The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Gender Differences in Gut Transit Shown with a Newly Developed Radiological Procedure
Abstract
BACKGROUND: Gut transit measurements are essential for understanding the pathophysiology of many gastrointestinal disorders. The ideal bowel transit test should be easy to perform, widely accessible, reproducible, non-invasive and inexpensive and the risks should be minimal. These requirements prompted us to develop a procedure for simultaneous measurement of gastric emptying, small-bowel transit and colonic transit at one visit. We assessed the influence of gender, body mass index, age, menopause and smoking on gastrointestinal transit in healthy subjects. METHODS: Eighty-three healthy subjects (43 women) were included. Colonic transit was based on 10 radiopaque rings given daily for 6 days with fluoroscopy on day 7. Then, the subjects had a test meal containing 20 radiopaque markers. Using fluoroscopy, gastric emptying and small-bowel transit of the markers were followed until they reached the colon. RESULTS: Gastric emptying, small-bowel transit and colonic transit were significantly slower in female healthy subjects compared to males (2.9 (1.6-4.9) h, median and percentile 10-90, versus 2.4 (0.7-3.7) h, P=0.005; 4.4 (2.1-11.1) h versus 3.2 (1.5-6.0) h, P=0.001; 1.5 (1.0-3.7) days versus 1.3 (0.8-1.9) days P=0.002), respectively. Small-bowel transit was significantly faster in women with overweight and in postmenopausal women compared to lean and premenopausal women, respectively. CONCLUSION: This procedure meets most of the requirements of the ideal bowel transit test and is easily performed at one visit. Small-bowel transit as well as gastric emptying and colonic transit were significantly slower for women.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“This increase was not attributable to a higher percentage of exogenous carbohydrate oxidation, but, alternatively, was attributed to a smaller decrease in endogenous CHO oxidation in eumenorrheic women during exercise [201].”
From International society of sports nutrition position stand: nutritional concerns of the female athlete (2023) · cites this paper as [201]
In the citing paper
“it has not been established if multiple transportable carbohydrate blends at high doses (up to 90 g · h−1) improve peak exogenous oxidation rates in females [201,211].”
From International society of sports nutrition position stand: nutritional concerns of the female athlete (2023) · cites this paper as [201]
In the citing paper
“Women using COC demonstrate a slightly lower reliance on exogenous CHO oxidation as compared to non-COC users [98,179,201].”
From International society of sports nutrition position stand: nutritional concerns of the female athlete (2023) · cites this paper as [201]
Citations
Cites
The publisher hasn’t deposited this paper’s reference list.
Cited by
Sorted by citations
An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota
Jeffery, I. B., O'Toole, P. W., Öhman, L., Claesson, M. J., Deane, J., Quigley, E. M. M., & Simrén, M. (2012) · Gut · doi:10.1136/gutjnl-2011-301501 · Cited by 835
Sex Differences in Pharmacokinetics and Pharmacodynamics
Gandhi, M., Aweeka, F. T., Greenblatt, R. M., & Blaschke, T. F. (2004) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.44.101802.121453 · Cited by 546
Gender differences in drug responses
Franconi, F., Brunelleschi, S., Steardo, L., & Cuomo, V. (2006) · Pharmacological Research · doi:10.1016/j.phrs.2006.11.001 · Cited by 475
“Regardng pharmacokinetic parameters of drugs assumed by the oral oute, gastrointestinal motility has been shown to be affected y sex hormones [37,38], with the transit time reported slower n females than in males [39,40].”
