Cited by 2,178Antioxidant Activity and Oxidative StressRedox biology and oxidative stressCancer and biochemical research

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Invited Review: Oxidation of Biological Systems: Oxidative Stress Phenomena, Antioxidants, Redox Reactions, and Methods for Their Quantification

Kohen, Ron, Nyska, Abraham·2002·Toxicologic Pathology

DOI 10.1080/01926230290166724

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Abstract

Reactive oxygen species (ROS) and other radicals are involved in a variety of biological phenomena, such as mutation, carcinogenesis, degenerative and other diseases, inflammation, aging, and development. ROS are well recognized for playing a dual role as deleterious and beneficial species. The objectives of this review are to describe oxidative stress phenomena, terminology, definitions, and basic chemical characteristics of the species involved; examine the biological targets susceptible to oxidation and the defense mechanisms of the organism against these reactive metabolites; and analyze methodologies, including immunohistochemical markers, used in toxicological pathology in the visualization of oxidative stress phenomena. Direct detection of ROS and other free radicals is difficult, because these molecules are short-lived and highly reactive in a nonspecific manner. Ongoing oxidative damage is, thus, generally analyzed by measurement of secondary products including derivatives of amino acids, nuclei acids, and lipid peroxidation. Attention has been focused on electrochemical methods based on voltammetry measurements for evaluating the total reducing power of biological fluids and tissues. This approach can function as a tool to assess the antioxidant-reducing profile of a biological site and follow changes in pathological situations. This review thus includes different topics essential for understanding oxidative stress phenomena and provides tools for those intending to conduct study and research in this field.

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Electrochemical Methods: Fundamentals and Applications
Bard, A. J., & Faulkner, L. R. (1980) · Cited by 22,436
Superoxide Dismutase
McCord, J. M., & Fridovich, I. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63504-5 · Cited by 12,952
Free Radicals in the Physiological Control of Cell Function
Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855
Oxidants, oxidative stress and the biology of ageing
Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413
Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567
The L-Arginine-Nitric Oxide Pathway
Epstein, F. H., Moncada, S., & Higgs, A. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312303292706 · Cited by 6,678
Oxidants, antioxidants, and the degenerative diseases of aging.
Ames, B. N., Shigenaga, M. K., & Hagen, T. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7915 · Cited by 5,958
Hydroperoxide metabolism in mammalian organs.
Chance, B., Sies, H., & Boveris, A. (1979) · Physiological Reviews · doi:10.1152/physrev.1979.59.3.527 · Cited by 5,827
Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly
Beckman, J. S., & Koppenol, W. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.5.c1424 · Cited by 5,513
Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases
Barnes, P. J., & Karin, M. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704103361506 · Cited by 4,622

Show all 264 references

Research works printed but not linked: 32

Ames BN, 1986, Prog Clin Biol Res, 206, 3
Baud I., 1986, Am J Physiol, 251, F765
Canas PE, 1999, Acta Physiol Pharmacol Ther Latinoam, 49, 13
Cuzzocrea S., 2001, Pharmacol Rev, 53, 135
Davies KJ, 1999, Life, 48, 41
Digiesi V., 2001, Ann Ital Med Int, 16, 93
Esterbauer H., 1996, Pathol Biol, 44, 25
Ezra T., 1996, Eur J Pharmaceutics Biopharmaceutics, 42, 291
Fenton HJH, 1894, J Chem Soc Proc, 10, 157
Gul M., 2000, Indian J Exp Biol, 38, 625
Halliwell B., 1999, Free Radicals inBiologyandMedicine, third edition
Hammer C., 1988, Comp Biochem Physiol, 90, 7
Iida T., 2001, Neuro-oncol, 3, 73
Kohen R., Int. Symposium on Antioxidants and Disease Prevention
Kohen R., Measurements of biological reducing power in health and diseases by voltammetric methods
Levine RL, 2000, Methods Mol Biol, 99, 15
Naito Y., 1998, Dig Dis Sci, 43, 30S
Najemnik C., 1999, Acta Med Austriaca, 26, 148
Packer L (ed) (1984, 1990, 1994, 1999). Methods in Enzymology , Vol 105, 186, 234, 299, 300.
Poulsen HE, 2000, Free Radic Res, 33, S33
Puppi A., 1985, Acta Biol Hun, 34, 323
Reiter RJ, 2002, Neuroendocrino l Lett, 23, 3
Rice-Evans CA, 1994, New Comprehensive Biochemistry: Free Radical Damage and its Control
Rioux N., 1998, Cancer Res, 58, 5354
Puppi A., 1991, Acta Physiol Hung, 77, 43
10.1080/15216540051081074 · DOI
Sen CK, 2000, Curr Top Cell Regul, 36, 1
Sies H., 1985, Oxidative Stress
Toyokuni S., 1997, Lab Invest, 76, 365
Weinstein DM, 2000, J Pharmacol Exp Ther, 294, 396
Zaken V., 2000, Early Pregnancy, 4, 110
Zimmermann KC, 1999, Cancer Res, 59, 198

