Holloszy, John O.

Biochemical Adaptations in Muscle

Holloszy, J. O. (1967) · Journal of Biological Chemistry

Cardiovascular and exercise physiologyMitochondrial Function and Pathology

Cited by 1,517

Biochemical Adaptations to Endurance Exercise in Muscle

Holloszy, J. O., & Booth, F. W. (1976) · Annual Review of Physiology

Cardiovascular and exercise physiologyExercise and Physiological Responses

Cited by 1,053

Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1

Baar, K., Wende, A. R., Jones, T. E., Marison, M., Nolte, L. A., Chen, M., Kelly, D. P., & Holloszy, J. O. (2002) · The FASEB Journal

Adipose Tissue and MetabolismMetabolism, Diabetes, and Cancer

Cited by 1,020

Long-Term Calorie Restriction Is Highly Effective in Reducing the Risk for Atherosclerosis in Humans

Fontana, L., Meyer, T. E., Klein, S., & Holloszy, J. O. (2004) · Proceedings of the National Academy of Sciences

Dietary Effects on HealthNutritional Studies and Diet

Cited by 902

Effects of Exercise Training on Frailty in Community‐Dwelling Older Adults: Results of a Randomized, Controlled Trial

Binder, E. F., Schechtman, K. B., Ehsani, A. A., Steger‐May, K., Brown, M., Sinacore, D. R., Yarasheski, K. E., & Holloszy, J. O. (2002) · Journal of the American Geriatrics Society

Frailty in Older AdultsNutrition and Health in Aging

Cited by 549

High-fat diets cause insulin resistance despite an increase in muscle mitochondria

Hancock, C. R., Han, D.-H., Chen, M., Terada, S., Yasuda, T., Wright, D. C., & Holloszy, J. O. (2008) · Proceedings of the National Academy of Sciences

Adipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

Cited by 538

Exercise-induced increase in muscle insulin sensitivity

Holloszy, J. O. (2005) · Journal of Applied Physiology

Metabolism, Diabetes, and CancerMuscle metabolism and nutrition

Cited by 494

A 2-year randomized controlled trial of human caloric restriction: Feasibility and effects on predictors of health span and longevity

Ravussin, E., Redman, L. M., Rochon, J., Das, S. K., Fontana, L., Kraus, W. E., Romashkan, S., Williamson, D. A., Meydani, S. N., Villareal, D. T., et al. (2015) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

Genetics, Aging, and Longevity in Model OrganismsDietary Effects on Health

Cited by 489

Exercise-induced mitochondrial biogenesis begins before the increase in muscle PGC-1α expression.

Wright, D. C., Han, D.-H., Garcia-Roves, P. M., Geiger, P. C., Jones, T. E., & Holloszy, J. O. (2007) · Journal of Biological Chemistry

Adipose Tissue and MetabolismMitochondrial Function and Pathology

Cited by 488

2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial

Kraus, W. E., Bhapkar, M., Huffman, K. M., Pieper, C. F., Krupa Das, S., Redman, L. M., Villareal, D. T., Rochon, J., Roberts, S. B., Ravussin, E., et al. (2019) · The Lancet Diabetes & Endocrinology

Dietary Effects on HealthNutritional Studies and Diet

Cited by 407

Long-term caloric restriction ameliorates the decline in diastolic function in humans

Meyer, T. E., Kovács, S. J., Ehsani, A. A., Klein, S., Holloszy, J. O., & Fontana, L. (2006) · Journal of the American College of Cardiology

Cardiovascular Function and Risk FactorsCardiovascular Health and Disease Prevention

Cited by 383

Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial

Weiss, E. P., Racette, S. B., Villareal, D. T., Fontana, L., Steger-May, K., Schechtman, K. B., Klein, S., & Holloszy, J. O. (2006) · The American Journal of Clinical Nutrition

Diabetes, Cardiovascular Risks, and LipoproteinsAdipokines, Inflammation, and Metabolic Diseases

Cited by 353

Calcium Induces Increases in Peroxisome Proliferator-activated Receptor γ Coactivator-1α and Mitochondrial Biogenesis by a Pathway Leading to p38 Mitogen-activated Protein Kinase Activation

Wright, D. C., Geiger, P. C., Han, D.-H., Jones, T. E., & Holloszy, J. O. (2007) · Journal of Biological Chemistry

