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Cited by 28Ovarian function and disordersSleep and related disordersObstructive Sleep Apnea Research

Relationships between polysomnographic variables, parameters of glucose metabolism, and serum androgens in obese adolescents with polycystic ovarian syndrome: Polysomnographic and endocrine variables in PCOS

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DE SOUSA, GIDEON, SCHLÜTER, BERNHARD, MENKE, THOMAS, TROWITZSCH, ECKARDT, ANDLER, WERNER, REINEHR, THOMAS·2011·Journal of Sleep Research
DOI 10.1111/j.1365-2869.2010.00902.x
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Abstract

The aim of this study was to compare polysomnographic variables of obese adolescents with polycystic ovarian syndrome (PCOS) to those of healthy controls and to analyse whether polysomnographic variables correlate to parameters of body weight/body composition, to serum androgens and to parameters of glucose metabolism. Thirty-one obese adolescents with PCOS (15.0 years ± 1.0, body mass index 32.7 kg per m(2) ± 6.2) and 19 healthy obese adolescents without PCOS (15.2 years ± 1.1, body mass index 32.4 kg per m(2) ± 4.0) underwent polysomnography to compare apnoea index, hypopnoea index, apnoea-hypopnoea index, the absolute number of obstructive apnoeas, percentage sleep Stages 1, 2, 3 and 4 of non-rapid eye movement (NREM) sleep, percentage of REM sleep, TIB, total sleep time (TST), sleep-onset latency, total wake time (TWT), wakefulness after sleep onset (WASO) and sleep efficiency. Furthermore, we correlated polysomnographic variables to parameters of body weight/body composition, to serum androgens and to parameters of glucose metabolism. We found no differences between the two groups concerning the respiratory indices, percentage sleep Stages 2, 3 and 4 of NREM sleep, TIB and sleep-onset latency. The girls with PCOS differed significantly from the controls regarding TST, WASO, TWT, sleep efficiency, percentage Stage 1 of NREM sleep and percentage of REM sleep. We found a weak significant correlation between insulin resistance and apnoea index and between insulin resistance and apnoea-hypopnoea index. Concerning the respiratory variables, adolescents with PCOS do not seem to differ from healthy controls; however, there seem to be differences concerning sleep architecture.

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Crossref · 10.1111/j.1365-2869.2010.00902.x

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  • The certainty of evidence for composite obstructive sleep apnea (OSA) was low.

    “GRADE assessments indicated that evidence certainty for composite OSA was low due to being twice downgraded for the moderate or high risk of bias of all included studies (serious risk of bias) and having no outcome events in two studies (serious imprecision) (20, 40).”

    From Obstructive sleep apnea syndrome in polycystic ovary syndrome: a systematic review and meta-analysis (2025) · cites this paper as [20]

    The Results (page unavailable) report no OSAS diagnoses in either the study or control group, supporting the cited paper’s contribution to the statement about studies with no outcome events. This paper does not report a GRADE assessment or establish that the certainty of the composite OSA evidence was low; nor can it establish the findings of the other cited study. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • Past cross-sectional studies have shown lower rates of obstructive sleep apnea syndrome (OSAS) in adolescents with polycystic ovary syndrome (PCOS) (0-57%).

    “Past cross-sectional studies have shown that OSAS is highly prevalent in women with PCOS (15–19) compared with the general population of reproductive-aged women (17-75% vs. 9-28%) (9, 10), with lower rates in adolescents with PCOS (0-57%) (20, 21).”

    From Obstructive sleep apnea syndrome in polycystic ovary syndrome: a systematic review and meta-analysis (2025) · cites this paper as [20]

    The Results report no OSAS diagnoses among 31 obese adolescents with PCOS, and the Discussion says OSAS does not seem frequent in adolescents with PCOS. This supports the low end of the cited range, but the paper does not report a 57% rate or establish the full 0–57% range. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • Variable adjustment for important confounders such as age, BMI and ethnicity is a limitation.

