The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
A Randomized Multicenter Study to Compare Two Treatment Regimens of Topical Methyl Aminolevulinate (Metvix ® )‐PDT in Actinic Keratosis of the Face and Scalp
Open accessAbstract
Photodynamic therapy (PDT) with topical methyl aminolevulinate (MAL) administered in two treatment sessions separated by 1 week is an effective treatment for actinic keratoses. This open prospective study compared the efficacy and safety of MAL-PDT given as a single treatment with two treatments of MAL-PDT 1 week apart. Two hundred and eleven patients with 413 thin to moderately thick actinic keratoses were randomized to either a single treatment with PDT using topical MAL (regimen I; n=105) or two treatments 1 week apart (regimen II; n=106). Each treatment involved surface debridement, application of Metvix cream (160 mg/g) for 3 h, followed by illumination with red light using a light-emitting diode system (peak wavelength 634+/-3 nm, light dose 37 J/cm2). Thirty-seven lesions (19%) with a non-complete response 3 months after a single treatment were re-treated. All patients were followed up 3 months after the last treatment. A total of 400 lesions, 198 initially treated once and 202 treated twice, were evaluable. Complete response rate for thin lesions after a single treatment was 93% (95% CI=87-97%), which was similar to 89% (82-96%) after repeated treatment. Response rates were lower after single treatment of thicker lesions (70% (60-78%) vs 84% (77-91%)), but improved after repeated treatment (88% (82-94%)). The conclusion of this study is that single treatment with topical MAL-PDT is effective for thin actinic keratosis lesions; however, repeated treatment is recommended for thicker or non-responding lesions.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Compared with cryotherapy for actinic keratosis MAL-PDT was found to have a better or similar effectiveness (complete response rate 68%–75% after single treatment) [129,130].”
From Aminolevulinic Acid (ALA) as a Prodrug in Photodynamic Therapy of Cancer (2011) · cites this paper as [129]
Citations
Cites
Epidemiology of actinic keratoses and squamous cell carcinoma
Salasche, S. J. (2000) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2000.103342 · Cited by 534
The risk of progression to invasive disease
Glogau, R. G. (2000) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2000.103339 · Cited by 485
Szeimies, R. (2002) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(02)00056-7 · Cited by 434
Olsen, E. A., Abernethy, M. L., Kulp‐Shorten, C. L., Callen, J. P., Glazer, S. D., Huntley, A. C., McCray, M. K., Monroe, A. B., Tschen, E. H., & Wolf, J. E. (1991) · Journal of the American Academy of Dermatology · doi:10.1016/0190-9622(91)70113-g · Cited by 401
Spontaneous remission of solar keratoses: the case for conservative management
Marks, R., Foley, P. A., Goodman, G. J., Hage, B., & Selwood, T. S. (1986) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1986.tb06644.x · Cited by 319
Photodynamic therapy vs. cryosurgery of basal cell carcinomas: results of a phase III clinical trial
Wang, I., Bendsøe, N., af Klinteberg, C., Enejder, A. M. K., Andersson‐Engels, S., Svanberg, S. R., & Svanberg, K. (2001) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2001.04141.x · Cited by 305
Self-citationPariser, D. M., Lowe, N. J., Stewart, D. M., Jarratt, M. T., Lucky, A. W., Pariser, R. J., & Yamauchi, P. S. (2003) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2003.49 · Cited by 302
Freeman, M., Vinciullo, C., Francis, D., Spelman, L., Nguyen, R., Fergin, P., Thai, K., Murrell, D., Weightman, W., Anderson, C., et al. (2003) · Journal of Dermatological Treatment · doi:10.1080/09546630310012118 · Cited by 285
Prevalence of solar damage and actinic keratosis in a Merseyside population
Memon, A., Tomenson, J. A., Bothwell, J., & Friedmann, P. S. (2000) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2000.03541.x · Cited by 259
Fritsch, C., Homey, B., Stahl, W., Lehmann, P., Ruzicka, T., & Sies, H. (1998) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1998.tb02492.x · Cited by 192
Cited by
Sorted by citations
Photodynamic therapy of cancer. Basic principles and applications
Juarranz, Á., Jaén, P., Sanz-Rodrı́guez, F., Cuevas, J., & González, S. (2008) · Clinical & Translational Oncology · doi:10.1007/s12094-008-0172-2 · Cited by 765
Braathen, L. R., Szeimies, R., Basset‐Séguin, N., Bissonnette, R., Foley, P. A., Pariser, D. M., Roelandts, R., Wennberg, A., & Morton, C. A. (2006) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2006.06.006 · Cited by 658
Self-citationGuidelines for topical photodynamic therapy: update
Morton, C. A., McKenna, K. E., & Rhodes, L. E. (2008) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.08882.x · Cited by 474
Morton, C. A., Szeimies, R. ‐., Sidoroff, A., & Braathen, L. R. (2013) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.12031 · Cited by 344
Wiegell, S. R., Hædersdal, M., Philipsen, P. A., Eriksen, P., Enk, C. D., & Wulf, H. C. (2008) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.08450.x · Cited by 344
Metadata
- Authors
- Tarstedt, M., Rosdahl, I., Berne, B., Svanberg, K., & Wennberg, A.
- Affiliations
- Karlstad Central Hospital (SE)
- ORCID
- Svanberg, Katarina
- Venue
- Acta Dermato-Venereologica
- Published
- 2005-09-01
- Volume
- 85
- Issue
- 5
- Pages
- 424-428
- ISSN
- 0001-5555 (ISSN-L)
- OpenAlex
- W2151481608
- Cited by
- 196
- References
- 16
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 9 · 2018: 10 · 2017: 5 · 2016: 6 · 2015: 23 · 2014: 11 · 2013: 8 · 2012: 11
- FWCI
- 10.45
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Acta Dermato Venereologica (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Nonmelanoma Skin Cancer Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Keywords
- actinic keratosis, methyl aminolevulinate, photodynamic therapy, treatment regimen comparison, lesion thickness, complete response rate, treatment safety
- MeSH terms
- Administration, Topical, Aged, Aminolevulinic Acid, Facial Dermatoses, Female, Humans, Keratosis, Male, Photochemotherapy, Scalp Dermatoses, Ultraviolet Rays, Photosensitizing Agents
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
