Cancer Cell Signaling Pathways Targeted by Spice-Derived Nutraceuticals

Cyclooxygenase-2-Dependent Expression of Angiogenic CXC Chemokines ENA-78/CXC Ligand (CXCL) 5 and Interleukin-8/CXCL8 in Human Non-Small Cell Lung Cancer

Pǒld, M., Zhu, L. X., Sharma, S. P., Burdick, M. D., Lin, Y., Lee, P. P. N., Põld, A., Luo, J., Krysan, K., Dohadwala, M., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3262 · Cited by 150

Capsaicin (8-methyl-N-vanillyl-6-nonenamide) is a potent inhibitor of nuclear transcription factor-kappa B activation by diverse agents

Singh, S., Natarajan, K., & Aggarwal, B. B. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.10.4412 · Cited by 148

Curcumin Inhibits Platelet-Derived Growth Factor–Stimulated Vascular Smooth Muscle Cell Function and Injury-Induced Neointima Formation

Yang, X., Thomas, D. P., Zhang, X., Culver, B. W., Alexander, B. M., Murdoch, W. J., Rao, M. N., Tulis, D. A., Ren, J. T., & Sreejayan, N. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000191635.00744.b6 · Cited by 148

AP-1 a Target for Cancer Prevention

Matthews, C. P., Colburn, N. H., & Young, M. R. (2007) · Current Cancer Drug Targets · doi:10.2174/156800907780809723 · Cited by 147

Diosgenin, a naturally occurring steroid, suppresses fatty acid synthase expression in HER2‐overexpressing breast cancer cells through modulating Akt, mTOR and JNK phosphorylation

Chiang, C.-T., Way, T., Tsai, S.-J., & Lin, J. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.11.021 · Cited by 144

A Randomized Phase IIb Trial of Anethole Dithiolethione in Smokers with Bronchial Dysplasia

Lam, S. C. (2002) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/94.13.1001 · Cited by 144

Targeting cell signaling pathways for drug discovery: An old lock needs a new key

Aggarwal, B. B., Sethi, G., Baladandayuthapani, V., Krishnan, S., & Shishodia, S. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21500 · Cited by 144

In vitroInhibitory Effects of Thymol and Quinones ofNigella sativaSeeds on Cyclooxygenase-1- and -2-Catalyzed Prostaglandin E2Biosyntheses

Maršík, P., Kokoška, L., Landa, P., Nepovím, A., Soudek, P., & Tomas, V. (2005) · Planta Medica · doi:10.1055/s-2005-871288 · Cited by 143

Interplay of RUNX1/MTG8 and DNA Methyltransferase 1 in Acute Myeloid Leukemia

Liu, S., Shen, T., Huynh, L., Klisovic, M. I., Rush, L. J., Ford, J. L., Yu, J., Becknell, B., Yu, L., Liu, C., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4532 · Cited by 142

Dietary Curcumin Attenuates Glioma Growth in a Syngeneic Mouse Model by Inhibition of the JAK1,2/STAT3 Signaling Pathway

Weissenberger, J., Priester, M., Bernreuther, C., Rakel, S., Glatzel, M., Seifert, V., & Kögel, D. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-0446 · Cited by 142

Curcumin suppresses constitutive activation of STAT‐3 by up‐regulating protein inhibitor of activated STAT‐3 (PIAS‐3) in ovarian and endometrial cancer cells

Saydmohammed, M., Joseph, D., & Syed, V. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22558 · Cited by 142

Curcumin induces cell‐arrest and apoptosis in association with the inhibition of constitutively active NF‐κB and STAT3 pathways in Hodgkin's lymphoma cells

Mackenzie, G. G., Queisser, N., Wolfson, M. L., Fraga, C. G., Adamo, A. M., & Oteiza, P. I. (2008) · International Journal of Cancer · doi:10.1002/ijc.23477 · Cited by 142

Natural derivatives of curcumin attenuate the Wnt/β-catenin pathway through down-regulation of the transcriptional coactivator p300

Ryu, M., Cho, M., Song, J., Yun, Y., Choi, I., Kim, D., Park, B., & Oh, S. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.10.171 · Cited by 140

Inhibitory effects of [6]‐gingerol on PMA‐induced COX‐2 expression and activation of NF‐κB and p38 MAPK in mouse skin

Kim, S. O., Chun, K., Kundu, J. K., & Surh, Y. (2004) · BioFactors · doi:10.1002/biof.552210107 · Cited by 140

Plasma Levels of Insulin-Like Growth Factor-1 and Binding Protein-3, and Their Association With Bladder Cancer Risk

Zhao, H., Grossman, H. B., Spitz, M. R., Lerner, S. P., ZHANG, K., & Wu, X. (2003) · The Journal of Urology · doi:10.1016/s0022-5347(05)63999-7 · Cited by 138

PPARγ as a therapeutic target for tumor angiogenesis and metastasis

Panigraphy, D., Huang, S., Kieran, M. W., & Kaipainen, A. (2005) · Cancer Biology & Therapy · doi:10.4161/cbt.4.7.2014 · Cited by 137 · cited 1×

Inhibition of ligand-induced activation of epidermal growth factor receptor tyrosine phosphorylation by curcumin

