Cited by 2,178Antioxidant Activity and Oxidative StressRedox biology and oxidative stressCancer and biochemical research

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Invited Review: Oxidation of Biological Systems: Oxidative Stress Phenomena, Antioxidants, Redox Reactions, and Methods for Their Quantification

Kohen, Ron, Nyska, Abraham·2002·Toxicologic Pathology

DOI 10.1080/01926230290166724

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Abstract

Reactive oxygen species (ROS) and other radicals are involved in a variety of biological phenomena, such as mutation, carcinogenesis, degenerative and other diseases, inflammation, aging, and development. ROS are well recognized for playing a dual role as deleterious and beneficial species. The objectives of this review are to describe oxidative stress phenomena, terminology, definitions, and basic chemical characteristics of the species involved; examine the biological targets susceptible to oxidation and the defense mechanisms of the organism against these reactive metabolites; and analyze methodologies, including immunohistochemical markers, used in toxicological pathology in the visualization of oxidative stress phenomena. Direct detection of ROS and other free radicals is difficult, because these molecules are short-lived and highly reactive in a nonspecific manner. Ongoing oxidative damage is, thus, generally analyzed by measurement of secondary products including derivatives of amino acids, nuclei acids, and lipid peroxidation. Attention has been focused on electrochemical methods based on voltammetry measurements for evaluating the total reducing power of biological fluids and tissues. This approach can function as a tool to assess the antioxidant-reducing profile of a biological site and follow changes in pathological situations. This review thus includes different topics essential for understanding oxidative stress phenomena and provides tools for those intending to conduct study and research in this field.

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Authors: Kohen, R., & Nyska, A.
Affiliations: Hebrew University of Jerusalem (IL)
National Institute of Environmental Health Sciences (US)
Corresponding author: Kohen, Ron
ORCID: Kohen, Ron
Nyska, Abraham
Venue: Toxicologic Pathology
Publisher: SAGE Publications
Published: 2002-10
Volume: 30
Issue: 6
Pages: 620-650
ISSN: 0192-6233 (ISSN-L)
1533-1601
DOI: 10.1080/01926230290166724
OpenAlex: W2133538175
Cited by: 2,178
References: 264
Citations by year: 2026: 46 · 2025: 75 · 2024: 92 · 2023: 97 · 2022: 120 · 2021: 138 · 2020: 125 · 2019: 139 · 2018: 122 · 2017: 161 · 2016: 139 · 2015: 144 · 2014: 122 · 2013: 122 · 2012: 110
FWCI: 15.27
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Toxicologic Pathology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
Keywords: oxidative stress, reactive oxygen species, free radicals, antioxidants, redox reactions, lipid peroxidation, oxidative DNA damage, immunohistochemical markers, electrochemical methods, voltammetry, reducing power, antioxidant capacity, biological fluids, carcinogenesis, aging
MeSH terms: Animals, Antioxidants, Electrochemistry, Female, Humans, Male, Oxidation-Reduction, Species Specificity, Biomarkers, Reactive Oxygen Species, Oxidative Stress, Mice, Rats

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