Specificity and Mechanism of Action of EHT 1864, a Novel Small Molecule Inhibitor of Rac Family Small GTPases

Cited by (339)

Items 301–339 of 339

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    Babak Razaghi · 2017 · DalSpace (Dalhousie University)
  2. Anti-Cryptococcal Signaling in NK Cells
    Richard F. Xiang · 2017 · Libraries and Cultural Resources (University of Calgary)
  3. The Role of Rho GTPases, Rac1 and Rac2, in Mast Cell Exocytosis
    Alicia Baier · 2012 · ERA: Education and Research Archive (University of Alberta)
  4. Targeting APC loss using synthetic lethality in Colorectal Cancer
    Hannah Shailes · 2018 · Queen Mary Research Online (Queen Mary University of London)
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    Gerald Keil · 2019 · UEA Digital Repository (University of East Anglia)
  6. Rho GTPases and RhoGDIs in the Regulation of Mast Cell Degranulation
    Avinash Sheshachalam · 2018 · ERA: Education and Research Archive (University of Alberta)
  7. Engineering Threshold-Based Selection Systems
    Katherine H. Pedone, Vanessa González‐Pérez, Luciana E. Leopold, Channing J. Der, Adrienne D. Cox, Shawn Cameron Ahmed, David J. Reiner · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
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  9. Engineering threshold-based selection systems
    Katherine H. Pedone, Vanessa González‐Pérez, Luciana E. Leopold, Neal R. Rasmussen, Channing J. Der, Adrienne D. Cox, Shawn Cameron Ahmed, David J. Reiner · 2021 · G3 Genes Genomes Genetics
  10. Using Light to Observe and Control Cellular Function: Improving Bioluminescence Imaging and Photocontrol of Rho GTPase Activation States: A Dissertation
    Katryn R. Harwood · 2011 · The Journal of the American Medical Association (JAMA) Network (American Medical Association)
  11. Signaling Mechanisms of Vav3, a Guanine Nucleotide Exchange Factor and Androgen Receptor Coactivator, in Physiology and Prostate Cancer Progression
    Leah S. Lyons, Kerry L. Burnstein · 2013 · Springer eBooks
  12. Faculty Opinions recommendation of PLEKHG2 promotes heterotrimeric G protein βγ-stimulated lymphocyte migration via Rac and Cdc42 activation and actin polymerization.
    Andrew Boris Goryachev · 2014 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  13. Faculty Opinions recommendation of Apoptotic cell clearance by bronchial epithelial cells critically influences airway inflammation.
    Bruce David Levy, Jennifer K. Colby · 2013 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  14. Optimizing metastatic-cascade-dependent Rac1 targeting in breast cancer: Guidance using optical window intravital FRET imaging
    Alessia Floerchinger, Kendelle Joan Murphy, Sharissa L. Latham, Sean C. Warren, Andrew T McCulloch, Young Kyung Lee, Janett Stoehr, Pauline Mélénec, Cris S.Guaman, Xanthe L. Metcalf et al. · 2023
  15. Human Cytomegalovirus Replication Enhanced By Placental MicroRNAs
    Kazufumi Ikuta, Misako Yajima, Hiroshi Kitamura, Sorama Aoki, Teru Kanda · 2024 · Journal of Medical Virology
  16. Vav2 is a master regulator of repair against bacterial pore-forming toxins
    Gbenga Victor Kayejo, A. Hensley, Tejal Katore, Peter A. Keyel · 2026 · Life Science Alliance
  17. PP2A activation drives aberrant macropinocytosis and cell death in pancreatic ductal adenocarcinoma
    Garima Baral, Claire M. Pfeffer, Sara N. Filippelli, Indiraa Doraivel, Brittany N. Heil, Lauren E. Gartenhaus, Kasi Hansen, Joy Wu, Goutham Narla, Emma H. Doud et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  18. Rac1 inhibition slows down the segmentation clock and increases the somite size
    Maria Pappa, Charisios D. Tsiairis · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  19. Transient Photoactivation of Rac1 Induces Persistent Structural LTP Independent of CaMKII in Hippocampal Dendritic Spines
    Takeo Saneyoshi, Chisato Suematsu, Yasunori Hayashi · 2025 · eNeuro
  20. Additional file 3 of Regulatory role of lncH19 in RAC1 alternative splicing: implication for RAC1B expression in colorectal cancer
    Aurora Cordaro, Maria Magdalena Barreca, Chiara Zichittella, Marco Loria, Denise Anello, Goffredo Orazio Arena, Nicolina Sciaraffa, Claudia Coronnello, Giuseppe Pizzolanti, Riccardo Alessandro et al. · 2024 · Figshare
  21. Additional file 1 of Regulatory role of lncH19 in RAC1 alternative splicing: implication for RAC1B expression in colorectal cancer