Korutla, L., Cheung, J. Y., Medelsohn, J., & Kumar, R. (1995) · Carcinogenesis · doi:10.1093/carcin/16.8.1741 · Cited by 133

Curcumin suppresses proliferation and invasion in human gastric cancer cells by down-regulation of PAK1 activity and cyclin D1 expression

Cai, X., Wang, J., Xiao-Dong, L., Wang, G., Liu, F., Cheng, M., & Li, F. (2009) · Cancer Biology & Therapy · doi:10.4161/cbt.8.14.8720 · Cited by 131

Inhibition of EGFR signaling in human prostate cancer PC-3 cells by combination treatment with β-phenylethyl isothiocyanate and curcumin

Kim, J. H., Xu, C., Keum, Y., Reddy, B. S., Conney, A. H., & Kong, A. T. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi272 · Cited by 131

Naturally Occurring Small‐Molecule Inhibitors of Hedgehog/GLI‐Mediated Transcription

Hosoya, T., Arai, M. A., Koyano, T., Kowithayakorn, T., & Ishibashi, M. (2008) · ChemBioChem · doi:10.1002/cbic.200700511 · Cited by 129

Suppression of dextran sodium sulfate-induced colitis in mice by zerumbone, a subtropical ginger sesquiterpene, and nimesulide: separately and in combination

Murakami, A., Hayashi, R., Takana, T., Kwon, K. H., Ohigashi, H., & Safitri, R. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(03)00446-5 · Cited by 128

Hedgehog Signal Activation in Gastric Pit Cell and in Diffuse-Type Gastric Cancer

Fukaya, M., Isohata, N., Ohta, H., Aoyagi, K., Ochiya, T., Saeki, N., Yanagihara, K., Nakanishi, Y., Taniguchi, H., Sakamoto, H., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.05.008 · Cited by 128

The type I insulin-like growth factor receptor pathway: a key player in cancer therapeutic resistance

Angelo, J. C. (2008) · Frontiers in bioscience · doi:10.2741/2925 · Cited by 126

Curcumin inhibits the Sonic Hedgehog signaling pathway and triggers apoptosis in medulloblastoma cells

Elamin, M. H., Shinwari, Z., Hendrayani, S., Al‐Hindi, H., Shail, E. A., Khafaga, Y., Al‐Kofide, A., & Aboussekhra, A. (2009) · Molecular Carcinogenesis · doi:10.1002/mc.20604 · Cited by 126

Inhibition of Bcr–Abl kinase activity by PD180970 blocks constitutive activation of Stat5 and growth of CML cells

Huang, M., Dorsey, J. F., Epling‐Burnette, P. K., Nimmanapalli, R., Landowski, T. H., Mora, L. B., Niu, G., Sinibaldi, D., Bai, F., Kraker, A. J., et al. (2002) · Oncogene · doi:10.1038/sj.onc.1206028 · Cited by 126

Antiemetic effect of ginger in gynecologic oncology patients receiving cisplatin

Manusirivithaya, S., Sripramote, M., Tangjitgamol, S., Sheanakul, C., Leelahakorn, S., Thavaramara, T., & Tangcharoenpanich, K. (2004) · International Journal of Gynecological Cancer · doi:10.1111/j.1048-891x.2004.14603.x · Cited by 123

Capsaicin Induces Heme Oxygenase-1 Expression in HepG2 Cells Via Activation of PI3K-Nrf2 Signaling: NAD(P)H:Quinone Oxidoreductase as a Potential Target

Joung, E.-J., Li, M., Lee, H. G., Somparn, N., Jung, Y. S., Na, H., Kim, S., Cha, Y., & Surh, Y. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1827 · Cited by 121

Oral capsaicin provides temporary relief for oral mucositis pain secondary to chemotherapy/radiation therapy

Berger, A. M., Henderson, M., Nadoolman, W., Duffy, V. B., COOPER, D. L., Saberski, L. R., & Bartoshuk, L. M. (1995) · Journal of Pain and Symptom Management · doi:10.1016/0885-3924(94)00130-d · Cited by 120

Diosgenin inhibits macrophage-derived inflammatory mediators through downregulation of CK2, JNK, NF-κB and AP-1 activation

Jung, D., Park, H., Byun, H.-E., Park, Y.-M., Kim, T., Kim, B.-O., Um, S.-H., & Pyo, S. (2010) · International Immunopharmacology · doi:10.1016/j.intimp.2010.06.004 · Cited by 119

Involvement of AMPK Signaling Cascade in Capsaicin‐Induced Apoptosis of HT‐29 Colon Cancer Cells

KIM, Y. M., Hwang, J., KWAK, D. W., Lee, Y. K., & Park, O. J. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1397.053 · Cited by 118

Developmental and environmental regulation of a mammary gland-specific nuclear factor essential for transcription of the gene encoding beta-casein.

Schmitt-Ney, M., Happ, B., Ball, R. K., & Groner, B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.7.3130 · Cited by 116

Targeting constitutive and interleukin‐6‐inducible signal transducers and activators of transcription 3 pathway in head and neck squamous cell carcinoma cells by curcumin (diferuloylmethane)

Chakravarti, N., Myers, J. N., & Aggarwal, B. B. (2006) · International Journal of Cancer · doi:10.1002/ijc.21967 · Cited by 115

Anti-tumor-promoting activities of selected pungent phenolic substances present in ginger.

