The Regenerative Activity of Interleukin-6

The ground state of embryonic stem cell self-renewal

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Principles of interleukin (IL)-6-type cytokine signalling and its regulation

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The pro- and anti-inflammatory properties of the cytokine interleukin-6

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A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

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Evidence for Cardiomyocyte Renewal in Humans

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Interleukin-6 and the acute phase response

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Transient Regenerative Potential of the Neonatal Mouse Heart

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IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer

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Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin

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Hepatogastroenterology

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Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides

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Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α

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Liver Failure and Defective Hepatocyte Regeneration in Interleukin-6-Deficient Mice

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Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation

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Molecular cloning and expression of an IL-6 signal transducer, gp130

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Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in Crohn disease and experimental colitis in vivo

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Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment.

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Cloning and Expression of the Human Interleukin-6 (BSF-2/IFNβ 2) Receptor

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Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart

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gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis

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STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells

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Mesenchymal Stem Cells

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Interleukin-6 Is an Essential Regulator of Satellite Cell-Mediated Skeletal Muscle Hypertrophy

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Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer

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IL-6 and Its Soluble Receptor Orchestrate a Temporal Switch in the Pattern of Leukocyte Recruitment Seen during Acute Inflammation

Hurst, S. M., Wilkinson, T. S., McLoughlin, R. M., Jones, S., Horiuchi, S., Yamamoto, N., Rose-John, S., Fuller, G. M., Topley, N., & Jones, S. A. (2001) · Immunity · doi:10.1016/s1074-7613(01)00151-0 · Cited by 811 · see citing works

Soluble receptors for cytokines and growth factors: generation and biological function

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A myocardial lineage derives from Tbx18 epicardial cells

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Sustained axon regeneration induced by co-deletion of PTEN and SOCS3

Sun, F., Park, K. K., Belin, S., Wang, D., Lu, T., Chen, G., Zhang, K., Yeung, C., Feng, G., Yankner, B. A., et al. (2011) · Nature · doi:10.1038/nature10594 · Cited by 754 · see citing works

TGF-β Suppresses Tumor Progression in Colon Cancer by Inhibition of IL-6 trans-Signaling

Becker, C., Fantini, M. C., Schramm, C., Lehr, H. A., Wirtz, S., Nikolaev, A., Burg, J., Strand, S., Kiesslich, R., Huber, S., et al. (2004) · Immunity · doi:10.1016/j.immuni.2004.07.020 · Cited by 726 · see citing works

Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling

Jones, S. A., Scheller, J., & Rose‐John, S. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57158 · Cited by 683 · see citing works

Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses.

Jostock, T., Müllberg, J., Özbek, S., Atreya, R., Blinn, G., Voltz, N., Fischer, M., Neurath, M., & Rose-John, S. (2001) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2001.01867.x · Cited by 665 · see citing works

Loss of a gp130 Cardiac Muscle Cell Survival Pathway Is a Critical Event in the Onset of Heart Failure during Biomechanical Stress

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Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer

Rose‐John, S., Scheller, J., Elson, G., & Jones, S. A. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.1105674 · Cited by 647 · see citing works

Haemopoietic receptors and helical cytokines

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A reproducible and well-tolerated method for 2/3 partial hepatectomy in mice

Mitchell, C., & Willenbring, H. (2008) · Nature Protocols · doi:10.1038/nprot.2008.80 · Cited by 577 · see citing works

Transcriptional profiling identifies Id2 function in dendritic cell development

Hacker, C., Kirsch, R. D., Ju, X., Hieronymus, T., Gust, T. C., Kuhl, C., Jorgas, T., Kurz, S. M., Rose‐John, S., Yokota, Y., et al. (2003) · Nature Immunology · doi:10.1038/ni903 · Cited by 544 · see citing works

A bioactive designer cytokine for human hematopoietic progenitor cell expansion

Fischer, M., Goldschmitt, J., Peschel, C., Brakenhoff, J. P. J., Kallen, K., Wollmer, A., Grötzinger, J., & Rose‐John, S. (1997) · Nature Biotechnology · doi:10.1038/nbt0297-142 · Cited by 532 · see citing works

