Comparison of self-reported alcohol intake with the urinary excretion of 5-hydroxytryptophol: 5-hydroxyindole-3-acetic acid, a biomarker of recent alcohol intake
Open accessAbstract
Under-reporting of alcohol intake has been frequently reported. However, due to the lack of an objective reference method, e.g. a biomarker, information about the extent of under-reporting of alcohol intake obtained with dietary assessment instruments is not available. The objective of this study was to compare reported alcohol intake data derived from a 24 h recall with a biomarker of recent alcohol intake, the urinary excretion of 5-hydroxytryptophol (5-HTOL):5-hydroxyindole-3-acetic acid (5-HIAA). Embedded into the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study, Germany, a validation study that collected 24 h recall data and 24 h urine samples was conducted. Cohort study participants (n 107) volunteered to participate in this validation study. Among them were five subjects who reported no consumption of alcoholic beverages but had a 5-HTOL:5-HIAA ratio that indicated recent alcohol intake when the clinical cut-off point was taken as a judging criterion. After exclusion of these under-reporters, the Pearson's correlation coefficient between reported alcohol intake and the 5-HTOL:5-HIAA ratio was 0.92 (P<0.0001). Except for low alcohol intake of <0.1 g/kg body mass, a significant increase in 5-HTOL:5-HIAA excretion was observed with increasing amounts of alcohol intake. In conclusion, the 5-HTOL:5-HIAA excretion ratio appears to be a valuable quantitative biomarker of recent alcohol consumption. Denial of alcohol intake can be detected, but for the quantification of under-reporting of alcohol intake 24 h reference data are not yet available. With these data at hand, however, 5-HTOL:5-HIAA could become a biomarker for validation purposes in nutritional epidemiology.
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Serotonin metabolism is altered by acute alcohol intake.
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- Authors
- Kroke, A., Klipstein-Grobusch, K., Hoffmann, K., Terbeck, I., Boeing, H., & Helander, A.
- Affiliations
- German Institute of Human Nutrition (DE)
- Karolinska Institutet (SE)
- Corresponding author
- Kroke, Anja
- Venue
- British Journal Of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2001-05
- Volume
- 85
- Issue
- 5
- Pages
- 621-627
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2067941620
- Cited by
- 29
- References
- 42
- Citations by year
- 2024: 2 · 2023: 1 · 2021: 2 · 2019: 1 · 2017: 1 · 2016: 2 · 2014: 3 · 2012: 1
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Keywords
- alcohol consumption, underreporting, 5-hydroxytryptophol, 5-hydroxyindoleacetic acid, urinary biomarkers, 24-hour dietary recall, dietary assessment validation
- MeSH terms
- Adult, Aged, Alcohol Drinking, Female, Humans, Hydroxyindoleacetic Acid, 5-Hydroxytryptophan, Male, Middle Aged, Predictive Value of Tests, Truth Disclosure, Biomarkers, Linear Models
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