siRNA Screening of the Kinome Identifies ULK1 as a Multidomain Modulator of Autophagy

Chan, Edmond Y.W.; Kir, Serkan; Tooze, Sharon A.

doi:10.1074/jbc.m703663200

Cited by 422

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siRNA Screening of the Kinome Identifies ULK1 as a Multidomain Modulator of Autophagy

Chan, Edmond Y.W., Kir, Serkan, Tooze, Sharon A.·2007·Journal of Biological Chemistry

DOI 10.1074/jbc.m703663200

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ULK2 has a higher degree of identity with ULK1 than any of the other homologs.
“ULK2 has a higher degree of identity with ULK1 than any of the other homologs”
From Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1 (2021) · cites this paper as [640]
ULK1 and ULK2 may have both similar and distinct functions that are tissue- or cell-type specific.
“they may have both similar and distinct functions that are tissue-or cell-type specific [637-641]”
From Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1 (2021) · cites this paper as [640]

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Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments
Smyth, G. K. (2004) · Statistical Applications in Genetics and Molecular Biology · doi:10.2202/1544-6115.1027 · Cited by 11,829
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.
Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605
Induction of autophagy and inhibition of tumorigenesis by beclin 1
Liang, X. H., Jackson, S., Seaman, M., Brown, K., Kempkes, B., Hibshoosh, H., & Levine, B. (1999) · Nature · doi:10.1038/45257 · Cited by 3,347
The role of autophagy during the early neonatal starvation period
Kuma, A., Hatano, M., Matsui, M., Yamamoto, A., Nakaya, H., Yoshimori, T., Ohsumi, Y., Tokuhisa, T., & Mizushima, N. (2004) · Nature · doi:10.1038/nature03029 · Cited by 2,865
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
Ravikumar, B., Vacher, C., Berger, Z., Davies, J. E., Luo, S., Oroz, L. G., Scaravilli, F., Easton, D. F., Duden, R., O'Kane, C. J., et al. (2004) · Nature Genetics · doi:10.1038/ng1362 · Cited by 2,347
Impairment of starvation-induced and constitutive autophagy in Atg7 -deficient mice
Komatsu, M., Waguri, S., Ueno, T., Iwata, J., Murata, S., Tanida, I., Ezaki, J., Mizushima, N., Ohsumi, Y., Uchiyama, Y., et al. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200412022 · Cited by 2,331
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
Qu, X., Yu, J., Bhagat, G., Furuya, N., Hibshoosh, H., Troxel, A., Rosen, J., Eskelinen, E.-L., Mizushima, N., Ohsumi, Y., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci20039 · Cited by 2,311
Autophagy Is a Defense Mechanism Inhibiting BCG and Mycobacterium tuberculosis Survival in Infected Macrophages
Gutierrez, M. G., Master, S. S., Singh, S. B., Taylor, G. A., Colombo, M. I., & Deretic, V. (2004) · Cell · doi:10.1016/j.cell.2004.11.038 · Cited by 2,252
Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
Yue, Z., Jin, S., Yang, C., Levine, A. J., & Heintz, N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2436255100 · Cited by 2,116
Beclin–phosphatidylinositol 3‐kinase complex functions at the trans‐Golgi network
Kihara, A., Kabeya, Y., Ohsumi, Y., & Yoshimori, T. (2001) · The EMBO Reports · doi:10.1093/embo-reports/kve061 · Cited by 813
LC3, an Autophagosome Marker, Can be Incorporated into Protein Aggregates Independent of Autophagy: Caution in the Interpretation of LC3 Localization
Kuma, A., Matsui, M., & Mizushima, N. (2007) · Autophagy · doi:10.4161/auto.4012 · Cited by 555