ADAM17: a molecular switch to control inflammation and tissue regeneration

Scheller, J., Chalaris, A., Garbers, C., & Rose‐John, S. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.05.005 · Cited by 526 · see citing works

The soluble interleukin‐6 receptor is generated by shedding

Müllberg, J., Schooltink, H., Stoyan, T., Günther, M., Graeve, L., Buse, G., Mackiewicz, A. A., Heinrich, P. C., & Rose‐John, S. (1993) · European Journal of Immunology · doi:10.1002/eji.1830230226 · Cited by 507 · see citing works

SOCS3 Deletion Promotes Optic Nerve Regeneration In Vivo

Smith, P. D., Sun, F., Park, K. K., Cai, B., Wang, C., Kuwako, K.-I., Martinez-Carrasco, I., Connolly, L., & He, Z. (2009) · Neuron · doi:10.1016/j.neuron.2009.11.021 · Cited by 500 · see citing works

Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration

Malato, Y., Naqvi, S., Schürmann, N., Ng, R., Wang, B., Zape, J., Kay, M. A., Grimm, D., & Willenbring, H. (2011) · Journal of Clinical Investigation · doi:10.1172/jci59261 · Cited by 434 · see citing works

The zebrafish heart regenerates after cryoinjury-induced myocardial infarction

Chablais, F., Veit, J., Rainer, G., & Jaźwińska, A. (2011) · BMC Developmental Biology · doi:10.1186/1471-213x-11-21 · Cited by 415 · see citing works

Cellular Cholesterol Depletion Triggers Shedding of the Human Interleukin-6 Receptor by ADAM10 and ADAM17 (TACE)

Matthews, V., Schuster, B., Schütze, S., Bussmeyer, I., Ludwig, A., Hundhausen, C., Sadowski, T., Saftig, P., Hartmann, D., Kallen, K.-J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210584200 · Cited by 390 · see citing works

Signal transducer and activator of transcription 3 is required for myocardial capillary growth, control of interstitial matrix deposition, and heart protection from ischemic injury

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IL-6/IL-6R axis plays a critical role in acute kidney injury.

Nechemia-Arbely, Y., Barkan, D., Pizov, G., Shriki, A., Rose-John, S., Galun, E., & Axelrod, J. (2008) · Journal of the American Society of Nephrology · doi:10.1681/asn.2007070744 · Cited by 371 · see citing works

Sympathetic neurons can produce and respond to interleukin 6.

März, P., Cheng, J. G., Gadient, R., Patterson, P. H., Stoyan, T., Otten, U., & Rose-John, S. (1998) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.95.6.3251 · Cited by 346 · see citing works

Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils

Chalaris, A., Rabe, B., Paliga, K., Lange, H., Laskay, T., Fielding, C. A., Jones, S. A., Rose‐John, S., & Scheller, J. (2007) · Blood · doi:10.1182/blood-2007-01-067918 · Cited by 330 · see citing works

Maintenance of Pluripotency in Human Embryonic Stem Cells Is STAT3 Independent

Humphrey, R. K., Beattie, G. M., Lopez, A. D., Bucay, N., King, C. C., Firpo, M. T., Rose‐John, S., & Hayek, A. (2004) · Stem Cells · doi:10.1634/stemcells.22-4-522 · Cited by 319 · see citing works

Acquiring signalling specificity from the cytokine receptor gp130

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Soluble IL-6 Receptor Governs IL-6 Activity in Experimental Arthritis: Blockade of Arthritis Severity by Soluble Glycoprotein 130

Nowell, M., Richards, P. J., Horiuchi, S., Yamamoto, N., Rose-John, S., Topley, N., Williams, A., & Jones, S. A. (2003) · Journal of Immunology · doi:10.4049/jimmunol.171.6.3202 · Cited by 293 · see citing works

The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6.

