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Ischemia in Tumors Induces Early and Sustained Phosphorylation Changes in Stress Kinase Pathways but Does Not Affect Global Protein Levels
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Phosphorylation at corresponding sites in SNX1, SNX3, SNX12, and SNX17 has been reported in various cancer types.
“phosphorylation at corresponding sites in SNX1, SNX3, SNX12, and SNX17 has been reported in various cancer types (47, 48, 49, 50, 51, 52)”
From Phosphorylation of SNX17 impedes activation of Retriever-mediated sorting (2025) · cites this paper as [47]
The Results passages discuss phosphorylation in tumor samples, including EGFR and stress-kinase pathways, but do not identify phosphorylation sites in SNX1, SNX3, SNX12, or SNX17. Searches for those protein names and for sorting-neXIN phosphorylation found no passage in our copy establishing the claimed sites across cancer types. (LLM, conf=0.75)
Experimental — accuracy not yet measuredIncreased phosphorylation of SNX3 and SNX17 PIP-stop motifs has been observed during cold ischemia, coinciding with MAPK stress-response pathway activation.
“increased phosphorylation of SNX3 and SNX17 PIP-stop motifs has been observed during cold ischemia, coinciding with MAPK stress-response pathway activation (47).”
From Phosphorylation of SNX17 impedes activation of Retriever-mediated sorting (2025) · cites this paper as [47]
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Metadata
- Authors
- Mertins, P., Yang, F., Liu, T., Mani, D. R., Petyuk, V. A., Gillette, M. A., Clauser, K. R., Qiao, J. W., Gritsenko, M. A., Moore, R. J., Levine, D. A., Townsend, R., Erdmann-Gilmore, P., Snider, J. E., Davies, S. R., Ruggles, K. V., Fenyo, D., Kitchens, R. T., Li, S., Olvera, N., Dao, F., Rodriguez, H., Chan, D. W., Liebler, D., White, F., Rodland, K. D., Mills, G. B., Smith, R. D., Paulovich, A. G., Ellis, M., & Carr, S. A.
- Venue
- Molecular & Cellular Proteomics
- Publisher
- Elsevier BV
- Published
- 2014-07
- Volume
- 13
- Issue
- 7
- Pages
- 1690-1704
- ISSN
- 1535-9476
- Cited by
- 400
- References
- 6
- Language
- en
- Licence
- Funders
- National Institutes of Health (U24CA160034, U24CA160019, U24CA160035, U24CA159988, U24CA160036, P30CA091842, 3P50 CA68438, CA016672, PO1CA099031, U54CA112970, KG081694, P30 CA16672)
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