BackgroundPhysical Activity Improves Symptoms in Irritable Bowel Syndrome: A Randomized Controlled Trial
Johannesson, E., Simrén, M., Strid, H., Bajor, A., & Sadik, R. (2011) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.480 · Cited by 431
“Oroanal transit time : To measure oroanal transit time (”
BackgroundSelf-citationGut instincts: Explorations in intestinal physiology and drug delivery
McConnell, E. L., Fadda, H. M., & Basit, A. W. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2008.05.012 · Cited by 442
Use and abuse of hydrogen breath tests
Simrén, M., & Stotzer, P.-O. (2006) · Gut · doi:10.1136/gut.2005.075127 · Cited by 415
Self-citationRao, S. S. C., Camilleri, M., Hasler, W. L., Maurer, A. H., Parkman, H. P., Saad, R., Scott, S. M., Simrén, M., Soffer, E., & Szarka, L. A. (2010) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01612.x · Cited by 383
AGRAWAL, A., HOUGHTON, L. A., MORRIS, J., REILLY, B., GUYONNET, D., GOUPIL FEUILLERAT, N., SCHLUMBERGER, A., JAKOB, S., & WHORWELL, P. J. (2009) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2008.03853.x · Cited by 334
Zorzi, M., Fedeli, U., Schievano, E., Bovo, E., Guzzinati, S., Baracco, S., Fedato, C., Saugo, M., & Dei Tos, A. P. (2015) · Gut · doi:10.1136/gutjnl-2014-307508 · Cited by 302
Bharucha, A. E., Kudva, Y. C., & Prichard, D. O. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00161 · Cited by 252
Increased colonic bile acid exposure: a relevant factor for symptoms and treatment in IBS
Bajor, A., Törnblom, H., Rudling, M., Ung, K., & Simrén, M. (2014) · Gut · doi:10.1136/gutjnl-2013-305965 · Cited by 215
Shah, A., Talley, N. J., Jones, M., Kendall, B. J., Koloski, N. A., Walker, M. M., Morrison, M., & Holtmann, G. (2020) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000000504 · Cited by 199
Does sex matter? The influence of gender on gastrointestinal physiology and drug delivery.
Freire, A. C., Basit, A., Choudhary, R., Chee, P., & Merchant, H. (2011) · International journal of pharmaceutics · doi:10.1016/j.ijpharm.2011.04.069 · Cited by 185
Colonic Transit Time and IBS Symptoms: What's the Link?
Törnblom, H., Van Oudenhove, L., Sadik, R., Abrahamsson, H., Tack, J., & Simrén, M. (2012) · American Journal of Gastroenterology · doi:10.1038/ajg.2012.5 · Cited by 185
Self-citationPharmacotherapy for Mood Disorders in Pregnancy
Deligiannidis, K. M., Byatt, N., & Freeman, M. P. (2014) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000000087 · Cited by 186
“For example, women have a slower gastric emptying(22) and small bowel and colonic transit time when compared with men, which are further slowed during pregnancy.(23,24) The increased plasma volume, change in protein binding, and lower ratio of lean muscle to adipose tissue in pregnant women may result in a greater vol…”
BackgroundHellmig, S., Schöning, F. V., Gadow, C., Katsoulis, S., Hedderich, J., Fölsch, U., & Stüber, E. (2006) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2006.04449.x · Cited by 190
Southwell, B. R., Clarke, M. C. C., Sutcliffe, J. R., & Hutson, J. M. (2009) · Pediatric Surgery International · doi:10.1007/s00383-009-2387-x · Cited by 165
“emptying [42, 43] and small bowel transit [26].”
BackgroundWang, Y., Mohammed, S. D., Farmer, A. D., Wang, D., Zárate-López, N., Hobson, A. R., Hellström, P. M., Semler, J. R., Kuo, B., Rao, S. S. C., et al. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13329 · Cited by 162
“demonstrated in a study of 83 healthy controls, using a combination technique of ROM and fluoroscopy, that gastric emptying, small-bowel transit and colonic transit were significantly slower in females.(20) The menstrual cycle per se may also influence GI transit, for example, Wald et al.”
ResultClinical translation of advanced colonic drug delivery technologies
Awad, A., Madla, C. M., McCoubrey, L. E., Ferraro, F., Gavins, F. K. H., Buanz, A. B. M., Gaisford, S., Orlu, M., Siepmann, F., Siepmann, J., et al. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.114076 · Cited by 171
Sarosiek, I., Selover, K., KATZ, L. A., Semler, J. R., Wilding, G. E., Lackner, J. M., Sitrin, M. D., Kuo, B., Chey, W. D., Hasler, W. L., et al. (2009) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2009.04162.x · Cited by 147
Steele, R. J., McClements, P. L., Watling, C., Libby, G., Weller, D., Brewster, D., Black, R. B., Carey, F. A., & Fraser, C. G. (2011) · Gut · doi:10.1136/gutjnl-2011-300535 · Cited by 147
Understanding the physiology of human defaecation and disorders of continence and evacuation
Heitmann, P. T., Vollebregt, P. F., Knowles, C. H., Lunniss, P. J., Dinning, P. G., & Scott, S. M. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00487-5 · Cited by 156
Simrén, M., Törnblom, H., Palsson, O. S., Van Oudenhove, L., Whitehead, W. E., & Tack, J. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.04.019 · Cited by 131
Sex Differences in Performance of Fecal Occult Blood Testing
Brenner, H., Haug, U., & Hundt, S. (2010) · The American Journal of Gastroenterology · doi:10.1038/ajg.2010.301 · Cited by 136
Farkouh, A., Riedl, T., Gottardi, R., Czejka, M. J., & Kautzky‐Willer, A. (2019) · Advances in Therapy · doi:10.1007/s12325-019-01201-3 · Cited by 135
How to Interpret a Functional or Motility Test - Colon Transit Study
Kim, E. R., & Rhee, P. (2012) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm.2012.18.1.94 · Cited by 138
Simrén, M., Bajor, A., Gillberg, P.-G., Rudling, M., & Abrahamsson, H. (2011) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04675.x · Cited by 114
“4 days).(17) The CTT was reduced in the highest dose groups from 4.”
