Cited by 1,172Biochemical Acid Research StudiesMitochondrial Function and PathologyMicrobial metabolism and enzyme function

The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

The Key Role of Anaplerosis and Cataplerosis for Citric Acid Cycle Function

Open access

Owen, Oliver E., Kalhan, Satish C., Hanson, Richard W.·2002·Journal of Biological Chemistry

DOI 10.1074/jbc.r200006200

Open this paper in CoChat — free account Open PDF

Abstract

tricarboxylic acid cycle phosphoenolpyruvate carboxykinase phosphoenolpyruvate The oxidation of acetyl-CoA to CO2by the TCA1 cycle is the central process in energy metabolism. However, the TCA cycle also functions in biosynthetic pathways in which intermediates leave the cycle to be converted primarily to glucose, fatty acids, or non-essential amino acids. If TCA cycle anions are removed from the cycle they must be replaced to permit its continued function. This process is termed anaplerosis. Pyruvate carboxylase, which generates oxalacetate directly in the mitochondria, is the major anaplerotic enzyme. Conversely, 4- and 5-carbon intermediates enter the TCA cycle during the catabolism of amino acids. Because the TCA cycle cannot fully oxidize 4- and 5-carbon compounds, these intermediates must be removed from the cycle by a process termedcataplerosis. Cataplerosis may be linked to biosynthetic processes such as gluconeogenesis in the liver and kidney cortex, fatty acid synthesis in the liver, and glyceroneogenesis in adipose tissue. Cataplerotic enzymes present in many mammalian tissues include P-enolpyruvate carboxykinase (PEPCK), glutamate dehydrogenase, aspartate aminotransferase, and citrate lyase. In this review we have evaluated the roles of anaplerosis and cataplerosis in whole body metabolism. The expression anaplerotic sequences was a term used in biochemistry by Sir Hans Kornberg (1Kornberg H.L. Essays Biochem. 1966; 2: 1-31Crossref Scopus (359) Google Scholar) to describe a series of enzymatic reactions or pathways that replenish the pools of metabolic intermediates in the TCA cycle. These intermediates are critical for the functioning of the TCA cycle, the primary role of which is the oxidation of acetyl-CoA to carbon dioxide. The pool of TCA cycle intermediates is sufficient to sustain the oxidative carbon flux over a fairly wide range, so that during high energy consumption (e.g. exercise) or during lower energy consumption (e.g. fasting), there is not a large change in the pool size of TCA intermediates (2Graham T.E. Gibala M.J. Richter E.A. Galbo H. Kiens B. Saltin B. Skeletal Muscle Metabolism in Exercise and Diabetes. Plenum Press, New York1998: 271-286Google Scholar). However, in several physiological states, there is a large influx (anaplerosis) of 4- and 5-carbon intermediates into the TCA cycle. Because the TCA cycle cannot act as a carbon sink, anaplerosis must be coupled with the exit of intermediates from the cycle via cataplerosis. The importance of anaplerotic reactions for cellular metabolism is thus apparent. However, the coupling of this process with cataplerosis and the roles that both pathways play in the regulation of amino acid, glucose, and fatty acid metabolism have not been emphasized to a sufficient extent. The terms anaplerosis and cataplerosis describe reciprocal and correlative reactions involved in the function of the TCA cycle. The enzymatic steps in these processes have long been known, but the overall concept of a linkage between anaplerosis and cataplerosis should be underscored, because the balance between these two processes controls the entry and exit of TCA cycle anions. Anaplerotic and cataplerotic reactions are involved in the ultimate disposal of all metabolic intermediates. The metabolic role of anaplerosis and cataplerosis in amino acid metabolism varies with specific organs and is dependent on the nutritional/metabolic status of the individual. During feeding, the intestine is an important site of catabolism of enterally derived amino acids, whereas in the starved state amino acid catabolism occurs primarily in the kidney, liver, and muscle. The catabolism of amino acids produces gluconeogenic or ketogenic precursors (Table I). The disposal of gluconeogenic anions in the TCA cycle employs anaplerotic and cataplerotic pathways for their terminal oxidation. The only known pathway for the terminal oxidation of leucine is through acetoacetate to acetyl-CoA and subsequent oxidation in the TCA cycle. However, other amino acids also have for their disposal alternate ketogenic pathways for terminal oxidation. Thus, the ketogenic amino acids from proteolysis can be terminally oxidized in muscle, whereas the gluconeogenic amino acids are dependent upon anaplerosis and cataplerosis for conversion to glucose in the liver and kidney before oxidation to CO2 and H2O.Table IMetabolic fates of amino acids in the TCA cycle1. Amino acids converted to pyruvate Alanine, serine, glycine, threonine, cysteine, tryptophan2. Amino acids converted to oxaloacetate Aspartate, asparagine3. Amino acids converted to α-ketoglutarate Glutamate, glutamine, proline, histidine, arginine4. Amino acids converted to fumarate Phenylalanine, tyrosine5. Amino acids converted to succinyl-CoA Methionine, isoleucine, valine6. Amino acids converted to acetyl-CoA Leucine, isoleucine, lysine, phenylalanine, tyrosine, tryptophan, threonine Open table in a new tab The first reaction of the TCA cycle,

