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Cited by 22Adipose Tissue and MetabolismRegulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

A role for brown adipose tissue in the genesis of obesity? Studies on experimental animals

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Trayhurn, P., Goodbody, Anne E., Tames, W. P. T.·1982·Proceedings of the Nutrition Society
DOI 10.1079/pns19820022
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Abstract

Whether or not the processes which constitute thermogenesis play a significant role in the regulation of energy balance has long been a matter of controversy.As some of the other contributors to this symposium will testify the controversy is still far from settled.It is our view, however, that in certain experimental circumstances the evidence in favour of a quantitatively important role for thermogenesis in energy balance is strong, while in others, particularly those relating to man, it is not impressive.The biochemical mechanisms responsible for thermogenesis and their tissue localization have also been matters of considerable uncertainty.Over the years skeletal muscle and the liver have generally been regarded as the most likely sites for adaptive thermogenesis, and a number of mechanisms within these tissues have been proposed.These mechanisms include protein turnover, the a-glycerophosphate shuttle, the Na+ pump, and various other specific substrate cycles.None of the mechanisms have been widely accepted, however, and this is partly because in many cases, e.g. the fructose-6-phosphate/fructose-1 ,&-biphosphate cycle, there does not seem to be the potential for generating substantial amounts of heat.The most recent tissue to receive attention as the main site of adaptive thermogenesis is brown adipose tissue (BAT).Although the importance of this organ to thermoregulatory non-shivering thermogenesis in many new-born and hibernating mammals has been accepted for some time, BAT was considered to be of little significance in the thermogenesis of adult animals (Jansky, 1973).This view has been altered radically in the past 3 years, however, by the results of Foster & Frydman (1978, 1979).Using radioactively labelled microspheres to determine regional blood flow, together with measurements of arterio-venous differences in oxygen tension across tissues, these authors were able to demonstrate that BAT was the most important site of non-shivering thermogenesis in adult rats (Foster & Frydman, I 978, 1979).Furthermore, skeletal muscle was shown to play at best only a very minor role.These results have had considerable impact and changes in the activity of BAT in three different situations relevant to energy balance and obesity have now been demonstrated and are described in this paper. Mechanism of heat production in BATA number of mechanisms for thermogenesis in B A T itself have been postulated, both mitochondria1 and extra-mitochondrial.However, the mechanism which has

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  • Studies of pair-fed genetically obese mice have clearly shown a defect in BAT-mediated thermogenesis.

    “Studies of pair-fed genetically obese mice have clearly shown a defect in BAT-mediated thermogenesis 50,51.”

    From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [51]

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Research works printed but not linked: 4

  1. G. Enzi, G. Crepaldi, G. Pozza and A. E. Renold, editors]. London and New York: Academic Press.
  2. Fraser, D. R. & Trayhurn, P. (1981). Biochem. SOC. Trans. 9,470.
  3. Sclafani, A. & Springer, D. (1976). Physiol. Behav. 17, 461.
  4. L. C. H. Wang and J. W. Hudson, editors]. London and New York: Academic Press. (1981). P'ugers Arch. 390, I . Printed in Great Britain https://doi.org/10.1079/PNS19820022 Published online by Cambridge University Press

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Authors
Trayhurn, P., Goodbody, A. E., & Tames, W. P. T.
Affiliations
University of Cambridge (GB)
ORCID
Trayhurn, P.
Venue
Proceedings of the Nutrition Society
Publisher
Cambridge University Press (CUP)
Published
1982-06
Volume
41
Issue
2
Pages
127-131
ISSN
  • 0029-6651 (ISSN-L)
  • 1475-2719
DOI
10.1079/pns19820022
OpenAlex
W2109193501
Cited by
22
References
32
Citations by year
2020: 1 · 2018: 1 · 2016: 1 · 2015: 2 · 2013: 1 · 2012: 1
FWCI
0.47
Type
journal article
Language
en
Open access
Licence
www.cambridge.org/core/terms (unspecified, 9038 d)
Locations
  • Proceedings of The Nutrition Society (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
brown adipose tissue, thermogenesis, obesity, energy balance, non-shivering thermogenesis, adaptive thermogenesis, skeletal muscle thermogenesis, mitochondrial thermogenesis, regional blood flow, oxygen partial pressure
MeSH terms
Animals, Body Temperature Regulation, Adipose Tissue, Brown, Energy Intake, Energy Metabolism, Food Preferences, Humans, Hyperphagia, Hypothalamus, Mice, Obese, Obesity, Mice

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