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Identification of a New Functional Domain in Angiopoietin-like 3 (ANGPTL3) and Angiopoietin-like 4 (ANGPTL4) Involved in Binding and Inhibition of Lipoprotein Lipase (LPL)
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The N-terminal domain of ANGPTL3 contains the conserved SE1/LPL inhibitory domain (amino acids 32-55), a domain found in ANGPTL3 and ANGPTL4 known to be important for the binding and inhibition of LPL.
“The N-terminal domain contains the conserved SE1/LPL inhibitory domain (amino acids 32–55), a domain found in ANGPTL3 and ANGPTL4 known to be important for the binding and inhibition of LPL (17).”
From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [17]
ANGPTL4 deficiency in mice results in lower plasma triglycerides.
“ANGPTL4 deficiency in mice also results in lower plasma triglycerides (16, 17, 59)”
From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [17]
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Wang, Y., Quagliarini, F., Gusarova, V., Gromada, J., Valenzuela, D. M., Cohen, J. C., & Hobbs, H. H. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1315292110 · Cited by 317
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Kersten, S. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.119 · Cited by 220
Gusarova, V., Alexa, C. A., Wang, Y., Rafique, A., Kim, J. H., Buckler, D., Mintah, I. J., Shihanian, L. M., Cohen, J. C., Hobbs, H. H., et al. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m054890 · Cited by 210
Adam, R. C., Mintah, I. J., Alexa-Braun, C. A., Shihanian, L. M., Lee, J. S., Banerjee, P., Hamon, S. C., Kim, H. I., Cohen, J. C., Hobbs, H. H., et al. (2020) · Journal of Lipid Research · doi:10.1194/jlr.ra120000888 · Cited by 208
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Minicocci, I., Montali, A., Robciuc, M. R., Quagliarini, F., Censi, V., Labbadia, G., Gabiati, C., Pigna, G., Sepe, M. L., Pannozzo, F., et al. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1298 · Cited by 168
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“Although a direct interaction has been established, exact mechanism of LPL inhibition is still not fully elucidated [3–5].”
Metadata
- Authors
- Lee, E.-C., Desai, U., Gololobov, G., Hong, S., Feng, X., Yu, X.-C., Gay, J., Wilganowski, N., Gao, C., Du, L.-L., Chen, J., Hu, Y., Zhao, S., Kirkpatrick, L., Schneider, M., Zambrowicz, B. P., Landes, G., Powell, D. R., & Sonnenburg, W. K.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 284
- Issue
- 20
- Pages
- 13735-13745
- ISSN
- 0021-9258
- Cited by
- 151
- References
- 3
- Language
- en
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