Surh, Y., Park, K. K., Chun, K., Lee, L. J., Lee, E., & Lee, S. S. (1999) · PubMed · Cited by 114

A prospective study of serum insulin-like growth factor-I (IGF-I), IGF-II, IGF-binding protein-3 and breast cancer risk

Allen, N. E., Roddam, A. W., Allen, D., Fentiman, I., Silva, I. D. S., Peto, J., Holly, J. M. P., & Key, T. J. (2005) · British Journal of Cancer · doi:10.1038/sj.bjc.6602471 · Cited by 114

Capsaicin, a Spicy Component of Hot Pepper, Induces Apoptosis by Activation of the Peroxisome Proliferator-Activated Receptor γ in HT-29 Human Colon Cancer Cells

Kim, C.-S., Park, W.-H., Park, J.-Y., Kang, J., Kim, M.-O., Kawada, T., Yoo, H., Han, I., & Yu, R. (2004) · Journal of Medicinal Food · doi:10.1089/jmf.2004.7.267 · Cited by 113

Curcumin Selectively Induces Apoptosis in Cutaneous T-Cell Lymphoma Cell Lines and Patients’ PBMCs: Potential Role for STAT-3 and NF-κB Signaling

Zhang, C., Li, B., Zhang, X., Hazarika, P., Aggarwal, B. B., & Duvic, M. A. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.86 · Cited by 112

Biologically Targeted Cancer Therapy and Marginal Benefits: Are We Making Too Much of Too Little or Are We Achieving Too Little by Giving Too Much?

Fojo, T., & Parkinson, D. R. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-1277 · Cited by 110

Ursolic acid inhibits proliferation and induces apoptosis of HT-29 colon cancer cells by inhibiting the EGFR/MAPK pathway

Shan, J., Xuan, Y., Zheng, S. S., Dong, Q., & Zhang, S. (2009) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b0920149 · Cited by 109

Diosgenin inhibits melanogenesis through the activation of phosphatidylinositol-3-kinase pathway (PI3K) signaling

Lee, J., Jung, K., Kim, Y. S., & Park, D. (2007) · Life Sciences · doi:10.1016/j.lfs.2007.05.009 · Cited by 107

Inhibition of 5-hydroxy-eicosatetraenoic acid (5-HETE) formation in intact human neutrophils by naturally-occurring diarylheptanoids: inhibitory activities of curcuminoids and yakuchinones

Flynn, D. L., Rafferty, M. F., & Boctor, A. M. (1986) · Prostaglandins Leukotrienes and Medicine · doi:10.1016/0262-1746(86)90146-0 · Cited by 107

Curcumin, a compound with anti-inflammatory and anti-oxidant properties, down-regulates chemokine expression in bone marrow stromal cells.

Xu, Y. X., Pindolia, K. R., Janakiraman, N., Noth, C. J., Chapman, R., & Gautam, S. C. (1997) · PubMed · Cited by 106

Expression of peroxisome proliferator‐activated receptors (PPARs) in human urinary bladder carcinoma and growth inhibition by its agonists

Yoshimura, R., Matsuyama, M., Segawa, Y., Hase, T., Mitsuhashi, M., Tsuchida, K., Wada, S., Kawahito, Y., Sano, H., & Nakatani, T. (2003) · International Journal of Cancer · doi:10.1002/ijc.10980 · Cited by 104

Signaling Pathways Activated by Oncogenic Forms of Abl Tyrosine Kinase

Zou, X., & Calame, K. L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.26.18141 · Cited by 104

A new class of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists that inhibit growth of breast cancer cells: 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes.

Qin, C., Morrow, D., Stewart, J., Spencer, K., Porter, W. W., Smith, R., Phillips, T. D., Abdelrahim, M., Samudio, I. J., & Safe, S. H. (2004) · PubMed · Cited by 103

Antiinvasive effect of xanthohumol, a prenylated chalcone present in hops (Humulus lupulus L.) and beer

Vanhoecke, B. W. A., Derycke, L., Marck, V. V., Depypere, H. T., Keukeleire, D. D., & Bracke, M. (2005) · International Journal of Cancer · doi:10.1002/ijc.21249 · Cited by 101

Increased expression of sonic hedgehog and altered methylation of its promoter region in gastric cancer and its related lesions

Wang, L., Choi, Y., Hua, X.-Y., Shin, Y. K., Song, Y., Youn, S.-J., Yun, H.-Y., Park, S.-M., Kim, W., Kim, H., et al. (2006) · Modern Pathology · doi:10.1038/modpathol.3800573 · Cited by 100

Inhibition of carcinogen induced c-Ha-ras and c-fos proto-oncogenes expression by dietary curcumin

Limtrakul, P., Anuchapreeda, S., Lipigorngoson, S., & Dunn, F. W. (2001) · BMC Cancer · doi:10.1186/1471-2407-1-1 · Cited by 99

Protein and Ginger for the Treatment of Chemotherapy-Induced Delayed Nausea

Levine, M. E., Gillis, M. G., YANCHIS, S., Voss, A. C., Stern, R. M., & Koch, K. L. (2008) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2007.0817 · Cited by 98