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Alhasawi, A. A., Castonguay, Z., Appanna, N. D., Auger, C., & Appanna, V. D. (2015) · Microbiological Research · doi:10.1016/j.micres.2014.12.001 · Cited by 46
Bio-conjugation of antioxidant peptide on surface-modified gold nanoparticles: a novel approach to enhance the radical scavenging property in cancer cell
Kalmodia, S., Vandhana, S., Rama, B. R. T., Balasubramanyam, J., Seethalakshmi, T. S., Vetrivel, U., Yang, W. R., Barrow, C. J., Krishnakumar, S., & Elchuri, S. V. (2016) · Cancer Nanotechnology · doi:10.1186/s12645-016-0013-x · Cited by 46
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Wang, Y., Plewa, M. J., Mukherjee, U. K., & Verma, V. (2018) · Atmospheric Environment · doi:10.1016/j.atmosenv.2018.02.025 · Cited by 46
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Kim, E., Li, J., Kang, M., Kelly, D. L., Chen, S., Napolitano, A., Panzella, L., Shi, X., Yan, K., Wu, S. Z., et al. (2019) · Proceedings of the IEEE · doi:10.1109/jproc.2019.2908582 · Cited by 47
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Haque, M. N., Lee, D.-H., Kim, B., Nam, S.-E., & Rhee, J. (2018) · Aquatic Toxicology · doi:10.1016/j.aquatox.2018.05.023 · Cited by 44
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Authors: Kohen, R., & Nyska, A.
Affiliations: Hebrew University of Jerusalem (IL)
National Institute of Environmental Health Sciences (US)
Corresponding author: Kohen, Ron
ORCID: Kohen, Ron
Nyska, Abraham
Venue: Toxicologic Pathology
Publisher: SAGE Publications
Published: 2002-10
Volume: 30
Issue: 6
Pages: 620-650
ISSN: 0192-6233 (ISSN-L)
1533-1601
DOI: 10.1080/01926230290166724
OpenAlex: W2133538175
Cited by: 2,178
References: 264
Citations by year: 2026: 46 · 2025: 75 · 2024: 92 · 2023: 97 · 2022: 120 · 2021: 138 · 2020: 125 · 2019: 139 · 2018: 122 · 2017: 161 · 2016: 139 · 2015: 144 · 2014: 122 · 2013: 122 · 2012: 110
FWCI: 15.27
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Toxicologic Pathology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
Keywords: oxidative stress, reactive oxygen species, free radicals, antioxidants, redox reactions, lipid peroxidation, oxidative DNA damage, immunohistochemical markers, electrochemical methods, voltammetry, reducing power, antioxidant capacity, biological fluids, carcinogenesis, aging
MeSH terms: Animals, Antioxidants, Electrochemistry, Female, Humans, Male, Oxidation-Reduction, Species Specificity, Biomarkers, Reactive Oxygen Species, Oxidative Stress, Mice, Rats

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Invited Review: Oxidation of Biological Systems: Oxidative Stress Phenomena, Antioxidants, Redox Reactions, and Methods for Their Quantification

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