Cited by 196Nonmelanoma Skin Cancer StudiesPhotodynamic Therapy Research StudiesSkin Protection and Aging

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A Randomized Multicenter Study to Compare Two Treatment Regimens of Topical Methyl Aminolevulinate (Metvix ® )‐PDT in Actinic Keratosis of the Face and Scalp

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Tarstedt, Mikael, Rosdahl, Inger, Berne, Berit, Svanberg, Katarina, Wennberg, Ann‐Marie·2005·Acta Dermato-Venereologica

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Abstract

Photodynamic therapy (PDT) with topical methyl aminolevulinate (MAL) administered in two treatment sessions separated by 1 week is an effective treatment for actinic keratoses. This open prospective study compared the efficacy and safety of MAL-PDT given as a single treatment with two treatments of MAL-PDT 1 week apart. Two hundred and eleven patients with 413 thin to moderately thick actinic keratoses were randomized to either a single treatment with PDT using topical MAL (regimen I; n=105) or two treatments 1 week apart (regimen II; n=106). Each treatment involved surface debridement, application of Metvix cream (160 mg/g) for 3 h, followed by illumination with red light using a light-emitting diode system (peak wavelength 634+/-3 nm, light dose 37 J/cm2). Thirty-seven lesions (19%) with a non-complete response 3 months after a single treatment were re-treated. All patients were followed up 3 months after the last treatment. A total of 400 lesions, 198 initially treated once and 202 treated twice, were evaluable. Complete response rate for thin lesions after a single treatment was 93% (95% CI=87-97%), which was similar to 89% (82-96%) after repeated treatment. Response rates were lower after single treatment of thicker lesions (70% (60-78%) vs 84% (77-91%)), but improved after repeated treatment (88% (82-94%)). The conclusion of this study is that single treatment with topical MAL-PDT is effective for thin actinic keratosis lesions; however, repeated treatment is recommended for thicker or non-responding lesions.

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Authors: Tarstedt, M., Rosdahl, I., Berne, B., Svanberg, K., & Wennberg, A.
Affiliations: Karlstad Central Hospital (SE)
ORCID: Svanberg, Katarina
Venue: Acta Dermato-Venereologica
Publisher: MJS Publishing, Medical Journals Sweden AB
Published: 2005-09-01
Volume: 85
Issue: 5
Pages: 424-428
ISSN: 0001-5555 (ISSN-L)
DOI: 10.1080/00015550510032887
OpenAlex: W2151481608
Cited by: 196
References: 16
Citations by year: 2026: 1 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 9 · 2018: 10 · 2017: 5 · 2016: 6 · 2015: 23 · 2014: 11 · 2013: 8 · 2012: 11
FWCI: 10.45
Type: journal article
Language: en
Open access: gold
doi.org
Locations: Acta Dermato Venereologica (publishedVersion)
PubMed (publishedVersion)
Lund University Publications (Lund University) (submittedVersion)
Topics: Health Sciences › Medicine › Dermatology › Nonmelanoma Skin Cancer Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Keywords: actinic keratosis, methyl aminolevulinate, photodynamic therapy, treatment regimen comparison, lesion thickness, complete response rate, treatment safety
MeSH terms: Administration, Topical, Aged, Aminolevulinic Acid, Facial Dermatoses, Female, Humans, Keratosis, Male, Photochemotherapy, Scalp Dermatoses, Ultraviolet Rays, Photosensitizing Agents

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A Randomized Multicenter Study to Compare Two Treatment Regimens of Topical Methyl Aminolevulinate (Metvix ® )‐PDT in Actinic Keratosis of the Face and Scalp

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