Lactobacillus rhamnosus CNCMI-4317 Modulates Fiaf/Angptl4 in Intestinal Epithelial Cells and Circulating Level in Mice
Open accessAbstract
BACKGROUND AND OBJECTIVES: Identification of new targets for metabolic diseases treatment or prevention is required. In this context, FIAF/ANGPTL4 appears as a crucial regulator of energy homeostasis. Lactobacilli are often considered to display beneficial effect for their hosts, acting on different regulatory pathways. The aim of the present work was to study the effect of several lactobacilli strains on Fiaf gene expression in human intestinal epithelial cells (IECs) and on mice tissues to decipher the underlying mechanisms. SUBJECTS AND METHODS: Nineteen lactobacilli strains have been tested on HT-29 human intestinal epithelial cells for their ability to regulate Fiaf gene expression by RT-qPCR. In order to determine regulated pathways, we analysed the whole genome transcriptome of IECs. We then validated in vivo bacterial effects using C57BL/6 mono-colonized mice fed with normal chow. RESULTS: We identified one strain (Lactobacillus rhamnosus CNCMI-4317) that modulated Fiaf expression in IECs. This regulation relied potentially on bacterial surface-exposed molecules and seemed to be PPAR-γ independent but PPAR-α dependent. Transcriptome functional analysis revealed that multiple pathways including cellular function and maintenance, lymphoid tissue structure and development, as well as lipid metabolism were regulated by this strain. The regulation of immune system and lipid and carbohydrate metabolism was also confirmed by overrepresentation of Gene Ontology terms analysis. In vivo, circulating FIAF protein was increased by the strain but this phenomenon was not correlated with modulation Fiaf expression in tissues (except a trend in distal small intestine). CONCLUSION: We showed that Lactobacillus rhamnosus CNCMI-4317 induced Fiaf expression in human IECs, and increased circulating FIAF protein level in mice. Moreover, this effect was accompanied by transcriptome modulation of several pathways including immune response and metabolism in vitro.
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Fermented foods or probiotics can improve stress-induced symptoms such as depression, mood disturbance and digestive issues.
“Fermented foods enriched with Lactobacillus sp. and Bifidobacteria sp [129] can result in specific changes in gut microbiota activity, improving stress-induced symptoms such as depression, mood disturbance as well as digestive issues [130].”
From Exercise-induced stress behavior, gut-microbiota-brain axis and diet: a systematic review for athletes (2016) · cites this paper as [163]
Lactobacillus rhamnosus CNCMI-4317 was able to regulate multiple pathways including cellular function and maintenance, lymphoid tissue structure and development, immune system response as well as lipid metabolism in epithelial cells.
“For instance, the strain Lactobacillus rhamnosus CNCMI–4317 was able to regulate multiple pathways including cellular function and maintenance, lymphoid tissue structure and development, immune system response as well as lipid metabolism in epithelial cells [163].”
From Exercise-induced stress behavior, gut-microbiota-brain axis and diet: a systematic review for athletes (2016) · cites this paper as [163]
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Vandesompele, J., De Preter, K., Pattyn, F., Poppe, B., Van Roy, N., De Paepe, A., & Speleman, F. (2002) · Genome Biology · doi:10.1186/gb-2002-3-7-research0034 · Cited by 20,038 · see citing works
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245 · see citing works
Richness of human gut microbiome correlates with metabolic markers
Le Chatelier, E., Nielsen, T., Qin, J., Prifti, E., Hildebrand, F., Falony, G., Almeida, M., Arumugam, M., Batto, J.-M., Kennedy, S., et al. (2013) · Nature · doi:10.1038/nature12506 · Cited by 4,662 · see citing works
Self-citationA network-based analysis of systemic inflammation in humans
Program, I. A. H. R. T. I. L. S. C. R., Calvano, S. E., Xiao, W., Richards, D. R., Felciano, R. M., Baker, H. V., Cho, R. J., Chen, R. O., Brownstein, B. H., Cobb, J. P., et al. (2005) · Nature · doi:10.1038/nature03985 · Cited by 1,429 · see citing works
Yan, F., Cao, H., Cover, T. L., Whitehead, R. H., Washington, M. K., & Polk, D. B. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.11.022 · Cited by 828 · see citing works
