Expression and localization of steroid receptors in human nasal mucosa
Abstract
OBJECTIVE: To investigate the expression of glucocorticoid receptor (GR), oestrogen receptor (ER), progesterone receptor (PR) and androgen receptor (AR) in nasal mucosa. MATERIAL AND METHODS: Human turbinates were obtained after turbinectomy from seven patients. The expression and localization of steroid receptors were examined using reverse transcriptase polymerase chain reaction (RT-PCR) and immunohistochemistry. RESULTS: Using RT-PCR, GR and ER alpha mRNA were detected in all cases. In contrast, ER beta, PR and AR mRNA were found in five, four and six cases, respectively. Using immunohistochemistry, antibodies to GR showed the presence of GR within all cells of nasal mucosa, with the highest quantities of GR being localized in epithelial cells, submucosal glands and inflammatory leukocytes. Immunohistochemical analysis of sex steroid receptor revealed that anti-ER alpha antibody labelled mainly mast cells and anti-ER beta antibody labelled submucosal glands, and that no PR or AR expression was detected in any of the samples tested. CONCLUSIONS: The role of ER in mast cells and submucosal glands has not been well clarified. However, precise knowledge of the identity and distribution of sex steroid receptor should be of considerable interest in understanding the role of sex hormones in upper airway diseases such as allergic and non-allergic rhinitis.
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The presence of sex steroid receptors on mast cells indicates that sex hormones may exert their biological effects by binding to these receptors.
“Furthermore, the presence of sex steroid receptors on MC indicates that sex hormones may exert their biological effects by binding to these receptors [20–23].”
From Gender-Related Effects of Sex Steroids on Histamine Release and Fc<i>ε</i>RI Expression in Rat Peritoneal Mast Cells (2015) · cites this paper as [22]
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Sex differences and sex steroids in lung health and disease
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- Authors
- Shirasaki, H., Watanabe, K., Kanaizumi, E., Konno, N., Sato, J., Narita, S.-I., & Himi, T.
- Affiliations
- Sapporo Medical University (JP)
- Corresponding author
- Shirasaki, Hideaki
- Venue
- Acta Oto-Laryngologica
- Publisher
- Informa UK Limited
- Published
- 2004-10
- Volume
- 124
- Issue
- 8
- Pages
- 958-963
- ISSN
- 0001-6489 (ISSN-L)
- 1651-2251
- OpenAlex
- W2104902177
- Cited by
- 41
- References
- 16
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 2 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 1 · 2016: 4 · 2015: 4 · 2014: 3 · 2013: 3 · 2012: 2
- FWCI
- 0.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Oto-Laryngologica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- steroid hormone receptors, nasal mucosa, glucocorticoid receptor, estrogen receptor alpha, estrogen receptor beta, progesterone receptor, androgen receptor, mast cells, submucosal glands, sex hormones, allergic rhinitis, non-allergic rhinitis, upper airway diseases
- MeSH terms
- Adolescent, Adult, Animals, Antibodies, Female, Humans, Immunohistochemistry, Male, Middle Aged, Nasal Mucosa, Rabbits, Receptors, Androgen, Receptors, Estrogen, Receptors, Glucocorticoid, Receptors, Progesterone, Receptors, Steroid, Rhinitis, RNA, Messenger, Turbinates, Gene Expression, Reverse Transcriptase Polymerase Chain Reaction, Mice
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