Specificity and Mechanism of Action of EHT 1864, a Novel Small Molecule Inhibitor of Rac Family Small GTPases

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9. Hormone-Dependent Prostate Cancers are Dependent on Rac Signaling for Growth and Survival
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17. Regulation of Adherens Junctions in Trabecular Meshwork Cells by Rac GTPase and their influence on Intraocular Pressure
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19. Up‐regulation of Rac1 in the bronchial smooth muscle of murine experimental asthma
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20. Role of Host Small GTPases in Apicomplexan Parasite Infection
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21. Angiotensin II acts through Rac1 to upregulate pendrin: role of NADPH oxidase
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24. Cdc42 regulates cytokine expression and trafficking in bronchial epithelial cells
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25. Role of Hypoxia and Rac1 Inhibition in the Metastatic Cascade
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26. Reciprocal activation within a kinase effector complex: A mechanism for the persistence of molecular memory
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30. Direkte Modulation von Aktivität und Funktion kleiner GTPasen
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31. Targeting dermatophyte Cdc42 and Rac GTPase signaling to hinder hyphal elongation and virulence
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32. HACE1 blocks HIF1α accumulation under hypoxia in a RAC1 dependent manner
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33. NPM1-Mutated Patient-Derived AML Cells Are More Vulnerable to Rac1 Inhibition
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34. RAC1-Amplified and RAC1-A159V Hotspot-Mutated Head and Neck Cancer Sensitive to the Rac Inhibitor EHop-016 In Vivo: A Proof-of-Concept Study
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35. Inhibition of exchange proteins directly activated by cAMP as a strategy for broad-spectrum antiviral development
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36. Activation of cerebral Ras-related C3 botulinum toxin substrate (Rac) 1 promotes post-ischemic stroke functional recovery in aged mice
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38. Local Arp2/3-dependent actin assembly modulates applied traction force during apCAM adhesion site maturation
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39. The HACE1 E3 ligase mediates RAC1‐dependent control of mTOR signaling complexes
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42. Macropinocytosis: Both a Target and a Tool for Cancer Therapy
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44. The Rac1-inhibitor EHop-016 attenuates AML cell migration and enhances the efficacy of daunorubicin in MOLM-13 transplanted zebrafish larvae
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53. A Rac-specific competitive inhibitor of guanine nucleotide binding reduces metastasis in triple-negative breast cancer
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54. The guanine nucleotide exchange factor Vav3 intervenes in the migration pathway of oligodendrocyte precursor cells on tenascin-C
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56. BTK-independent regulation of calcium signalling downstream of the B-cell receptor in malignant B-cells
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57. Small GTPase control of pituitary hormone secretion: Evidence from studies in the goldfish (Carassius auratus) neuroendocrine model
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58. Wnt/beta-catenin signaling in embryonic stem cell converted tumor cells
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59. Small GTPase Signaling and the Unfolded Protein Response
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60. Nexinhib20 inhibits JFC1-mediated mobilization of a subset of CD11b/CD18+ vesicles decreasing integrin avidity, but does not inhibit Rac1
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61. Pyrin inflammasome-driven erosive arthritis caused by unprenylated RHO GTPase signaling
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62. Spatiotemporal dynamics exhibited by horizontal basal cells reveal a pro-neurogenic pathway during injury-induced olfactory epithelium regeneration
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63. Rho and Rac, but not ROCK , are required for secretion of human and mouse eosinophil‐associated RN ases
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65. Rac Inhibition Causes Impaired GPVI Signalling in Human Platelets through GPVI Shedding and Reduction in PLCγ2 Phosphorylation
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71. Targeting the Dbl and Dock-Family RhoGEFs
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72. Targeting Ras for Anticancer Drug Discovery
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73. Increased Rac1 Activation in the Enhanced Carbachol-Induced Bronchial Smooth Muscle Contraction of Repeatedly Antigen-Challenged Mice
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79. Incarvine C and its analogues inhibit the formation of cell cytoskeleton by targeting Rac1
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80. Rac1 GTPase Regulates the βTrCP-Mediated Proteolysis of YAP Independently of the LATS1/2 Kinases
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83. Hyperglycemic Conditions Promote Rac1-Mediated Serine536 Phosphorylation of p65 Subunit of NFκB (RelA) in Pancreatic Beta Cells
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84. High Glucose-induced ROS Production is Mediated by c-Src in Mesangial Cells
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85. Allometric tissue-scale forces activate mechanoresponsive immune cells to drive pathological foreign body response to biomedical implants
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88. Vasoactivity of Rac GTPase , Cytohesin and Kinase Inhibitors in Renal Interlobar and Coronary Arteries Reveals Shared and Distinct Patterns of Inhibitory Effects in Vascular and Prostate Smooth Muscle Contraction
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89. Design, synthesis and biological evaluation of Rac1-targeting carbazole–pyrimidines as host-directed antimalarials
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91. Targeting Cancer by Using Nanoparticles to Modulate RHO GTPase Signaling
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92. Rac1b: An emerging therapeutic target for chemoresistance in colorectal cancer
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93. Chemical Biology of Cell Motility Inhibitors
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96. Machine learning reveals heterogeneous responses to FAK, Rac, Rho, and Cdc42 inhibition on vascular smooth muscle cell spheroid formation and morphology
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98. Glutamate and early functional NMDA Receptors promote axonal elongation modulating both actin cytoskeleton dynamics and H 2 O 2 production dependent on Rac1 activity
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99. Vav Proteins in Cancer
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100. The function of Tiam1 in tumor cell biology
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