BackgroundDeiteren, A., Camilleri, M., Bharucha, A. E., Burton, D. D., McKinzie, S., Rao, A. S., & Zinsmeister, A. R. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01441.x · Cited by 111
“In the most commonly applied radiopaque marker transit technique, subjects ingest radiopaque markers on three [9] or six [12] consecutive days, and a single abdominal x-ray is obtained on the subsequent day and, if necessary, on one or more days later [13].”
BackgroundVarum, F., Merchant, H., & Basit, A. (2010) · International journal of pharmaceutics · doi:10.1016/j.ijpharm.2010.04.046 · Cited by 111
METHODS FOR THE ASSESSMENT OF SMALL BOWEL AND COLONIC TRANSIT
Szarka, L., & Camilleri, M. (2012) · Seminars in nuclear medicine · doi:10.1053/j.semnuclmed.2011.10.004 · Cited by 96
“This method has also been used to determine differences in small bowel residence time between healthy men and women (48).”
MethodAccelerated Regional Bowel Transit and Overweight Shown in Idiopathic Bile Acid Malabsorption
Sadik, R., Abrahamsson, H., Ung, K., & Stotzer, P. (2004) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2004.04139.x · Cited by 103
“These markers were plotted against time to obtain the small bowel transit profile (8).”
BackgroundMethodResultInfluentialSelf-citationTests and investigations for colorectal cancer screening
Carroll, M., Seaman, H. E., & Halloran, S. P. (2014) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2014.04.019 · Cited by 93
International society of sports nutrition position stand: nutritional concerns of the female athlete
Sims, S. T., Kerksick, C. M., Smith-Ryan, A. E., Janse de Jonge, X. A. K., Hirsch, K. R., Arent, S. M., Hewlings, S. J., Kleiner, S. M., Bustillo, E., Tartar, J. L., et al. (2023) · Journal of the International Society of Sports Nutrition · doi:10.1080/15502783.2023.2204066 · Cited by 129
“Second, females exhibit slower gastric emptying and gut motility [202,203], a greater incidence of exercise-”
BackgroundNandhra, G. K., Mark, E. B., Tanna, G. L. D., Haase, A., Poulsen, J. L., Christodoulides, S., Kung, V., Klinge, M. W., Knudsen, K., Borghammer, P., et al. (2019) · Neurogastroenterology & Motility · doi:10.1111/nmo.13734 · Cited by 90
Ashiru-Oredope, D. A. I., Patel, R., & Basit, A. W. (2008) · Pharmaceutical Research · doi:10.1007/s11095-008-9635-y · Cited by 88
Sadik, R., Bjornsson, E. S., & Simrén, M. (2009) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e32832ffd9b · Cited by 86
Self-citationSadik, R., Stotzer, P. ‐., Simrén, M., & Abrahamsson, H. (2008) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2007.01025.x · Cited by 81
Self-citationDiaz Tartera, H. O., Webb, D. ‐., Al‐Saffar, A. K., Halim, M. A., Lindberg, G., Sangfelt, P., & Hellström, P. M. (2017) · Neurogastroenterology & Motility · doi:10.1111/nmo.13107 · Cited by 81
Öhman, L., Stridsberg, M., Isaksson, S., Jerlstad, P., & Simrén, M. (2012) · The American Journal of Gastroenterology · doi:10.1038/ajg.2011.458 · Cited by 74
Jaruvongvanich, V., Patcharatrakul, T., & Gonlachanvit, S. (2017) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm17022 · Cited by 73
Abrahamsson, H., Östlund-Lindqvist, A.-M., Nilsson, R., Simrén, M., & Gillberg, P.-G. (2008) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520802321212 · Cited by 67
“3 days based on measurements in 76 healthy women [8,9].”