Downregulation of survivin and activation of caspase-3 through the PI3K/Akt pathway in ursolic acid-induced HepG2 cell apoptosis

Tang, C., Lu, Y.-H., Xie, J., Wang, F., Zou, J.-N., Yang, J.-S., Xing, Y., & Xi, T. (2009) · Anti-Cancer Drugs · doi:10.1097/cad.0b013e328327d476 · Cited by 97

Ursolic acid-induced down-regulation of MMP-9 gene is mediated through the nuclear translocation of glucocorticoid receptor in HT1080 human fibrosarcoma cells

Cha, H., Park, M., Chung, H., Kim, N. D., Sato, H., Seiki, M., & Kim, K. (1998) · Oncogene · doi:10.1038/sj.onc.1201587 · Cited by 94

PDGF receptor kinase inhibitors for the treatment of PDGF driven diseases

Levitzki, A. (2004) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2004.03.010 · Cited by 94

Analysis of Signal Transducer and Activator of Transcription 3 (Stat 3) Pathway in Multiple Myeloma

Quintanilla-Martinez, L., Kremer, M., Specht, K., Calzada-Wack, J., Nathrath, M., Schaich, R., Höfler, H., & Fend, F. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64278-2 · Cited by 93

Regulatory Effect of the AMPK–COX‐2 Signaling Pathway in Curcumin‐Induced Apoptosis in HT‐29 Colon Cancer Cells

Lee, Y., Park, S. Y., Kim, Y., & Park, O. J. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04699.x · Cited by 93

Cardamonin, inhibits pro-inflammatory mediators in activated RAW 264.7 cells and whole blood

Ahmad, S., Israf, D. A., Lajis, N. H., Shaari, K., Mohamed, H., Wahab, A. A., Ariffin, K. T., Hoo, W. Y., Aziz, N. A., Kadir, A. A., et al. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.03.070 · Cited by 93

Antitumor Effects of Ursolic Acid in a Mouse Model of Postmenopausal Breast Cancer

de Angel, R. E., Smith, S. M., Glickman, R. D., Perkins, S. N., & Hursting, S. D. (2010) · Nutrition and Cancer · doi:10.1080/01635581.2010.492092 · Cited by 93

Growth inhibitory and apoptosis-inducing effects of xanthohumol, a prenylated chalone present in hops, in human prostate cancer cells.

Deeb, D., Gao, X., Jiang, H., Arbab, A. S., Dulchavsky, S. A., & Gautam, S. C. (2010) · PubMed · Cited by 93

Combining Radiation and Molecular Targeting in Cancer Therapy

Camphausen, K., & Tofilon, P. J. (2004) · Cancer Biology & Therapy · doi:10.4161/cbt.3.3.544 · Cited by 93

Cooperation of cyclooxygenase 1 and cyclooxygenase 2 in intestinal polyposis.

Takeda, H., Sonoshita, M., Oshima, H., Sugihara, K.-I., Chulada, P. C., Langenbach, R. J., Oshima, M., & Taketo, M. M. (2003) · PubMed · Cited by 92

Curcumin induces growth-arrest and apoptosis in association with the inhibition of constitutively active JAK–STAT pathway in T cell leukemia

Rajasingh, J., Raikwar, H. P., Muthian, G., Johnson, C., & Bright, J. J. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.12.014 · Cited by 90

The Role of IGF-1R in Pediatric Malignancies

Kim, S. Y., Toretsky, J. A., Scher, D., & Helman, L. J. (2009) · The Oncologist · doi:10.1634/theoncologist.2008-0189 · Cited by 90

Induction of apoptosis by ursolic acid through activation of caspases and down-regulation of c-IAPs in human prostate epithelial cells.

Choi, Y. H., Baek, J. H., Yoo, M., Chung, H. Y., Kim, N. D., & Kim, K.-W. (2000) · International Journal of Oncology · doi:10.3892/ijo.17.3.565 · Cited by 87

Eugenol suppressed the expression of lipopolysaccharide-induced proinflammatory mediators in human macrophages

Lee, Y.-Y., Hung, S.-L., Pai, S.-F., Lee, Y.-H., & Yang, S.-F. (2007) · Journal of Endodontics · doi:10.1016/j.joen.2007.02.010 · Cited by 87

Activation of peroxisome proliferator-activated receptor-γ by curcumin blocks the signaling pathways for PDGF and EGF in hepatic stellate cells

Lin, J., & Chen, A. (2008) · Laboratory Investigation · doi:10.1038/labinvest.2008.20 · Cited by 86

Basic evidence of molecular targeted therapy for oral cancer and salivary gland cancer

Hamakawa, H., Nakashiro, K., Sumida, T., Shintani, S., Myers, J. N., Takes, R. P., Rinaldo, A., & Ferlito, A. (2008) · Head & Neck · doi:10.1002/hed.20830 · Cited by 86

Capsiate, a Nonpungent Capsaicin-Like Compound, Inhibits Angiogenesis and Vascular Permeability via a Direct Inhibition of Src Kinase Activity

Pyun, B., Choi, S., Lee, Y., Kim, T., Min, J., Kim, Y., Kim, B.-D., Kim, J.-H., Kim, T., Kim, Y.-M., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2799 · Cited by 85

