Metabolic effect of obesity on polycystic ovary syndrome in adolescents: a meta-analysis
Abstract
This meta-analysis provides an updated and comprehensive estimate of the effects of obesity on metabolic disorders in adolescent polycystic ovary syndrome (PCOS). Relevant articles consistent with the search terms published up to 31 January 2014 were retrieved from PubMed, EMBASE, PsycINFO and CENTRAL. Thirteen articles (16 independent studies) conformed to the inclusion criteria. The evaluated outcomes were the metabolic parameters of obese adolescents with PCOS (case group) relative to normal-weight adolescents with PCOS, or obese adolescents without PCOS. Compared with normal-weight adolescents with PCOS, the case group had significantly lower sex hormone-binding globulin and high-density lipoprotein cholesterol, and significantly higher triglycerides, leptin, fasting insulin, low-density lipoprotein cholesterol and free testosterone levels. Relative to obese adolescents without PCOS, the case group had significantly higher fasting insulin, low-density lipoprotein cholesterol, free testosterone levels and 2-h glucose during the oral glucose tolerance test. These results indicate that metabolic disorders in adolescent PCOS are worsened by concomitant obesity. This study highlights the importance of preventing obesity during the management of adolescent PCOS. Impact statement What is already known about this subject: Obesity and PCOS share many of the same metabolic disorders, for example, hyperandrogenism and hyperinsulinemia with subsequent insulin resistance. Knowledge regarding metabolic features in obese adolescents with PCOS is limited, and there is concern whether obesity and PCOS are related. What do the results of this study add: Relative to PCOS adolescents of normal weight, obese adolescents with PCOS (the case group) had significantly lower SHBG and HDL-C, and significantly higher triglycerides, leptin, fasting insulin, LDL-C and free testosterone levels. The results indicate that metabolic disorders in adolescent PCOS are worsened by concomitant obesity. What are the implications of these findings for clinical practice and/or further research: Obesity, metabolic disorders and PCOS in adolescents are associated. Obesity exacerbates metabolic disorders in adolescent PCOS. This study highlights the importance of preventing obesity during the management of adolescent PCOS. Therapeutic intervention combined with lifestyle modification may provide better treatment for adolescent PCOS. The aetiologies of PCOS combined with obesity in adolescents require further investigation.
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A meta-analysis showed that subjects with PCOS had remarkably lower levels of SHBG and that this effect was even more pronounced in subjects with concomitant obesity.
“A meta-analysis showed that subjects with PCOS had remarkably lower levels of SHBG and that this effect was even more pronounced in subjects with concomitant obesity [196].”
From Role of sex hormone-binding globulin in the free hormone hypothesis and the relevance of free testosterone in androgen physiology (2022) · cites this paper as [196]
Obesity exacerbates metabolic and psychological comorbidities of PCOS.
“Prevention of weight gain and effective weight management is important in adolescent PCOS, as obesity exacerbates metabolic and psychological comorbidities of PCOS [175, 176].”
From Polycystic Ovary Syndrome: Pathophysiology, Presentation, and Treatment With Emphasis on Adolescent Girls (2019) · cites this paper as [175]
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- Authors
- Li, L., Feng, Q., Ye, M., He, Y., Yao, A., & Shi, K.
- Affiliations
- Guangzhou Women and Children Medical Center (CN)
- Southern Medical University (CN)
- Corresponding author
- Shi, Kun
- Venue
- Journal of Obstetrics and Gynaecology
- Publisher
- Informa UK Limited
- Published
- 2017-06-28
- Volume
- 37
- Issue
- 8
- Pages
- 1036-1047
- ISSN
- 0144-3615 (ISSN-L)
- 1364-6893
- OpenAlex
- W2726818742
- Cited by
- 85
- References
- 28
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 16 · 2023: 11 · 2022: 16 · 2021: 14 · 2020: 7 · 2019: 4 · 2018: 1
- FWCI
- 0.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Obstetrics and Gynaecology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Guangzhou Women and Childrens Medical Center
- Southern Medical University
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Keywords
- polycystic ovary syndrome, adolescent obesity, metabolic disorders, insulin resistance, hyperinsulinemia, hyperandrogenism, sex hormone-binding globulin, HDL cholesterol, LDL cholesterol, triglycerides, leptin, free testosterone, oral glucose tolerance test, obesity prevention
- MeSH terms
- Adolescent, Blood Glucose, Female, Glucose Tolerance Test, Humans, Insulin, Cholesterol, HDL, Cholesterol, LDL, Metabolic Diseases, Obesity, Polycystic Ovary Syndrome, Sex Hormone-Binding Globulin, Testosterone, Triglycerides, Body Mass Index, Leptin
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