The Regulation of Synaptic Protein Turnover
Open accessAbstract
Emerging evidence indicates that protein synthesis and degradation are necessary for the remodeling of synapses. These two processes govern cellular protein turnover, are tightly regulated, and are modulated by neuronal activity in time and space. The anisotropic anatomy of the neurons presents a challenge for the study of protein turnover, but the understanding of protein turnover in neurons and its modulation in response to activity can help us to unravel the fine-tuned changes that occur at synapses in response to activity. Here we review the key experimental evidence demonstrating the role of protein synthesis and degradation in synaptic plasticity, as well as the turnover rates of specific neuronal proteins.
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Local protein synthesis and degradation are crucial for the remodeling of synapses.
“Emerging evidence has shown that local protein synthesis and degradation are crucial for the remodeling of synapses (Alvarez-Castelao and Schuman, 2015).”
From Altered Phosphorylation of the Proteasome Subunit Rpt6 Has Minimal Impact on Synaptic Plasticity and Learning (2021) · cites this paper as Alvarez-Castelao and Schuman, 2015
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Direct observation of individual endogenous protein complexes in situ by proximity ligation
Söderberg, O., Gullberg, M., Jarvius, M., Ridderstråle, K., Leuchowius, K.-J., Jarvius, J., Wester, K., Hydbring, P., Bahram, F., Larsson, L.-G., et al. (2006) · Nature Methods · doi:10.1038/nmeth947 · Cited by 2,419 · see citing works
NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses
Autry, A. E., Adachi, M., Nosyreva, E., Na, E. S., Los, M. F., Cheng, P.-F., Kavalali, E. T., & Monteggia, L. M. (2011) · Nature · doi:10.1038/nature10130 · Cited by 1,926 · see citing works
Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system
Ehlers, M. D. (2003) · Nature Neuroscience · doi:10.1038/nn1013 · Cited by 977 · see citing works
Ubiquitination Regulates PSD-95 Degradation and AMPA Receptor Surface Expression
Colledge, M., Snyder, E. M., Crozier, R. A., Soderling, J. A., Jin, Y., Langeberg, L. K., Lu, H., Bear, M. F., & Scott, J. D. (2003) · Neuron · doi:10.1016/s0896-6273(03)00687-1 · Cited by 567 · see citing works
Dynamic profiling of the protein life cycle in response to pathogens
Jovanovic, M., Rooney, M. S., Mertins, P., Przybylski, D., Chevrier, N., Satija, R., Rodriguez, E. H., Fields, A. P., Schwartz, S., Raychowdhury, R., et al. (2015) · Science · doi:10.1126/science.1259038 · Cited by 460 · see citing works
Analysis of proteome dynamics in the mouse brain
Price, J. C., Guan, S., Burlingame, A., Prusiner, S. B., & Ghaemmaghami, S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006551107 · Cited by 357 · see citing works
The single dendritic branch as a fundamental functional unit in the nervous system
Branco, T., & Häusser, M. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.07.009 · Cited by 355 · see citing works
Synaptic vesicle recycling: steps and principles
Rizzoli, S. O. (2014) · The EMBO Journal · doi:10.1002/embj.201386357 · Cited by 317 · see citing works
Autophosphorylated CaMKIIα Acts as a Scaffold to Recruit Proteasomes to Dendritic Spines
Bingol, B., Wang, C.-F., Arnott, D., Cheng, D., Peng, J., & Sheng, M. (2010) · Cell · doi:10.1016/j.cell.2010.01.024 · Cited by 268 · see citing works
Regulation of the proteasome by neuronal activity and calcium/calmodulin-dependent protein kinase II
Djakovic, S. N., Schwarz, L. A., Barylko, B., DeMartino, G. N., & Patrick, G. N. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.021956 · Cited by 236 · see citing works