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1074/jbc.r200006200

Cites

21 of 21 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Liver and kidney metabolism during prolonged starvation
Owen, O. E., Felig, P., Morgan, A. P., Wahren, J., & Cahill, G. F. (1969) · Journal of Clinical Investigation · doi:10.1172/jci106016 · Cited by 871
Amino acid metabolism during prolonged starvation
Felig, P., Owen, O. E., Wahren, J., & Cahill, G. F. (1969) · Journal of Clinical Investigation · doi:10.1172/jci106017 · Cited by 729
The Production and Release of Glycerol by Adipose Tissue Incubated in Vitro
Vaughan, M. M. (1962) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70821-7 · Cited by 428
Endocrinology and Metabolism
Izenstein, B. Z. (1996) · JAMA · doi:10.1001/jama.1996.03530350062036 · Cited by 357
Do the Differences between the Amino Acid Compositions of Acute-Phase and Muscle Proteins Have a Bearing on Nitrogen Loss in Traumatic States?
Reeds, P. J., Fjeld, C. R., & Jahoor, F. (1994) · Journal of Nutrition · doi:10.1093/jn/124.6.906 · Cited by 338
Quantitative analysis of amino acid oxidation and related gluconeogenesis in humans
Jungas, R. L., Halperin, M. L., & Brosnan, J. T. (1992) · Physiological Reviews · doi:10.1152/physrev.1992.72.2.419 · Cited by 309
The metabolic fates of amino acids and the formation of glutamine in skeletal muscle.
Chang, T. W., & Goldberg, A. L. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34855-x · Cited by 274
Tricarboxylic acid cycle intermediates in human muscle during prolonged exercise
Sahlin, K., Katz, A., & Broberg, S. (1990) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1990.259.5.c834 · Cited by 271
GLUTAMINE AS SOURCE MATERIAL OF URINARY AMMONIA
Slyke, D. D. V., Phillips, R. A., Hamilton, P., Archibald, R. M., Futcher, P. H., & Hiller, A. (1943) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)72173-x · Cited by 208
Alanine and glutamine synthesis and release from skeletal muscle. I. Glycolysis and amino acid release.
Garber, A. J., Karl, I. E., & KIPNIS, D. M. (1976) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33859-0 · Cited by 207

Show all 21 references

Research works printed but not linked: 6

Kornberg, 1966, Essays Biochem., 2, 1
Castillo, 1991, Am. J. Physiol., 261, E598
Gibala, 1998, Am. J. Physiol., 275, E235
Matthews, 1993, Am. J. Physiol., 264, E848
Haisch, 2000, Am. J. Physiol., 278, E593
Devapatla, 2002, Pediatr. Res., 51, 286A