Kersten, S., Mandard, S., Tan, N. S., Escher, P., METZGER, D., Chambon, P., Gonzalez, F. J., Desvergne, B., & Wahli, W. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004029200 · Cited by 560 · see citing works
Mandard, S., Zandbergen, F., van Straten, E., Wahli, W., Kuipers, F., Müller, M., & Kersten, S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m506519200 · Cited by 433 · see citing works
Yoon, J. C., Chickering, T. W., Rosen, E. D., Dussault, B. J., Qin, Y., Soukas, A. A., Friedman, J. M., Holmes, W. E., & Spiegelman, B. M. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.14.5343-5349.2000 · Cited by 399 · see citing works
van Baarlen, P., Troost, F. J., van Hemert, S., van Kraaij, C., de Vos, W. M., de Groot, P. J., Hooiveld, G. J. E. J., Brummer, R. J., & Kleerebezem, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809919106 · Cited by 384 · see citing works
Yoshida, K., Shimizugawa, T., Ono, M., & Furukawa, H. (2002) · Journal of Lipid Research · doi:10.1194/jlr.c200010-jlr200 · Cited by 368 · see citing works
Lee, H.-Y., Park, J.-H., Seok, S.-H., Baek, M.-W., Kim, D.-J., Lee, K.-E., Paek, K.-S., Lee, Y., & Park, J.-H. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2006.05.007 · Cited by 342 · see citing works
Xu, A., Lam, M. C., Chan, K. W., Wang, Y., Zhang, J., Hoo, R. L. C., Xu, J. Y., Chen, B., Chow, W.-S., Tso, A. W. K., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408452102 · Cited by 315 · see citing works
Aronsson, L., Huang, Y., Parini, P., Korach-André, M., Håkansson, J., Gustafsson, J.-Å., Pettersson, S., Arulampalam, V., & Rafter, J. J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013087 · Cited by 298 · see citing works
Lichtenstein, L., Mattijssen, F., de Wit, N. J. W., Georgiadi, A., Hooiveld, G. J. E. J., van der Meer, R., He, Y., Qi, L., Koster, A. M., Tamsma, J. T., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.11.002 · Cited by 269 · see citing works
Macia, L., Tsai, V. W.-W., Nguyen, A. D., Johnen, H., Kuffner, T., Shi, Y.-C., Lin, S., Herzog, H., Brown, D. A., Breit, S. N., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034868 · Cited by 211 · see citing works
Lichtenstein, L., Berbée, J. F. P., van Dijk, S. J., van Dijk, K. W., Bensadoun, A., Kema, I. P., Voshol, P. J., Müller, M. M., Rensen, P. C. N., & Kersten, S. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.151894 · Cited by 196 · see citing works
Li, H., Ge, C., Zhao, F., Yan, M., Chen, H., Jia, D., Tian, H., Zhu, M., Chen, T., Jiang, G., et al. (2011) · Hepatology · doi:10.1002/hep.24479 · Cited by 180 · see citing works
Lee, K., Paek, K., Lee, H. Y., Park, J. H., & Lee, Y. (2007) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2007.03336.x · Cited by 175 · see citing works
Koliwad, S. K., Kuo, T., Shipp, L. E., Gray, N. E., Backhed, F., So, A. Y.-L., Farese, R. V., & Wang, J.-C. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.025452 · Cited by 164 · see citing works
Lee, E.-C., Desai, U., Gololobov, G., Hong, S., Feng, X., Yu, X., Gay, J. P., Wilganowski, N., Gao, C., Du, L.-L., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m807899200 · Cited by 161 · see citing works
Galaup, A., Perdiguero, E. G., Souktani, R., Durand, M., Cazes, A., Monnot, C., Teillon, J., Jan, S. L., Bouleti, C., Briois, G., et al. (2011) · Circulation · doi:10.1161/circulationaha.111.049072 · Cited by 152 · see citing works
Gray, N. E., Lam, L. N., Yang, K., Zhou, A. Y., Koliwad, S., & Wang, J.-C. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.294124 · Cited by 116 · see citing works
Talmud, P. J., Smart, M., Presswood, E., Cooper, J. A., Nicaud, V., Drenos, F., Palmen, J., Marmot, M. G., Boekholdt, S. M., Wareham, N. J., et al. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.176917 · Cited by 103 · see citing works
Korecka, A., de Wouters, T., Cultrone, A., Lapaque, N., Pettersson, S., Dore, J. M., Blottière, H. M., & Arulampalam, V. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00293.2012 · Cited by 96 · see citing works
Self-citationAnti-diabetic effects of lactic acid bacteria in normal and type 2 diabetic mice
Honda, K., Moto, M., Uchida, N., He, F., & Hashizume, N. (2012) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.11-07 · Cited by 96 · see citing works
