The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
A Review of Antimicrobial Peptides and Their Therapeutic Potential as Anti-Infective Drugs
Open accessAbstract
PURPOSE: Antimicrobial peptides (AMPs) are an essential part of innate immunity that evolved in most living organisms over 2.6 billion years to combat microbial challenge. These small cationic peptides are multifunctional as effectors of innate immunity on skin and mucosal surfaces and have demonstrated direct antimicrobial activity against various bacteria, viruses, fungi, and parasites. This review summarizes their progress to date as commercial antimicrobial drugs for topical and systemic indications. METHODS: Literature review. RESULTS: Despite numerous clinical trials, no modified AMP has obtained Food & Drug Administration approval yet for any topical or systemic medical indications. CONCLUSIONS: While AMPs are recognized as essential components of natural host innate immunity against microbial challenge, their usefulness as a new class of antimicrobial drugs still remains to be proven.
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Cites
1 retracted
Contribution of Human α-Defensin 1, 2, and 3 to the Anti-HIV-1 Activity of CD8 Antiviral Factor
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RetractedAntimicrobial peptides of multicellular organisms
Zasloff, M. (2002) · Nature · doi:10.1038/415389a · Cited by 8,457
Defensins: antimicrobial peptides of innate immunity
Ganz, T. (2003) · Nature Reviews Immunology · doi:10.1038/nri1180 · Cited by 3,066
Mechanisms of Antimicrobial Peptide Action and Resistance
Yeaman, M. R., & Yount, N. Y. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.1.2 · Cited by 3,001
Zasloff, M. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.15.5449 · Cited by 2,305
Mode of action of membrane active antimicrobial peptides
Shai, Y. (2002) · Peptide Science · doi:10.1002/bip.10260 · Cited by 1,576
Cationic peptides: a new source of antibiotics
Hancock, R. E. W., & Lehrer, R. (1998) · Trends in Biotechnology · doi:10.1016/s0167-7799(97)01156-6 · Cited by 1,336
Beutler, B. (2004) · Molecular Immunology · doi:10.1016/j.molimm.2003.10.005 · Cited by 1,276
Antiviral drugs in current clinical use
De Clercq, E. (2004) · Journal of Clinical Virology · doi:10.1016/j.jcv.2004.02.009 · Cited by 947
Mammalian defensins in immunity: more than just microbicidal
Yang, D., Biragyn, A., Kwak, L. W., & Oppenheim, J. J. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02246-9 · Cited by 696
Cited by
Pseudomonas aeruginosa Biofilms
Thi, M. T. T., Wibowo, D., & Rehm, B. H. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228671 · Cited by 911
A New Era of Antibiotics: The Clinical Potential of Antimicrobial Peptides
Browne, K., Chakraborty, S., Chen, R., Willcox, M. D., Black, D. S., Walsh, W. R., & Kumar, N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197047 · Cited by 482
Mookherjee, N., & Hancock, R. E. W. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-6475-6 · Cited by 462
Recent advances in design of antimicrobial peptides and polypeptides toward clinical translation
Jiang, Y., Chen, Y., Song, Z., Tan, Z., & Cheng, J. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.12.016 · Cited by 267
Antimicrobial peptides and bacteriocins: alternatives to traditional antibiotics
Sang, Y., & Blecha, F. (2008) · Animal Health Research Reviews · doi:10.1017/s1466252308001497 · Cited by 254
Metadata
- Authors
- Gordon, Y. J., Romanowski, E. G., & McDermott, A. M.
- Venue
- Current Eye Research
- Publisher
- Informa UK Limited
- Published
- 2005-01
- Volume
- 30
- Issue
- 7
- Pages
- 505-515
- ISSN
- 0271-3683 (ISSN-L)
- 1460-2202
- OpenAlex
- W1969711244
- Cited by
- 697
- References
- 51
- FWCI
- 11.20
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