Flagged first, then by citations

Research works printed but not linked: 46

Iwata, 2005, J. Biol. Chem., 280, 40282, 10.1074/jbc.M508786200 · DOI · Paper page
Rodriguez-Enriquez, 2004, Int. J. Biochem. Cell Biol., 36, 2463, 10.1016/j.biocel.2004.04.009 · DOI
Melendez, 2003, Science, 301, 1387, 10.1126/science.1087782 · DOI · Paper page
Otto, 2004, J. Biol. Chem., 279, 15621, 10.1074/jbc.M311139200 · DOI
Lum, 2005, Cell, 120, 237, 10.1016/j.cell.2004.11.046 · DOI · Paper page
Shimizu, 2004, Nat Cell Biol., 6, 1221, 10.1038/ncb1192 · DOI · Paper page
Daido, 2004, Cancer Res., 64, 4286, 10.1158/0008-5472.CAN-03-3084 · DOI
Scarlatti, 2004, J. Biol. Chem., 279, 18384, 10.1074/jbc.M313561200 · DOI · Paper page
Boya, 2005, Mol. Cell. Biol., 25, 1025, 10.1128/MCB.25.3.1025-1040.2005 · DOI
Ogawa, 2005, Science, 307, 727, 10.1126/science.1106036 · DOI
Thumm, 1994, FEBS Lett., 349, 275, 10.1016/0014-5793(94)00672-5 · DOI
Tsukada, 1993, FEBS Lett., 333, 169, 10.1016/0014-5793(93)80398-E · DOI
Klionsky, 2003, Dev. Cell, 5, 539, 10.1016/S1534-5807(03)00296-X · DOI
Suzuki, 2001, EMBO J., 20, 5971, 10.1093/emboj/20.21.5971 · DOI
Mizushima, 2001, J. Cell Biol., 152, 657, 10.1083/jcb.152.4.657 · DOI · Paper page
Kirisako, 2000, J. Cell Biol., 151, 263, 10.1083/jcb.151.2.263 · DOI
Kuma, 2002, J. Biol. Chem., 277, 18619, 10.1074/jbc.M111889200 · DOI
Ichimura, 2000, Nature, 408, 488, 10.1038/35044114 · DOI
Mizushima, 2004, Mol. Biol. Cell, 15, 1101, 10.1091/mbc.e03-09-0704 · DOI · Paper page
Kochl, 2006, Traffic, 7, 129, 10.1111/j.1600-0854.2005.00368.x · DOI
Kamada, 2000, J. Cell Biol., 150, 1507, 10.1083/jcb.150.6.1507 · DOI · Paper page
Budovskaya, 2005, Proc. Natl. Acad. Sci. U. S. A., 102, 13933, 10.1073/pnas.0501046102 · DOI
Scott, 2004, Dev Cell, 7, 167, 10.1016/j.devcel.2004.07.009 · DOI
Scott, 2007, Curr. Biol., 17, 1, 10.1016/j.cub.2006.10.053 · DOI
Kuroyanagi, 1998, Genomics, 51, 76, 10.1006/geno.1998.5340 · DOI
Yan, 1999, Oncogene, 18, 5850, 10.1038/sj.onc.1202988 · DOI
Young, 2006, J. Cell Sci., 119, 3888, 10.1242/jcs.03172 · DOI · Paper page
Lee, 2007, EMBO Rep., 8, 360, 10.1038/sj.embor.7400917 · DOI
Zhou, 2007, Proc. Natl. Acad. Sci. U. S. A., 104, 5842, 10.1073/pnas.0701402104 · DOI · Paper page
Tomoda, 1999, Neuron, 24, 833, 10.1016/S0896-6273(00)81031-4 · DOI
Ogier-Denis, 1996, J. Biol. Chem., 271, 28593, 10.1074/jbc.271.45.28593 · DOI
Ogier-Denis, 2000, J. Biol. Chem., 275, 39090, 10.1074/jbc.M006198200 · DOI
Blommaart, 1995, J. Biol. Chem., 270, 2320, 10.1074/jbc.270.5.2320 · DOI · Paper page
Moffat, 2007, Trends Pharmacol. Sci., 28, 149, 10.1016/j.tips.2007.02.009 · DOI
Houri, 1993, Biochem. Biophys. Res. Commun., 197, 805, 10.1006/bbrc.1993.2550 · DOI
Mavrakis, 2006, Hum. Mol. Genet., 15, 2962, 10.1093/hmg/ddl239 · DOI
Tomoda, 2004, Genes Dev., 18, 541, 10.1101/gad.1151204 · DOI
Okazaki, 2000, Brain Res. Mol. Brain Res., 85, 1, 10.1016/S0169-328X(00)00218-7 · DOI · Paper page
Kim, 2002, J. Biol. Chem., 277, 763, 10.1074/jbc.M109134200 · DOI · Paper page
Arico, 2001, J. Biol. Chem., 276, 35243, 10.1074/jbc.C100319200 · DOI
Samari, 2005, Biochem. J., 386, 237, 10.1042/BJ20040609 · DOI · Paper page
Inbal, 2002, J. Cell Biol., 157, 455, 10.1083/jcb.200109094 · DOI
Blommaart, 1997, Eur. J. Biochem., 243, 240, 10.1111/j.1432-1033.1997.0240a.x · DOI
Yan, 1998, Biochem. Biophys. Res. Commun., 246, 222, 10.1006/bbrc.1998.8546 · DOI
Tekinay, 2006, Eukaryot Cell, 5, 1797, 10.1128/EC.00342-05 · DOI
Abeliovich, 2003, Mol. Biol. Cell, 14, 477, 10.1091/mbc.e02-07-0413 · DOI