Angiopoietin-like Protein 4 Inhibition of Lipoprotein Lipase
Lafferty, M. J., Bradford, K. C., Erie, D. A., & Neher, S. B. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.497602 · Cited by 88 · see citing works
Robciuc, M. R., Naukkarinen, J., Ortega‐Alonso, A., Tyynismaa, H., Raivio, T., Rissanen, A., Kaprio, J. A., Ehnholm, C., Jauhiainen, M., & Pietiläinen, K. H. (2011) · Journal of Lipid Research · doi:10.1194/jlr.p015867 · Cited by 67 · see citing works
Transcriptional Profiling Identifies Functional Interactions of TGFβ and PPARβ/δ Signaling
Kaddatz, K., Adhikary, T., Finkernagel, F., Meißner, W., Müller‐Brüsselbach, S., & Müller, R. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.142018 · Cited by 66 · see citing works
Grootaert, C., de Wiele, T. V., Roosbroeck, I. V., Possemiers, S., Vercoutter‐Edouart, A., Verstraete, W., Bracke, M., & Vanhoecke, B. W. A. (2011) · Environmental Microbiology · doi:10.1111/j.1462-2920.2011.02482.x · Cited by 64 · see citing works
ANGPTL4 is produced by entero-endocrine cells in the human intestinal tract
Alex, S., Lichtenstein, L., Dijk, W., Mensink, R. P., Tan, N. S., & Kersten, S. (2013) · Histochemistry and Cell Biology · doi:10.1007/s00418-013-1157-y · Cited by 46 · see citing works
Study, T. L. A., Smart, M., Kelley-Hedgepeth, A., Montefusco, M. C., Cooper, J. A., Kopin, A. S., McCaffery, J. M., Balasubramanyam, A., Pownall, H. J., Nathan, D. M., et al. (2011) · BMC Medical Genetics · doi:10.1186/1471-2350-12-89 · Cited by 37 · see citing works
Neuronal functions, feeding behavior, and energy balance inSlc2a3+/−mice
Schmidt, S., Richter, M., Montag, D., Sartorius, T., Gawlik, V., Hennige, A. M., Scherneck, S., Himmelbauer, H., Lutz, S. Z., Augustin, R., et al. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90491.2008 · Cited by 34 · see citing works
Tannock, G. W., Taylor, C., Lawley, B., Loach, D. M., Gould, M. L., Dunn, A. C., McLellan, A. D., Black, M. A., McNoe, L. A., Dekker, J., et al. (2014) · Applied and Environmental Microbiology · doi:10.1128/aem.00336-14 · Cited by 11 · see citing works
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Cani, P. D., & Hul, M. V. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00867-z · Cited by 212 · see citing works
Checa-Ros, A., Jeréz-Calero, A., Molina-Carballo, A., Campoy, C., & Muñoz-Hoyos, A. (2021) · Nutrients · doi:10.3390/nu13010249 · Cited by 164 · see citing works
Ashrafian, F., Raftar, S. K. A., Lari, A., Shahryari, A., Abdollahiyan, S., Moradi, H. R., Masoumi, M., Davari, M., Khatami, S., Omrani, M. D., et al. (2021) · Microbial Cell Factories · doi:10.1186/s12934-021-01709-w · Cited by 138 · see citing works
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Zeppa, S. D., Agostini, D., Gervasi, M., Annibalini, G., Amatori, S., Ferrini, F., Sisti, D., Piccoli, G., Barbieri, E., Sestili, P., et al. (2019) · Nutrients · doi:10.3390/nu12010017 · Cited by 122 · see citing works
Duan, C., Kuang, L., Xiang, X., Zhang, J., Zhu, Y., Wu, Y., Yan, Q., Liu, L., & Li, T. (2020) · Aging · doi:10.18632/aging.102690 · Cited by 82 · see citing works
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- Authors
- Jacouton, E., Mach, N., Cadiou, J., Lapaque, N., Clément, K., Doré, J., van Hylckama Vlieg, J. E. T., Smokvina, T., & Blottière, H. M.
- Affiliations
- AgroParisTech (FR)
- Inserm (FR)
- Danone (France) (FR)
- Corresponding author
- Blottière, Hervé M
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2015-10-06
- Volume
- 10
- Issue
- 10
- Pages
- e0138880
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4595210
- OpenAlex
- W1947077777
- Cited by
- 32
- References
- 33
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 3 · 2018: 1 · 2017: 3 · 2016: 2
- FWCI
- 2.68
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- Danone
- Association Nationale de la Recherche et de la Technologie
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- FIAF, ANGPTL4, intestinal epithelial cells, probiotic bacteria, gene expression regulation, PPARα, PPARγ, lipid metabolism, energy homeostasis, intestinal transcriptome, immune response
- MeSH terms
- Angiopoietin-Like Protein 4, Animals, Epithelial Cells, Humans, Intestines, Lactobacillus, Mice, Inbred C57BL, HT29 Cells, Angiopoietins, Mice, Lacticaseibacillus rhamnosus
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