5-Lipoxygenase, a Marker for Early Pancreatic Intraepithelial Neoplastic Lesions

Hennig, R., Grippo, P. J., Ding, X.-Z., Rao, S. M., Büchler, M. W., Friess, H., Talamonti, M., Bell, R. H., & Adrian, T. E. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4090 · Cited by 84

Mammary Epithelial Reconstitution with Gene-Modified Stem Cells Assigns Roles to Stat5 in Luminal Alveolar Cell Fate Decisions, Differentiation, Involution, and Mammary Tumor Formation

Vafaizadeh, V., Klemmt, P. A. B., Brendel, C., Riecken, K., Doebele, C., Britt, K. L., Grez, M., Fehse, B., Desrivières, S., & Groner, B. (2010) · Stem Cells · doi:10.1002/stem.407 · Cited by 83

AMPK mediates curcumin-induced cell death in CaOV3 ovarian cancer cells

Di (1994) · Oncology Reports · doi:10.3892/or_00000179 · Cited by 83

Inhibition of tumor growth and vasculogenic mimicry by curcumin through down-regulation of the EphA2/PI3K/MMP pathway in a murine choroidal melanoma model

Chen, L.-X., He, Y.-J., Zhao, S.-Z., Wu, J.-G., Wang, J.-T., Zhu, L.-M., Lin, T.-T., Sun, B., & Li, X.-R. (2011) · Cancer Biology & Therapy · doi:10.4161/cbt.11.2.13842 · Cited by 82

The potentiation of curcumin on insulin-like growth factor-1 action in MCF-7 human breast carcinoma cells

Xia, Y., Jin, L., Zhang, B., Xue, H., Li, Q., & Xu, Y. (2007) · Life Sciences · doi:10.1016/j.lfs.2007.04.008 · Cited by 81

Curcumin regulates signal transducer and activator of transcription (STAT) expression in K562 cells

Blasius, R., Reuter, S., Henry, E., Dicato, M. A., & Diederich, M. F. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.07.029 · Cited by 81

The chemopreventive compound curcumin is an efficient inhibitor of Epstein‐Barr virus BZLF1 transcription in Raji DR‐LUC cells*

Hergenhahn, M., Soto, U., Weninger, A., Polack, A., Hsu, C., Cheng, A., & Rösl, F. (2002) · Molecular Carcinogenesis · doi:10.1002/mc.10029 · Cited by 81

Antileukemia effects of xanthohumol in Bcr/Abl-transformed cells involve nuclear factor-κB and p53 modulation

Monteghirfo, S., Tosetti, F., Ambrosini, C., Stigliani, S., Pozzi, S., Frassoni, F., Fassina, G., Soverini, S., Albini, A., & Ferrari, N. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-0132 · Cited by 80

Differential expression of arachidonate 5-lipoxygenase transcripts in human brain tumors: evidence for the expression of a multitranscript family.

Boado, R. J., Pardridge, W. M., Vinters, H. V., & Black, K. L. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.19.9044 · Cited by 78

Energy Homeostasis and Cancer Prevention: The AMP-Activated Protein Kinase

Fay, J. R., Steele, V. E., & Crowell, J. A. (2009) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-08-0166 · Cited by 77

Contact Urticaria from Curcumin

Liddle, M., Hull, C. M., Liu, C., & Powell, D. L. (2006) · Dermatitis · doi:10.2310/6620.2006.06004 · Cited by 72

Curcumin Inhibits Carcinogen and Nicotine-Induced Mammalian Target of Rapamycin Pathway Activation in Head and Neck Squamous Cell Carcinoma

Clark, C. A., McEachern, M. D., Shah, S. H., Rong, Y., Rong, X., Smelley, C. L., Caldito, G. C., Abreo, F. W., & Nathan, C. O. (2010) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-09-0244 · Cited by 71

Increased susceptibility to hepatocarcinogenicity of Nrf2‐deficient mice exposed to 2‐amino‐3‐methylimidazo[4,5‐f]quinoline

Kitamura, Y., Umemura, T., Kanki, K., Kodama, Y., Kitamoto, S., Saito, K., Itoh, K., Yamamoto, M. P., Masegi, T., Nishikawa, A., et al. (2006) · Cancer Science · doi:10.1111/j.1349-7006.2006.00352.x · Cited by 70

Signal transduction pathways involving RAS

Wiesmüller, L., & Wittinghofer, F. (1994) · Cellular Signalling · doi:10.1016/0898-6568(94)90030-2 · Cited by 63

Curcumin: A potential radio‐enhancer in head and neck cancer

Khafif, A., Lev‐Ari, S., Vexler, A. M., Barnea, I., Starr, A., Karaush, V., Haif, S., & Ben‐Yosef, R. (2009) · The Laryngoscope · doi:10.1002/lary.20582 · Cited by 63

Macrophage-derived cytokine and nitric oxide profiles in type I and type II diabetes mellitus: effect of thymoquinone

El-Mahmoudy, A. M., Shimizu, Y., Shiina, T., Matsuyama, H., Nikami, H., & Takewaki, T. (2005) · Acta Diabetologica · doi:10.1007/s00592-005-0170-6 · Cited by 61

Aberrant expression of 5-lipoxygenase-activating protein (5-LOXAP) has prognostic and survival significance in patients with breast cancer

