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Cited by 288

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Cell biological effects of hyperthermia alone or combined with radiation or drugs: A short introduction to newcomers in the field

Open access
Kampinga, Harm H.·2006·International Journal of Hyperthermia
DOI 10.1080/02656730500532028
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Abstract

Hyperthermia results in protein unfolding that, if not properly chaperoned by Heat Shock Proteins (HSP), can lead to irreversible and toxic protein aggregates. Elevating HSP prior to heating makes cells thermotolerant. Hyperthermia also can enhance the sensitivity of cells to radiation and drugs. This sensitization to drugs or radiation is not directly related to altered HSP expression. However, altering HSP expression before heat and radiation or drug treatment will affect the extent of thermal sensitization because the HSP will attenuate the heat-induced protein damage that is responsible for radiation- or drug-sensitization. For thermal radiosensitization, nuclear protein damage is considered to be responsible for hyperthermic effects on DNA repair, in particular base excision repair. Hyperthermic drug sensitization can be seen for a number of anti-cancer drugs, especially of alkylating agents. Synergy between heat and drugs may arise from multiple events such as heat damage to ABC transporters (drug accumulation), intra-cellular drug detoxification pathways and repair of drug-induced DNA adducts. This may be why cells with acquired drug resistance (often multi-factorial) can be made responsive to drugs again by combining the drug treatment with heat.

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Metadata

Authors
Kampinga, H. H.
Venue
International Journal of Hyperthermia
Publisher
Informa UK Limited
Published
2006-01-01
Volume
22
Issue
3
Pages
191-196
ISSN
  • 0265-6736 (ISSN-L)
  • 1464-5157
DOI
10.1080/02656730500532028
OpenAlex
W2127315335
Cited by
288
References
11
FWCI
3.56
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Cell biological effects of hyperthermia alone or combined with radiation or drugs: A short introduction to newcomers in the field. https://app.cochat.ai/papers/10.1080/02656730500532028
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Kampinga, H. H. (2006). Cell biological effects of hyperthermia alone or combined with radiation or drugs: A short introduction to newcomers in the field. International Journal of Hyperthermia. https://doi.org/10.1080/02656730500532028

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.