Cited by 257Adipose Tissue and MetabolismMetabolism, Diabetes, and CancerMuscle Physiology and Disorders

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A role for the transcriptional coactivator PGC-1α in muscle refueling.

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Wende, Adam R., Schaeffer, Paul J., Parker, Glendon J., Zechner, Christoph, Han, Dong-Ho, Chen, May M., Hancock, Chad R., Lehman, John J., Huss, Janice M., McClain, Donald A., Holloszy, John O., Kelly, Daniel P.·2007·Journal of Biological Chemistry

DOI 10.1074/jbc.m707006200

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Abstract

The transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) has been identified as an inducible regulator of mitochondrial function. Skeletal muscle PGC-1alpha expression is induced post-exercise. Therefore, we sought to determine its role in the regulation of muscle fuel metabolism. Studies were performed using conditional, muscle-specific, PGC-1alpha gain-of-function and constitutive, generalized, loss-of-function mice. Forced expression of PGC-1alpha increased muscle glucose uptake concomitant with augmentation of glycogen stores, a metabolic response similar to post-exercise recovery. Induction of muscle PGC-1alpha expression prevented muscle glycogen depletion during exercise. Conversely, PGC-1alpha-deficient animals exhibited reduced rates of muscle glycogen repletion post-exercise. PGC-1alpha was shown to increase muscle glycogen stores via several mechanisms including stimulation of glucose import, suppression of glycolytic flux, and by down-regulation of the expression of glycogen phosphorylase and its activating kinase, phosphorylase kinase alpha. These findings identify PGC-1alpha as a critical regulator of skeletal muscle fuel stores.

