Association between probiotic supplementation and asthma incidence in infants: a meta-analysis of randomized controlled trials
Abstract
Objective: The increased social and economic burdens for asthma in infants make the prevention of asthma a major public health goal. Probiotics may reduce the risk of asthma in infants. However, randomized controlled trials (RCTs) have shown mixed efficacy outcomes. We performed a meta-analysis of RCTs to investigate whether probiotics are associated with a lower asthma incidence in infants. Methods: The PubMed, Cochrane library, and EMBASE databases were systematically searched from the inception dates to August 2018. RCTs comparing the effects of probiotic supplements with a placebo for asthma or wheeze incidence in infants were included. A meta-analysis was performed to calculate risk ratio (RR) and 95% confidence interval (CI) using the Mantel-Haenszel statistical method. Results: A total of 19 randomized trials involving 5157 children fulfilled the inclusion criteria. There was no significant association of probiotics with risk of asthma (RR, 0.94 [95% CI, 0.82–1.09]) or wheeze (RR, 0.97 [95% CI, 0.88–1.06]) compared with placebo. Subgroup analysis by asthma risk showed that probiotics significantly reduced wheeze incidence among infants with atopy disease (RR, 0.61 [95% CI, 0.42–0.90]), but no significant associations were found in the other subgroup analyses by participants receiving the intervention, timing of intervention, prevention regimen, probiotic organism, duration of intervention, and duration of follow-up. Conclusions: The use of probiotic supplementation compared with placebo was not associated with a lower risk of asthma in infants. These findings do not support recommendation to use probiotics in the prevention of asthma in infants.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Early life treatment with probiotics reduces the incidence of some atopic diseases such as atopic dermatitis, but results in asthma have been less impressive.
“Although early life treatment with probiotics have demonstrated a benefit in reducing the incidence of some atopic diseases, such as atopic dermatitis (Li L. et al., 2019), the results in asthma, to date, have been less impressive (Wei et al., 2020).”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Wei et al., 2020
Cites
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000100 · Cited by 28,164 · see citing works
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gotzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · BMJ · doi:10.1136/bmj.b2700 · Cited by 17,648 · see citing works
Hill (2014) · doi:10.1038/nrgastro.2014.66 · Cited by 9,592 · see citing works
Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.1. The Cochrane Collaboration
Higgins, J., Green, S. R., & Higgins, J. (2008) · Cited by 5,544 · see citing works
Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial
Kalliomäki, M. A., Salminen, S., Arvilommi, H. S., Kero, P. O., Koskinen, P. J., & Isolauri, E. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04259-8 · Cited by 2,434 · see citing works
Kalliomäki, M. A., Salminen, S., Poussa, T. A., Arvilommi, H. S., & Isolauri, E. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13490-3 · Cited by 1,340 · see citing works
Probiotic use in clinical practice: what are the risks?
