Cited by 159Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

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Understanding the Association of Apolipoprotein E4 with Alzheimer Disease: Clues from Its Structure

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Zhong, Ning, Weisgraber, Karl H.·2009·Journal of Biological Chemistry

DOI 10.1074/jbc.r800009200PMC PMC2649104

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Abstract

Despite intense interest, the molecular mechanisms underlying the association of apoE4 with Alzheimer disease are not clear. Because the function (or dysfunction) of a protein is based on its structure, this review focuses on the effects of the structural differences among the isoforms on neurodegeneration. Understanding how apoE4 structure impacts neurodegeneration is likely to provide mechanistic insight as well as potential therapeutic approaches to blunt or reduce its effects.

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Authors: Zhong, N., & Weisgraber, K. H.
Affiliations: Gladstone Institutes (US)
Corresponding author: Weisgraber, Karl H.
ORCID: Zhong, Ning
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 2009-03
Volume: 284
Issue: 10
Pages: 6027-6031
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.r800009200
PMC: PMC2649104
OpenAlex: W2007282102
Cited by: 159
References: 43
Citations by year: 2026: 6 · 2025: 8 · 2024: 7 · 2023: 7 · 2022: 5 · 2021: 8 · 2020: 13 · 2019: 14 · 2018: 4 · 2017: 6 · 2016: 9 · 2015: 4 · 2014: 12 · 2013: 8 · 2012: 11
FWCI: 1.34
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 4196 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Alzheimer's Association
American Health Assistance Foundation
Gladstone Institutes
National Institutes of Health (CO6 RR0118928, AG‐022074)
National Institute on Aging (P01AG022074)
National Center for Research Resources (C06 RR0118928)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: APOE ε4, Alzheimer's disease, APOE isoforms, protein structure, neurodegeneration, molecular mechanisms, therapeutic target
MeSH terms: Alzheimer Disease, Animals, Humans, Structure-Activity Relationship, Protein Structure, Tertiary, Protein Isoforms, Apolipoprotein E4

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Understanding the Association of Apolipoprotein E4 with Alzheimer Disease: Clues from Its Structure

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