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Regeneration of Cryoinjury Induced Necrotic Heart Lesions in Zebrafish Is Associated with Epicardial Activation and Cardiomyocyte Proliferation

Schnabel, K., Wu, C. C., Kurth, T., & Weidinger, G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018503 · Cited by 274 · see citing works

Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice

Chalaris, A., Adam, N., Sina, C., Rosenstiel, P. C., Lehmann‐Koch, J., Schirmacher, P., Hartmann, D., Cichy, J., Gavrilova, O., Schreiber, S., et al. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20092366 · Cited by 269 · see citing works

Interleukin-6 regulates pancreatic α-cell mass expansion

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IL-6 <i>Trans</i>-Signaling Modulates TLR4-Dependent Inflammatory Responses via STAT3

Greenhill, C. J., Rose-John, S., Lissilaa, R., Ferlin, W., Ernst, M., Hertzog, P. J., Mansell, A., & Jenkins, B. J. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002971 · Cited by 264 · see citing works

IL-6 Signaling Promotes Tumor Growth in Colorectal Cancer

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A metalloprotease inhibitor blocks shedding of the IL-6 receptor and the p60 TNF receptor

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Therapeutic Targeting of IL-6 <i>Trans</i> Signaling Counteracts STAT3 Control of Experimental Inflammatory Arthritis

Nowell, M. A., Williams, A. S., Carty, S. A., Scheller, J., Hayes, A. J., Jones, G. W., Richards, P. J., Slinn, S., Ernst, M., Jenkins, B. J., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.1.613 · Cited by 215 · see citing works

Essential Roles of IL-6 Trans -Signaling in Colonic Epithelial Cells, Induced by the IL-6/Soluble–IL-6 Receptor Derived from Lamina Propria Macrophages, on the Development of Colitis-Associated Premalignant Cancer in a Murine Model

Matsumoto, S., Hara, T., Mitsuyama, K., Yamamoto, M., Tsuruta, O., Sata, M., Scheller, J., Rose‐John, S., Kado, S., & Takada, T. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0801217 · Cited by 211 · see citing works

The Cytokine Interleukin-6 Is Sufficient But Not Necessary to Mimic the Peripheral Conditioning Lesion Effect on Axonal Growth

Cao, Z.-X., Gao, Y., Bryson, J., Hou, J.-W., Chaudhry, N., Siddiq, M. M., Martinez, J., Spencer, T., Carmel, J., Hart, R. B., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0815-06.2006 · Cited by 201 · see citing works

Species Specificity of ADAM10 and ADAM17 Proteins in Interleukin-6 (IL-6) Trans-signaling and Novel Role of ADAM10 in Inducible IL-6 Receptor Shedding

Garbers, C., Jänner, N., Chalaris, A., Moss, M. L., Floss, D. M., Meyer, D., Koch-Nolte, F., Rose-John, S., & Scheller, J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.229393 · Cited by 201 · see citing works

The IL-6–gp130–STAT3 pathway in hepatocytes triggers liver protection in T cell–mediated liver injury

Klein, C., Wüstefeld, T., Assmus, U., Roskams, T., Rose-John, S., Müller, M., Manns, M. P., Ernst, M., & Trautwein, C. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200523640 · Cited by 200 · see citing works

Leukemia Inhibitory Factor Determines the Growth Status of Injured Adult Sensory Neurons

Cafferty, W. B. J., Gardiner, N. J., Gavazzi, I., Powell, J., McMahon, S. B., Heath, J. K., Munson, J. B., Cohen, J., & Thompson, S. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07161.2001 · Cited by 199 · see citing works

IL-6 Trans-Signaling in Formation and Progression of Malignant Ascites in Ovarian Cancer

Lo, C.-W., Chen, M., Hsiao, M., Wang, S., Chen, C., Hsiao, S., Chang, J., Lai, T., Rose‐John, S., Kuo, M., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1496 · Cited by 193 · see citing works

Novel Path to Activation of Vascular Smooth Muscle Cells: Up-Regulation of gp130 Creates an Autocrine Activation Loop by IL-6 and Its Soluble Receptor

Klouche, M., Bhakdi, S., Hemmes, M., & Rose‐John, S. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.8.4583 · Cited by 178 · see citing works

Interleukin-6/Glycoprotein 130-dependent Pathways Are Protective during Liver Regeneration

Wüestefeld, T., Klein, C., Streetz, K. L., Betz, U. A. K., Lauber, J., Buer, J., Manns, M. P., Müller, W., & Trautwein, C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208470200 · Cited by 176 · see citing works

