Cited by 88Substance Abuse Treatment and OutcomesNeurotransmitter Receptor Influence on BehaviorHistorical and Modern Theater Studies

Cocaine users differ from normals on cognitive tasks which show poorer performance during drug abstinence

Pace-Schott, Edward F., Morgan, Peter T., Malison, Robert T., Hart, Carl L., Edgar, Chris, Walker, Matthew, Stickgold, Robert·2008·The American Journal of Drug and Alcohol Abuse

Abstract

Seventeen non-treatment seeking cocaine-dependent individuals participated in three-week longitudinal inpatient studies of cognitive changes during drug use and abstinence. Protocols included three days drug-free baseline, three days cocaine self-administration, and two weeks complete abstinence. A repeatable cognitive battery showed attention and delayed verbal recognition memory but not working memory to be impaired in cocaine users compared to age- and sex-matched normative values. Attention was significantly poorer during the first and second week of abstinence compared to days on which cocaine was used suggesting that certain cocaine-induced impairments may be acutely normalized by cocaine use, but resurface during abstinence.

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Crossref · 10.1080/00952990701764821

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Authors
Pace-Schott, E. F., Morgan, P. T., Malison, R. T., Hart, C. L., Edgar, C., Walker, M., & Stickgold, R.
Affiliations
  • Beth Israel Deaconess Medical Center (US)
  • Yale University (US)
  • New York State Psychiatric Institute (US)
Corresponding author
Pace-Schott, Edward F.
Venue
The American Journal of Drug and Alcohol Abuse
Published
2008-01
Volume
34
Issue
1
Pages
109-121
ISSN
  • 0095-2990 (ISSN-L)
  • 1097-9891
OpenAlex
W2003411858
Cited by
88
References
27
Citations by year
2026: 1 · 2025: 3 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2019: 7 · 2018: 3 · 2017: 4 · 2016: 8 · 2015: 5 · 2014: 6 · 2013: 6 · 2012: 14
FWCI
3.91
Type
journal article
Language
en
Open access
closed
Locations
  • The American Journal of Drug and Alcohol Abuse (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Drug Abuse (K02 DA00397, R01DA11744, R01DA011744, K02DA000397)
  • National Center for Research Resources (M01RR000125, K12 RR 17594, M01 RR-00125, K12RR017594)
Topics
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
Keywords
cocaine dependence, cocaine self-administration, drug abstinence, cognitive impairment, attention, verbal recognition memory, working memory, longitudinal cognitive change
MeSH terms
Adult, Attention, Clinical Protocols, Cognition Disorders, Connecticut, Female, Humans, Longitudinal Studies, Male, Neuropsychological Tests, New York, Reference Values, Self Administration, Smoking, Substance Withdrawal Syndrome, Crack Cocaine, Cocaine-Related Disorders

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