Colonic Transit Time and IBS Symptoms: What's the Link?
Open accessAbstract
OBJECTIVES: The relevance of colonic transit alterations for the overall symptom pattern in irritable bowel syndrome (IBS) is incompletely understood. The aim of this study was to assess the total and segmental colonic transit time (CTT) and their relationship to symptoms and subgroups in a large sample of IBS patients. METHODS: Total and segmental CTT was assessed using radiopaque markers in 359 patients with IBS (279 females). These results were compared with existing normal values for healthy men and women without gastrointestinal (GI) symptoms. Stool frequency and consistency (Bristol Stool Form (BSF) scale), and the perceived severity of three GI symptoms (bloating, flatulence, and abdominal pain) were noted in a daily diary during the measurement week. Patients could be classified by the BSF scale characteristics into Rome III subtypes (n=338), or by use of the Rome II modular questionnaire into Rome II subtypes (n=143). RESULTS: CTT was normal in 287 patients (80%), whereas 53 (15%) had accelerated and 19 (5%) had delayed CTT. Transit abnormalities in relation to gender-specific reference values were more common in males (30.0%) than in females (17.2%; P < 0.05). IBS subgrouping according to Rome III (P < 0.0001) and Rome II criteria (P < 0.001) was associated with the presence of abnormal CTT. Stool form (r=-0.40; P < 0.0001) and stool frequency (r=-0.30; P<0.0001) were moderately and negatively correlated to total CTT. No correlations of clinical significance were found between transit data and the three GI symptoms. CONCLUSIONS: Total and segmental colonic transit alterations are of importance for the abnormal bowel habit seen in men and women with IBS, but of no or minor importance for other IBS symptoms.
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Colonic transit time correlates inversely with stool consistency and, to a lesser extent, with stool frequency.
“Colonic transit time correlates inversely with stool consistency and, to a lesser extent, with stool frequency.45”
From British Society of Gastroenterology guidelines on the management of irritable bowel syndrome (2021) · cites this paper as [45]
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- Authors
- Törnblom, H., Van Oudenhove, L., Sadik, R., Abrahamsson, H., Tack, J., & Simrén, M.
- Affiliations
- Karolinska University Hospital (SE)
- University of Gothenburg (SE)
- KU Leuven (BE)
- Corresponding author
- Törnblom, Hans
- Venue
- American Journal of Gastroenterology
- Published
- 2012-05
- Volume
- 107
- Issue
- 5
- Pages
- 754-760
- ISSN
- 0002-9270 (ISSN-L)
- OpenAlex
- W2118738825
- Cited by
- 185
- References
- 38
- Citations by year
- 2026: 8 · 2025: 12 · 2024: 10 · 2023: 8 · 2022: 16 · 2021: 28 · 2020: 14 · 2019: 11 · 2018: 10 · 2017: 7 · 2016: 18 · 2015: 13 · 2014: 12 · 2013: 14 · 2012: 4
- FWCI
- 13.39
- Type
- journal article
- Language
- en
- Open access
- green
- lirias.kuleuven.be
- Licence
- Locations
- The American Journal of Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Lirias (submittedVersion, other-oa)
- Funders
- Fonds Wetenschappelijk Onderzoek
- Göteborgs Universitet
- Vlaamse regering
- Medical Research Council
- Sahlgrenska Akademin
- Centrum fÖr Personcentrerad Vård
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Rheumatology › Pelvic floor disorders treatments
- Health Sciences › Health Professions › Pharmacy › Infant Health and Development
- Keywords
- irritable bowel syndrome, colonic transit time, radiopaque markers, IBS subtypes, Rome III criteria, Rome II criteria, stool frequency, stool consistency, Bristol Stool Form Scale, bloating, flatulence, abdominal pain, sex differences, bowel habits
- MeSH terms
- Adolescent, Adult, Aged, Colon, Defecation, Female, Gastrointestinal Transit, Humans, Male, Middle Aged, Surveys and Questionnaires, Irritable Bowel Syndrome, Young Adult
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