Cited by 204Medicinal Plant ResearchCurcumin's Biomedical ApplicationsBioactive natural compounds

The DOI matches its Crossref record; 324 of the 324 references it cites were found in a registry or an index.

Cancer Cell Signaling Pathways Targeted by Spice-Derived Nutraceuticals

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Abstract

Extensive research within the last half a century has revealed that cancer is caused by dysregulation of as many as 500 different gene products. Most natural products target multiple gene products and thus are ideally suited for prevention and treatment of various chronic diseases, including cancer. Dietary agents such as spices have been used extensively in the Eastern world for a variety of ailments for millennia, and five centuries ago they took a golden journey to the Western world. Various spice-derived nutraceuticals, including 1'-acetoxychavicol acetate, anethole, capsaicin, cardamonin, curcumin, dibenzoylmethane, diosgenin, eugenol, gambogic acid, gingerol, thymoquinone, ursolic acid, xanthohumol, and zerumbone derived from galangal, anise, red chili, black cardamom, turmeric, licorice, fenugreek, clove, kokum, ginger, black cumin, rosemary, hop, and pinecone ginger, respectively, are the focus of this review. The modulation of various transcription factors, growth factors, protein kinases, and inflammatory mediators by these spice-derived nutraceuticals are described. The anticancer potential through the modulation of various targets is also the subject of this review. Although they have always been used to improve taste and color and as a preservative, they are now also used for prevention and treatment of a wide variety of chronic inflammatory diseases, including cancer.

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Crossref · 10.1080/01635581.2012.630551

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Research works printed but not linked: 37

  1. Shishodia S, 2003, Cancer Res, 63, 4375
  2. Buettner R, 2002, Clin Cancer Res, 8, 945
  3. Brown P H, 1993, Oncogene, 8, 877
  4. O’Shaughnessy J A, 2002, Clin Cancer Res, 8, 314
  5. Choi Y H, 2000, Int J Oncol, 17, 565
  6. Lev-Ari S, 2006, Anticancer Res, 26, 4423
  7. Molina M A, 2001, Cancer Res, 61, 4744
  8. Hong R L, 1999, Clin Cancer Res, 5, 1884
  9. Pajusola K, 1992, Cancer Res, 52, 5738
  10. Barleon B, 1997, Cancer Res, 57, 5421
  11. Zhao Z D, 2009, Zhong Yao Cai, 32, 732
  12. Chen L X, 2011, Cancer Biol Ther, 11
  13. Pan W, 2008, Oncol Rep, 20, 1553
  14. Wu L X, 2003, Acta Pharmacol Sin, 24, 1155
  15. Clark C A, 2010, Cancer Prev Res (Phila)
  16. Johnson S M, 2009, Anticancer Res, 29, 3185
  17. Deeb D, 2010, Anticancer Res, 30, 3333
  18. Surh Y J, 1999, J Environ Pathol Toxicol Oncol, 18, 131
  19. Arlt A, 2002, Cancer Res, 62, 910
  20. Xu Y X, 1997, Exp Hematol, 25, 413
  21. DuBois R N, 1996, Cancer Res, 56, 733
  22. Takeda H, 2003, Cancer Res, 63, 4872
  23. Einspahr J G, 2003, Cancer Res, 63, 3891
  24. Half E, 2002, Cancer Res, 62, 1676
  25. Kundu N, 2002, Cancer Res, 62, 2343
  26. Wolff H, 1998, Cancer Res, 58, 4997
  27. Huang M T, 1991, Cancer Res, 51, 813
  28. Lee Y S, 2002, J Environ Pathol Toxicol Oncol, 21, 113
  29. Faronato M, 2007, Histol Histopathol, 22, 1109
  30. Lepage C, 2010, Int J Oncol, 36, 1183
  31. Lust S, 2009, Anticancer Res, 29, 3797
  32. Waddington C H, 1942, Endeavour, 1, 18
  33. Reuter S, 2011, Genes Nutr
  34. Sharma R A, 2001, Clin Cancer Res, 7, 1894
  35. Cheng A L, 2001, Anticancer Res, 21, 2895
  36. Ireson C, 2001, Cancer Res, 61, 1058
  37. Futrell J M, 1993, Cutis, 52, 288

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Metadata

Authors
Sung, B., Prasad, S., Yadav, V. R., & Aggarwal, B. B.
Affiliations
The University of Texas MD Anderson Cancer Center (US)
Venue
Nutrition and Cancer
Published
2012-02
Volume
64
Issue
2
Pages
173-197
ISSN
  • 0163-5581 (ISSN-L)
  • 1532-7914
OpenAlex
W2035997417
Cited by
204
References
324
Citations by year
2026: 7 · 2025: 6 · 2024: 11 · 2023: 10 · 2022: 18 · 2021: 28 · 2020: 11 · 2019: 17 · 2018: 9 · 2017: 15 · 2016: 18 · 2015: 14 · 2014: 13 · 2013: 20 · 2012: 7
FWCI
1.31
Type
journal article
Language
en
Open access
Locations
  • Nutrition and Cancer (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Cancer Institute (CA-16672, P01CA124787, CA-124787-01A2, P30CA016672)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Bioactive natural compounds
Keywords
anticancer agents, curcumin, gingerol, xanthohumol, eugenol, thymoquinone, capsaicin, anethole, cardamonin, gambogic acid, ursolic acid, dibenzoylmethane, diosgenin, Nigella sativa, licorice, turmeric, Syzygium aromaticum, black cardamom, galangal, red chili, Rosmarinus officinalis, Humulus lupulus, fenugreek, kokum, transcription factors, protein kinases, growth factors, inflammatory mediators, cancer prevention
MeSH terms
Animals, Antineoplastic Agents, Phytogenic, Humans, Phytotherapy, Neoplasms, Protein Kinases, Transcription Factors, Signal Transduction, NF-kappa B, Spices, Receptors, Growth Factor, Inflammation Mediators, Dietary Supplements, Intercellular Signaling Peptides and Proteins, Cell Line, Tumor, Protein Kinase Inhibitors

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