BackgroundMethodSelf-citationRapid Gastric Emptying Is More Common than Gastroparesis in Patients With Autonomic Dysfunction
Lawal, A., Barboi, A., Krasnow, A., Hellman, R., Jaradeh, S., & Massey, B. T. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00946.x · Cited by 66
“27 ), many studies have in fact identified a similar difference in gastric emptying times among men and women”
BackgroundEffect of heavy exercise on gastrointestinal transit in endurance athletes
Strid, H., Simrén, M., Störsrud, S., Stotzer, P.-O., & Sadik, R. (2011) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521.2011.558110 · Cited by 65
“Reference values for gastrointestinal transit were obtained from 83 healthy subjects (40 male and 43 female) [16].”
BackgroundMethodInfluentialSelf-citationSpecial population considerations and regulatory affairs for clinical research
Grimsrud, K., Sherwin, C. M. T., Constance, J. E., Tak, C. R., Zuppa, A. F., Spigarelli, M. G., & Mihalopoulos, N. L. (2015) · Clinical Research and Regulatory Affairs · doi:10.3109/10601333.2015.1001900 · Cited by 66
“(39), in reviewing population PK studies in newborns and infants, found that 51% of studies that used these software tool and advanced clinical trial designs and techniques reported an estimate for PK parameters in that population, with 49% concluding with dosing recommendations, despite the fact these studies had not…”
ResultWollmer, E., Ungell, A.-L. B., Nicolas, J.-M., & Klein, S. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.114084 · Cited by 64
Parkman, H. P., Sharkey, E. P., McCallum, R. W., Hasler, W. L., Koch, K. L., Sarosiek, I., Abell, T. L., Kuo, B., Shulman, R. J., Grover, M., et al. (2020) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2020.10.045 · Cited by 59
Moradi, T., Gridley, G., Björk, J. A., Dosemeci, M., Ji, B., Berkel, H. J., & Lemeshow, S. A. (2008) · European Journal of Cancer Prevention · doi:10.1097/cej.0b013e3282b6fd78 · Cited by 59
Epidemiology of slow and fast colonic transit using a scale of stool form in a community
Choung, R. S., Locke, G. R., ZINSMEISTER, A. R., Schleck, C. D., & Talley, N. J. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03456.x · Cited by 58
Chronic Intestinal Pseudo-Obstruction due to Buserelin-Induced Formation of Anti-GnRH Antibodies
Ohlsson, B., VERESS, B., Janciauskiene, S. M., Montgomery, A. K., Haglund, M., & Wallmark, A. (2007) · Gastroenterology · doi:10.1053/j.gastro.2006.10.036 · Cited by 57
Timm, D. A., Willis, H. J., Thomas, W. T. B., Sanders, L., Boileau, T. W.-M., & Slavin, J. L. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510004988 · Cited by 59
Peripheral factors in the pathophysiology of irritable bowel syndrome
Gunnarsson, J., & Simrén, M. (2009) · Digestive and Liver Disease · doi:10.1016/j.dld.2009.07.006 · Cited by 57
“In our centre, we have developed a procedure for simultaneous measurement of gastric emptying, small-bowel transit and colonic transit at one visit using radiopaque markers [48], and altered small intestinal transit is a frequent finding in patients with a wide range of symptoms suggestive of a functional gastrointest…”
MethodSex-Bias in Irritable Bowel Syndrome: Linking Steroids to the Gut-Brain Axis
So, S. Y., & Savidge, T. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.684096 · Cited by 62
Deoula, M. M. S., Kinany, K. E., Huybrechts, I., Gunter, M. J., Hatime, Z., Boudouaya, H. A., Benslimane, A., Nejjari, C., Abkari, M. E., Badre, W., et al. (2019) · International Journal of Cancer · doi:10.1002/ijc.32689 · Cited by 44
“This was an unexpected finding in women because Sadik et al.(23) demonstrated that the prolonged gastrointestinal transit time in women compared to men may lead to a prolonged exposure of the mucosa to carcinogens.”
