Understanding the Association of Apolipoprotein E4 with Alzheimer Disease: Clues from Its Structure

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429

Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology

Mahley, R. W. (1988) · Science · doi:10.1126/science.3283935 · Cited by 4,028

Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

Saunders, A. M., Strittmatter, W. J., Schmechel, D., St. George-Hyslop, P. H., Pericak-Vance, M. A., Joo, S. H., Rosi, B. L., Gusella, J. F., Crapper-MacLachlan, D. R., Alberts, M. J., et al. (1993) · Neurology · doi:10.1212/wnl.43.8.1467 · Cited by 3,786

Alzheimer’s Dementia

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Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.

Schmechel, D. E., Saunders, A. M., Strittmatter, W. J., Crain, B. J., Hulette, C. M., Joo, S. H., Pericak-Vance, M. A., Goldgaber, D., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.20.9649 · Cited by 1,525

Molten Globule and Protein Folding

Ptitsyn, O. B. (1995) · Advances in protein chemistry · doi:10.1016/s0065-3233(08)60546-x · Cited by 1,222

Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

Holtzman, D. M., Bales, K. R., Tenkova, T., Fagan, A. M., Parsadanian, M., Sartorius, L. J., Mackey, B., Olney, J., McKeel, D., Wozniak, D., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.050004797 · Cited by 937

Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer’s disease

Mahley, R. W., Weisgraber, K. H., & Huang, Y. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600549103 · Cited by 912

Apolipoprotein E: Structure-Function Relationships

Weisgraber, K. H. (1994) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(08)60642-7 · Cited by 830

Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid

Wisniewski, T., & Frangione, B. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90444-c · Cited by 802

Neuroinflammation drives APOE genotype-dependent differential expression of neprilysin

Graykowski, D. R., Kasparian, K., Caniglia, J. L., Gritsaeva, Y., & Cudaback, E. (2020) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2020.577315 · Cited by 12

DHA-Enriched Fish Oil Ameliorates Deficits in Cognition Associated with Menopause and the APOE4 Genotype in Rodents

Pontifex, M. G., Martinsen, A., Saleh, R. N. M., Harden, G., Fox, C., Müller, M. M., Vauzour, D., & Minihane, A. M. (2022) · Nutrients · doi:10.3390/nu14091698 · Cited by 13

Alzheimer’s disease: unraveling APOE4 binding to amyloid-beta peptide and lipids with molecular dynamics and quantum mechanics

Gillet, J.-N. (2020) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2020.1784287 · Cited by 8

Genetic Variation in the Ontario Neurodegenerative Disease Research Initiative

Dilliott, A. A., Evans, E. C., Farhan, S. M. K., Ghani, M., Sato, C., Zhang, M., McIntyre, A. D., Cao, H., Racacho, L., Robinson, J. F., et al. (2019) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/cjn.2019.228 · Cited by 8

Proposal of novel ApoE4 inhibitors from the natural spice Cinnamon for the treatment of Alzheimer's disease: Ab initio molecular simulations

Shaji, D., Das, A., Suzuki, R., Nagura, Y., Sabishiro, H., & Kurita, N. (2023) · Biophysical Chemistry · doi:10.1016/j.bpc.2023.106990 · Cited by 7

Conformational Reorganization of Apolipoprotein E Triggered by Phospholipid Assembly

Prakashchand, D. D., & Mondal, J. (2021) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.1c03011 · Cited by 7

Apolipoprotein E Genotype: The Innocent Bystander or Active Bridge Between Metabolic Syndrome and Cognitive Impairment?

Frisardi, V. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-111568 · Cited by 7

New APOE-related therapeutic options for Alzheimer’s disease

Li, Z. (2019) · AIP conference proceedings · doi:10.1063/1.5085515 · Cited by 8

The Role of Genetics in Alzheimer's Disease and Parkinson's Disease

Porter, T., Gozt, A., Mastaglia, F. L., & Laws, S. M. (2019) · Wiley eBooks · doi:10.1002/9781119356752.ch15 · Cited by 6

Unraveling APOE4: The dual role in CNS and peripheral inflammation in Alzheimer's disease