Boyle, R. J., Robins-Browne, R. M., & Tang, M. L. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.6.1256 · Cited by 776 · see citing works
Kukkonen, A. K., Savilahti, E., Haahtela, T., Juntunen‐Backman, K., Korpela, R., Poussa, T. A., Tuure, T., & Kuitunen, M. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.09.009 · Cited by 708 · see citing works
Taylor, A. L., Dunstan, J. A., & Prescott, S. L. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.08.036 · Cited by 538 · see citing works
Abrahamsson, T., Jakobsson, T., Böttcher, M. F., Fredrikson, M. G., Jenmalm, M. C., Björkstén, B., & Oldæus, G. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.01.007 · Cited by 476 · see citing works
Kalliomäki, M. A., Salminen, S., Poussa, T. A., & Isolauri, E. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.12.608 · Cited by 453 · see citing works
Wickens, K. L., Black, P., Stanley, T., Mitchell, E. A., Fitzharris, P., Tannock, G. W., Purdie, G., & Crane, J. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.07.011 · Cited by 430 · see citing works
Kuitunen, M., Kukkonen, A. K., Juntunen‐Backman, K., Korpela, R., Poussa, T. A., Tuure, T., Haahtela, T., & Savilahti, E. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.11.019 · Cited by 408 · see citing works
The ‘microflora hypothesis’ of allergic diseases
Noverr, M. C., & Huffnagle, G. B. (2005) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2005.02379.x · Cited by 394 · see citing works
Kopp, M., Hennemuth, I., Heinzmann, A., & Urbanek, R. (2008) · PEDIATRICS · doi:10.1542/peds.2007-1492 · Cited by 386 · see citing works
Oral Treatment with Live Lactobacillus reuteri Inhibits the Allergic Airway Response in Mice
Forsythe, P., Inman, M. D., & Bienenstock, J. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200606-821oc · Cited by 306 · see citing works
Probiotics in pregnant women to prevent allergic disease: a randomized, double-blind trial
Dotterud, C. K., Storrø, O., Johnsen, R., & Øien, T. (2010) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2010.09889.x · Cited by 296 · see citing works
Probiotics Supplementation During Pregnancy or Infancy for the Prevention of Atopic Dermatitis
Pelucchi, C., Chatenoud, L., Turati, F., Galeone, C., Moja, L., Bach, J., & Vecchia, C. L. (2012) · Epidemiology · doi:10.1097/ede.0b013e31824d5da2 · Cited by 281 · see citing works
Wold, A. E. (1998) · Allergy · doi:10.1111/j.1398-9995.1998.tb04953.x · Cited by 263 · see citing works
Asthma Status and Severity Affects Missed School Days
Moonie, S. A., Sterling, D. A., Figgs, L. W., & Castro, M. (2006) · Journal of School Health · doi:10.1111/j.1746-1561.2006.00062.x · Cited by 263 · see citing works
Canani, R. B., Costanzo, M. D., Bedogni, G., Amoroso, A., Cosenza, L., Scala, C. D., Granata, V., & Nocerino, R. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.10.050 · Cited by 253 · see citing works
The effects of selected probiotic strains on the development of eczema (the PandA study)
Niers, L. E. M., Martín, R., Rijkers, G. T., Sengers, F., Timmerman, H. M., van Uden, N. O. P., Smidt, H., Kimpen, J. L. L., & Hoekstra, M. (2009) · Allergy · doi:10.1111/j.1398-9995.2009.02021.x · Cited by 247 · see citing works
Lyons, A., O'Mahony, D., O'Brien, F., MacSharry, J. A., Sheil, B., Ceddia, M. A., Russell, W. M., Forsythe, P., Bienenstock, J., Kiely, B., et al. (2010) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2009.03437.x · Cited by 233 · see citing works
Boyle, R. J., Ismail, I. H., Kivivuori, S., Licciardi, P. V., Robins-Browne, R. M., Mah, L. ‐., Axelrad, C. M., Moore, S., Donath, S. M., Carlin, J. B., et al. (2010) · Allergy · doi:10.1111/j.1398-9995.2010.02507.x · Cited by 228 · see citing works
