Mediators in the association between affective temperaments and suicide risk among psychiatric inpatients
Abstract
BACKGROUND: Affective temperaments have been shown to be related to psychiatric disorders and suicidal behaviors. Less is known about the potential contributory role of affective temperaments on suicide risk factors. In the present study, we investigated whether the effect of affective temperaments on suicide risk was mediated by other variables, such as hopelessness, mentalization deficits, dissociation, psychological pain, and depressive symptoms. METHODS: Several assessment instruments, including the Mini International Neuropsychiatric Interview (MINI); the Temperament Evaluation of Memphis, Pisa, and San Diego Autoquestionnaire (TEMPS-A); the Beck Hopelessness Scale (BHS); the Gotland Male Depression Scale (GMDS); the Dissociative Experiences Scale (DES); the Psychological Pain Assessment Scale (PPAS); and the Mentalization Questionnaire (MZQ), were administered to 189 psychiatrically hospitalized patients (103 women, 86 men) in Rome, Italy. RESULTS: In single-mediator models, hopelessness, depressive symptoms, and mentalization, but not psychological pain or dissociation, were significant mediators in the association between prevalent temperament and suicide risk. In a multiple-mediator model, a significant indirect effect was found only for depression. Results demonstrated that patients with negative temperaments reported higher suicide risk, psychological pain, hopelessness, and depression, and less mentalization than patients with no prevalent temperament or hyperthymic temperaments. CONCLUSIONS: Hopelessness, depression, and mentalization are all factors that mediate the relation between affective temperaments and suicide risk. Identifying factors that mediate the effects of affective temperamental makeup on suicide risk should enhance screening and intervention efforts.
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Mental pain features are crucial for the early detection of suicide risk.
“Mental pain features are also crucial for the early detection of suicide risk [50].”
From High depression symptomatology and mental pain characterize suicidal psychiatric patients (2022) · cites this paper as [50]
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Ahola, A., Rautio, N., Timonen, M., Nordström, T., Jääskeläinen, E., & Miettunen, J. (2022) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2022.152359 · Cited by 6 · see citing works
Vecchiotti, R., Mansueto, G., Marziali, R. A., Marconi, M., Valchera, A., & Cosci, F. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.01.021 · Cited by 6 · see citing works
Observational study of suicide in Switzerland: comparison between psychiatric in- and outpatients
Stauffacher, M. W. D., Stiefel, F., Dorogi, Y., & Michaud, L. (2022) · Swiss Medical Weekly · doi:10.4414/smw.2022.w30140 · Cited by 5 · see citing works
Innamorati, M., Erbuto, D., Rogante, E., Sarubbi, S., Trocchia, M. A., Cifrodelli, M., Migliorati, M., Comparelli, A., Berardelli, I., & Pompili, M. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-06482-3 · Cited by 5 · see citing works
Self-citationŞair, Y., & Saraçoğlu, İ. (2024) · Postgraduate medicine · doi:10.1080/00325481.2024.2402210 · Cited by 1 · see citing works
Discriminative Accuracy of Affective Temperaments in Assessing Suicide Risk
Kang, K. A., Lee, S., Kim, S. Y., & Park, C. H. K. (2025) · Psychiatry Investigation · doi:10.30773/pi.2025.0036
Affective Temperaments and Seasonality in Patients with Mood Disorders
Vincenzo, M. D., Rocca, B. D., Sampogna, G., Toni, C., Cerbo, A. D., Calamaro, S., Guida, F., Atti, A. R., Valenta, S. T., Sani, G., et al. (2025) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s529156
Self-citationMartín-Calvete, J. M., & Ramírez-Uclés, I. (2026) · Child and Adolescent Psychiatry and Mental Health · doi:10.1186/s13034-026-01061-0
- Authors
- Erbuto, D., Innamorati, M., Lamis, D. A., Berardelli, I., Forte, A., De Pisa, E., Migliorati, M., Serafini, G., Gonda, X., Rihmer, Z., Fiorillo, A., Amore, M., Girardi, P., & Pompili, M.
- Affiliations
- Azienda Ospedaliera Sant'Andrea (IT)
- European University of Rome (IT)
- Emory University (US)
- Department of Neurosciences, Mental Health, and Sensory Organs, Suicide Prevention Center, Sant’Andrea Hospital, Sapienza University of Rome, Rome, Italy
- University of Genoa (IT)
- Department of Psychiatry and Psychotherapy, Kútvölgyi Clinical Center, Semmelweis University, Budapest, Hungary
- University of Campania "Luigi Vanvitelli" (IT)
- Corresponding author
- Erbuto, Denise
- ORCID
- Venue
- Psychiatry
- Publisher
- Informa UK Limited
- Published
- 2018-07-03
- Volume
- 81
- Issue
- 3
- Pages
- 240-257
- ISSN
- 0033-2747 (ISSN-L)
- 1943-281X
- OpenAlex
- W2891084198
- Cited by
- 32
- References
- 66
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 2 · 2023: 2 · 2022: 8 · 2021: 2 · 2020: 6 · 2019: 5 · 2018: 1
- FWCI
- 4.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Repository of the Academy's Library (Library of the Hungarian Academy of Sciences) (acceptedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Semmelweis University Repository (Semmelweis University) (submittedVersion)
- Funders
- Fondazione Internazionale Menarini
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Keywords
- affective temperament, suicide risk, psychiatric inpatients, hopelessness, mentalization, depressive symptoms, psychological suffering, dissociation, hyperthymic temperament, mediation, suicide risk screening
- MeSH terms
- Mentalization, Adult, Affect, Mental Disorders, Depression, Female, Humans, Inpatients, Male, Middle Aged, Psychiatric Department, Hospital, Risk Factors, Suicide, Temperament, Hope
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