Li, X., Li, Z., Chen, H., Guo, H., Ge, Y., Dong, F., Zhang, F., & Zhang, F. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115199 · Cited by 7

From APOE to cellular changes: Unraveling the multidimensional mechanisms of blood-brain barrier damage in Alzheimer's disease

Jiang, F., Wang, N., & Meng, Q. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251360321 · Cited by 6

Future Treatment of Alzheimer Disease

Keskin, A. O., Durmaz, N., Uncu, G., Erzurumluoglu, E., Yıldırım, Z., Tuncer, N., & Adapınar, D. Ö. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.85096 · Cited by 6

Targeting apolipoprotein E for treating Alzheimer’s disease

Bales, K. R., & Paul, S. M. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134366 · Cited by 7

Aberrant environment and PS-binding to calnuc C-terminal tail drives exosomal packaging and its metastatic ability

Vignesh, R., Sjölander, A., Venkatraman, G., Rayala, S. K., & Aradhyam, G. K. (2021) · Biochemical Journal · doi:10.1042/bcj20210016 · Cited by 6

Influence of apolipoprotein E and its receptors on cerebral amyloid precursor protein metabolism following traumatic brain injury.

Zhou, S., & Sun, X. (2012) · PubMed · Cited by 5

Full-length apolipoprotein E protects against the neurotoxicity of an apoE-related peptide

Crutcher, K. A., Lilley, H. N., Anthony, S., Zhou, W., & Narayanaswami, V. (2009) · Brain Research · doi:10.1016/j.brainres.2009.10.021 · Cited by 5

Key Enzymes and Proteins in Amyloid-Beta Production and Clearance

Santos, C. R. A., Cardoso, I., & Gonçalves, I. (2011) · InTech eBooks · doi:10.5772/17646 · Cited by 5

Intérêt du régime cétogène dans la prise en charge de la maladie d’Alzheimer

Charlot, A., Lernould, A., Plus, I., & Zoll, J. (2023) · Biologie Aujourd hui · doi:10.1051/jbio/2023031 · Cited by 2

Molecular etiopathogenesis of neurodegenerative diseases

Divya, D., Thekkekkara, D., Sai, T. E., Ramakrishna, D., Manjula, S. N., & Goswami, S. K. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-28822-7.00002-7 · Cited by 2

The neuronal functions of human apolipoprotein E

Ong, Q., & Wong, B. (2013) · OA Biochemistry · doi:10.13172/2052-9651-1-1-442 · Cited by 2

CASE REPORT OF A PATIENT WITH RARE P.ARG136CYS (APOE2*) MUTATION IN APOLIPOPROTEIN E GENE

Lisyova (2014) · OnLine Journal of Biological Sciences · doi:10.3844/ojbsci.2014.36.43 · Cited by 2

Türk Popülasyonunda APOE Polimorfizmleri ve Alzheimer Hastalığı Arasındaki İlişki

Çilingir, O., Adapınar, B. D. Ö., Aras, B. D., Gökalp, E. E., Özkan, S., Arslan, S., Haziyeva, K., Kocagil, S., Bilgin, M., & Artan, S. (2019) · OSMANGAZİ JOURNAL OF MEDICINE · doi:10.20515/otd.553900 · Cited by 2

Apolipoprotein M – Studies of Structure and Function

Ahnström, J. (2009) · Lund University Publications (Lund University) · Cited by 2

Netrin-1 as a molecular mediator linking APOE ε4 to alzheimer’s disease pathogenesis

He, B., Fu, Z., Liang, Y., Liang, J., Zeng, D., Zhong, Y., Chen, H., & Wang, X. (2025) · Scientific Reports · doi:10.1038/s41598-025-19693-1 · Cited by 1

Genetic Factors in Alzheimer Disease and Dementia

Bird, T. D. (2009) · Springer eBooks · doi:10.1007/978-3-540-37654-5_28 · Cited by 1

Postnatal chlorpyrifos exposure influences the gut microbiota and the expression of biological and neurobehavioral characteristics of the APOE genotype in an age-dependent manner

Guardia-Escote, L. (2019) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · Cited by 1

Genular: An Integrated Platform for Defining Cellular Identity and Function through Single-Cell Gene Expression and Multi-Domain Biological DataPreprint