    “Other limitations include, variable adjustment for important confounders such as age, BMI and ethnicity (16, 19, 20)”

    From Obstructive sleep apnea syndrome in polycystic ovary syndrome: a systematic review and meta-analysis (2025) · cites this paper as [20]

    The Statistics section (page unavailable) describes unpaired t-tests and Pearson correlations, with no adjustment for age, BMI or ethnicity. The Discussion says cases and controls were matched for weight status, but its stated limitations do not identify variable confounder adjustment as a limitation. The paper therefore illustrates limited statistical adjustment without supporting the full characterization attributed to it. (LLM, conf=0.76)

    Experimental — accuracy not yet measured

  • Past cross-sectional studies have shown that obstructive sleep apnea syndrome (OSAS) is highly prevalent in women with polycystic ovary syndrome (PCOS) compared with the general population of reproductive-aged women (17-75% vs. 9-28%).

    “Past cross-sectional studies have shown that OSAS is highly prevalent in women with PCOS (15–19) compared with the general population of reproductive-aged women (17-75% vs. 9-28%) (9, 10), with lower rates in adolescents with PCOS (0-57%) (20, 21).”

    From Obstructive sleep apnea syndrome in polycystic ovary syndrome: a systematic review and meta-analysis (2025) · cites this paper as [20]

  • All eight included studies employed polysomnography (PSG) to measure obstructive sleep apnea (OSA).

    “All eight studies employed PSG to measure OSAS (as this was an inclusion criterion) (15–21, 40), five of which also assessed the presence of other OSAS-related symptoms such as excessive daytime sleepiness (15, 16, 18, 19, 21).”

    From Obstructive sleep apnea syndrome in polycystic ovary syndrome: a systematic review and meta-analysis (2025) · cites this paper as [20]

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Cites

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Research works printed but not linked: 3

  1. Cole, T. J. The LMS method for constructing normalized growth standards. Eur. J. Clin. Nutr., 1990, 44: 45-60.
  2. Kromeyer-Hauschild, K., Wabitsch, M., Kunze, D. et al. Percentiles of body mass index in children and adolescents evaluated from different regional German studies. Monatsschr. Kinderheilkd., 2001, 149: 807-818.
  3. Kromeyer-Hausschild, K., Gla¨ßer, N. and Zellner, K. Waist circum- ference percentile in Jena children (Germany) 6 to 18 years of age. Aktuel. Ernahrungsmed., 2008, 33: 116-122.

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Authors
DE SOUSA, G., SCHLÜTER, B., MENKE, T., TROWITZSCH, E., ANDLER, W., & REINEHR, T.
Affiliations
Witten/Herdecke University (DE)
ORCID
REINEHR, THOMAS
Venue
Journal of Sleep Research
Publisher
Wiley
Published
2010-12-29
Volume
20
Issue
3
Pages
472-478
ISSN
0962-1105 (ISSN-L)
DOI
10.1111/j.1365-2869.2010.00902.x
OpenAlex
W1523927095
Cited by
28
References
38
Citations by year
2026: 2 · 2025: 2 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 3 · 2012: 6
FWCI
2.66
Type
journal article
Language
en
Open access
Licence
doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 1707 d)
Locations
  • Journal of Sleep Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
Keywords
polycystic ovary syndrome, adolescent obesity, sleep architecture, sleep-disordered breathing, insulin resistance, glucose metabolism, serum androgens, obstructive sleep apnea, wake after sleep onset, REM sleep, NREM sleep stages
MeSH terms
Adolescent, Androgens, Androstenedione, Blood Glucose, Female, Glucose, Humans, Obesity, Polycystic Ovary Syndrome, Sleep, Sleep, REM, Testosterone, Wakefulness, Body Mass Index, Case-Control Studies, Polysomnography, Dehydroepiandrosterone Sulfate

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