 2011 · Microbiology
50. Optimizing metastatic-cascade-dependent Rac1 targeting in breast cancer: Guidance using optical window intravital FRET imaging
    Alessia Floerchinger, Kendelle Joan Murphy, Sharissa L. Latham, Sean C. Warren, Andrew T McCulloch, Young-Kyung Lee, Janett Stoehr, Pauline Mélénec, Cris S.Guaman, Xanthe L. Metcalf et al. · 2021 · Cell Reports
51. Control of Cerebellar Long-Term Potentiation by P-Rex-Family Guanine-Nucleotide Exchange Factors and Phosphoinositide 3-Kinase
    Claire L. M. Jackson, Heidi C. E. Welch, Tomas C. Bellamy · 2010 · PLoS ONE
52. Peptide modulators of Rac1/Tiam1 protein‐protein interaction: An alternative approach for cardiovascular diseases
    Alessandro Contini, Nicola Ferri, Raffaella Bucci, Maria Giovanna Lupo, Emanuela Erba, Maria Luisa Gelmi, Sara Pellegrino · 2017 · Peptide Science
53. Actin cytoskeleton deregulation confers midostaurin resistance in FLT3-mutant acute myeloid leukemia
    Andoni Garitano-Trojaola, Ana Sancho, Ralph Götz, Patrick Eiring, Susanne Walz, Hardikkumar Jetani, Jesús Gil‐Pulido, Matteo Da Vià, Eva Teufel, Nadine Rhodes et al. · 2021 · Communications Biology
54. Signal Transduction Pathways Provide Opportunities to Enhance HDL and apoAI-Dependent Reverse Cholesterol Transport
    Vishwaroop Mulay, Peta Wood, Carles Rentero, Carlos Enrich, Thomas Grewal · 2012 · Current Pharmaceutical Biotechnology
55. LRRK2 GTPase dysfunction in the pathogenesis of Parkinson's disease
    Yulan Xiong, Valina Lynn Dawson, Ted M. Dawson · 2012 · Biochemical Society Transactions
56. 3-Aryl-N-aminoylsulfonylphenyl-1H-pyrazole-5-carboxamides: a new class of selective Rac inhibitors
    Nicola Ferri, Sergio Kevin Bernini, Alberto Corsini, Francesca Clerici, Emanuela Erba, Stefano Stragliotto, Alessandro Contini · 2012 · MedChemComm
57. Rac1 acts in conjunction with Nedd4 and Dishevelled-1 to promote maturation of cell-cell contacts
    Micha Nethe, Bart-Jan de Kreuk, Daniele V. F. Tauriello, Eloise C. Anthony, Barbara C. Snoek, Thomas Stumpel, Patricia C. Salinas, Madelon M. Maurice, Dirk Geerts, André M. Deelder et al. · 2012 · Journal of Cell Science
58. Glioma Cell Secretion: A Driver of Tumor Progression and a Potential Therapeutic Target
    Damian A. Almiron Bonnin, Matthew C. Havrda, Mark A. Israel · 2018 · Cancer Research
59. WASP Restricts Active Rac to Maintain Cells’ Front-Rear Polarization
    Clelia Amato, Peter A. Thomason, Andrew J. Davidson, Karthic Swaminathan, Shehab Ismail, Laura M. Machesky, Robert H. Insall · 2019 · Current Biology
60. Activation of neuronal Ras‐related C3 botulinum toxin substrate 1 (Rac1) improves post‐stroke recovery and axonal plasticity in mice
    Fan Bu, Yashasvee Munshi, J. Weldon Furr, Jia‐Wei Min, Qi Li, Anthony Patrizz, Zachary R. Spahr, Akihiko Urayama, Julia Kofler, Louise D. McCullough et al. · 2020 · Journal of Neurochemistry
61. RAC1 Activation as a Potential Therapeutic Option in Metastatic Cutaneous Melanoma
    Paula Colón‐Bolea, Rocío García‐Gómez, Berta Casar · 2021 · Biomolecules
62. A machine learning pipeline revealing heterogeneous responses to drug perturbations on vascular smooth muscle cell spheroid morphology and formation