    Aurora Cordaro, Maria Magdalena Barreca, Chiara Zichittella, Marco Loria, Denise Anello, Goffredo Orazio Arena, Nicolina Sciaraffa, Claudia Coronnello, Giuseppe Pizzolanti, Riccardo Alessandro et al. · 2024 · Figshare
  22. Additional file 4 of Regulatory role of lncH19 in RAC1 alternative splicing: implication for RAC1B expression in colorectal cancer
    Aurora Cordaro, Maria Magdalena Barreca, Chiara Zichittella, Marco Loria, Denise Anello, Goffredo Orazio Arena, Nicolina Sciaraffa, Claudia Coronnello, Giuseppe Pizzolanti, Riccardo Alessandro et al. · 2024 · Figshare
  23. Inhibitors of Mitogen-Activated Protein Kinase signaling transduction pathway are lethal to regenerating planarians
    Emily Scarrow, Percival Liu, Daniel Farber, Keevan Kearns, Eve Kolker, William Wallace · 2024 · Journal of High School Science
  24. Additional file 2 of Regulatory role of lncH19 in RAC1 alternative splicing: implication for RAC1B expression in colorectal cancer
    Aurora Cordaro, Maria Magdalena Barreca, Chiara Zichittella, Marco Loria, Denise Anello, Goffredo Orazio Arena, Nicolina Sciaraffa, Claudia Coronnello, Giuseppe Pizzolanti, Riccardo Alessandro et al. · 2024 · Figshare
  25. Additional file 5 of Regulatory role of lncH19 in RAC1 alternative splicing: implication for RAC1B expression in colorectal cancer
    Aurora Cordaro, Maria Magdalena Barreca, Chiara Zichittella, Marco Loria, Denise Anello, Goffredo Orazio Arena, Nicolina Sciaraffa, Claudia Coronnello, Giuseppe Pizzolanti, Riccardo Alessandro et al. · 2024 · Figshare
  26. Rac1 contributes to brain connectivity impairments and neuropsychiatric disorders in Tuberous Sclerosis Complex
    Tomasz Dulski, Olga Doszyń, Justyna Zmorzyńska · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  27. Advancement in preclinical development of cancer treatment agents through modulation of Rac1: From EHop-016 to natural products
    Yingyi Liu, Sze-nga Wong, Aiping Lü, Joshua Ka-Shun Ko · 2025 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
  28. Disulfidptosis-based cancer therapy: Opportunity and challenge
    Bo Wang, Zihui Liu, Junjie Li, Jiaxing Xu, Yamei Guo, J. Zhang, Ti Chu, Zhifen Feng, Qiying Jiang, Dongdong Wu · 2026 · Genes & Diseases
  29. KCNA2 variants cause dilated cardiomyopathy, obesity and sleep apnea through RAC-ERK pathway
    Prasanth Chimata, Sahil Lall, Tarmo Annilo, M K Mathew, Andres Metspalu, Jayaprakash Shenthar, Perundurai Subramaniam Dhandapany · 2026 · EMBO Molecular Medicine
  30. The gp120 Envelope Glycoprotein of HIV-1 Triggers Macropinocytosis in Primary CD4+ T Cells to Promote HIV-1 Infection
    Praveen Manivannan, Cristina Santos da Costa, Yipei Tang, Xinghao Wang, Joel A. Swanson, Tomoyuki Murakami, Akira Ono, Philip D. King · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  31. Research advances of disulfidptosis in inflammatory diseases
    Yizhao Ma, Xingpeng Yang, Yichen Bao, Lin Qi, Xiaohui Du, Pengyue Zhao · 2026 · Genes & Diseases
  32. Roles of Ras Homolog Guanosine Triphosphate Phosphohydrolases in Adipocyte Differentiation, Insulin Signaling, and Lipid Droplet Dynamics
    Yuping Huang, Guoxun Chen, Yan Zhang · 2026 · Journal of Nutrition
  33. Perturbation of Rac1 signaling alters segmentation clock dynamics and somite size
    Maria Pappa, Charisios D. Tsiairis · 2026 · Development
  34. Functions of TIAM1 at the interface of centriole assembly and autolysosome cycling
    Paula Almeida Coelho, Chenrong Yu, David Moore Glover · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  35. An Iridium(III) Complex Induces Immunogenic Methuosis and Reprograms Tumor-Associated Macrophages for Chemoimmunotherapy against KRAS-Mutated Tumors
    Zhuoli Chen, Lina Xie, Tianying Wang, Jinzhe Liang, Yu Chen, Hui Chao · 2026 · Journal of Medicinal Chemistry
  36. GPC6 Lipid Shielding Sustains WNT5A Gradients to Prevent a RASopathy-like Developmental State
    Yeonjoo Kim, Yuguang Zhao, Aurora Xinshu Xu, Asif Nakhuda, Ana-Miruna Androniciuc, Gennadiy Tenin, Bernard D. Keavney, E. Yvonne Jones, Ian John McGough · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  37. BindingDB Entry 50019371: Advances in the development of Rho GTPase inhibitors.
    BindingDB · 2024 · UC San Diego
  38. BindingDB Entry 50030727: Structure-activity relationship of isoform selective inhibitors of Rac1/1b GTPase nucleotide binding.
    BindingDB · 2010 · UC San Diego
  39. Vav3 Potentiation of Androgen Receptor Activity in Prostate Cancer
    Shuyun Rao · 2010