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Background
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Background
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Growth hormone secretagogue receptor‐1a mediates ghrelin's effects on attenuating tumour‐induced loss of muscle strength but not muscle mass
Liu, H. M., Zang, P., Lee, I., Anderson, B., Christiani, A. J., Strait‐Bodey, L., Breckheimer, B. A., Storie, M., Tewnion, A., Krumm, K., et al. (2021) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12743 · Cited by 15
“Kelly’s lab.(44) Briefly, the GAS/PL sections were incubated with a mixed solution with 10 ml”
Method
Skeletal muscle PGC-1β signaling is sufficient to drive an endurance exercise phenotype and to counteract components of detraining in mice
Lee, S., Leone, T. C., Rogosa, L., Rumsey, J. W., Ayala, J. E., Coen, P. M., Fitts, R. H., Vega, R. B., & Kelly, D. P. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00380.2016 · Cited by 16
PPARGC1A rs8192678 and NRF1 rs6949152 Polymorphisms Are Associated with Muscle Fiber Composition in Women
Yvert, T. P., Miyamoto‐Mikami, E., Tobina, T., Shiose, K., Kakigi, R., Tsuzuki, T., Takaragawa, M., Ichinoseki‐Sekine, N., Pérez, M., Kobayashi, H., et al. (2020) · Genes · doi:10.3390/genes11091012 · Cited by 17
Acute low-intensity cycling with blood-flow restriction has no effect on metabolic signaling in human skeletal muscle compared to traditional exercise
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“Furthermore, PGC-1a was shown to play a role in improving glucose homeostasis and fuel storage in skeletal muscle (Wende et al., 2007; Summermatter et al., 2013).”
Background
Effects of exercise training with short‐duration intermittent hypoxia on endurance performance and muscle metabolism in well‐trained mice
Suzuki, J. (2019) · Physiological Reports · doi:10.14814/phy2.14182 · Cited by 16
“Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society. replenishment in skeletal muscle (Wende et al. 2007).”
Background
The guardian of the genome p53 regulates exercise‐induced mitochondrial plasticity beyond organelle biogenesis
Smiles, W. J., & CAMERA, D. M. (2017) · Acta Physiologica · doi:10.1111/apha.13004 · Cited by 15
Transcriptomic Responses of Skeletal Muscle to Acute Exercise in Diabetic Goto-Kakizaki Rats
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“In addition, transgenic increased expression of Ppargc1a in the skeletal muscle enhanced glucose uptake (Wende et al., 2007; Zhang et al., 2013; Wu et al., 2016).”
Background
PGC-1α: important for exercise performance?
Pilegaard, H., & Richter, E. A. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90346.2008 · Cited by 17
Differential acute and chronic responses in insulin action in cultured myotubes following from nondiabetic severely obese humans following gastric bypass surgery
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“shown by previous groups to be altered with PGC1α overexpression [16], tended to increase in myotubes derived from surgery patients at 7 months following RYGB surgery (Fig.”
Background
Effect of endurance training and PGC-1α overexpression on calculated lactate production volume during exercise based on blood lactate concentration
Takeda, R., Nonaka, Y., Kakinoki, K., Miura, S., Kano, Y., & Hoshino, D. (2022) · Scientific Reports · doi:10.1038/s41598-022-05593-1 · Cited by 16
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Muscles proteome analysis; irisin administration mimics some molecular effects of exercise in quadriceps muscle
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The Arylamine N-Acetyltransferases as Therapeutic Targets in Metabolic Diseases Associated with Mitochondrial Dysfunction
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Nuclear receptors and epigenetic signaling: Novel regulators of glycogen metabolism in skeletal muscle
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The effects of PGC-1α on control of microvascular P o 2kinetics following onset of muscle contractions
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Dietary β-Conglycinin Modulates Insulin Sensitivity, Body Fat Mass, and Lipid Metabolism in Obese Otsuka Long-Evans Tokushima Fatty (OLETF) Rats
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“Transgenically over-expressed PGC-1a in mice induces mitochondrial biogenesis and yields muscle with an increased oxidative capacity (Wende et al. 2007).”
BackgroundMethod
Genomics as a practical tool in sport - have we reached the starting line?
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Molecular Mechanisms Mediating Adaptation to Exercise
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More than mitochondrial biogenesis: alternative roles of PGC‐1α in exercise adaptation
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“Previous experiments also show that PGC-1α regulates the expression of PDK4, an enzyme responsible for restraining glucose oxidation, along with genes involved in post-exercise glucose uptake (GLUT1 and GLUT4 transporters) and glycogen storage (hexokinase) (Wende et al. 2007).”
Background
Modulation of PGC-1α activity as a treatment for metabolic and muscle-related diseases
Svensson, K., & Handschin, C. (2014) · Drug Discovery Today · doi:10.1016/j.drudis.2014.02.013 · Cited by 13
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p38α MAPK Regulation of Energy Metabolism in Skeletal Muscle Offers a Therapeutic Path for Type 2 Diabetes
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Effectiveness of sub-maximal intermittent exercise on muscle glycogen depletion, PGC-1α and PDK-4 gene expression
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“nuclear respiratory factors, transcription factor A) [4-6].”
Effect of PPARGC1A on the development and metabolism of early rabbit embryos in vitro
Zhang, G., Guo, Y., Deng, M., Wan, Y., Deng, K., Xiao, S., Meng, F., Wang, F., & Lei, Z. (2019) · Molecular Reproduction and Development · doi:10.1002/mrd.23269 · Cited by 10
“PPARGC1A overexpression in transgenic mice increased glucose uptake concomitant with the augmentation of glycogen stores (Wende et al., 2007), while PPARGC1A knockdown dramatically reduced glucose‐6‐phosphatase level and caused abnormal glycolysis (Shlomai et al., 2012).”
Background
Skeletal muscle alterations in tachycardia-induced heart failure are linked to deficient natriuretic peptide signalling and are attenuated by RAS-/NEP-inhibition
Dietl, A., Winkel, I., Pietrzyk, G., Paulus, M. G., Bruckmann, A., Schröder, J. A., Sossalla, S. T., Luchner, A., Maier, L. S., & Birner, C. M. (2019) · PLoS ONE · doi:10.1371/journal.pone.0225937 · Cited by 9
“Forming an overall perspective of the results so far, the histological and metabolic findings drew the picture of an suppressed PGC-1α signalling, as PGC-1α exerts pleiotropic effects [78], which are opposite to our findings: PGC-1α mediates the maintenance of normal muscle fibre-type composition[79,80], suppresses th…”
Result
Mechanisms of exercise- and training-induced fatty acid oxidation in skeletal muscle
Miura, S., Tadaishi, M., Kamei, Y., & Ezaki, O. (2014) · The Journal of Physical Fitness and Sports Medicine · doi:10.7600/jpfsm.3.43 · Cited by 9
Effect of 12-wk Training in Ovariectomised Rats on PGC-1α, NRF-1 and Energy Substrates
Pejon, T. M. M., Faria, V. S., Gobatto, C. A., Manchado-Gobatto, F. D. B., Scariot, P. P. M., Cornachione, A. S., & Beck, W. R. (2022) · International Journal of Sports Medicine · doi:10.1055/a-1717-1693 · Cited by 7
Chromium propionate in turkeys: effects on insulin sensitivity
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Respiratory issues in patients with multiple sclerosis as a risk factor during SARS-CoV-2 infection: a potential role for exercise
Razi, O., Teixeira, A. M., Tartibian, B., Zamani, N., & Knechtle, B. (2022) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04610-1 · Cited by 8
CREB-regulated transcription during glycogen synthesis in astrocytes
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Skeletal Muscle Adaptation to Exercise
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Muscle-specific deletion of Arid5b causes metabolic changes in skeletal muscle that affect adipose tissue and liver
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Vitamin C supplementation does not alter high-intensity endurance training-induced mitochondrial biogenesis in rat epitrochlearis muscle
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Skeletal muscle metabolic gene response to carbohydrate feeding during exercise in the heat
Dumke, C. L., Slivka, D. R., Cuddy, J. S., Hailes, W. S., & Ruby, B. C. (2013) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-10-40 · Cited by 6
“For the other genes investigated, this study is consistent with previous literature which shows that the expression of GLUT4 [22] and PGC-1α mRNA is elevated following exercise [6,17,18].”
BackgroundResult