Jiang, W. G., Douglas-Jones, A. G., & Mansel, R. E. (2005) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2005.10.005 · Cited by 60

Capsiate inhibits ultraviolet B-induced skin inflammation by inhibiting Src family kinases and epidermal growth factor receptor signaling

Lee, E., Jeon, M., Kim, B.-D., Kim, J.-H., Kwon, Y., Lee, H., Lee, Y. S., Yang, J.-H., & Kim, T. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.01.034 · Cited by 59

Xanthohumol from Hop (Humulus lupulus L.) Is an Efficient Inhibitor of Monocyte Chemoattractant Protein-1 and Tumor Necrosis Factor-α Release in LPS-Stimulated RAW 264.7 Mouse Macrophages and U937 Human Monocytes

Lupinacci, E., Meijerink, J., Vincken, J., Gabriele, B., Gruppen, H., & Witkamp, R. F. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf901244k · Cited by 59

Curcumin-induced degradation of ErbB2: A role for the E3 ubiquitin ligase CHIP and the Michael reaction acceptor activity of curcumin

Jung, Y., Xu, W., Kim, H., Ha, N., & Neckers, L. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.11.004 · Cited by 59

Curcumin inhibits the proliferation of human hepatocellular carcinoma J5 cells by inducing endoplasmic reticulum stress and mitochondrial dysfunction

Su (2010) · International Journal of Molecular Medicine · doi:10.3892/ijmm_00000513 · Cited by 58

The anti-cancer efficacy of curcumin scrutinized through core signaling pathways in glioblastoma

Chiu, Y. (2010) · International Journal of Molecular Medicine · doi:10.3892/ijmm_00000455 · Cited by 58

Differential in vivo mechanism of chemoprevention of tumor formation in azoxymethane/dextran sodium sulfate mice by PEITC and DBM

Cheung, K. L., Khor, T. O., Huang, M.-N., & Kong, A. N. T. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp285 · Cited by 56

Gambogic acid inhibits Hsp90 and deregulates TNF-α/NF-κB in HeLa cells

Zhang, L., Yi, Y., Chen, J., Sun, Y., Guo, Q., Zheng, Z., & Song, S. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.11.018 · Cited by 56

Curcumin Dually Inhibits Both Mammalian Target of Rapamycin and Nuclear Factor-κB Pathways through a Crossed Phosphatidylinositol 3-Kinase/Akt/IκB Kinase Complex Signaling Axis in Adenoid Cystic Carcinoma

Sun, Z., Chen, G., Zhang, W., Hu, X., Liu, Y., Zhou, Q., Zhu, L.-X., & Zhao, Y. (2010) · Molecular Pharmacology · doi:10.1124/mol.110.066910 · Cited by 56

Effects of thymoquinone on isolated and cellular proteasomes

Cecarini, V., Quassinti, L., Blasio, A. D., Bonfili, L., Bramucci, M., Lupidi, G., Cuccioloni, M., Mozzicafreddo, M., Angeletti, M., & Eleuteri, A. M. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2010.07629.x · Cited by 53

Association between Cyclooxygenase expression and colorectal adenoma characteristics.

Einspahr, J. G., Krouse, R. S., Yochim, J. M., Danenberg, P. V., Danenberg, K. D., Bhattacharyya, A. K., Martı́nez, M. E., & Alberts, D. S. (2003) · PubMed · Cited by 52

Modulatory effect of curcumin on survival of irradiated human intestinal microvascular endothelial cells: role of Akt/mTOR and NF-κB

Rafiee, P., Binion, D. G., Wellner, M. R., Behmaram, B., Floer, M., Mitton‐Fitzgerald, E., Nie, L., Zhang, Z., & Otterson, M. F. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00339.2009 · Cited by 49

Spice allergy evaluated by results of patch tests.

Futrell, J. M., & Rietschel, R. L. (1993) · PubMed · Cited by 48

Cyclooxygenase-2 and 5-lipoxygenase pathways in diosgenin-induced apoptosis in HT-29 and HCT-116 colon cancer cells

Liagre (2010) · International Journal of Oncology · doi:10.3892/ijo_00000601 · Cited by 48

Proteasome Inhibition Causes Regression of Leukemia and Abrogates BCR-ABL–Induced Evasion of Apoptosis in Part through Regulation of Forkhead Tumor Suppressors

Jagani, Z., Song, K., Kutok, J. L., Dewar, M. R., Melet, A., Santos, T., Grassian, A. R., Ghaffari, S., Wu, C. J., Ren, R., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-0605 · Cited by 48

Regulation of the c-jun Gene in p210 BCR-ABL Transformed Cells Corresponds With Activity of JNK, the c-jun N-Terminal Kinase

Burgess, G. S., Williamson, E. A., Cripe, L. D., Litz-Jackson, S., Bhatt, J. A., Stanley, K., Stewart, M. J., Kraft, A. S., Nakshatri, H., & Boswell, H. S. (1998) · Blood · doi:10.1182/blood.v92.7.2450 · Cited by 48

Regulation of the Phosphatidylinositol 3-Kinase-Akt and the Mitogen-Activated Protein Kinase Pathways by Ursolic Acid in Human Endometrial Cancer Cells

Achiwa, Y., Hasegawa, K., & Udagawa, Y. (2007) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.60288 · Cited by 45

A Phase II/III Randomized, Placebo-Controlled, Double-Blind Clinical Trial of Ginger (Zingiber officinale) for Nausea Caused by Chemotherapy for Cancer: A Currently Accruing URCC CCOP Cancer Control Study

Hickok, J. T., Roscoe, J. A., Morrow, G. R., & Ryan, J. L. (2007) · Supportive Cancer Therapy · doi:10.3816/sct.2007.n.022 · Cited by 43

Xanthohumol activates the proapoptotic arm of the unfolded protein response in chronic lymphocytic leukemia.