Asthma disparities in urban environments
Bryant-Stephens, T. C. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.04.030 · Cited by 207 · see citing works
Azad, M. B., Coneys, J. G., Kozyrskyj, A. L., Field, C. J., Ramsey, C. D., Becker, A. B., Friesen, C., Abou-Setta, A., & Zarychanski, R. (2013) · BMJ · doi:10.1136/bmj.f6471 · Cited by 206 · see citing works
Hol, J., van Leer, E. H. G., Schuurman, B. E. E. E., de Ruiter, L. F., Samsom, J. N., Hop, W. C. J., Neijens, H. J., de Jongste, J. C., & Nieuwenhuis, E. E. S. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.03.018 · Cited by 192 · see citing works
The Hygiene Hypothesis of Atopic Disease–An Extended Version
Rautava, S., Ruuskanen, O., Ouwehand, A. C., Salminen, S., & Isolauri, E. (2004) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200404000-00004 · Cited by 181 · see citing works
Probiotics during weaning reduce the incidence of eczema
West, C. E., Hammarström, M., & Hernell, O. (2009) · Pediatric Allergy and Immunology · doi:10.1111/j.1399-3038.2009.00745.x · Cited by 179 · see citing works
Wickens, K. L., Black, P., Stanley, T., Mitchell, E. A., Barthow, C. A., Fitzharris, P., Purdie, G., & Crane, J. (2012) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2012.03975.x · Cited by 177 · see citing works
Synbiotics prevent asthma-like symptoms in infants with atopic dermatitis
van der Aa, L. B., van Aalderen, W. M. C., Heymans, H. S. A., Henk Sillevis Smitt, J., Nauta, A. J., Knippels, L. M. J., Ben Amor, K., Sprikkelman, A. B., & the Synbad Study Group (2011) · Allergy · doi:10.1111/j.1398-9995.2010.02416.x · Cited by 172 · see citing works
Hougee, S., Vriesema, A. J. M., Wijering, S. C., Knippels, L. M. J., Folkerts, G., Nijkamp, F. P., Knol, J., & Garssen, J. (2009) · International Archives of Allergy and Immunology · doi:10.1159/000236000 · Cited by 162 · see citing works
The infant gut bacterial microbiota and risk of pediatric asthma and allergic diseases
Johnson, C. C., & Ownby, D. R. (2016) · Translational research · doi:10.1016/j.trsl.2016.06.010 · Cited by 162 · see citing works
Huang, R., Ning, H., Shen, M., Li, J., Zhang, J., & Chen, X. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00392 · Cited by 154 · see citing works
Early Probiotic Supplementation for Eczema and Asthma Prevention: A Randomized Controlled Trial
Cabana, M. D., McKean, M., Caughey, A. B., Fong, L. H., Lynch, S. V., Wong, A., Leong, R., Boushey, H. A., & Hilton, J. F. (2017) · PEDIATRICS · doi:10.1542/peds.2016-3000 · Cited by 150 · see citing works
Abrahamsson, T., Jakobsson, T., Björkstén, B., Oldæus, G., & Jenmalm, M. C. (2013) · Pediatric Allergy and Immunology · doi:10.1111/pai.12104 · Cited by 129 · see citing works
Spacova, I., Petrova, M., Fremau, A., Pollaris, L., Vanoirbeek, J. A., Ceuppens, J. L., Seys, S., & Lebeer, S. (2018) · Allergy · doi:10.1111/all.13502 · Cited by 125 · see citing works
Simpson, M. R., Dotterud, C. K., Storrø, O., Johnsen, R., & Øien, T. (2015) · BMC Dermatology · doi:10.1186/s12895-015-0030-1 · Cited by 124 · see citing works
Wickens, K. L., Stanley, T., Mitchell, E. A., Barthow, C. A., Fitzharris, P., Purdie, G., Siebers, R. W. L., Black, P., & Crane, J. (2013) · Clinical & Experimental Allergy · doi:10.1111/cea.12154 · Cited by 117 · see citing works
Gore, C., Čustović, A., Tannock, G. W., Munro, K., Kerry, G., Johnson, K., Peterson, C., Morris, J., Chaloner, C., Murray, C. S., et al. (2011) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2011.03885.x · Cited by 110 · see citing works
Probiotics in primary prevention of allergic disease - follow-up at 8-9 years of age