Tomic, I., Hao, S. P., & Tomić, A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.23.619445 · Cited by 1

Inhibition of ApoE4 Endocytosis with LDLR-LA PeptidesPreprint

Park, S. H., Gomes, G.-N. W., Beyer, B. A., & Levine, Z. A. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.20.726622 · Cited by 1

Influence of genetic variability and external regulating factors on amyloid-beta peptide aggregation

Hubin, E. (2014) · doi:10.3990/1.9789036537643

The Advancement of Mass Spectrometry-based Hydroxyl Radical Protein Footprinting: Application of Novel Analysis Methods to Model Proteins and Apolipoprotein E

Gau, B. C. (2011) · Open Scholarship Institutional Repository (Washington University in St. Louis) · doi:10.7936/k72r3pq8

ABCA1, Apoe and apoA-I As Potential Therapeutic Targets for Treating Alzheimer’s Disease

Namjoshi, D., Stukas, S. K., & Wellington, C. L. (2011) · Neurodegenerative Disease Management · doi:10.2217/nmt.11.23

Reinforcement Learning, Error-Related Negativity, and Genetic Risk for Alzheimer's Disease

Figueroa, C. M. (2016) · e-Publications@Marquette (Marquette University)

Phenotypic Pattern of Astrocyte Activation in Response to Aging and Alzheimer's-Like Pathology in Chimpanzees

Munger, E. L. (2016) · OhioLink ETD Center (Ohio Library and Information Network)

Genes, Aging, and Parkinson’s Disease

Milanese, C., & Mastroberardino, P. G. (2017) · Royal Society of Chemistry eBooks · doi:10.1039/9781782622888-00389

POLIMORFISMO DA APOLIPOPROTEÍNA E E SUA ASSOCIAÇÃO COM INCAPACIDADE FUNCIONAL EM IDOSOS: PROJETO BAMBUÍ

da Saúde, M. (2014)

The role of apolipoprotein E in traumatic brain injury as determined by isoform and Abca1 haplodeficiency

Castranio, E. L. (2018) · D-Scholarship@Pitt (University of Pittsburgh)

A novel Lipid-Carrier Initiator prion hypothesisPreprint

Reddy, K. (2020) · doi:10.22541/au.158870182.20724084

The interactive impact of omega-3 fatty acids, APOE genotype and sex hormones on cognition

Pontifex, M. G. (2020) · UEA Digital Repository (University of East Anglia)

Evaluación del potencial terapéutico de un extracto de raíz de Zanthoxylum caribaeum en un modelo triple transgénico de Enfermedad de Alzheimer

González, R., & Carlos, J. (2021)

Mudança cognitiva em obesos com comprometimento cognitivo leve submetidos à perda intencional de peso

Horie, N. C. (2015) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2015.tde-11052015-114427

Busca por alcaloides presentes em Caliphuria subedentata como potenciais candidatos a fármacos para a Doença de Alzheimer

Marques, R. B. (2021) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.17.2021.tde-06122021-121359

Perspective Chapter: Alzheimer - A Complex Genetic Background

Calabrò, M., & Crisafulli, C. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.101455

DHA for Optimal Health

Meyer, B. J. (2018) · MDPI eBooks · doi:10.3390/books978-3-03842-972-2

Identify Complex Higher-Order Associations Between Alzheimer’s Disease Genes and Imaging Markers Through Improved Adaptive Sparse Multi-view Canonical Correlation Analysis

Wang, Y., Kong, X.-Z., Guan, B., Zheng, C.-H., & Gao, Y.-L. (2023) · Lecture notes in computer science · doi:10.1007/978-981-99-4749-2_28

Asociación entre enfermedad periodontal y enfermedad de Alzheimer

García-Vásquez, A. T., Vidal-Chávez, S. R., Anccasi-Zevallos, M., Franco-Quispe, G. A., Ramos-Perfecto, D., & Mattos-Vela, M. A. (2023) · Bionatura · doi:10.21931/rb/2023.08.04.26

Conformational Dynamics in Risk and Resilience Alleles of Apolipoprotein E (APOE) for Alzheimer's DiseasePreprint

