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Cited by 83T-cell and B-cell ImmunologyAntioxidant Activity and Oxidative StressImmunotherapy and Immune Responses

Studies of immunomodulating actions of carotenoids. II. astaxanthin enhances in vitro antibody production to T‐dependent antigens without facilitating polyclonal B‐cell activation

Jyonouchi, Harumi, Zhang, Lei, Tomita, Yoshifumi·1993·Nutrition and Cancer
DOI 10.1080/01635589309514258
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Abstract

Previously we have shown that astaxanthin, a carotenoid without provitamin A activity, enhances in vitro antibody (Ab) production to sheep red blood cells in normal B6 mice. In this study, we further attempted to examine the mechanisms of this enhancing action of carotenoids on specific Ab production in vitro in relation to different antigen (Ag) stimuli, cytokine production, and T- and B-cell interactions in both normal and autoimmune strains of mice. When the actions of carotenoids were tested in normal strains of mice, we found that astaxanthin enhanced in vitro Ab production to T cell-dependent Ag, but not to T-independent Ag, and did not augment total immunoglobulin production. Astaxanthin exerted maximum enhancing actions when it was present at the initial period of Ag priming. This action of astaxanthin was abolished when T cells were depleted from spleen cell suspensions and appeared to require direct interactions between T and B cells. The results also indicated that carotenoids may modulate the production of interferon-tau in this assay system. When the actions of carotenoids were tested in autoimmune-prone MRL and NZB mice, the enhancing action of astaxanthin on in vitro Ab production was less significant. Furthermore, carotenoids did not potentiate or augment spontaneous Ab and immunoglobulin production by spleen cells in these strains. Taken together, carotenoids without provitamin A activity may be able to augment in vitro specific Ab production to T cell-dependent Ag partly through affecting the initial stage of Ag presentation without facilitating polyclonal B-cell activation or autoantibody production.

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  • Astaxanthin enhances in vitro immunoglobulin antibody production by mouse spleen cells stimulated with sheep red blood cells, at least in part by acting on T-cells, especially T-helper cells.

    “Astaxanthin enhances in vitro immunoglobulin antibody production by mouse spleen cells stimulated with sheep red blood cells, at least in part by exerting actions on T-cells, especially T-helper cells (Tanaka et al., 1995, Jyonouchi et al., 1993, Park et al., 2010).”

    From Microalgae Metabolites: A Rich Source for Food and Medicine (2019) · cites this paper as Jyonouchi et al., 1993

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Authors
Jyonouchi, H., Zhang, L., & Tomita, Y.
Affiliations
  • University of Minnesota (US)
  • University of Miyazaki (JP)
ORCID
Zhang, Lei
Venue
Nutrition and Cancer
Publisher
Informa UK Limited
Published
1993-01
Volume
19
Issue
3
Pages
269-280
ISSN
  • 0163-5581 (ISSN-L)
  • 1532-7914
DOI
10.1080/01635589309514258
OpenAlex
W1966565649
Cited by
83
References
26
Citations by year
2026: 1 · 2025: 3 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 1 · 2015: 2 · 2014: 3 · 2012: 4
FWCI
2.16
Type
journal article
Language
en
Open access
closed
Locations
  • Nutrition and Cancer (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Allergy and Infectious Diseases (AI25064)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords
astaxanthin, carotenoids, immunomodulation, antibody production, T-dependent antigens, T-independent antigens, T cell-dependent B cell activation, T cell depletion, interferon-gamma, antigen presentation, autoimmune mice, MRL mice, NZB mice, autoantibodies
MeSH terms
Adjuvants, Immunologic, Animals, Antibody Formation, Autoimmune Diseases, B-Lymphocytes, Carotenoids, Cells, Cultured, Lymphocyte Activation, Mice, Inbred Strains, T-Lymphocytes, Cytokines, beta Carotene, Xanthophylls, Mice

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