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A20: Central Gatekeeper in Inflammation and Immunity

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Coornaert, Beatrice, Carpentier, Isabelle, Beyaert, Rudi·2009·Journal of Biological Chemistry
DOI 10.1074/jbc.r800032200
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Abstract

Inappropriate functioning of the immune system is linked to immune deficiency, autoimmune disease, and cancer. It is therefore not surprising that intracellular immune signaling pathways are tightly controlled. One of the best studied transcription factors in immune signaling is NF-kappaB, which is activated by multiple receptors and regulates the expression of a wide variety of proteins that control innate and adaptive immunity. A20 is an early NF-kappaB-responsive gene that encodes a ubiquitin-editing protein that is involved in the negative feedback regulation of NF-kappaB signaling. Here, we discuss the mechanism of action of A20 and its role in the regulation of inflammation and immunity.

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Metadata

Authors
Coornaert, B., Carpentier, I., & Beyaert, R.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
2009-03
Volume
284
Issue
13
Pages
8217-8221
ISSN
0021-9258 (ISSN-L)
DOI
10.1074/jbc.r800032200
OpenAlex
W2028882640
Cited by
309
References
4
FWCI
8.29
Type
journal article
Language
en
Open access
hybrid
Licence

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CoChat. (2026). Citation check: A20: Central Gatekeeper in Inflammation and Immunity. https://app.cochat.ai/papers/10.1074/jbc.r800032200
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Coornaert, B., Carpentier, I., & Beyaert, R. (2009). A20: Central Gatekeeper in Inflammation and Immunity. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.r800032200

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