The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.
Arylalkylamine N-Acetyltransferase: “the Timezyme”
Open accessAbstract
Arylalkylamine N-acetyltransferase controls daily changes in melatonin production by the pineal gland and thereby plays a unique role in biological timing in vertebrates. Arylalkylamine N-acetyltransferase is also expressed in the retina, where it may play other roles in addition to signaling, including neurotransmission and detoxification. Large changes in activity reflect cyclic 3',5'-adenosine monophosphate-dependent phosphorylation of arylalkylamine N-acetyltransferase, leading to formation of a regulatory complex with 14-3-3 proteins. This activates the enzyme and prevents proteosomal proteolysis. The conserved features of regulatory systems that control arylalkylamine N-acetyltransferase are a circadian clock and environmental lighting.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Coordination of circadian timing in mammals
Reppert, S. M., & Weaver, D. R. (2002) · Nature · doi:10.1038/nature00965 · Cited by 4,379
Overview of retinoid metabolism and function
Blomhoff, R., & Blomhoff, H. K. (2006) · Journal of Neurobiology · doi:10.1002/neu.20242 · Cited by 947
14-3-3 proteins: A historic overview
Aitken, A. (2006) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2006.03.005 · Cited by 826
Melatonin and the Mammalian Pineal Gland
Arendt, J. (1994) · Cited by 788
Indole Metabolism in the Pineal Gland: A Circadian Rhythm in N -Acetyltransferase
Klein, D. C., & Weller, J. L. (1970) · Science · doi:10.1126/science.169.3950.1093 · Cited by 746
Self-citationRPE lipofuscin and its role in retinal pathobiology
Sparrow, J. R., & Boulton, M. (2005) · Experimental Eye Research · doi:10.1016/j.exer.2005.01.007 · Cited by 644
Structure and functions of the GNAT superfamily of acetyltransferases
Vetting, M. W., S. de Carvalho, L. P., Yu, M., Hegde, S. S., Magnet, S., Roderick, S. L., & Blanchard, J. S. (2005) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2004.09.003 · Cited by 631
Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development
Nishida, A., Furukawa, A., Koike, C., Tano, Y., Aizawa, S., Matsuo, I., & Furukawa, T. (2003) · Nature Neuroscience · doi:10.1038/nn1155 · Cited by 604
Klein, D. C., Coon, S. L., Roseboom, P. H., Weller, J. L., Bernard, M., Gastel, J. A., Zatz, M., Iuvone, P. M., Rodríguez, I. R., Bégay, V., et al. (1997) · PubMed · Cited by 550
Self-citationRetinopathy and attenuated circadian entrainment in Crx-deficient mice
Furukawa, T., Morrow, E. M., Li, T., Davis, F. C., & Cepko, C. L. (1999) · Nature Genetics · doi:10.1038/70591 · Cited by 538
Cited by
Cellular and Molecular Basis of Deiodinase-Regulated Thyroid Hormone Signaling1
Gereben, B., Zavacki, A. M., Ribich, S., Kim, B. W., Huang, S. A., Simonides, W. S., Zeöld, A., & Bianco, A. C. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0019 · Cited by 891
Circadian Rhythm and Sleep Disruption: Causes, Metabolic Consequences, and Countermeasures
Potter, G. D. M., Skene, D. J., Arendt, J., Cade, J. E., Grant, P. J., & Hardie, L. J. (2016) · Endocrine Reviews · doi:10.1210/er.2016-1083 · Cited by 709
Melatonin Synthesis and Function: Evolutionary History in Animals and Plants
Zhao, D., Yu, Y., Shen, Y., Liu, Q., Zhao, Z., Sharma, R., & Reiter, R. J. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00249 · Cited by 689
Slominski (2012) · doi:10.1007/978-3-642-19683-6_1 · Cited by 461
Pandi-Perumal, S. R., BaHammam, A. S., Brown, G. M., Spence, D. W., Bharti, V. K., Kaur, C., Hardeland, R., & Cardinali, D. P. (2013) · Neurotoxicity Research · doi:10.1007/s12640-012-9337-4 · Cited by 320
Metadata
- Authors
- Klein, D. C.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2007-02
- Volume
- 282
- Issue
- 7
- Pages
- 4233-4237
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1965532359
- Cited by
- 422
- References
- 76
- FWCI
- 5.88
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Arylalkylamine N-Acetyltransferase: “the Timezyme”. https://app.cochat.ai/papers/10.1074/jbc.r600036200
- The paper
- Klein, D. C. (2007). Arylalkylamine N-Acetyltransferase: “the Timezyme”. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.r600036200
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