Sorted by citations

Items 801–900 of 999

Electrospun Microfibers Modulate Intracellular Amino Acids in Liver Cells via Integrin β1
Huang, T., Terrell, J. A., Chung, J. H., & Chen, C. (2021) · Bioengineering · doi:10.3390/bioengineering8070088 · Cited by 7
“For example, glutamic acid and aspartic acid enter the TCA cycle after their conversion to TCA intermediates α−ketoglutarate and oxaloacetic acid, respectively [37].”
Background
Serine active site containing protein 1 depletion alters lipid metabolism and protects against high fat diet-induced obesity in mice
Du, M., Li, X., Xiao, F., Fu, Y., Shi, Y., Guo, S., Chen, L., Shen, L., Wang, L., Cheng, H., et al. (2022) · Metabolism · doi:10.1016/j.metabol.2022.155244 · Cited by 6
Hyperpolarized [1-13C]Acetyl- l -Carnitine Probes Tricarboxylic Acid Cycle Activity In Vivo
Chen, J., Singh, T. K., Nemri, S. A., Zaidi, M., Billingsley, K. L., & Park, J. M. (2023) · ACS Sensors · doi:10.1021/acssensors.3c01046 · Cited by 6
Hepatic metabolic response of Holstein cows in early and mid lactation is altered by nutrient supply and lipopolysaccharide in vitro
García, M., Bequette, B. J., & Moyes, K. M. (2015) · Journal of Dairy Science · doi:10.3168/jds.2014-9034 · Cited by 7
“Therefore, the available pyruvate can be used for synthesis of acetyl-CoA (Owen et al., 2002).”
Regulação metabólica e produção de espécies reativas de oxigênio durante a contração muscular: efeito do glicogênio na manutenção do estado redox intracelular
Silveira, L. R., Hirabara, S. M., Lambertucci, R. H., Leandro, C. V. G., Fiamoncini, J., Pinheiro, C. H. D. J., D'Angelo, A. C. A., Bassit, R. A., Pithon‐Curi, T. C., & Curi, R. (2008) · Revista Brasileira de Medicina do Esporte · doi:10.1590/s1517-86922008000100011 · Cited by 7
Hsp90 and its mitochondrial homologue TRAP-1 independently regulate hypoxia adaptations in Caenorhabditis elegans
Pant, A., Krishnakumar, K. C., Dileep, N. C., Yamana, M., Alamelu, N. M., Paithankar, K., Vijayalakshmi, A., & Subbarao, S. A. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.08.002 · Cited by 7
Amelioration of Endotoxemia by a Synthetic Analog of Omega-3 Epoxyeicosanoids
Shikuma, A., Kami, D., Maeda, R., Suzuki, Y., Sano, A., Taya, T., Ogata, T., Konkel, A., Matoba, S., Schunck, W., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.825171 · Cited by 7
“Another intermediate, succinates, is exported out of mitochondria through glutaminolysis through a mechanism called anaplerosis (42), and inhibits prolyl hydroxylase, which degrades HIF-1a, driving inflammation (43).”
Background
Impact of Maternal Feed Restriction at Different Stages of Gestation on the Proteomic Profile of the Newborn Skeletal Muscle
Costa, T. C., Dutra, L. L., Mendes, T. A. D. O., Fontes, M. M. D. S., Veroneze, R., Gionbelli, M. P., & Duarte, M. D. S. (2022) · Animals · doi:10.3390/ani12081011 · Cited by 7
“The protein GLUL, exclusively expressed in the treatment MR, uses ammonia to catalyze the conversion of glutamate into glutamine [58,59].”
Background
Role of Glutamate Dehydrogenase in Cancer Growth and Homeostasis
Friday, E., Oliver, R., Turturro, F., & Welbourne, T. (2012) · InTech eBooks · doi:10.5772/48606 · Cited by 7
“Interestingly enough, the in vivo kidney switches fuels from lactate to glutamine oxidation in metabolic acidosis[31] so that the anaplerotic glutaminolysis-GDH reactions matches [32] the cataplerotic reactions(CO2, biomass formation, [30,31] as does acid excretion (2NH4+/glutamine) and base(2HCO3-/glutamine) generati…”
Background
Effects of segregation and impact of specific feeding behaviour and additional fruit on voluntary nutrient and energy intake in yellow-shouldered amazons (Amazona barbadensis) when fed a multi-component seed diet ad libitum
Kalmar, I. D., Veys, A. C., Geeroms, B., Reinschmidt, M., Waugh, D. R., Werquin, G., & Janssens, G. P. J. (2010) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/j.1439-0396.2010.01026.x · Cited by 7
“This can be hypothesized based on the critical role of amino acids as anaplerotic intermediates in the citric acid cycle, permitting the continued function of the latter (Owen et al., 2002).”
Background
Hepatocellular apoptosis in mice is associated with early upregulation of mitochondrial glucose metabolism
Gottschalk, S., Zwingmann, C., Raymond, V., Hohnholt, M. C., Chan, T. S., & Bilodeau, M. (2011) · APOPTOSIS · doi:10.1007/s10495-011-0669-y · Cited by 7
Delineating metabolic dysfunction in cellular metabolism of oral submucous fibrosis using 1H nuclear magnetic resonance spectroscopy
Rai, V., Bose, S., Saha, S., Kumar, V., & Chakraborty, C. (2018) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2018.10.016 · Cited by 7
Metabolic Biomarkers in Aging and Anti-Aging Research
Guest, P. C. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-25650-0_13 · Cited by 7
Metabolomic Profiles in Adipocytes Differentiated from Adipose-Derived Stem Cells Following Exercise Training or High-Fat Diet
Osawa, S., Kato, H., Maeda, Y., Takakura, H., Ogasawara, J., & Izawa, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020966 · Cited by 6
“Amino acids are metabolized and integrated into the TCA cycle [38].”
Background
The fate of medium-chain fatty acids in very long-chain acyl‑CoA dehydrogenase deficiency (VLCADD): A matter of sex?
Wehbe, Z., Alatibi, K. I., Jellusova, J., Spiekerkoetter, U., & Tucci, S. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2019.08.001 · Cited by 8
Regulation of brown adipose tissue recruitment, metabolism and thermogenic function by peroxisome proliferator-activated receptorγ
Lopes, A. B., Deshaies, Y., & Festuccia, W. T. (2015) · Temperature · doi:10.1080/23328940.2015.1011564 · Cited by 6
Krebs cycle anions in metabolic acidosis.
Bowling, F. G., & Morgan, T. J. (2005) · Critical Care · doi:10.1186/cc3878 · Cited by 7
“anaplerotic and cataplerotic processes that normally keep each station of the citric acid cycle replenished but not overloaded [12].”
Background
Isotopomer analysis of cellular metabolism in tissue culture: A comparative study between the pathway and network-based methods
Vo, T. D., Lim, S. K., Lee, W. N. P., & Palsson, B. Ø. (2006) · Metabolomics · doi:10.1007/s11306-006-0033-3 · Cited by 7
“Anaplerosis conserves and refills the TCA cycle intermediate pool which is depleted by biosynthesis processes (Owen et al., 2002).”
Background
Production and export of metabolites from liver and heart mitochondria and anaplerosis
MacDonald, M. J. (2004) · Molecular and Cellular Biochemistry · doi:10.1023/b:mcbi.0000012856.31929.91 · Cited by 7
“Since the synthesis of cycle intermediates (anaplerosis) would cause them to accumulate to high levels inside the mitochondrion and this would likely alter mitochondrial function, especially of the citric acid cycle itself, it is necessary that synthesis of metabolites be balanced by their export to the cytosol [2].”
Background
Secondary Structure in Protein Analysis
Rose, G. D. (2004) · Encyclopedia of Biological Chemistry · doi:10.1016/b0-12-443710-9/00613-x · Cited by 7
Effect of thermal and nutritional conditions on fatty acid metabolism and oxidative stress response in juvenile European sea bass (Dicentrarchus labrax)