Extramedullary Expansion of Hematopoietic Progenitor Cells in Interleukin (IL)-6–sIL-6R Double Transgenic Mice

Peters, M., Schirmacher, P., Goldschmitt, J., Odenthal, M., Peschel, C., Fattori, E., Ciliberto, G., Dienes, H., Buschenfelde, K. Z. Z., & Rose-John, S. (1997) · Journal of Experimental Medicine · doi:10.1084/jem.185.4.755 · Cited by 176 · see citing works

Targeted Activation of Innate Immunity for Therapeutic Induction of Autophagy and Apoptosis in Melanoma Cells

Tormo, D., Chęcińska, A., Alonso‐Curbelo, D., Pérez‐Guijarro, E., Cañón, E., Riveiro‐Falkenbach, E., Calvo, T. G., Larribère, L., Megı́as, D., Mulero, F., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.07.004 · Cited by 176 · see citing works

Interleukin-6 and Neural Stem Cells: More Than Gliogenesis

Islam, O., Gong, X.-D., Rose‐John, S., & Heese, K. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-05-0463 · Cited by 172 · see citing works

Selective blockade of interleukin-6 trans-signaling improves survival in a murine polymicrobial sepsis model

Barkhausen, T., Tschernig, T., Rosenstiel, P., van Griensven, M., Vonberg, R.-P., Dorsch, M., Mueller-Heine, A., Chalaris, A., Scheller, J., Rose-John, S., et al. (2011) · Critical Care Medicine · doi:10.1097/ccm.0b013e318211ff56 · Cited by 169 · see citing works

Shedding of interleukin‐6 receptor and tumor necrosis factor α

Althoff, K., Reddy, P., Voltz, N., Rose‐John, S., & Müllberg, J. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01278.x · Cited by 162 · see citing works

Regulation of liver regeneration and hepatocarcinogenesis by suppressor of cytokine signaling 3

Riehle, K. J., Campbell, J. S., McMahan, R. S., Johnson, M. M., Beyer, R. P., Bammler, T. K., & Fausto, N. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20070820 · Cited by 161 · see citing works

Neural activities of IL‐6‐type cytokines often depend on soluble cytokine receptors

März, P., Otten, U., & Rose-John, S. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00755.x · Cited by 142 · see citing works

Distinct role of gp130 activation in promoting self-renewal divisions by mitogenically stimulated murine hematopoietic stem cells

Audet, J., Miller, C., Rose‐John, S., Piret, J. M., & Eaves, C. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.1757 · Cited by 137 · see citing works

Intravenous Gene Therapy With PIM-1 Via a Cardiotropic Viral Vector Halts the Progression of Diabetic Cardiomyopathy Through Promotion of Prosurvival Signaling

Katare, R., Caporali, A., Zentilin, L., Avolio, E., Sala‐Newby, G. B., Oikawa, A., Cesselli, D., Beltrami, A. P., Giacca, M., Emanueli, C., et al. (2011) · Circulation Research · doi:10.1161/circresaha.110.239111 · Cited by 130 · see citing works

Kidney regeneration

Benigni, A., Morigi, M., & Remuzzi, G. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60237-1 · Cited by 130 · see citing works

Combined interleukin 6 and soluble interleukin 6 receptor accelerates murine liver regeneration

Peters, M., Blinn, G., Jostock, T., Schirmacher, P., Büschenfelde, K. M. Z., Galle, P. R., & Rose–John, S. (2000) · Gastroenterology · doi:10.1053/gast.2000.20236 · Cited by 129 · see citing works

Suppressor of Cytokine Signaling-3 Suppresses the Ability of Activated Signal Transducer and Activator of Transcription-3 to Stimulate Neurite Growth in Rat Primary Sensory Neurons

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Coexpression of IL‐6 and soluble IL‐6R causes nodular regenerative hyperplasia and adenomas of the liver

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In Vivo and In Vitro Activities of the gp130-Stimulating Designer Cytokine Hyper-IL-6

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Ligand/Receptor Signaling Threshold (LIST) Model Accounts for gp130‐Mediated Embryonic Stem Cell Self‐Renewal Responses to LIF and HIL‐6

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Hyper-IL-6 Gene Therapy Reverses Fulminant Hepatic Failure

