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Cited by 59Muscle metabolism and nutritionMetabolism, Diabetes, and CancerDiet, Metabolism, and Disease

The DOI matches its Crossref record; 38 of the 41 references it cites were found in a registry or an index.

Dietary whey protein increases liver and skeletal muscle glycogen levels in exercise-trained rats

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Morifuji, Masashi, Sakai, Kensuke, Sanbongi, Chiaki, Sugiura, Katsumi·2005·British Journal of Nutrition
DOI 10.1079/bjn20051373
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Abstract

We investigated the effect of different types of dietary protein on glycogen content in liver and skeletal muscle of exercise-trained rats. Twenty-four male Sprague-Dawley rats (approximately 100 g;n 6 per group) were divided into sedentary or exercise-trained groups with each group being fed either casein or whey protein as the source of dietary protein. Rats in the exercised groups were trained during 2 weeks using swimming exercise for 120 min/d, 6 d/week. Exercise training resulted in an increase in the skeletal muscle glycogen content. Furthermore, the whey protein group significantly increased the skeletal muscle glycogen content compared with the casein group. The increase in glycogen content in liver was significantly greater in rats fed the whey protein diet compared with those fed the casein diet. We also found that the whey protein diet increased the activity of liver glucokinase, whereas it decreased the activities of 6-phosphofructokinase and pyruvate kinase compared with the casein diet. However, hepatic total glycogen synthase activity and mRNA expression were similar with the two diets. In the skeletal muscle, whey protein decreased only 6-phosphofructokinase activity compared with casein. Total glycogen synthase activity in the skeletal muscle in the whey protein group was significantly higher than that in the casein group. The present study is the first to demonstrate that a diet based on whey protein may increase glycogen content in liver and skeletal muscle of exercise-trained rats. We also observed that whey protein regulated glycogen metabolism in these two tissues by different mechanisms.

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Metadata

Authors
Morifuji, M., Sakai, K., Sanbongi, C., & Sugiura, K.
Affiliations
Meiji Seika Pharma Co., Ltd. (Japan) (JP)
Corresponding author
Morifuji, Masashi
ORCID
Venue
British Journal of Nutrition
Publisher
Cambridge University Press (CUP)
Published
2005-04
Volume
93
Issue
4
Pages
439-445
ISSN
  • 0007-1145 (ISSN-L)
  • 1475-2662
DOI
10.1079/bjn20051373
OpenAlex
W2066097229
Cited by
58
References
41
Citations by year
2025: 1 · 2024: 1 · 2021: 2 · 2020: 2 · 2018: 1 · 2017: 3 · 2016: 4 · 2015: 4 · 2014: 8 · 2013: 5 · 2012: 4
FWCI
1.22
Type
journal article
Language
en
Open access
Licence
www.cambridge.org/core/terms (unspecified, 706 d)
Locations
  • British Journal Of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords
whey protein, casein, dietary protein, glycogen, liver glycogen, skeletal muscle glycogen, exercise training, swimming training, glucokinase, 6-phosphofructokinase, pyruvate kinase, glycogen synthase, glycogen metabolism, rats
MeSH terms
Whey Proteins, Animals, Blood Glucose, Caseins, Dietary Proteins, Glycogen, Liver, Liver Glycogen, Male, Milk Proteins, Physical Conditioning, Animal, Proteins, RNA, Messenger, Weight Gain, Rats, Sprague-Dawley, Muscle, Skeletal, Rats

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