Gourtay, C., Chabot, D., Audet, C., Madec, L., Huelvan, C., Ducros, L., Claireaux, G., Mazurais, D., & Zambonino‐Infante, J. (2020) · Marine Biology · doi:10.1007/s00227-020-03729-3 · Cited by 6
Iron-based microbial interactions: the role of iron metabolism in the cheese ecosystem
Mekuli, R., Shoukat, M., Dugat‐Bony, É., Bonnarme, P., Landaud, S., Swennen, D., & Hervé, V. (2025) · Journal of Bacteriology · doi:10.1128/jb.00539-24 · Cited by 7
“Anaplerosis is the replenishment of depleted TCA cycle intermediates to ensure a partial maintenance of TCA cycle function (166).”
Metabolic reprogramming driven by Ant2 deficiency augments T Cell function and anti-tumor immunity in mice
Yosef, O., Cohen‐Daniel, L., Shamriz, O., Bar-On, Z., Salaymeh, W., Saragovi, A., Abramovich, I., Agranovich, B., Lutz, V., Tam, J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59310-3 · Cited by 8
“Cataplerosis, the process of carbon exiting the TCA cycle for precursor generation, is known to occur during T-cell stimulation, enabling the cells to generate macromolecules for proliferation 57 .”
Accumulation of succinate in the blood is a potential early indicator of metabolic dysfunction-associated steatotic liver disease (MASLD)
Chalifoux, O., Dagostino, C., Li, M., Trezza, S., Grayson, C., Russo, M. D. S. T., Avizonis, D. Z., Michalak, M., Agellon, L. B., & Mailloux, R. J. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.09.029 · Cited by 9
Impact of Chromium Picolinate on Breast Muscle Metabolomics and Glucose and Lipid Metabolism-Related Genes in Broilers Under Heat Stress
Wang, G., Li, X., Yu, M., Huang, Z., Feng, J., & Zhang, M. (2025) · Animals · doi:10.3390/ani15192897 · Cited by 6
“Citric acid plays a critical role in the TCA cycle [35].”
CDC5L drives FAH expression to promote metabolic reprogramming in melanoma
Gu, Z., Zhang, H., Li, Y., Shen, S., Yin, X., Zhang, W., Cheng, R., Zhang, Y., Zhang, X., Chen, H., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.23107 · Cited by 7
“Anaplerotic flux must balance cataplerotic flux to maintain the homeostasis of multiple metabolic pathways, such as the TCA cycle, in normal tissues and in tumors such as melanoma [13, 17].”
Background
High-intensity interval resistance training (HIIRT) improves liver gluconeogenesis from lactate in Swiss mice
Muller, G. Y., Matos, F. D. O., Perego, J. E., Kurauti, M. A., & Pedrosa, M. M. D. (2022) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2021-0721 · Cited by 8
Unraveling the Sweet Secrets of HCC: Glucometabolic Rewiring in Hepatocellular Carcinoma
Bhat, S. A., Farooq, Z., Ismail, H., Corona‐Avila, I., & Khan, M. W. (2023) · Technology in Cancer Research & Treatment · doi:10.1177/15330338231219434 · Cited by 6
“84 Anaplerotic enzyme pyruvate carboxylase supports the TCA cycle by supplying it with oxaloacetate and catalyzing pyruvate ’ s carboxylation into oxaloacetate.”
Background
Progesterone inhibits endometrial cancer growth by inhibiting glutamine metabolism through ASCT2
Guo, J., Fan, J., Zhang, Y., Li, M., Jin, Z., Shang, Y., Zhang, H., & Kong, Y. (2024) · Bioscience Reports · doi:10.1042/bsr20232035 · Cited by 6
“Tumor cells must compensate for this deficiency caused by their metabolic metastasis [45].”
Background
Exercise increases TCA intermediate concentrations during low‐calorie diet independent of insulin resistance among women with obesity
Ragland, T. J., & Malin, S. K. (2024) · Physiological Reports · doi:10.14814/phy2.15987 · Cited by 7
“This observation would be consistent with the notion that energy deficit may have promoted greater flux through the TCA cycle thereby increasing the TCA pool size and shifting balance of anaplerosis toward cataplerosis (Owen et al., 2002; Ryan et al., 2019).”
Background
Ferric uptake regulator (Fur) in Vibrio mimicus acts as an activator of citrate cycle and oxidative phosphorylation pathways, while enhancing virulence potential
Peng, K., Zhou, K., Jiang, Q., Wang, Y., Ai, M., Xu, L., Wang, J., Ouyang, P., Huang, X., Chen, D., et al. (2024) · Aquaculture · doi:10.1016/j.aquaculture.2024.741628 · Cited by 6
Carbon-13 Nuclear Magnetic Resonance for Analysis of Metabolic Pathways
Malloy, C. R., Maher, E. A., Marin‐Valencia, I., Mickey, B., DeBerardinis, R. J., & Sherry, A. D. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9780511996634.024 · Cited by 6
MicroRNA regulating metabolic reprogramming in tumor cells: New tumor markers
Felipe‐Abrio, B., & Otero-Albiol, D. (2016) · Cancer translational medicine · doi:10.4103/2395-3977.196909 · Cited by 6
REX technologies for profiling and decoding the electrophile signaling axes mediated by Rosetta Stone proteins
Long, M. J. C., Urul, D. A., & Aye, Y. (2019) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2019.02.039 · Cited by 7
Expression of pyruvate carboxylase in cultured human astrocytoma, glioblastoma and neuroblastoma cells
Gondáš, E., Trancikova, A. K., Majerčíková, Z., Pokusa, M., Baranovičová, E., Bystrický, P., Dobrota, D., & Murín, R. (2021) · General Physiology and Biophysics · doi:10.4149/gpb_2021003 · Cited by 6
“To compensate for a loss of withdrawn CAC intermediates by cataplerotic processes and to avoid the cellular metabolic collapse, the cells should replenish the CAC by anaplerotic reactions (Owen et al. 2002; Jitrapakdee et al. 2006; Lao-On et al. 2018).”
Background
Odd- and even-numbered medium-chained fatty acids protect against glutathione depletion in very long-chain acyl-CoA dehydrogenase deficiency
Lund, M., Heaton, R. A., Hargreaves, I. P., Gregersen, N., & Olsen, R. K. J. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2022.159248 · Cited by 6
Tricarboxylic Acid Metabolite Imbalance in Rats with Acute Thioacetamide-Induced Hepatic Encephalopathy Indicates Incomplete Recovery
Shurubor, Y. I., Rogozhin, A. E., Isakova, E. P., Deryabina, Y. I., & Krasnikov, B. F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021384 · Cited by 6
“The central process in it is the oxidation of ACoA to CO2 [35].”
Background
A Randomized Controlled Study on the Effects of Acetate‐Free Biofiltration on Organic Anions and Acid‐Base Balance in Hemodialysis Patients
Sánchez-Canel, J. J., Hernández‐Jaras, J., & Prades, R. P. (2014) · Therapeutic Apheresis and Dialysis · doi:10.1111/1744-9987.12180 · Cited by 6
Oral administration of D-galactose increases brain tricarboxylic acid cycle enzymes activities in Wistar rats
Budni, J., Brandão, A. B., da Silva, S., Garcez, M. L., Mina, F., Bellettini‐Santos, T., Zabot, G. C., Medeiros, E. B., Scaini, G., de Oliveira, J., et al. (2021) · Metabolic Brain Disease · doi:10.1007/s11011-021-00682-y · Cited by 6
Comprehensive Analysis of 13C6 Glucose Fate in the Hypoxia-Tolerant Blind Mole Rat Skin Fibroblasts
Miskevich, D. A., Chaban, A., Dronina, M. A., Abramovich, I., Gottlieb, E., & Shams, I. (2021) · Metabolites · doi:10.3390/metabo11110734 · Cited by 6
“The alternative processing of Pyr M + 3, pyruvate anaplerosis, occurs via PC and serves as the way of compensation of the anabolic metabolites leakages [19,20].”
Background
Cellular and Physiological Effects of Arginine in Seniors
Albaugh, V. L., Stewart, M. K., & Barbul, A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805376-8.00027-7 · Cited by 6