Lust, S., Vanhoecke, B. W. A., Gele, M. V., Boelens, J., Melckebeke, H. V., Kaileh, M., Berghe, W. V., Haegeman, G., Philippé, J., Bracke, M., et al. (2009) · PubMed · Cited by 42

Regulation of activator protein-1 activity in the mediastinal lymph node metastasis of lung cancer

Ichiki, K., Mitani, N., Doki, Y., Hara, H., Misaki, T., & Saiki, I. (2000) · Clinical & Experimental Metastasis · doi:10.1023/a:1011980313237 · Cited by 41

Down-regulation of p210bcr/abl by curcumin involves disrupting molecular chaperone functions of Hsp901

Wu, L., Xu, J., Huang, X., ZHANG, K.-Z., Cai-xia, W. E. N., & Chen, Y. (2006) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2006.00326.x · Cited by 40

Ultraviolet Radiation‐induced Transcription is Associated with Gene‐specific Histone Acetylation

Pollack, B. P., Sapkota, B., & Boss, J. M. (2008) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2008.00485.x · Cited by 39

Dibenzoylmethane Activates Nrf2-Dependent Detoxification Pathway and Inhibits Benzo(a)pyrene Induced DNA Adducts in Lungs

Thimmulappa, R. K., Rangasamy, T., Alam, J., & Biswal, S. S. (2008) · Medicinal Chemistry · doi:10.2174/157340608785700199 · Cited by 39

Cytotoxic Triterpenoids from the Stems of Microtropis japonica

Chen, I.-H., Lu, M., Du, Y.-C., Yen, M., Wu, C., Chen, Y., Hung, C.-S., Chen, S., Chang, F., & Wu, Y. (2009) · Journal of Natural Products · doi:10.1021/np800694b · Cited by 38

Capsaicin induces apoptosis through ubiquitin–proteasome system dysfunction

Maity, R., Sharma, J., & Jana, N. R. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22469 · Cited by 38

Inhibitory effect of curcumin on proliferation of K562 cells involves down-regulation of p210(bcr/abl) initiated Ras signal transduction pathway.

Wu, L., Xu, J., Wu, G.-H., & Chen, Y. (2003) · PubMed · Cited by 36

PPAR trilogy from metabolism to cancer

Nahle, Z. A. (2004) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/01.mco.0000134360.30911.bb · Cited by 34

Increased expression of 5-lipoxygenase is common in clear cell renal cell carcinoma.

Faronato, M., Muzzonigro, G., Milanese, G., Menna, C., Bonfigli, A. R., Catalano, A., & Procopio, A. D. (2007) · PubMed · doi:10.14670/hh-22.1109 · Cited by 32

Curcumin inhibits proliferation and induces apoptosis of leukemic cells expressing wild-type or T315I-BCR-ABL and prolongs survival of mice with acute lymphoblastic leukemia

William, B. M., Goodrich, A., Peng, C., & Li, S. (2008) · Hematology · doi:10.1179/102453308x343437 · Cited by 32

Chronic human immunodeficiency virus type 1 infection of myeloid cells disrupts the autoregulatory control of the NF-kappaB/Rel pathway via enhanced IkappaBalpha degradation

DeLuca, C., Roulston, A., Koromilas, A. E., Wainberg, M. A., & Hiscott, J. B. (1996) · Journal of Virology · doi:10.1128/jvi.70.8.5183-5193.1996 · Cited by 31

Update on HER-2 as a target for cancer therapy: Alternative strategies for targeting the epidermal growth factor system in cancer

Gullick, W. J. (2001) · Breast Cancer Research · doi:10.1186/bcr328 · Cited by 31

The Role of Zyflamend, an Herbal Anti-inflammatory, as a Potential Chemopreventive Agent Against Prostate Cancer: A Case Report

Rafailov, S., Cammack, S., Stone, B. A., & Katz, A. E. (2007) · Integrative Cancer Therapies · doi:10.1177/1534735406298843 · Cited by 30

Gambogic Acid Induces G0/G1 Cell Cycle Arrest and Cell Migration Inhibition Via Suppressing PDGF Receptor β Tyrosine Phosphorylation and Rac1 Activity in Rat Aortic Smooth Muscle Cells

Liu, Y., Li, W., Ye, C., Lin, Y., Cheang, T., Wang, M., Zhang, H., Wang, S., Zhang, L., & Wang, S. (2010) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.3491 · Cited by 29

Transcription factor Stat5a/b as a therapeutic target protein for prostate cancer

Liao, Z., Lutz, J., & Nevalainen, M. T. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.11.001 · Cited by 29