Regulation of AMPA receptor surface diffusion by PSD-95 slots
Opazo, P., Sainlos, M., & Choquet, D. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.10.010 · Cited by 234 · see citing works
Cohen, L. D., Zuchman, R., Sorokina, O., Müller, A., Dieterich, D. C., Armstrong, J. D., Ziv, T., & Ziv, N. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063191 · Cited by 215 · see citing works
Lee, Y.-S., Choi, S.-L., Jun, H., Yim, S.-J., Lee, J.-A., Kim, H. F., Lee, S.-H., Shim, J., Lee, K., Jang, D.-J., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116224109 · Cited by 15 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- Yin, Y., Edelman, G. M., and Vanderklish, P. W. (2002) The brain-derived neurotrophic factor enhances synthesis of Arc in synaptoneurosomes. Proc. Natl. Acad. Sci. U.S.A. 99, 2368 -2373
- Hegde, A. N., Goldberg, A. L., and Schwartz, J. H. (1993) Regulatory sub- units of cAMP-dependent protein kinases are degraded after conjugation to ubiquitin: a molecular mechanism underlying long-term synaptic plas- ticity. Proc. Natl. Acad. Sci. U.S.A. 90, 7436 -7440
- Brooks, S. A. (2010) Functional interactions between mRNA turnover and surveillance and the ubiquitin proteasome system. Wiley Interdiscip. Rev. RNA 1, 240 -252
Cited by
Sorted by citations
Modulation of Autophagy by BDNF Underlies Synaptic Plasticity
Nikoletopoulou, V., Sidiropoulou, K., Kallergi, E., Dalezios, Y., & Tavernarakis, N. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.06.005 · Cited by 280 · see citing works
Cell-type-specific metabolic labeling of nascent proteomes in vivo
Alvarez-Castelao, B., Schanzenbächer, C. T., Hanus, C., Glock, C., tom Dieck, S., Dörrbaum, A. R., Bartnik, I., Nassim-Assir, B., Ciirdaeva, E., Mueller, A., et al. (2017) · Nature Biotechnology · doi:10.1038/nbt.4016 · Cited by 219 · see citing works
Self-citationLeon, J., Moreno, A. J., Garay, B. I., Chalkley, R. J., Burlingame, A. L., Wang, D., & Dubal, D. B. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.07.024 · Cited by 123 · see citing works
Cell-type-specific metabolic labeling, detection and identification of nascent proteomes in vivo
Alvarez-Castelao, B., Schanzenbächer, C. T., Langer, J. D., & Schuman, E. M. (2019) · Nature Protocols · doi:10.1038/s41596-018-0106-6 · Cited by 84 · see citing works
Self-citationScudder, S. L., Gonzales, F. R., Howell, K. K., Stein, I. S., Dozier, L. E., Anagnostaras, S. G., Zito, K., & Patrick, G. N. (2021) · eNeuro · doi:10.1523/eneuro.0073-20.2021 · Cited by 10 · see citing works
“Emerging evidence has shown that local protein synthesis and degradation are crucial for the remodeling of synapses (Alvarez-Castelao & Schuman, 2015).”
Background
- Authors
- Alvarez-Castelao, B., & Schuman, E. M.
- Affiliations
- Max Planck Institute for Brain Research (DE)
- Corresponding author
- Schuman, Erin M.
- ORCID
- Schuman, Erin M.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2015-11
- Volume
- 290
- Issue
- 48
- Pages
- 28623-28630
- ISSN
- 0021-9258 (ISSN-L)
- PMC
- PMC4661377
- OpenAlex
- W2261583454
- Cited by
- 110
- References
- 13
- Citations by year
- 2026: 9 · 2025: 6 · 2024: 2 · 2023: 7 · 2022: 6 · 2021: 9 · 2020: 14 · 2019: 11 · 2018: 16 · 2017: 21 · 2016: 7 · 2015: 2
- FWCI
- 1.84
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt) (submittedVersion, cc-by)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Keywords
- protein synthesis, protein degradation, synaptic plasticity, synaptic remodeling, neuronal activity, neuronal proteins, turnover rate
- MeSH terms
- Animals, Humans, Nerve Tissue Proteins, Neurons, Synapses, Protein Biosynthesis, Proteolysis
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