The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Triggering the Innate Antiviral Response through IRF-3 Activation
Open accessAbstract
Rapid induction of type I interferon (IFN) expression is a central event in the establishment of the innate immune response against viral infection and requires the activation of multiple transcriptional proteins following engagement and signaling through Toll-like receptor-dependent and -independent pathways. The transcription factor interferon regulatory factor-3 (IRF-3) contributes to a first line of defense against viral infection by inducing the production of IFN-beta that in turn amplifies the IFN response and the development of antiviral activity. In murine knock-out models, the absence of IRF-3 and the closely related IRF-7 ablates IFN production and increases viral pathogenesis, thus supporting a pivotal role for IRF-3/IRF-7 in the development of the host antiviral response.
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Cites
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IKKε and TBK1 are essential components of the IRF3 signaling pathway
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IRF-7 is the master regulator of type-I interferon-dependent immune responses
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Cited by
Recognition of microorganisms and activation of the immune response
Medzhitov, R. (2007) · Nature · doi:10.1038/nature06246 · Cited by 2,862
Distinct RIG-I and MDA5 Signaling by RNA Viruses in Innate Immunity
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Metadata
- Authors
- Hiscott, J.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2007-05
- Volume
- 282
- Issue
- 21
- Pages
- 15325-15329
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2085459501
- Cited by
- 458
- References
- 63
- FWCI
- 12.50
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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