The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.
Bioavailability of phyto-oestrogens
Open accessAbstract
The term phyto-oestrogen encompasses isoflavone compounds, such as genistein and daidzein, found predominantly in soya products and the lignans, such as matairesinol and secoisolariciresinol, found in many fruits, cereals and in flaxseed. There is evidence that they have potential health benefits in man particularly against hormone-dependent diseases such as breast and prostate cancers and osteoporosis. This has led to intense interest in their absorption and biotransformation in man. The metabolism of isoflavones and lignans in animals and man is complex and involves both mammalian and gut microbial processes. Isoflavones are present predominantly as glucosides in most commercially available soya products; there is evidence that they are not absorbed in this form and that their bioavailability requires initial hydrolysis of the sugar moiety by intestinal β-glucosidases. After absorption, phyto-oestrogens are reconjugated predominantly to glucuronic acid and to a lesser degree to sulphuric acid. Only a small portion of the free aglycone has been detected in blood, demonstrating that the rate of conjugation is high. There is extensive further metabolism of isoflavones (to equol and O-desmethylangolensin) and lignans (to enterodiol and enterolactone) by gut bacteria. In human subjects, even those on controlled diets, there is large interindividual variation in the metabolism of isoflavones and lignans, particularly in the production of the gut bacterial metabolite equol (from daidzein). Factors influencing absorption and metabolism of phyto-oestrogens include diet and gut microflora.
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Cites
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Self-citationPhytoestrogens: the biochemistry, physiology, and implications for human health of soy isoflavones
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Setchell, K. D. R., Brown, N. M., Desai, P., Zimmer-Nechemias, L., Wolfe, B. E., Brashear, W. T., Kirschner, A. S., Cassidy, A., & Heubi, J. E. (2001) · The Journal of Nutrition · doi:10.1093/jn/131.4.1362s · Cited by 973
Self-citationSoy Isoflavone Aglycones Are Absorbed Faster and in Higher Amounts than Their Glucosides in Humans
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Self-citationExposure of infants to phyto-oestrogens from soy-based infant formula
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Cited by
Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
Manach, C., Williamson, G., Morand, C., Scalbert, A., & Rémésy, C. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.230s · Cited by 4,219
Gut microbiota functions: metabolism of nutrients and other food components
Rowland, I., Gibson, G., Heinken, A., Scott, K., Swann, J., Thiele, I., & Tuohy, K. (2018) · European Journal of Nutrition · doi:10.1007/s00394-017-1445-8 · Cited by 2,878
“The most well-studied example of such inter-individual variation is the microbial metabolism of the soy isoflavone daidzein which is metabolized by two different pathways depending on the gut microbiota of the subjects [96].”
BackgroundInteraction between Phenolics and Gut Microbiota: Role in Human Health
Selma, M. V., Espín, J. C., & Tomás-Barberán, F. A. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf902107d · Cited by 1,324
Darmon, N., & Drewnowski, A. (2015) · Nutrition Reviews · doi:10.1093/nutrit/nuv027 · Cited by 1,258
Flavonoid Bioavailability and Attempts for Bioavailability Enhancement
Thilakarathna, S., & Rupasinghe, H. (2013) · Nutrients · doi:10.3390/nu5093367 · Cited by 787
Metadata
- Authors
- Rowland, I., Faughnan, M., Hoey, L., Wähälä, K., Williamson, G., & Cassidy, A.
- Venue
- British Journal of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2003-06
- Volume
- 89
- Issue
- S1
- Pages
- S45-S58
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2135880728
- Cited by
- 396
- References
- 76
- FWCI
- 12.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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