ResultKalaitzakis, E., Sadik, R., Holst, J. J., Öhman, L., & Bjornsson, E. S. (2008) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2008.11.022 · Cited by 46
Self-citationFunctional Constipation: Individualising Assessment and Treatment
Pannemans, J., Masuy, I., & Tack, J. (2020) · Drugs · doi:10.1007/s40265-020-01305-z · Cited by 46
Prevalence of constipation in the German population – a representative survey (GECCO)
Enck, P., Leinert, J., Smid, M., Köhler, T., & Schwille‐Kiuntke, J. (2015) · United European Gastroenterology Journal · doi:10.1177/2050640615603009 · Cited by 43
Segmental colonic transit studies: comparison of a radiological and a scintigraphic method
Lundin, E., Graf, W., Garske, U., Nilsson, S., Maripuu, E., & Karlbom, U. (2007) · Colorectal Disease · doi:10.1111/j.1463-1318.2006.01153.x · Cited by 46
The National Health Service Bowel Cancer Screening Program: the early years
Rees, C. J., & Bevan, R. (2013) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2013.811045 · Cited by 43
Andersson, S., Lönroth, H., Simrén, M., Ringstrom, G., Elfvin, A., & Abrahamsson, H. (2006) · Neurogastroenterology and Motility · doi:10.1111/j.1365-2982.2006.00801.x · Cited by 39
Self-citationTrenaman, S. C., Bowles, S. K., Andrew, M. K., & Goralski, K. B. (2021) · Pharmacology Research & Perspectives · doi:10.1002/prp2.775 · Cited by 42
Olausson, E. A., Brock, C., Drewes, A. M., Grundin, H., Isaksson, M., Stotzer, P.-O., Abrahamsson, H., Attvall, S., & Simrén, M. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12075 · Cited by 40
Self-citationArora, Z., Parungao, J. M., López, R., Heinlein, C. A., Santisi, J. M., & Birgisson, S. (2014) · Digestive Diseases and Sciences · doi:10.1007/s10620-014-3431-9 · Cited by 40
Sex Effect on Average Bioequivalence
Ibarra, M., Vázquez, M., & Fagiolino, P. L. (2016) · Clinical Therapeutics · doi:10.1016/j.clinthera.2016.11.024 · Cited by 40
Medium-Term Outcome of Sacral Nerve Modulation for Constipation
Govaert, B., Maeda, Y., Alberga, J., et al. (2011) · Diseases of the Colon & Rectum · doi:10.1097/dcr.0b013e31823898a5 · Cited by 40
The Effect of Sex and Age on Small Intestinal Transit Times in Humans
Fischer, M., & Fadda, H. M. (2015) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.24619 · Cited by 39
Brenner, H., Qian, J., & Werner, S. (2018) · Clinical Epidemiology · doi:10.2147/clep.s155548 · Cited by 37
“There might be several plausible explanations for the lower sensitivity and higher specificity of FITs among women compared with men, such as the higher proportion of AN located in the proximal colon which are more difficult to detect by FIT,(28) lower rates of aspirin use for cardioprotection,(21) and the longer colo…”
BackgroundAuge, J. M., Fraser, C. G., Rodriguez, C., et al. (2015) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2015-0388 · Cited by 36
Diagnosis of small intestinal bacterial overgrowth: the challenges persist!
Abu-Shanab, A., & Quigley, E. M. M. (2009) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.3.1.77 · Cited by 35
Development of Irritable Bowel Syndrome Features Over a 5-year Period
Clevers, E., Tack, J., Törnblom, H., Ringström, G., Luyckx, K., Simrén, M., & Van Oudenhove, L. (2018) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.02.043 · Cited by 34
The influence of female sex and estrogens on drug pharmacokinetics: what is the evidence?
Bosch, E., Sommer, I. E., & Touw, D. J. (2025) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2025.2481891 · Cited by 38
“Thirdly, gastrointestinal transit times in the small intestine are longer in women than in men, with estrogens contributing to these prolonged transit times by relaxing smooth muscle and reducing gastrointestinal motility [18,19].”