Differential Network Analysis Reveals Molecular Determinants Associated with Blood Pressure and Heart Rate in Healthy Subjects
Vignoli, A., Tenori, L., Luchinat, C., & Saccenti, E. (2020) · Journal of Proteome Research · doi:10.1021/acs.jproteome.0c00882 · Cited by 6
Anaplerosis
Russell, R. R., & Taegtmeyer, H. (2013) · Encyclopedia of Biological Chemistry · doi:10.1016/b978-0-12-378630-2.00395-9 · Cited by 6
Oxaloacetate anaplerosis differently contributes to pathogenicity in plant pathogenic fungi Fusarium graminearum and F. oxysporum
Shin, S., Bong, S., Moon, H., Jeon, H., Kim, H., Choi, G. J., Lee, D. Y., & Son, H. (2024) · PLoS Pathogens · doi:10.1371/journal.ppat.1012544 · Cited by 5
“…carboxylase (PYC, [EC 6.4.1.1]), has an important anaplerotic function by catalyzing the carboxylation of pyruvate to form oxaloacetate (OAA), a key intermediate in the TCA cycle involved in gluconeogenesis, lipogenesis, amino acid biosynthesis, the urea cycle, and the glyoxylate cycle [2, 3].”
BackgroundInfluential
Unveiling the Impact of Organic Fertilizer on Rice (Oryza sativa L.) Salinity Tolerance: Insights from the Integration of NDVI and Metabolomics
Li, J., Li, Y. C., Xu, Q., Niu, X., Cao, G., & Liu, H. (2025) · Plants · doi:10.3390/plants14060902 · Cited by 5
“Citric acid is a key intermediate in the TCA cycle, providing cellular energy and serving as a carbon skeleton for synthesizing amino acids (e.g., pipecolic acid) and fatty acids (e.g., myristoleic acid, tridecylic acid) [32].”
CircPSD3 aggravates tumor progression by maintaining TCA cycle and mitochondrial function via regulating SUCLG2 in thyroid carcinoma
Sun, Y., Han, B., Ge, J., Huo, Z., Li, J., Lin, B., Du, X., Zhang, Y., Weng, H., Yu, S., et al. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07856-x · Cited by 5
“Besides its catabolic role, the TCA cycle also serves an anabolic function, providing precursors for other biosynthetic processes, including gluconeogenesis, fatty acid, steroids, and amino acids biosynthesis [25].”
Leucine inhibits degradation of outer mitochondrial membrane proteins to adapt mitochondrial respiration
Li, Q., Weiss, K., Niwa, F., Riemer, J., & Hoppe, T. (2025) · Nature Cell Biology · doi:10.1038/s41556-025-01799-3 · Cited by 6
“Disruption of the TCA cycle has a profound effect on amino acid metabolism 39,40 .”
Multidimensional study on mitochondrial dysfunction in pulmonary hypertension
Yuan, X.-T., Zhang, Y., Liu, Y., Guo, X., Jia, S., Xiong, X., Xiuying, S., & Jin, Z. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1716485 · Cited by 5
“When the mitochondrial function is impaired, it can promote the outflow of cytochrome C, and then activate the apoptosis signal pathway (84).”
Stroma-driven horizontal transfer of TCA-related proteins mediates metabolic plasticity and imatinib resistance in chronic myeloid leukemia
Chrościcki, P., Kasak, N., Dymkowska, D., Turos-Korgul, L., Cysewski, D., Chumak, V., Stępnik, D., Kusio-Kobiałka, M., Kominek, A., Lebiedzińska, M., et al. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02564-7 · Cited by 5
“In addition to its role in catabolism, the TCA cycle is also critical for the biosynthesis of various molecules, including amino acids, lipids, and nucleotides (anaple-rotic function) [48].”
Efficient nitrogen removal performance and mechanism of a novel salt-tolerant bacterium Vreelandella sp. J1-11
Zhou, X., Qing, S., Zhou, H., Cheng, H., Chen, Z., Wang, Y., & Wang, Y. (2026) · Journal of Environmental Management · doi:10.1016/j.jenvman.2026.128642 · Cited by 5
Human metabolic chambers reveal a coordinated metabolic-physiologic response to nutrition
Perry, A., Piaggi, P., Huang, S., Nayor, M. G., Freedman, J. E., North, K. E., Below, J. E., Clish, C. B., Murthy, V. L., Krakoff, J. A., et al. (2024) · JCI Insight · doi:10.1172/jci.insight.184279 · Cited by 5
“19, 20), and (d) generalized decrease in multiple anapleurotic amino acid substrates for TCA cycle flux (e.g., alanine, glycine, threonine, tryptophan, proline, tyrosine) (21).”
Metabolomic analysis of C2C12 myoblasts induced by the transcription factor FOXO 1
Matsuda, R., Uchitomi, R., Oyabu, M., Hatazawa, Y., & Kamei, Y. (2019) · FEBS Letters · doi:10.1002/1873-3468.13445 · Cited by 5
The Growth Response to Beta-Hydroxybutyrate in SH-SY5Y Neuroblastoma Cells is Suppressed by Glucose and Pyruvate Supplementation
Alherz, M., Lee, D. J., Alshangiti, A. M., Roddy, D. W., O’Keeffe, G. W., White, R., & Barry, D. (2021) · Neurochemical Research · doi:10.1007/s11064-020-03203-y · Cited by 7
Metabolic Profiling of Praziquantel-mediated Prevention ofOpisthorchis viverrini-induced Cholangiocyte Transformation in the Hamster Model of Cholangiocarcinoma
PROMMAJUN, P., Phetcharaburanin, J., Namwat, N., Klanrit, P., Sa-Ngiamwibool, P., Thanee, M., Dokduang, H., Kittirat, Y., Li, J. V., & Loilome, W. (2021) · Cancer Genomics & Proteomics · doi:10.21873/cgp.20239 · Cited by 5
Quantitative proteomic analysis of Neosartorya pseudofischeri ascospores subjected to heat treatment
Chen, S., Fan, L., Song, J. I., Zhang, H., Doucette, C., Hughes, T., & Campbell, L. (2021) · Journal of Proteomics · doi:10.1016/j.jprot.2021.104446 · Cited by 5
Association of N-Acetyl Asparagine with QTc in Diabetes: A Metabolomics Study
Gravina, G., Moey, M., Prifti, E., Ichou, F., Bourron, O., Balse, E., Badilini, F., Funck‐Brentano, C., & Salem, J. (2022) · Biomedicines · doi:10.3390/biomedicines10081955 · Cited by 5
“Asparagine is converted to aspartate that is then transaminated to oxaloacetate, a critical early metabolite in gluconeogenesis, and plays a key role in the regulation of Krebs cycle intermediates [30].”
Background
Targeting hypoxia-related metabolism molecules: How to improve tumour immune and clinical treatment?
Liang, B., Deng, L., & Zhou, X. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113917 · Cited by 6
Integrating multiple regulations on enzyme activity: the case of phosphoenolpyruvate carboxykinases
Rojas, B. E., & Iglesias, A. (2023) · AoB Plants · doi:10.1093/aobpla/plad053 · Cited by 7
“These enzymatic steps, known as cataplerotic reactions, are critical to cellular homeostasis (Owen et al. 2002).”
Differential detection of aspartic acid in MCF-7 breast cancer cells
Ghosh, P., Das, T., Chattopadhyay, A., & Sahoo, P. (2023) · Organic & Biomolecular Chemistry · doi:10.1039/d3ob01072d · Cited by 5
Integrated Transcriptome Analysis of miRNAs and mRNAs in the Skeletal Muscle of Wuranke Sheep
Yun, Y., Wu, R., He, X., Qin, X., Chen, L., Sha, L., Yun, X., Nishiumi, T., & Borjigin, G. (2023) · Genes · doi:10.3390/genes14112034 · Cited by 5
“This study’s ﬁndings provide a theoretical basis for a deeper understanding of the functions of the miRNAs and their candidate target mRNAs that underlie skeletal muscle development in sheep.”
Background
Effect of source and frequency of rumen-protected protein supplementation on mammary gland amino acid metabolism and nitrogen balance of dairy cattle
Nichols, K., Wever, N., Rolland, M., & Dijkstra, J. (2024) · Journal of Dairy Science · doi:10.3168/jds.2023-24370 · Cited by 5
Identification of 1-Methylnicotinamide as a specific biomarker for the progression of cirrhosis to hepatocellular carcinoma
