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Cancer Cell Signaling Pathways Targeted by Spice-Derived Nutraceuticals
Open accessAbstract
Extensive research within the last half a century has revealed that cancer is caused by dysregulation of as many as 500 different gene products. Most natural products target multiple gene products and thus are ideally suited for prevention and treatment of various chronic diseases, including cancer. Dietary agents such as spices have been used extensively in the Eastern world for a variety of ailments for millennia, and five centuries ago they took a golden journey to the Western world. Various spice-derived nutraceuticals, including 1'-acetoxychavicol acetate, anethole, capsaicin, cardamonin, curcumin, dibenzoylmethane, diosgenin, eugenol, gambogic acid, gingerol, thymoquinone, ursolic acid, xanthohumol, and zerumbone derived from galangal, anise, red chili, black cardamom, turmeric, licorice, fenugreek, clove, kokum, ginger, black cumin, rosemary, hop, and pinecone ginger, respectively, are the focus of this review. The modulation of various transcription factors, growth factors, protein kinases, and inflammatory mediators by these spice-derived nutraceuticals are described. The anticancer potential through the modulation of various targets is also the subject of this review. Although they have always been used to improve taste and color and as a preservative, they are now also used for prevention and treatment of a wide variety of chronic inflammatory diseases, including cancer.
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“Eugenol inhibits tumor proliferation and formation, increases reactive oxygen species (ROS), generates apoptosis, and has a genotoxic effect in different cancer cells [23,29,30,31].”
From Clove essential oil (Syzygium aromaticum L. Myrtaceae): Extraction, chemical composition, food applications, and essential bioactivity for human health (2021) · cites this paper as [29]
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Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases
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Metadata
- Authors
- Sung, B., Prasad, S., Yadav, V. R., & Aggarwal, B. B.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Venue
- Nutrition and Cancer
- Publisher
- Informa UK Limited
- Published
- 2012-02
- Volume
- 64
- Issue
- 2
- Pages
- 173-197
- ISSN
- 0163-5581 (ISSN-L)
- 1532-7914
- PMC
- PMC3645308
- OpenAlex
- W2035997417
- Cited by
- 204
- References
- 324
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 11 · 2023: 10 · 2022: 18 · 2021: 28 · 2020: 11 · 2019: 17 · 2018: 9 · 2017: 15 · 2016: 18 · 2015: 14 · 2014: 13 · 2013: 20 · 2012: 7
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Nutrition and Cancer (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (CA-16672, P01CA124787, CA-124787-01A2, P30CA016672)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Bioactive natural compounds
- Keywords
- anticancer agents, curcumin, gingerol, xanthohumol, eugenol, thymoquinone, capsaicin, anethole, cardamonin, gambogic acid, ursolic acid, dibenzoylmethane, diosgenin, Nigella sativa, licorice, turmeric, Syzygium aromaticum, black cardamom, galangal, red chili, Rosmarinus officinalis, Humulus lupulus, fenugreek, kokum, transcription factors, protein kinases, growth factors, inflammatory mediators, cancer prevention
- MeSH terms
- Animals, Antineoplastic Agents, Phytogenic, Humans, Phytotherapy, Neoplasms, Protein Kinases, Transcription Factors, Signal Transduction, NF-kappa B, Spices, Receptors, Growth Factor, Inflammation Mediators, Dietary Supplements, Intercellular Signaling Peptides and Proteins, Cell Line, Tumor, Protein Kinase Inhibitors
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