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy · doi:10.1080/15548627.2015.1100356 · Cited by 5,894
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Guidelines for the use and interpretation of assays for monitoring autophagy
Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., et al. (2012) · Autophagy · doi:10.4161/auto.19496 · Cited by 3,996
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Mizushima, N., Yoshimori, T., & Ohsumi, Y. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154005 · Cited by 2,978
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1
Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy · doi:10.1080/15548627.2020.1797280 · Cited by 2,897
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Jung, C. H., Ro, S.-H., Cao, J., Otto, N. M., & Kim, D.-H. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.01.017 · Cited by 2,090
Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy
Hosokawa, N., Hara, T., Kaizuka, T., Kishi, C., Takamura, A., Miura, Y., Iemura, S.-I., Natsume, T., Takehana, K., Yamada, N., et al. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-12-1248 · Cited by 2,076
ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery
Jung, C. H., Jun, C. B., Ro, S.-H., Kim, Y.-M., Otto, N. M., Cao, J., Kundu, M., & Kim, D.-H. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-12-1249 · Cited by 2,025
Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks
Alers, S., Löffler, A. S., Wesselborg, S., & Stork, B. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.06159-11 · Cited by 1,483
The role of the Atg1/ULK1 complex in autophagy regulation
Mizushima, N. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.12.004 · Cited by 1,062
Regulation of endoplasmic reticulum turnover by selective autophagy
Khaminets, A., Heinrich, T., Mari, M., Grumati, P., Huebner, A. K., Akutsu, M., Liebmann, L., Stolz, A., Nietzsche, S., Koch, N., et al. (2015) · Nature · doi:10.1038/nature14498 · Cited by 956
The mammalian ULK1 complex and autophagy initiation
Zachari, M., & Ganley, I. G. (2017) · Essays in Biochemistry · doi:10.1042/ebc20170021 · Cited by 789
RETRACTED: Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells
Martinez, J., Almendinger, J., Oberst, A., Ness, R., Dillon, C. P., Fitzgerald, P., Hengartner, M. O., & Green, D. R. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113421108 · Cited by 655
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Autophagy is a protective mechanism in normal cartilage, and its aging‐related loss is linked with cell death and osteoarthritis
Caramés, B., Taniguchi, N., Otsuki, S., Blanco, F. J., & Lotz, M. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27305 · Cited by 632
Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes
Narita, M., Young, A. R. J., Arakawa, S., Samarajiwa, S. A., Nakashima, T., Yoshida, S., Hong, S., Berry, L. S., Reichelt, S., Ferreira, M., et al. (2011) · Science · doi:10.1126/science.1205407 · Cited by 594
Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies
Sarkar, S., Ravikumar, B., Floto, R. A., & Rubinsztein, D. C. (2009) · Cell Death & Differentiation · doi:10.1038/cdd.2008.110 · Cited by 578
mTOR , metabolism, and the regulation of T‐cell differentiation and function
Waickman, A. T., & Powell, J. D. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01152.x · Cited by 420
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Sellier, C., Campanari, M., Julie Corbier, C., Gaucherot, A., Kolb‐Cheynel, I., Oulad‐Abdelghani, M., Ruffenach, F., Page, A., Ciura, S., Kabashi, E., et al. (2016) · The EMBO Journal · doi:10.15252/embj.201593350 · Cited by 414
Autophagy inhibitors
Pasquier, B. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2104-y · Cited by 329
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Löffler, A. S., Alers, S., Dieterle, A. M., Keppeler, H., Franz-Wachtel, M., Kundu, M., Campbell, D. G., Wesselborg, S., Alessi, D. R., & Stork, B. (2011) · Autophagy · doi:10.4161/auto.7.7.15451 · Cited by 258
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An, H., & Harper, J. W. (2018) · Nature Cell Biology · doi:10.1038/s41556-017-0007-x · Cited by 181
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Phadwal, K., Alegre-Abarrategui, J., Watson, A. S., Pike, L., Anbalagan, S., Hammond, E. M., Wade-Martins, R., McMichael, A., Klenerman, P., & Simon, A. K. (2012) · Autophagy · doi:10.4161/auto.18935 · Cited by 155
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Nakahira, K., Pabon Porras, M. A., & Choi, A. M. K. (2016) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201512-2468so · Cited by 78

Authors: Chan, E. Y. W., Kir, S., & Tooze, S. A.
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 2007-08
Volume: 282
Issue: 35
Pages: 25464-25474
ISSN: 0021-9258
DOI: 10.1074/jbc.m703663200
Cited by: 422
References: 11
Language: en
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 4838 d)

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siRNA Screening of the Kinome Identifies ULK1 as a Multidomain Modulator of Autophagy

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