West, C. E., Hammarström, M., & Hernell, O. (2013) · Allergy · doi:10.1111/all.12191 · Cited by 98 · see citing works
Prescott, S. L., Wiltschut, J., Taylor, A. L., Westcott, L., Jung, W., Currie, H., & Dunstan, J. A. (2008) · Allergy · doi:10.1111/j.1398-9995.2008.01778.x · Cited by 95 · see citing works
Ou, C. ‐., Kuo, H., Wang, L., Hsu, T. ‐., Chuang, H., Liu, C. ‐., Chang, J., Yu, H., & Yang, K. D. (2012) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2012.04037.x · Cited by 91 · see citing works
Early probiotic supplementation for allergy prevention: Long-term outcomes
Jensen, M. P., Meldrum, S. J., Taylor, A. L., Dunstan, J. A., & Prescott, S. L. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.07.018 · Cited by 77 · see citing works
Treating Pediatric Asthma According Guidelines
Tesse, R., Borrelli, G., Mongelli, G., Mastrorilli, V., & Cardinale, F. (2018) · Frontiers in Pediatrics · doi:10.3389/fped.2018.00234 · Cited by 70 · see citing works
Wickens, K. L., Barthow, C. A., Mitchell, E. A., Stanley, T., Purdie, G., Rowden, J., Kang, J., Hood, F. E., van den Elsen, L. W. J., Forbes‐Blom, E., et al. (2018) · Pediatric Allergy and Immunology · doi:10.1111/pai.12874 · Cited by 67 · see citing works
Loo, E. X. L., Llanora, G., Lu, Q., Aw, M., Lee, B. W., & Shek, L. P. (2013) · International Archives of Allergy and Immunology · doi:10.1159/000356338 · Cited by 62 · see citing works
Akinbami, L. J., Simon, A. E., & Schoendorf, K. C. (2015) · Journal of Asthma · doi:10.3109/02770903.2015.1126848 · Cited by 57 · see citing works
Gorissen, D. M. W., Rutten, N. B. M. M., Oostermeijer, C. M. J., Niers, L. E. M., Hoekstra, M. O., Rijkers, G. T., & van der Ent, C. K. (2014) · Clinical & Experimental Allergy · doi:10.1111/cea.12413 · Cited by 50 · see citing works
Pediatric Asthma: Natural History, Assessment, and Treatment
Herzog, R., & Cunningham–Rundles, S. (2011) · Mount Sinai Journal of Medicine A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20285 · Cited by 41 · see citing works
Clarke, S.-A., & Calam, R. M. (2011) · Quality of Life Research · doi:10.1007/s11136-011-9996-2 · Cited by 31 · see citing works
Lee, J. (2013) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.1211.11079 · Cited by 23 · see citing works
Kauppi, P., Kuokkanen, M., Kukkonen, A. K., Laitinen, T., & Kuitunen, M. (2014) · Allergologia et Immunopathologia · doi:10.1016/j.aller.2013.10.001 · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Methods in Lung Microbiome Research
Carney, S. M., Clemente, J. C., Cox, M. J., Dickson, R. P., Huang, Y. J., Kitsios, G. D., Kloepfer, K. M., Leung, J. M., LeVan, T. D., Molyneaux, P. L., et al. (2019) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2019-0273tr · Cited by 189 · see citing works
The Lung Microbiome during Health and Disease
Yagi, K., Huffnagle, G. B., Lukacs, N. W., & Asai, N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910872 · Cited by 180 · see citing works
Viral Infections, the Microbiome, and Probiotics
Harper, A., Vijayakumar, V., Ouwehand, A. C., ter Haar, J., Obis, D., Espadaler, J., Binda, S., Desiraju, S., & Day, R. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.596166 · Cited by 177 · see citing works
The maternal gut microbiome during pregnancy and offspring allergy and asthma
Gao, Y., Nanan, R. K. H., Macia, L., Tan, J., Sominsky, L., Quinn, T. P., O’Hely, M., Ponsonby, A., Tang, M. L. K., Collier, F., et al. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.07.011 · Cited by 121 · see citing works
García-Mauriño, C., Paes, V. M., Shao, Y., Oeser, C., Miltz, A. R., Lawley, T. D., Brocklehurst, P., Rodger, A. J., & Field, N. M. (2022) · The Lancet Microbe · doi:10.1016/s2666-5247(22)00184-7 · