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Membrane cholesterol as regulator of human rhomboid protease RHBDL4.
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Lowering cholesterol could increase RHBDL4 activity on full-length APP, with consequent generation of CTFs and decrease in Aβ generation.
“Thus, it is possible that lowering cholesterol could increase RHBDL4 activity on full-length APP, with the consequent generation of CTFs and the decrease in Aβ generation (Paschkowsky et al., 2018).”
From Emerging Alternative Proteinases in APP Metabolism and Alzheimer’s Disease Pathogenesis: A Focus on MT1-MMP and MT5-MMP (2019) · cites this paper as Paschkowsky et al., 2018
High cholesterol levels inhibit RHBDL4 activity, which has been correlated with an increase in the formation of Aβ.
“high cholesterol levels inhibit RHBDL4 activity, which has been correlated with an increase in the formation of Aβ (Paschkowsky et al., 2018).”
From Emerging Alternative Proteinases in APP Metabolism and Alzheimer’s Disease Pathogenesis: A Focus on MT1-MMP and MT5-MMP (2019) · cites this paper as Paschkowsky et al., 2018
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A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins
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η-Secretase processing of APP inhibits neuronal activity in the hippocampus
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Cited by
Sorted by citations
García-González, L., Pilat, D., Baranger, K., & Rivera, S. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00244 · Cited by 88
Metadata
- Authors
- Paschkowsky, S., Recinto, S. J., Young, J. C., Bondar, A.-N., & Munter, L. M.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 293
- Issue
- 40
- Pages
- 15556-15568
- ISSN
- 0021-9258
- Cited by
- 29
- References
- 5
- Language
- en
- Funders
- Fonds de Recherche du Québec - Santé (FRQS) (Pfizer-FRQS 31288)
- Government of Canada | Natural Sciences and Engineering Research Council of Canada (NSERC) (RGPIN-2015–04645)
- Canada Foundation for Innovation (CFI) (LOF 32565)
- Alzheimer Society (PT-58872 and 17–02)
- Scottish Rite Charitable Foundation of Canada (SRCFC) (16112)
- Deutsche Forschungsgemeinschaft (DFG) (FUB Excellence Initiative)
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