Redox Status-Dependent Regulation of Cyclooxygenases Mediates the Capsaicin-Induced Apoptosis in Human Neuroblastoma Cells

Lee, Y. S., Kwon, E. J., Jin, D. Q., Park, S. H., Kang, Y. S., Huh, K. Y., & Kim, J. (2002) · Journal of Environmental Pathology Toxicology and Oncology · doi:10.1615/jenvironpatholtoxicoloncol.v21.i2.40 · Cited by 27

COX 2 inhibitors may increase risk of heart attack

Gottlieb, S. L. (2001) · BMJ · doi:10.1136/bmj.323.7311.471/a · Cited by 26

COX 2 inhibitors may increase risk of heart attack

Gottlieb, S. (2001) · BMJ · doi:10.1136/bmj.323.7311.471a · Cited by 25

Inhibitory Effect of Dehydrozingerone on Vascular Smooth Muscle Cell Function

Liu, Y., Dolence, J. M., Ren, J. T., Rao, M., & Sreejayan, N. (2008) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e31818aed93 · Cited by 24

Eugenol Modulates Cyclooxygenase-2 Expression Through the Activation of Nuclear Factor Kappa B in Human Osteoblasts

Lee, Y., Yang, S.-F., Ho, W.-H., Lee, Y.-H., & Hung, S. (2007) · Journal of Endodontics · doi:10.1016/j.joen.2007.05.011 · Cited by 21

Capsaicin inhibits the IL-6/STAT3 pathway by depleting intracellular gp130 pools through endoplasmic reticulum stress

Lee, H. K., Seo, I. A., Shin, Y. K., Park, J. W., Suh, D. J., & Park, H. T. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.03.046 · Cited by 19

Dietary Curcumin Enhances Benzo(a)pyrene-Induced Apoptosis Resulting in a Decrease in BPDE-DNA Adducts in Mice

Garg, R., & Maru, G. B. (2009) · Journal of Environmental Pathology Toxicology and Oncology · doi:10.1615/jenvironpatholtoxicoloncol.v28.i2.40 · Cited by 13

Efficacy of Dibenzoylmethane Derivatives in Protecting against Endoplasmic Reticulum Stress and Inhibiting Nuclear Factor Kappa B on Dextran Sulfate Sodium Induced Colitis in Mice

Murakami, R., Uchida, M., Hori, O., Matsuura, N., Choshi, T., Hibino, S., & Yamada, M. (2010) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.33.2029 · Cited by 5

[Study on effects of curcumin on expressions of PDGF-BB, PDGFRbeta and ERK1 of HSC].

Zhao, Z.-D., & Huang, Z.-S. (2009) · PubMed · Cited by 3

Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases

Kunnumakkara, A. B., Bordoloi, D., Padmavathi, G., Monisha, J., Roy, N. K., Prasad, S., & Aggarwal, B. B. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13621 · Cited by 1,068

The role and place of medicinal plants in the strategies for disease prevention

Sofowora, A., Ogunbodede, E. O., & Onayade, A. A. (2013) · African Journal of Traditional Complementary and Alternative Medicines · doi:10.4314/ajtcam.v10i5.2 · Cited by 1,047

Targeting the STAT3 signaling pathway in cancer: Role of synthetic and natural inhibitors

Siveen, K. S., Sikka, S., Surana, R., Dai, X., Zhang, J., Kumar, A. P., Tan, B. K. H., Sethi, G., & Bishayee, A. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2013.12.005 · Cited by 645

Curcumin, Inflammation, and Chronic Diseases: How Are They Linked?

He, Y., Yue, Y., Zheng, X., Zhang, K., Chen, S., & Du, Z. (2015) · Molecules · doi:10.3390/molecules20059183 · Cited by 632

Curcumin and Health

Pulido‐Moran, M., Moreno‐Fernández, J., Ramírez-Tortosa, C. L., & Ramírez-Tortosa, M. C. (2016) · Molecules · doi:10.3390/molecules21030264 · Cited by 571

Molecular Targets of Nutraceuticals Derived from Dietary Spices: Potential Role in Suppression of Inflammation and Tumorigenesis

Aggarwal, B. B., Kuiken, M. E. V., Iyer, L. H., Harikumar, K. B., & Sung, B. (2009) · Experimental Biology and Medicine · doi:10.3181/0902-mr-78 · Cited by 204

Antitumor promoting potential of selected phytochemicals derived from spices

Rajput, S., & Mandal, M. (2011) · European Journal of Cancer Prevention · doi:10.1097/cej.0b013e32834a7f0c · Cited by 76

Potential of Spice-Derived Phytochemicals for Cancer Prevention

Aggarwal, B. B., Kunnumakkara, A. B., Harikumar, K. B., Tharakan, S. T., Sung, B., & Anand, P. (2008) · Planta Medica · doi:10.1055/s-2008-1074578 · Cited by 269

Spice up your food for cancer prevention: Cancer chemo-prevention by natural compounds from common dietary spices

Gao, J., Mamouni, K., Zhang, L., & Lokeshwar, B. L. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-821710-8.00013-8 · Cited by 11

Anti-oncogenic perspectives of spices/herbs: A comprehensive review.

Butt, M. S., Naz, A., Sultan, M. T., & Qayyum, M. M. N. (2013) · EXCLI journal · Cited by 34