    Kalyanaraman Vaidyanathan, Chuangqi Wang, Amanda Krajnik, Yudong Yu, Moses Choi, Bolun Lin, Junbong Jang, Su‐Jin Heo, John J. Kolega, Kwonmoo Lee et al. · 2021 · Scientific Reports
63. Two Rac paralogs regulate polarized growth in the human fungal pathogen Cryptococcus neoformans
    Elizabeth Ripley Ballou, Kyla S. Ost, Jessica L. Narloch, Connie B. Nichols, J. Andrew Alspaugh · 2013 · Fungal Genetics and Biology
64. Par-1b is required for morphogenesis and differentiation of myoepithelial cells during salivary gland development
    Elise M. Gervais, Sharon J. Sequeira, Weihao Wang, Stanley Abraham, Janice H. Kim, Daniel Leonard, Kara A. DeSantis, Melinda Larsen · 2016 · Organogenesis
65. hace1 Influences zebrafish cardiac development via ROS‐dependent mechanisms
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66. Rac1 and Rac2 control distinct events during antigen-stimulated mast cell exocytosis
    Alicia Baier, Vivian N E Ndoh, Paige Lacy, Gary Eitzen · 2014 · Journal of Leukocyte Biology
67. Regulation of smooth muscle contraction by monomeric non‐RhoA GTPases
    Bingsheng Li, Ruixiao Wang, Yiming Wang, Christian Georg Stief, Martin Hennenberg · 2020 · British Journal of Pharmacology
68. PLEKHG2 Promotes Heterotrimeric G Protein βγ-Stimulated Lymphocyte Migration via Rac and Cdc42 Activation and Actin Polymerization
    Caitlin Runne, Songhai Chen · 2013 · Molecular and Cellular Biology
69. Rac1 Promotes Cell Motility by Controlling Cell Mechanics in Human Glioblastoma
    Jing Xu, Nicola Galvanetto, Jihua Nie, Yili Yang, Vincent Torre · 2020 · Cancers
70. Rac1 as a Target to Treat Dysfunctions and Cancer of the Bladder
    Vincent Sauzeau, Julien Beignet, Christian Bailly · 2022 · Biomedicines
71. Faulty Epithelial Polarity Genes and Cancer
    Topi Aulis Tervonen, Johanna I. Partanen, Sirkku T. Saarikoski, Mikko Myllynen, Elsa Marques, Katriina Paasonen, Anu Moilanen, Gerd Wohlfahrt, Panu E. Kovanen, Juha T. Klefström · 2011 · Advances in cancer research
72. Rac GTPases in Hematological Malignancies
    Valerie Durand-Onaylı, Theresa Haslauer, Andrea Härzschel, Tanja Nicole Hartmann · 2018 · International Journal of Molecular Sciences
73. Rac1 silencing, NSC23766 and EHT1864 reduce growth and actin organization of bladder smooth muscle cells
    Ruixiao Wang, Qingfeng Yu, Xiaolong Wang, Bingsheng Li, Anna Ciotkowska, Beata Rutz, Yiming Wang, Christian Georg Stief, Martin Hennenberg · 2020 · Life Sciences
74. The Rac activator Tiam1 is required for polarized protrusional outgrowth of primary astrocytes by affecting the organization of the microtubule network
    Saskia I. J. Ellenbroek, Sandra Iden, John G. Collard · 2012 · Small GTPases
75. The Rho GTPase Rac1 is required for recycling endosome-mediated secretion of TNF in macrophages
    Stanley, Amanda C, Wong, Colin X, Micaroni, Massimo, Venturato, Juliana, Khromykh, Tatiana, Stow, Jennifer L, Lacy, Paige · 2014 · Immunology & Cell Biology
76. Dock5 is a new regulator of microtubule dynamic instability in osteoclasts