Zhang, S., Tuo, P., Ji, Y., Huang, Z., Xiong, Z., Li, H., & Ruan, C. (2024) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-024-05848-6 · Cited by 5
“…“β-alanine metabo-lism” and “pyrimidine metabolism” were dysregulated in both two comparisons. β-alanine β-alanine is an important metabolite in humans and is involved in a variety of metabolic pathways, including gluconeogenesis and fatty acid synthesis (Metallo et al. 2011; Owen et al. 2002).”
Background
Nanoformulated fenbendazole as an attractive approach for treating neurocysticercosis: in vitro and in vivo studies
da Silva, Y. B., Bedogni, G., Picanço, G. D. A., de Souza, J. Y., Nunes, W. S., da Costa, T. L., de Campos, G. B., Michelena, L. V., Salomon, C. J., & Vinaud, M. C. (2024) · Pharmaceutical Development and Technology · doi:10.1080/10837450.2024.2422936 · Cited by 5
“…not produce succinate but produced citrate, malate, and a -ketoglutarate in higher concentrations than in the control group; this is also an example of TCA simplification since citrate can be transported to the cyto-sol and used as a precursor for the synthesis of fatty acids (Owen et al. 2002).”
Troglitazone Regulates Anaplerosis via a Pull/Push Affect on Glutamate Dehydrogenase Mediated Glutamate Deamination in Kidney-derived Epithelial Cells; Implications for the Warburg Effect
Oliver, R., Friday, E., Turturro, F., & Welbourne, T. (2010) · Cellular Physiology and Biochemistry · doi:10.1159/000322329 · Cited by 5
Is serum biotinidase enzyme activity a potential marker of perturbed glucose and lipid metabolism?
Forny, P., Burda, P., Bode, P. K., & Rohrbach, M. (2020) · JIMD Reports · doi:10.1002/jmd2.12168 · Cited by 5
“Together with the increased PC transcript level, the ACACA gene also shows higher expression in the GSD IV patient liver, possibly due to an effect termed carboxylic acid cycle cataplerosis.(19) Eventually, our data suggests that as a consequence of the increased levels of the two biotin-dependent carboxylases ACACA a…”
Background
Differential Effect of Non-Purified and Semi-Purified Standard Diets on Kynurenine and Peripheral Metabolites in Male C57BL/6J Mice
Yajima, Y., Okuno, A., Nakamura, I., Miyazaki, T., Honda, A., & Toyoda, A. (2022) · International Journal of Tryptophan Research · doi:10.1177/11786469211066285 · Cited by 5
Nutritional Regulation of Mitochondrial Function
Vasam, G., Reid, K., Burelle, Y., & Menzies, K. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-811752-1.00004-3 · Cited by 6
3,4-Methylenedioxymethamphetamine Hepatotoxicity under the Heat Stress Condition: Novel Insights from in Vitro Metabolomic Studies
Araújo, A. M., Enea, M., Fernandes, E. G. R., Carvalho, F. D., Bastos, M. D. L., Carvalho, M. C., & de Pinho, P. G. (2020) · Journal of Proteome Research · doi:10.1021/acs.jproteome.9b00741 · Cited by 5
Expression of specific signaling components related to muscle protein turnover and of branched-chain amino acid catabolic enzymes in muscle and adipose tissue of preterm and term calves
Sadri, H., Ghaffari, M. H., Steinhoff‐Wagner, J., Görs, S., Hammon, H. M., & Sauerwein, H. (2021) · Journal of Dairy Science · doi:10.3168/jds.2021-20527 · Cited by 5
Serum ALT activity and its isoenzymes as potential biomarkers for diagnosis of Sarcopenia in older adults: a retrospective, cross-sectional study
Zeng, J., Li, N., Ge, J., Ma, H., Sun, S., Jing, Y., Qian, C., Cui, R., Qu, S., & Sheng, H. (2025) · BMC Geriatrics · doi:10.1186/s12877-025-05697-z · Cited by 4
“ALT, an enzyme catalyzing the reversible transfer between alanine and α-ketoglutaric acid to form pyruvate and glutamate [7, 20], could provide raw materials for the tri-carboxylic acid cycle, thereby enhancing muscle energy supply [21].”
The metabolic signature of salt intake: a cross-sectional analysis from the SCAPIS-study
Wuopio, J., Yi-Ting, L., Dekkers, K. F., Fall, T., Smith, J. G., Larsson, A., Engström, G., Orho‐Melander, M., Johnson, L., & Ärnlöv, J. (2025) · Nutrition & Metabolism · doi:10.1186/s12986-025-00997-y · Cited by 4
“This increase in TCA intermediates, a process known as “anaplerosis”, replenishes the TCA cycle to support sustained energy production [22].”
Moving towards a novel therapeutic strategy for hyperammonemia that targets glutamine metabolism
Fukui, K., Takahashi, T., Matsunari, H., Uchikura, A., Watanabe, M., Nagashima, H., Ishihara, N., Kakuma, T., Watanabe, Y., Yamashita, Y., et al. (2022) · Journal of Inherited Metabolic Disease · doi:10.1002/jimd.12540 · Cited by 4
“However, such a suppressive intervention must ensure anaplerosis at the same time because glutaminolysis is a major anaplerotic pathway.(21) We focused on AKG, which is a known inhibitor of GLUD,(6,22) that meets the two prerequisites.”
Background
Preliminary study to classify mechanisms of mitochondrial toxicity by in vitro metabolomics and bioinformatics
Hibino, Y., Iguchi, A., & Zaitsu, K. (2022) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2022.116316 · Cited by 4
Evolutionary Adaptation of Protein Turnover in White Muscle of Stenothermal Antarctic Fish: Elevated Cold Compensation at Reduced Thermal Responsiveness
Krebs, N., Bock, C., Tebben, J., Mark, F. C., Lucassen, M., Lannig, G., & Pörtner, H. (2023) · Biomolecules · doi:10.3390/biom13101507 · Cited by 4
“Depending on the metabolic state, it is released from skeletal muscle and often a precursor of other non-essential amino acids [69].”
Background
Skeletal Muscle Metabolism Is Dynamic during Porcine Postnatal Growth
Rimmer, L. A., Geisbrecht, E. R., Chao, M. D., O’Quinn, T. G., Woodworth, J. C., & Zumbaugh, M. D. (2024) · Metabolites · doi:10.3390/metabo14070357 · Cited by 4
“In conclusion, these data depict the intricacies of muscle metabolism and highlight potential avenues in mitochondria metabolism that may be necessary for optimal nutrient utilization during lean muscle deposition.”
Background
Loss of mitochondrial enzyme GPT2 leads to reprogramming of synaptic glutamate metabolism
Baytaş, O., Davidson, S. M., Kauer, J. A., & Morrow, E. M. (2024) · Molecular Brain · doi:10.1186/s13041-024-01154-x · Cited by 5
“Loss of GPT2 leads to deficits in the TCA cycle intermediates in the mouse brain, likely through impaired ana-plerosis [11, 38].”
Alteration of mitochondrial function in arthropods during arboviruses infection: a review of the literature
Santana-Román, M. E., Ramírez-Carreto, S., Maycotte, P., & Pando‐Robles, V. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1507059 · Cited by 4
Metabolic control of microglia in health and disease
Colombo, G., Monsorno, K., & Paolicelli, R. C. (2025) · Handbook of clinical neurology · doi:10.1016/b978-0-443-19104-6.00009-7 · Cited by 4
The mdx mouse as a model for carnitine deficiency in the pathogenesis of duchenne muscular dystrophy
Zolkipli‐Cunningham, Z., Mai, L., Lamhonwah, A., & Tein, I. (2012) · Muscle & Nerve · doi:10.1002/mus.23368 · Cited by 4
Long-chain fatty acid oxidation disorders: managed care and specialty pharmacy implications
Alan Pannier, P. (2020) · The American Journal of Managed Care · doi:10.37765/ajmc.2020.88479 · Cited by 4
Polydatin Attenuates Intra-Uterine Growth Retardation-Induced Liver Injury and Mitochondrial Dysfunction in Weanling Piglets by Improving Energy Metabolism and Redox Balance