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TGF-beta suppresses tumor progression in colon cancer by inhibition of IL–6 trans-signaling

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Dendritic cell lineage commitment is instructed by distinct cytokine signals

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gp130-Stimulating designer cytokine Hyper-interleukin-6 synergizes with murine stroma for long-term survival of primitive human hematopoietic progenitor cells

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Interleukin-6 Trans-Signaling Regulates Glycogen Consumption After d -Galactosamine-Induced Liver Damage

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Crystal structure of a recombinant form of the maltodextrin-binding protein carrying an inserted sequence of a B-cell epitope from the preS2 region of hepatitis B virus

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The Transcription Factor Repertoire of Flt3+ Hematopoietic Stem Cells

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dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration

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Mesenchymal Stromal Cells and Exosomes: Progress and Challenges

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Therapeutic Irrigant Procedures for Treating Apical Periodontitis ( TIPTAP ): A triple‐blinded parallel‐group randomized controlled phase I/ II trial

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Treatment of Equine Tarsus Long Medial Collateral Ligament Desmitis with Allogenic Synovial Membrane Mesenchymal Stem/Stromal Cells Enhanced by Umbilical Cord Mesenchymal Stem/Stromal Cell-Derived Conditioned Medium: Proof of Concept

Reis, I. L., Lopes, B., Sousa, P., Sousa, A. C., Branquinho, M., Caseiro, A. R., Rêma, A., Briote, I., Mendonça, C., Santos, J. M., et al. (2024) · Animals · doi:10.3390/ani14030370 · Cited by 5 · see citing works

Reprint of: Preclinical characterization of DUOC-01, a cell therapy product derived from banked umbilical cord blood for use as an adjuvant to umbilical cord blood transplantation for treatment of inherited metabolic diseases

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Interleukin-11 plays a key role in human and mouse alcohol-related liver diseasePreprint

Effenberger, M., Grabherr, F., Schaefer, B., Grander, C., Mayr, L., Schwärzler, J., Enrich, B., Moser, P. L., Fink, J., Pedrini, A., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.24.456749 · Cited by 2 · see citing works

Innate Immunity and Disorders of the Liver

Heikenwalder, M., Knolle, P., & Protzer, U. (2014) · Springer eBooks · doi:10.1007/978-3-319-02096-9_6

Microwell Geometry Modulates Interleukin-6 Secretion in Human Mesenchymal Stem Cells

Xu, X., Wang, W., Li, Z., Kratz, K. L., Ma, N., & Lendlein, A. (2017) · MRS Advances · doi:10.1557/adv.2017.487 · Cited by 1 · see citing works

Overturning the paradigm that IL6 signaling drives liver regrowth while shining light on a new therapeutic target for regenerative medicinePreprint

Dong, J., Viswanathan, S., Adami, E., Schäfer, S., Kuthubudeen, F. F., Widjaja, A. A., & Cook, S. A. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.04.05.438446 · Cited by 1 · see citing works

Strahleninduzierte Expression von pro-inflammatorischen Zytokinen nach selektiver Ganzleberbestrahlung in vivo (Ratte)

Reuter, F. (2017) · doi:10.53846/goediss-6611

Title page

Filippo, R., & Alberto, R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-817838-6.00012-7

Recent Advances In Interventional Pain Management

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IL-6 Trans-Signaling via the Soluble IL-6 Receptor: Importance for the Pro-Inflammatory Activities of IL-6

Rose-John, S. (2012) · International Journal of Biological Sciences · doi:10.7150/ijbs.4989 · Cited by 1,040 · see citing works

Combined interleukin 6 and soluble interleukin 6 receptor accelerates murine liver regeneration

Peters, M., Blinn, G., Jostock, T., Schirmacher, P., Büschenfelde, K. M. Z., Galle, P. R., & Rose–John, S. (2000) · Gastroenterology · doi:10.1053/gast.2000.20236 · Cited by 129 · see citing works

Interleukin-6 and its receptor: from bench to bedside

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Impact of interleukin-6 classic- and trans-signaling on liver damage and regeneration

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Interleukin-6 Trans-Signaling Regulates Glycogen Consumption After d -Galactosamine-Induced Liver Damage

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