Adipose Tissue and MetabolismMetabolism, Diabetes, and Cancer

Cited by 309

Insulin resistance in aging is related to abdominal obesity

Kohrt, W. M., Kirwan, J. P., Staten, M. A., Bourey, R. E., King, D. S., & Holloszy, J. O. (1993) · Diabetes

Diabetes, Cardiovascular Risks, and LipoproteinsAdipokines, Inflammation, and Metabolic Diseases

Cited by 303

Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice

Li, B., Nolte, L. A., Ju, J.-S., Ho Han, D., Coleman, T., Holloszy, J. O., & Semenkovich, C. F. (2000) · Nature Medicine

Adipose Tissue and MetabolismMetabolism, Diabetes, and Cancer

Cited by 291

A potential link between muscle peroxisome proliferator- activated receptor-α signaling and obesity-related diabetes

Finck, B. N., Bernal-Mizrachi, C., Han, D. H., Coleman, T., Sambandam, N., LaRiviere, L. L., Holloszy, J. O., Semenkovich, C. F., & Kelly, D. P. (2005) · Cell Metabolism

Peroxisome Proliferator-Activated ReceptorsMetabolism, Diabetes, and Cancer

Cited by 270

A role for the transcriptional coactivator PGC-1α in muscle refueling.

Wende, A. R., Schaeffer, P. J., Parker, G. J., Zechner, C., Han, D.-H., Chen, M. M., Hancock, C. R., Lehman, J. J., Huss, J. M., McClain, D. A., et al. (2007) · Journal of Biological Chemistry

Adipose Tissue and MetabolismMetabolism, Diabetes, and Cancer

Cited by 257

Raising plasma fatty acid concentration induces increased biogenesis of mitochondria in skeletal muscle

Garcia-Roves, P., Huss, J. M., Han, D.-H., Hancock, C. R., Iglesias-Gutierrez, E., Chen, M., & Holloszy, J. O. (2007) · Proceedings of the National Academy of Sciences

Adipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

Cited by 246

Activation of AMP kinase enhances sensitivity of muscle glucose transport to insulin

Fisher, J. S., Gao, J., Han, D.-H., Holloszy, J. O., & Nolte, L. A. (2002) · American Journal of Physiology-Endocrinology and Metabolism

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 244

Effect of DHEA on Abdominal Fat and Insulin Action in Elderly Women and Men: A Randomized Controlled Trial

Villareal, D. T., & Holloszy, J. O. (2004) · JAMA

Hormonal and reproductive studiesMenopause: Health Impacts and Treatments

Cited by 241

One Year of Caloric Restriction in Humans: Feasibility and Effects on Body Composition and Abdominal Adipose Tissue

Racette, S. B., Weiss, E. P., Villareal, D. T., Arif, H., Steger-May, K., Schechtman, K. B., Fontana, L., Klein, S., & Holloszy, J. O. (2006) · The Journals of Gerontology: Series A

Dietary Effects on HealthRegulation of Appetite and Obesity

Cited by 237

Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans

Meydani, S. N., Das, S. K., Pieper, C. F., Lewis, M. R., Klein, S., Dixit, V. D., Gupta, A. K., Villareal, D. T., Bhapkar, M., Huang, M., et al. (2016) · Aging

Dietary Effects on HealthGenetics, Aging, and Longevity in Model Organisms

Cited by 228

Lower extremity muscle size and strength and aerobic capacity decrease with caloric restriction but not with exercise-induced weight loss

Weiss, E. P., Racette, S. B., Villareal, D. T., Fontana, L., Steger-May, K., Schechtman, K. B., Klein, S., Ehsani, A. A., Holloszy, J. O., & Washington University School of Medicine CALERIE Group (2007) · Journal of Applied Physiology

Cardiovascular and exercise physiologyNutrition and Health in Aging

Cited by 218

Effects of 7 days of exercise training on insulin sensitivity and responsiveness in type 2 diabetes mellitus

Kirwan, J. P., Solomon, T. P. J., Wojta, D. M., Staten, M. A., & Holloszy, J. O. (2009) · American Journal of Physiology-Endocrinology and Metabolism

Diabetes, Cardiovascular Risks, and LipoproteinsPhysical Activity and Health

Cited by 218