Chen, Y., Li, Y., Jia, P., Ji, S., Zhang, H., & Wang, T. Z. (2022) · Antioxidants · doi:10.3390/antiox11040666 · Cited by 4
“The metabolic products of fatty acid oxidation include acetyl-CoA and reducing equivalents, and these substrates can be further utilized by the mitochondrial citrate cycle or ETC complexes [50].”
Background
Tissue Metabolic Responses to Artificial Bending and Gravitation Stimuli in Betula platyphylla
Yao, C., Zhang, N., Zou, A., Yu, Y., Wang, Y., & Wang, C. (2023) · Forests · doi:10.3390/f14030457 · Cited by 4
The metabolic role of the CD73/adenosine signaling pathway in HTR-8/SVneo cells: A Double-Edged Sword?
Song, G., Zhang, D., Zhu, J., Wang, A., Zhou, X., Han, T.-L., & Zhang, H. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e25252 · Cited by 4
“It is known that PDK1 inactivates mitochondrial pyruvate dehydrogenase (PDH), which in turn decarboxylates pyruvate to acetyl-CoA and subsequently adds an acetyl group to TCA cycle intermediates to maintain mitochondrial function [25].”
Background
Mitochondria and Tumor Metabolic Flexibility: Mechanisms and Therapeutic Perspectives
Rovini, A. M. F., Heslop, K. A., & Maldonado, E. N. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820472-6.00090-6 · Cited by 5
Understanding the aging fly through physiological genetics
Missirlis, F. (2003) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(03)14007-2 · Cited by 4
“This raises the intriguing possibility that the enzymes functioning in the mitochondria are geared towards ATP production (NADH and FADH2), while their cytosolic counterparts may be primarily involved in cataplerotic and anaplerotic functions (Owen et al., 2002).”
Background
Epistemic Consequences of Two Different Strategies for Decomposing Biological Networks
Krohs, U. (2010) · Springer eBooks · doi:10.1007/978-90-481-3252-2_15 · Cited by 4
“But each metabolic intermediate of the cycle is, besides its two edges within the cycle, also involved in many reactions that do not belong to the cycle but link it to other functional modules and help regulate the size of the pools of each of the intermediates (Kornberg 1965; Owen et al. 2002 ).”
Background
A fundamental regulatory role of formate on thuringiensin production by resting cell of Bacillus thuringiensis YBT-032
Wang, Z., Chen, S., Lifang, R., Ming, S., & Ziniu, Y. (2007) · Bioprocess and Biosystems Engineering · doi:10.1007/s00449-007-0118-z · Cited by 4
“Glycolysis and TCA cycle are the main pathways of central carbon metabolism [18] providing building blocks for the synthesis of cellular components [19].”
Background
Ketone Bodies
Owen, O. E., & Hanson, R. W. (2004) · Elsevier eBooks · doi:10.1016/b0-12-475570-4/01447-5 · Cited by 4
Characterising Sex-Specific Metabolite Differences in New Zealand Geoduck (Panopea zelandica) Using LC-MS/MS Metabolomics
Venter, L., Alfaro, A. C., Lindeque, J. Z., van Rensburg, P. J., Delorme, N. J., Ragg, N. L. C., & Zamora, L. N. (2025) · Animals · doi:10.3390/ani15060860 · Cited by 3
“The metabolites, malic acid (in both gill and muscle tissue), citric acid, and cis-aconitic are linked directly to the tricarboxylic acid (TCA) cycle, the central process of energy metabolism [33].”
Increase in plasma succinate is associated with aerobic lactate production in a model of endotoxic shock
Ruiz, J. D. C., Sánchez, J. I. A., Fernández, J. J. D., Díaz‐Brochero, C., & Martínez, L. (2025) · Experimental Physiology · doi:10.1113/ep092109 · Cited by 3
Enzyme-assisted ultrasonication pretreated co-fermentation (Lactobacillus plantarum and Acetobacter pasteurianus) of jujube-based vinegar production: Optimization, volatile metabolomics, sensory, and integration of microbial pathways using metagenomics
Boasiako, T. A., Han, Y., Boateng, I. D., Afoakwa, E. O., & Ma, Y. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.106951 · Cited by 4
Changes in Redox Balance and Mitochondrial Activity in the Retinas of Cystine/Glutamate Antiporter Knockout Mice
Knight, L. J., Martis, R. M., Donaldson, P. J., Acosta, M. L., & Lim, J. C.-H. (2025) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.66.12.31 · Cited by 3
Brown adipose tissue activity impacts systemic lactate clearance in male mice
Montané, R., Jeanson, Y., Lagarde, D., Khoury, S., Porcher‐Bibes, L., Nakhle, J., Sallese, M., Parny, M., Raymond‐Letron, I., Huard, E., et al. (2025) · The Journal of Physiology · doi:10.1113/jp288871 · Cited by 3
Glucose metabolism in the pathogenic free‐living amoebae: Tempting targets for treatment development
Milanes, J. E., Kwain, S., Drawdy, A., Dodson, L., Monaghan, M. T., Rice, C. A., Dominy, B. N., Whitehead, D. C., & Morris, J. C. (2023) · Chemical Biology & Drug Design · doi:10.1111/cbdd.14377 · Cited by 3
“Anaplerosis is particularly important due to depletion of malate that would happen during lipid metabolism (Owen et al., 2002).”
Background
The effect of pregnancy toxemia on serum carnitine and amino acid levels in goats
Akkuş, T., & Yaprakcı, Ö. (2024) · Arquivo Brasileiro de Medicina Veterinária e Zootecnia · doi:10.1590/1678-4162-13216 · Cited by 3
A systematic review of omics discovery studies to identify pertinent metabolic pathways for locally advanced rectal cancer in response to neoadjuvant chemoradiotherapy
Kler, A., Fok, M., Grundy, G. J., Sciacovelli, M., Dunn, W. B., & Vimalachandran, D. (2025) · Metabolomics · doi:10.1007/s11306-025-02319-y · Cited by 3
“However, the TCA cycle will also simultaneously supply precursors for other biological pathways (Owen et al., 2002 ), as well as provide more NADPH production through the reductive carboxylation pathway.”
Targeting pyruvate metabolism generates distinct CD8+ T cell responses to gammaherpesvirus and B lymphoma
Kang, T., Usherwood, Y.-K., Reisz, J. A., Kamerkar, S. C., Culp‐Hill, R., Wilkins, O. M., Veríssimo, A. F., Kolling, F., Hung, A. M., Musial, S. C., et al. (2025) · JCI Insight · doi:10.1172/jci.insight.187680 · Cited by 4
“…source utilization, it is increasingly reported that the intermediate molecules of glycolysis and TCA cycle are not solely committed to one pathway but can be transferred in and out of mitochondria to be used in other pathways, such as anaplero-sis/cataplerosis and alternative TCA cycle (33–37).”
The role of succinylation-mediated metabolic reprogramming in tumor progression
He, S., Wang, C., Li, R., Xu, K., Zhang, W., Feng, B., Cheng, S., Ren, J., & Chen, J. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-11061-6 · Cited by 3
“Since succinyl-CoA is primarily produced in the mitochondria through the oxidation of odd-chain fatty acids (FAO) [45] or the TCA cycle [46], nonen-zymatic succinylation was initially believed to be confined to the mitochondria and regulated by pH and succinyl-CoA concentration [3, 5].”
Pharmacological effects on anaplerotic pathways alter the metabolic landscape in the tumor microenvironment, causing unpredictable, sustained anti-tumor immunity
Udono, H., & Nishida, M. (2021) · International Immunology · doi:10.1093/intimm/dxab067 · Cited by 3
The ubiquitous expression of pyruvate carboxylase among human prostate tumors
Gondáš, E., Híveš, M., Kliment, J., Sivoňová, M. K., Dobrota, D., & Murín, R. (2022) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.4149/bll_2022_077 · Cited by 3