Shah, A., Talley, N. J., & Holtmann, G. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.830356 · Cited by 34
Hasler, W. L. (2006) · Elsevier eBooks · doi:10.1016/b978-012088394-3/50041-6 · Cited by 11
Waseem, M. R., Shin, A., Siwiec, R. M., James-Stevenson, T. N., Bohm, M. E., Rogers, N. A., Wo, J. M., Waseem, L., Gupta, A., Jarrett, M., et al. (2022) · Clinical and Translational Gastroenterology · doi:10.14309/ctg.0000000000000541 · Cited by 33
“Over a 7-day period, participants underwent CTT assessments using a validated radiopaque marker method (19), submitted stool samples for SCFA and BA quantification by high-performance liquid chromatography, and completed4-day fooddiaries (seeAppendix, SupplementaryDigital Content 1, http://links.”
Accuracy in assessment of colonic transit time with particles: how many markers should be used?
Abrahamsson, H., & Antov, S. (2010) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01543.x · Cited by 29
Self-citationColon transit time in healthy children and adolescents
Velde, S. V., Notebaert, A., Meersschaut, V., Herregods, N., Winckel, M. V., & Biervliet, S. V. (2013) · International Journal of Colorectal Disease · doi:10.1007/s00384-013-1750-5 · Cited by 29
“[17] (55 h adults).”
Brenner, H., Calderazzo, S., Seufferlein, T. T. W., et al. (2019) · JAMA · doi:10.1001/jama.2019.4755 · Cited by 28
Montagnani, M. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i47.7710 · Cited by 28
Benini, F., Mora, A., Turini, D., Bertolazzi, S., Lanzarotto, F., Ricci, C., Villanacci, V., Barbara, G., Stanghellini, V., & Lanzini, A. (2012) · Neurogastroenterology and Motility · doi:10.1111/j.1365-2982.2011.01822.x · Cited by 27
Go with the flow: modeling unique biological flows in engineered in vitro platforms
Wasson, E. M., Dubbin, K., & Moya, M. L. (2021) · Lab on a Chip · doi:10.1039/d1lc00014d · Cited by 27
Malagelada, C., & Malagelada, J. R. (2017) · Current Gastroenterology Reports · doi:10.1007/s11894-017-0565-x · Cited by 27
Borg, J., Simrén, M., & Ohlsson, B. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01599.x · Cited by 26
Bach, T., Galbiati, S., Kennedy, J. K., et al. (2020) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01018-20 · Cited by 26
Effects of female steroid hormones on A‐type K+currents in murine colon
Beckett, E. A. H., McCloskey, C., O'Kane, N., Sanders, K. M., & Koh, S. D. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.107375 · Cited by 25
“Previous clinical studies (Lawson et al. 1985; Hutson et al. 1989; Baron et al. 1993; Meier et al. 1995; Bond et al. 1996; Jung et al. 2003; Sadik et al. 2003) and in vivo and in vitro animal experiments (Ryan & Bhojwani, 1986; Chen et al.”
ResultGut Transit in Celiac Disease: Delay of Small Bowel Transit and Acceleration after Dietary Treatment
Sadik, R., Abrahamsson, H., Kilander, A. F., et al. (2004) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2004.40406.x · Cited by 26
“For colonic transit measurements the patients ingested 10 radiopaque rings daily for 6 days (8, 9, 13).”
BackgroundMethodResultInfluentialSelf-citationGhoshal, U., Sengar, V., & Srivastava, D. (2012) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm.2012.18.2.227 · Cited by 26
Imaging and clinical assessment of functional defecatory disorders with emphasis on defecography
Lalwani, N., Sayed, R. F. E., Kamath, A., Lewis, S. C., Arif, H., & Chernyak, V. (2019) · Abdominal Radiology · doi:10.1007/s00261-019-02142-9 · Cited by 24
Clark, G., Strachan, J. A., McPherson, A., Digby, J., Mowat, C., Steele, R. J., & Fraser, C. G. (2020) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2020-0268 · Cited by 24
Andersson, S., Ringström, G., Elfvin, A., et al. (2010) · Digestion · doi:10.1159/000291905 · Cited by 24
Self-citationA future for faecal haemoglobin measurements in the medical laboratory
Fraser, C. G. (2012) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1258/acb.2012.012065 · Cited by 23
Vulcan, A., Manjer, J., Ericson, U., & Ohlsson, B. (2017) · Food & Nutrition Research · doi:10.1080/16546628.2017.1341810 · Cited by 23
“The prolonged gastrointestinal transit time in women compared with men may lead to a prolonged exposure of the mucosa to carcinogens [28].”
