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Cited by 29Coffee research and impactsCardiovascular and exercise physiologyThermoregulation and physiological responses

Metabolic and cardiovascular responses to exercise with caffeine

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TONER, M. M., KIRKENDALL, D. T., DELIO, D. J., CHASE, J. M., CLEARY, P. A., Fox, E. L.·1982·Ergonomics
DOI 10.1080/00140138208925074
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Abstract

The effect of caffeine on circulation and metabolism was studied during a discontinuous maximal oxygen uptake (VO2 max) test on a bicycle ergometer. Eight male subjects were chosen for their minimal use of caffeine of which six normally did not ingest caffeinated beverages. Two caffeinated and two decaffeinated (control) trials were administered to each subject following double-blind and counterbalanced testing procedures. One hour before exercise, subjects ingested decaffeinated coffee with or without 350 mg of caffeine anhydrous added. Cardiac output (Q) was measured by a C02 rebreathing technique. Compared to control trials, caffeine increased the VO2 max by an average of 140ml min−1 (p <0-0·5)l. In addition, during caffeine trials, the average maximal heart rate (HR max) was elevated by 5 beats min−1 (p<0·01). There were no other statistically significant changes in metabolic (VO2 and R) and cardiovascular (Q, HR, SV and (a-v) 02 diff) variables during either submaximal or maximal exercise. Performance, as measured by total exercise time on the VO2 max test, was not significantly different (p>0·05). It was concluded that caffeine has a small physiological but a statistically significant effect on VQ2 max and HR max. During submaximal exercise, caffeine did not significantly effect the cardiovascular system.

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  • Caffeine has previously been shown to prolong time to exhaustion and increase oxygen consumption during endurance exercise.

    “Caffeine has previously been shown to prolong time to exhaustion and increase oxygen consumption during endurance exercise.29,30”

    From Caffeine delays autonomic recovery following acute exercise (2015) · cites this paper as [29]

    In the Results and Conclusions (page not provided), the paper reports increased maximal oxygen consumption after caffeine. It also explicitly says exercise time to exhaustion was unchanged, so it does not support the claimed prolongation. (LLM, conf=0.91)

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Cites

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Research works printed but not linked: 18

  1. [1]1. Chapman, R. A. and C. Leotz. The time-dependent and dose dependent effects of caffeine on the contracture of the ferret heart. Journal of Physiology, 256: 287-314, 1976.
  2. [2]2. Clark, A. and C. B. Olson. Effects of caffeine and iso- prenaline on mammalian ventricular muscle. British Journal of Pharmacology, 47: 1 -11, 1973.
  3. [4]4. Collier, C. Determination of mixed venous COp tension by rebreathing. Journal of Applied Physiology, 9:25-29, 1956.
  4. [6]6. Consolazio, C. R . , R. E. Johnson, and L. J. Pecora. Physiological Measurements of Metabolic Functions in M a n . New York: McGraw-Hill Co., I n c ., 1963.
  5. [7]7. Corbin, J. D . , E. M. Rumann, D. A. Walsh and E. G. Krebs. Activation of adipose tissue lipase by skeletal muscle cyclic adenosine 3 * s5'-monophosphate stimulated protein kinase. Journal of Biological Chemistry, 245: 4849-4851, 1970.
  6. [9]9. Cotten, M. de V. , M. E. Logan and J. I. Moore. Relation ships among cardiac inotropic responses to norepinephrine and cardiac and blood concentrations of H3-norepinephrine during hypothermia. Journal of Pharmacology and Experi mental Therapeutics, 155: 231-241, 1967.
  7. [10]10. Defares, J. G. Determination of Pvco2 from the exponen tial COp rise during rebreathing. Journal of Applied Physiology, 13: 159-164, 1958.
  8. [13]13. Washington, D. C . : University Press of America, 1977.
  9. [14]14. Klausen, K. Comparison of CO2 rebreathing and acetylene methods for cardiac output. Journal of Applied Physiology, 20: 763-766, 1965.
  10. [15]15. Kotchen, T. A., L. H. Hartley, T. W. Rice, E. H. Mougly, L. G. Jones and J. W. Mason. Renin, norepinephrine, and epinephrine responses to graded exercise. Journal of Applied Physiology, 31(2): 178-184, 1971.
  11. [17]17. Logan, M. E. and Cotten, M. de V. Influence of ovalain on the positive inotropic responses to norepinephrine in isolated guinea pig and dog heart preparations at 37° and 25 . Journal of Pharmacology and Experimental Therapeu tics, 155: 242, i W T .
  12. [20]20. Magel, J. R., G. F. Foglia, W. D. McArdle, B. Gutin, G. S. Pechar, and F. I. Katch. Specificity of swim train ing on maximum oxygen uptake. Journal of Applied Physio logy;, 38: 151-155, 1975.
  13. [26]26. McArdle, W. D . , J. R. Magel, G. R. Lesmes and G. S. Pechar. Metabolic and cardiovascular adjustment to work in air and water at 18,25 and 33°C. Journal of Applied Physio logy, 40: 85-90, 1976.
  14. [27]27. Muiesen, G . , C. A. Sorbine, E. Solinas, V. Grassi, G. Casucci and E. Pety. Comparison of CO2 rebreathing and direct Fick methods for determining cardiac output. Journal of Applied Physiology, 24: 424-429, 1968.
  15. [29]29. Pechar, G. S., W. D. McArdle, F. I. Katch, J. R. Magel, and J. DeLuca. Specificity of cardiorespiratory adap tation to bicycle and treadmill training. Journal of Applied Physiology, 3 6 : 753-756, 1974.
  16. [35]35. Von Euler, U. S. Sympatho-adrenal activity in physical exercise. Medicine and Science in Sports, 6(3): 165-173S 1974.
  17. [37]37. Waldeck, B. Sensitization by caffeine of central cate cholamine receptors. Journal of Neurological Trans mission, 34: 61-72,1973.
  18. [38]38. Winsor, A. L. and E. I. Strongin. A study of the develop ment of tolerance for caffeinated beverages. Journal of Experimental Psychology, 16: 725-744, 1933.

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Authors
TONER, M. M., KIRKENDALL, D. T., DELIO, D. J., CHASE, J. M., CLEARY, P. A., & Fox, E. L.
Affiliations
The Ohio State University (US)
ORCID
KIRKENDALL, D. T.
Venue
Ergonomics
Publisher
Informa UK Limited
Published
1982-12
Volume
25
Issue
12
Pages
1175-1183
ISSN
  • 0014-0139 (ISSN-L)
  • 1366-5847
DOI
10.1080/00140138208925074
OpenAlex
W2002988829
Cited by
28
References
33
Citations by year
2024: 3 · 2022: 1 · 2020: 1 · 2019: 1 · 2017: 1 · 2014: 1
FWCI
1.62
Type
journal article
Language
en
Open access
Locations
  • Ergonomics (publishedVersion)
  • PubMed (publishedVersion)
  • OhioLink ETD Center (Ohio Library and Information Network) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Coffee research and impacts
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
Keywords
caffeine, physical activity, VO2max, cardiac output, heart rate, stroke volume, oxygen consumption, submaximal exercise, caffeine ingestion, exercise performance, cardiovascular response, metabolic response
MeSH terms
Adult, Caffeine, Cardiac Output, Physical Exertion, Heart Rate, Humans, Male, Oxygen Consumption

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