The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Cell Cycle-dependent Complex Formation of BRCA1·CtIP·MRN Is Important for DNA Double-strand Break Repair
Open accessAbstract
BRCA1 plays an important role in the homologous recombination (HR)-mediated DNA double-strand break (DSB) repair, but the mechanism is not clear. Here we describe that BRCA1 forms a complex with CtIP and MRN (Mre11/Rad50/Nbs1) in a cell cycle-dependent manner. Significantly, the complex formation, especially the ionizing radiation-enhanced association of BRCA1 with MRN, requires cyclin-dependent kinase activity. CtIP directly interacts with Nbs1. The in vivo association of BRCA1 with MRN is largely dependent on the association of CtIP with the BRCT domains at the C terminus of BRCA1, whereas the N terminus of BRCA1 also contributes to its association with MRN. CtIP, as well as the interaction of BRCA1 with CtIP and MRN, is critical for IR-induced single-stranded DNA formation and cellular resistance to radiation. Consistently, CtIP itself is required for efficient HR-mediated DSB repair, like BRCA1 and MRN. These studies suggest that the complex formation of BRCA1.CtIP.MRN is important for facilitating DSB resection to generate single-stranded DNA that is needed for HR-mediated DSB repair. Because cyclin-dependent kinase is important for establishing IR-enhanced interaction of MRN with BRCA1, we propose that the cell cycle-dependent complex formation of BRCA1, CtIP, and MRN contributes to the activation of HR-mediated DSB repair in the S and G(2) phases of the cell cycle.
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Cites
Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes
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Human CtIP promotes DNA end resection
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Brca1 Controls Homology-Directed DNA Repair
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ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
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DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1
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Chk2 Phosphorylation of BRCA1 Regulates DNA Double-Strand Break Repair
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Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes
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Cited by
Mechanisms of DNA damage, repair, and mutagenesis
Chatterjee, N., & Walker, G. C. (2017) · Environmental and Molecular Mutagenesis · doi:10.1002/em.22087 · Cited by 2,039
“Initial resection occurs by the endonuclease activity of MRN, with the help of CtIP, followed by long-range resection by EXO1 or BLM together with DNA2 [Chen et al., 2008; Nimonkar et al., 2011].”
Non-homologous DNA end joining and alternative pathways to double-strand break repair
Chang, H. H. Y., Pannunzio, N. R., Adachi, N., & Lieber, M. R. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.48 · Cited by 1,757
53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks
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Playing the End Game: DNA Double-Strand Break Repair Pathway Choice
Chapman, J. R., Taylor, M. R. G., & Boulton, S. J. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.07.029 · Cited by 1,625
Double-Strand Break End Resection and Repair Pathway Choice
Symington, L. S., & Gautier, J. (2011) · Annual Review of Genetics · doi:10.1146/annurev-genet-110410-132435 · Cited by 1,493
Metadata
- Authors
- Chen, L., Nievera, C. J., Lee, A. Y.-L., & Wu, X.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2008-03
- Volume
- 283
- Issue
- 12
- Pages
- 7713-7720
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1592309404
- Cited by
- 424
- References
- 11
- FWCI
- 12.28
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Chen, L., Nievera, C. J., Lee, A. Y.-L., & Wu, X. (2008). Cell Cycle-dependent Complex Formation of BRCA1·CtIP·MRN Is Important for DNA Double-strand Break Repair. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m710245200
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