BackgroundInterpretation of overall colonic transit in defecation disorders in males and females
Shin, A., Camilleri, M., Nadeau, A. M., Nullens, S., Rhee, P., Jeong, I. D., & Burton, D. D. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12095 · Cited by 23
Sex differences of brain and their implications for personalized therapy
Rezzani, R., Franco, C., & Rodella, L. F. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.01.030 · Cited by 24
Sex-dependent modulation of treatment response
Rubinow, D. R., & Moore, M. (2004) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2004.6.1/drubinow · Cited by 23
Glucagon-like peptide (GLP)-1 regulation of lipid and lipoprotein metabolism
HOFFMAN, S. S., & Adeli, K. (2024) · Medical Review · doi:10.1515/mr-2024-0011 · Cited by 23
“However, the initial peak in GLP-1 ’ s biphasic secretion is likely mediated not by direct nutrient contact but via a more rapid mechanism such as neural signaling, since the majority of intestinal L-cells are located in the distal ileum, and small intestinal transit time can exceed 3 h [17, 18].”
Backgroundvan Giersbergen, P. L. M., & Dingemanse, J. (2007) · The Journal of Clinical Pharmacology · doi:10.1177/0091270007305298 · Cited by 21
“As for the effect of food on the tmax of miglustat, the effect of gender may possibly be explained by a difference in gastric emptying time, which is longer in women.(20,21) The observed gender difference in tmax is not considered clinically relevant because miglustat is indicated for the treatment of a chronic condit…”
BackgroundSex, age, and genetics in anesthesia
Booij, L. H. (2008) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0b013e3283007ea3 · Cited by 21
Sex-Related Differences in Chronic Pain: A Narrative Review by a Multidisciplinary Task Force
Marchesini, M., Fornasari, D., Natoli, S., Vegni, E. A. M., & Cuomo, A. (2025) · Medicina · doi:10.3390/medicina61071172 · Cited by 24
Faecal Occult Blood Testing for Colorectal Cancer Screening: the Past or the Future
Benton, S. C., Seaman, H. E., & Halloran, S. P. (2015) · Current Gastroenterology Reports · doi:10.1007/s11894-015-0428-2 · Cited by 21
Kalaitzakis, E., Josefsson, A., Castedal, M., Henfridsson, P., Bengtsson, M., Andersson, B. A., & Bjornsson, E. S. (2013) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521.2013.836755 · Cited by 20
“Gut transit has been reported to be slower in women compared to men [34] and visceral sensitivity to be influenced by ovarian hormones [15,18].”
BackgroundBajor, A., Kilander, A. F., Sjövall, H., Rudling, M., & Ung, K. (2008) · Digestive Diseases and Sciences · doi:10.1007/s10620-008-0256-4 · Cited by 20
“A high BMI has been shown to be correlated to a more rapid transit [24, 25 ], and subjects with severe overweight also have a higher bile acid synthesis rate [26].”
Background
Metadata
- Authors
- Sadik, R., Abrahamsson, H., & Stotzer, P.-O.
- Affiliations
- Sahlgrenska University Hospital (SE)
- ORCID
- Sadik, R.
- Venue
- Scandinavian Journal of Gastroenterology
- Publisher
- Informa UK Limited
- Published
- 2003-01
- Volume
- 38
- Issue
- 1
- Pages
- 36-42
- ISSN
- 0036-5521 (ISSN-L)
- 1502-7708
- OpenAlex
- W2041872557
- Cited by
- 183
- References
- 0
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 6 · 2023: 8 · 2022: 7 · 2021: 14 · 2020: 10 · 2019: 13 · 2018: 7 · 2017: 6 · 2016: 5 · 2015: 8 · 2014: 7 · 2013: 10 · 2012: 12
- FWCI
- 3.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Scandinavian Journal of Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eli Lilly and Company
- Vetenskapsrådet
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Urology › Pelvic floor disorders treatments
- Health Sciences › Medicine › Surgery › Enhanced Recovery After Surgery
- Keywords
- gastrointestinal transit, gender differences, gastric emptying, small intestinal transit, colonic transit, radiopaque markers, fluoroscopy, menopause, body mass index, smoking, healthy volunteers
- MeSH terms
- Adolescent, Adult, Age Factors, Aged, Colon, Digestive System, Digestive System Physiological Phenomena, Female, Fluoroscopy, Gastric Emptying, Gastrointestinal Transit, Humans, Intestine, Small, Male, Menopause, Middle Aged, Sex Factors, Body Mass Index
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