Authors: Wende, A. R., Schaeffer, P. J., Parker, G. J., Zechner, C., Han, D.-H., Chen, M. M., Hancock, C. R., Lehman, J. J., Huss, J. M., McClain, D. A., Holloszy, J. O., & Kelly, D. P.
Affiliations: Washington University in St. Louis (US)
University of Utah (US)
Corresponding author: Kelly, Daniel P.
ORCID: Wende, Adam R.
Parker, Glendon J.
Zechner, Christoph
Hancock, Chad R.
McClain, Donald A.
Kelly, Daniel P.
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 2007-12
Volume: 282
Issue: 50
Pages: 36642-36651
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.m707006200
OpenAlex: W2130246533
Cited by: 257
References: 69
Citations by year: 2026: 2 · 2025: 8 · 2024: 5 · 2023: 6 · 2022: 7 · 2021: 9 · 2020: 10 · 2019: 10 · 2018: 15 · 2017: 18 · 2016: 14 · 2015: 10 · 2014: 26 · 2013: 23 · 2012: 17
FWCI: 13.42
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 4708 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p60dk020579-35)
National Institute on Aging (R01AG000425)
National Heart, Lung, and Blood Institute (T32HL007275)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK045416, P60-DK-020579, P30DK056341, P30DK052574, R01DK074700)
Topics: Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords: PGC-1α, glycogen stores, glucose uptake, post-exercise recovery, mitochondrial biogenesis, glycogen phosphorylase, glycolytic flux, glucose transport
MeSH terms: Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Animals, Glucose, Glycogen, Mice, Transgenic, Mitochondria, Muscle, Muscle Proteins, Phosphorylase Kinase, Transcription Factors, Trans-Activators, Muscle, Skeletal, Glycogen Phosphorylase, Mice

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A role for the transcriptional coactivator PGC-1α in muscle refueling.

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