    Sarah Guimbal, Anne Morel, David Guérit, Manon Chardon, Anne Blangy, Virginie Vives · 2019 · Biology of the Cell
77. Attenuation of apoptotic cell detection triggers thymic regeneration after damage
    Sinead M. Kinsella, Cindy Evandy, Kirsten Cooper, Lorenzo Iovino, Paul C. DeRoos, Kayla S. Hopwo, David Granadier, Colton W Smith, Shahin Rafii, Jarrod A. Dudakov · 2021 · Cell Reports
78. Ciliary GPCR‐based transcriptome as a key regulator of cilia length control
    Yuki Kobayashi, Sakura Tomoshige, Kosuke Imakado, Yuko Sekino, Noriko Koganezawa, Tomoaki Shirao, Giovanne Baroni Diniz, Tatsuo Miyamoto, Yumiko Saito · 2021 · FASEB BioAdvances
79. Aging-related alterations in mechanistic target of rapamycin signaling promote platelet hyperreactivity and thrombosis
    Irina Portier, Bhanu Kanth Manne, Yasuhiro Kosaka, Neal D. Tolley, Frederik Denorme, Özgün Babur, Ashok P. Reddy, Phillip A. Wilmarth, Joseph E. Aslan, Andrew S. Weyrich et al. · 2024 · Journal of Thrombosis and Haemostasis
80. New strategies for inhibition of non‐adrenergic prostate smooth muscle contraction by pharmacologic intervention
    Qingfeng Yu, Christian Gratzke, Yiming Wang, Xiaolong Wang, Bingsheng Li, Frank Strittmatter, Annika Herlemann, Ruixiao Wang, Alexander J. Tamalunas, Raphaela M. Waidelich et al. · 2019 · The Prostate
81. Structure–activity relationship of isoform selective inhibitors of Rac1/1b GTPase nucleotide binding
    Eric Beausoleil, Cédric Chauvignac, Thierry Taverne, Sandrine Lacombe, Laure Pognante, Bertrand Leblond, Diego Pallares, Catherine De Oliveira, Florence Bachelot, Rachel Carton et al. · 2009 · Bioorganic & Medicinal Chemistry Letters
82. Integrin-Rac signalling for mammary epithelial stem cell self-renewal
    Safiah Olabi, Ahmet Uçar, Keith R. Brennan, Charles H. Streuli · 2018 · Breast Cancer Research
83. In vitro fluorescence assay to measure GDP/GTP exchange of guanine nucleotide exchange factors of Rho family GTPases
    Alyssa M. Blaise, Ellen E Corcoran, Eve S. Wattenberg, Yan-Ling Zhang, Jeffrey R. Cottrell, Anthony J. Koleske · 2021 · Biology Methods and Protocols
84. Inhibition of Vps34 and p110δ PI3K Impairs Migration, Invasion and Three-Dimensional Spheroid Growth in Breast Cancer Cells
    Marzia Di Donato, Pia Giovannelli, Antimo Migliaccio, Antonio Bilancio · 2022 · International Journal of Molecular Sciences
85. Rho GTPase Signaling in Platelet Regulation and Implication for Antiplatelet Therapies
    Akhila Dandamudi, Huzoor Akbar, José A. Cancelas, Yi Zheng · 2023 · International Journal of Molecular Sciences
86. Inhibition of Female and Male Human Detrusor Smooth Muscle Contraction by the Rac Inhibitors EHT1864 and NSC23766
    Bingsheng Li, Qingfeng Yu, Ruixiao Wang, Christian Gratzke, Xiaolong Wang, Annabel Spek, Annika Herlemann, Alexander J. Tamalunas, Frank Strittmatter, Raphaela M. Waidelich et al. · 2020 · Frontiers in Pharmacology
87. Characterization of the erythrocyte GTPase Rac1 in relation to Plasmodium falciparum invasion
    Silvio Paone, Sarah D’Alessandro, Silvia Parapini, Francesco Celani, Valentina Tirelli, M. Pourshaban, Anna Olivieri · 2020 · Scientific Reports