Authors: Owen, O. E., Kalhan, S. C., & Hanson, R. W.
Affiliations: MetroHealth Medical Center (US)
Corresponding author: Owen, Oliver E.
ORCID: Kalhan, Satish C.
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 2002-08
Volume: 277
Issue: 34
Pages: 30409-30412
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.r200006200
OpenAlex: W2134294998
Cited by: 1,172
References: 21
Citations by year: 2026: 51 · 2025: 73 · 2024: 72 · 2023: 71 · 2022: 87 · 2021: 108 · 2020: 101 · 2019: 84 · 2018: 67 · 2017: 67 · 2016: 61 · 2015: 50 · 2014: 49 · 2013: 27 · 2012: 38
FWCI: 6.84
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 6663 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (DK-58620, R01DK058620)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD11089)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Biochemical Acid Research Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial metabolism and enzyme function
Keywords: anaplerosis, cataplerosis, TCA cycle, TCA cycle intermediates, pyruvate carboxylase, oxaloacetate, phosphoenolpyruvate carboxykinase, gluconeogenesis, fatty acid synthesis, glyceroneogenesis, amino acid catabolism, glutamate dehydrogenase
MeSH terms: Adipose Tissue, Amino Acids, Animals, Citric Acid Cycle, Gluconeogenesis, Glutamine, Humans, Intestine, Small, Kidney, Triglycerides, Muscle, Skeletal

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Key Role of Anaplerosis and Cataplerosis for Citric Acid Cycle Function

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks