Immunomodulating actions of carotenoids: Enhancement of in vivo and in vitro antibody production to T‐dependent antigens
Abstract
Previously, we demonstrated an enhancement of in vitro antibody (Ab) production in response to T-dependent antigens (TD-Ag) by astaxanthin, a carotenoid without vitamin A activity. The effects of beta-carotene, a carotenoid with vitamin A activity, and lutein, another carotenoid without vitamin A activity, on in vitro Ab production were examined with spleen cells from young and old B6 mice. In addition, the in vivo effects of lutein, astaxanthin, and beta-carotene on Ab production were studied in young and old B6 mice. Lutein, but not beta-carotene, enhanced in vitro Ab production in response to TD-Ags. The depletion of T-helper cells prevented the enhancement of Ab production by lutein and astaxanthin. In vivo Ab production in response to TD-Ag was significantly enhanced by lutein, astaxanthin, and beta-carotene. The numbers of immunoglobulin M- and G-secreting cells also increased in vivo with the administration of these carotenoids when mice were primed with TD-Ags. Antibody production in response to TD-Ags in vivo and in vitro was significantly lower in old than in young B6 mice. Astaxanthin supplements partially restored decreased in vivo Ab production in response to TD-Ags in old B6 mice. Lutein and beta-carotene also enhanced in vivo Ab production in response to TD-Ags in old B6 mice, although to a lesser extent than did astaxanthin. However, none of the carotenoids had an effect on in vivo or in vitro Ab production in response to T-independent antigen. These results indicate significant immunomodulating actions of carotenoids for humoral immune responses to TD-Ags and suggest that carotenoid supplementation may be beneficial in restoring humoral immune responses in older animals.
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Jyonouchi et al. observed that lutein and astaxanthin increased the ex vivo antibody response of mouse splenocytes to T-cell antigens.
“Jyonouchi et al. observed that lutein and astaxanthin increased the ex vivo antibody response of mouse splenocytes to T-cell antigens (136).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [136]
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- Authors
- Jyonouchi, H., Zhang, L., Gross, M., & Tomita, Y.
- Affiliations
- University of Minnesota (US)
- University of Miyazaki (JP)
- ORCID
- Zhang, Lei
- Venue
- Nutrition and Cancer
- Publisher
- Informa UK Limited
- Published
- 1994-01
- Volume
- 21
- Issue
- 1
- Pages
- 47-58
- ISSN
- 0163-5581 (ISSN-L)
- 1532-7914
- OpenAlex
- W1977929214
- Cited by
- 183
- References
- 33
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 1 · 2023: 4 · 2022: 4 · 2021: 12 · 2020: 4 · 2019: 5 · 2018: 6 · 2017: 5 · 2016: 7 · 2015: 5 · 2014: 5 · 2013: 3 · 2012: 9
- FWCI
- 1.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutrition and Cancer (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (AI25064)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- carotenoids, immunomodulation, antibody production, T-dependent antigens, astaxanthin, beta-carotene, lutein, humoral immune response, T helper cells, immunosenescence, immunoglobulin secretion, vitamin A activity
- MeSH terms
- Adjuvants, Immunologic, Age Factors, Animals, Antibody Formation, Antigens, Antigens, T-Independent, Carotenoids, Dose-Response Relationship, Drug, Enzyme-Linked Immunosorbent Assay, Female, T-Lymphocytes, Helper-Inducer, Immunoglobulin G, Immunoglobulin M, Mice, Inbred C57BL, T-Lymphocytes, beta Carotene, Xanthophylls, Mice, In Vitro Techniques
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