Martin, W., & Cheng, F. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4705580

Relationship Between Dyslipidemia and Alzheimer’s Disease

Bolayırlı, M., & Kücür, M. (2024) · doi:10.69860/nobel.9786053359166.12

The biochemical pathways of Alzheimer's disease

El-Gammal, M. A., & Kodous, F. E. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15702-8.00001-4

APOE, Pesticides, Environmental Pollutants, and Epigenetics

Biosca-Brull, J., Colomina, M. T., Cabré, M., & Guardia-Escote, L. (2025) · Springer eBooks · doi:10.1007/978-3-031-52641-1_50-1

ApoE and Methylmercury Intoxication

Bittencourt, L. O., Aschner, M., & Lima, R. R. (2025) · Springer eBooks · doi:10.1007/978-3-031-52641-1_45-1

Rôle des ADAM dans le processus physiopathologique de la maladie d'Alzheimer

Laumet, G. O. (2010) · theses.fr (ABES) · doi:10.70675/94126786zf990z488ezb471z5f1d5686766c

Étude des perturbations astrocytaires sous l’influence de l’apolipoprotéine E4 : implications et applications dans la maladie d’Alzheimer

Arnaud, L. (2021) · theses.fr (ABES) · doi:10.70675/11e3cc48zf040z4b8azb1d3zb7f6a6eed96b

Contribution à l'étude des facteurs de risque pour la maladie d'Alzheimer : analyse de candidats identifiés par étude d'association pangénomique ou GWAS

Bauer, C. (2023) · theses.fr (ABES) · doi:10.70675/0d82043ezd7c7z4fb4z9fc8ze2d05d18b02b

ApoE and Methylmercury Intoxication

Bittencourt, L. O., Aschner, M., & Lima, R. R. (2026) · Springer eBooks · doi:10.1007/978-3-031-96089-5_45

Overinvestment in ultra‑rare APOE variants and highly speculative apoE–inhibitor docking risks undermining translational progress in sporadic Alzheimer’s disease

Gillet, J.-N. (2026) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2026.2671163

Apolipoprotein E and infectious diseases: A framework for therapeutic developments

Viswalingam, V., Kumar, D., Tewari, S., & Ganeshpurkar, A. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-40563-1.00018-1

APOE 4/4 promotes dysfunctional and inflammatory phenotypes concomitant with impaired maturation of hiPSC-derived astrocytesPreprint

Vecino, R., Díaz‐Guerra, E., Arribas-González, E., Gil, D. S., Acosta, F. J. F., Serra, I., Moreno‐Jiménez, E. P., Moratalla, R., Navarrete, M., & Vicario‐Abejón, C. (2026) · Research Square · doi:10.21203/rs.3.rs-10968101/v1

Physicochemical Insights into Apolipoprotein E Isoform-Dependent Inhibition of α-Synuclein Fibrillation

Namba, N., Ariyoshi, S., Shimba, A., Shiroshita, H., Ohgita, T., & Saito, H. (2026) · ACS Omega · doi:10.1021/acsomega.6c09295

Apolipoprotein E: from cardiovascular disease to neurodegenerative disorders

Mahley, R. W. (2016) · Journal of Molecular Medicine · doi:10.1007/s00109-016-1427-y · Cited by 837

Apolipoprotein E structure: insights into function

Hatters, D. M., Peters-Libeu, C. A., & Weisgraber, K. H. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.06.008 · Cited by 583

Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis

Chen, Y., Strickland, M. R., Soranno, A., & Holtzman, D. M. (2021) · Neuron · doi:10.1016/j.neuron.2020.10.008 · Cited by 298

Apolipoprotein E: Diversity of Cellular Origins, Structural and Biophysical Properties, and Effects in Alzheimer's Disease

Huang, Y., Weisgraber, K. H., Mucke, L., & Mahley, R. W. (2004) · Journal of Molecular Neuroscience · doi:10.1385/jmn:23:3:189 · Cited by 242

Apolipoprotein E: From lipid transport to neurobiology

Hauser, P. S., Narayanaswami, V., & Ryan, R. O. (2011) · Progress in Lipid Research · doi:10.1016/j.plipres.2010.09.001 · Cited by 320