88. Advances in the development of Rho GTPase inhibitors
    Yijing Zhang, Guanyi Li, Yaxue Zhao · 2023 · Bioorganic & Medicinal Chemistry
89. EHT 1864, a small molecule inhibitor of Ras-related C3 botulinum toxin substrate 1 (Rac1), attenuates glucose-stimulated insulin secretion in pancreatic β-cells
    Vaibhav Sidarala, Rajakrishnan Veluthakal, Khadija Syeda, Anjaneyulu Kowluru · 2015 · Cellular Signalling
90. Actin-Mediated Gene Expression Depends on RhoA and Rac1 Signaling in Proximal Tubular Epithelial Cells
    Klaudia Giehl, Christof Keller, Susanne Muehlich, Margarete Goppelt‐Struebe · 2015 · PLoS ONE
91. Ras-related C3 Botulinum Toxin Substrate (Rac) and Src Family Kinases (SFK) Are Proximal and Essential for Phosphatidylinositol 3-Kinase (PI3K) Activation in Natural Killer (NK) Cell-mediated Direct Cytotoxicity against Cryptococcus neoformans
    Richard F. Xiang, Danuta Stack, Shaunna M. Huston, Shu Shun Li, Henry Ogbomo, Stephen K. Kyei, Christopher H. Mody · 2016 · Journal of Biological Chemistry
92. Rac1 modulates G-protein-coupled receptor-induced bronchial smooth muscle contraction
    Hiroyasu Sakai, Yuki Kai, Ken Sato, Mitsuo Ikebe, Yohihiko Chiba · 2017 · European Journal of Pharmacology
93. Mechanisms and consequences of dysregulation of the Tiam family of Rac activators in disease
    Joe Maltas, Hannah Reed, Andrew Porter, Angeliki Malliri · 2020 · Biochemical Society Transactions
94. Transcriptome- and proteome-oriented identification of dysregulated eIF4G, STAT3, and Hippo pathways altered by PIK3CA H1047R in HER2/ER-positive breast cancer
    Feixiong Cheng, Junfei Zhao, Ariella B. Hanker, Monica Red Brewer, Carlos L. Arteaga, Zhongming Zhao · 2016 · Breast Cancer Research and Treatment
95. Actin Waves Do Not Boost Neurite Outgrowth in the Early Stages of Neuron Maturation
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96. WAVE complex forms linear arrays at negative membrane curvature to instruct lamellipodia formation
    Muziyue Wu, Raj Kumar Sadhu, Kirstin Meyer, Ziqi Tang, Paul Marchando, Derek N. Woolfson, Nir S. Gov, Orion David Weiner · 2025 · The Journal of Cell Biology
97. Small-molecule inhibitors of P-Rex guanine-nucleotide exchange factors
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98. RAC1B function is essential for breast cancer stem cell maintenance and chemoresistance of breast tumor cells
    Fuhui Chen, Sevim Beyza Gürler, David Novo, Çiğdem Selli, Denis Alférez, Seçil Eroğlu, Kyriaki Pavlou, Jingwei Zhang, Andrew H. Sims, Neil E. Humphreys et al. · 2023 · Oncogene
99. Combinatorial genetics reveals the Dock1-Rac2 axis as a potential target for the treatment of NPM1;Cohesin mutated AML
    Alison E. Meyer, Cary T. Stelloh, Kirthi Pulakanti, Robert T Burns, Joseph B. Fisher, Katelyn E. Heimbruch, Sergey S. Tarima, Quinlan Furumo, John D. Brennan, Yongwei Zheng et al. · 2022 · Leukemia
100. Rac1 signaling protects monocytic AML cells expressing the MLL-AF9 oncogene from caspase-mediated apoptotic death
     Clemens Hinterleitner, Johannes Huelsenbeck, Christian Henninger, Friedrich Wartlick, Anne Schorr, Bernd Kaina, Gerhard Fritz · 2013 · APOPTOSIS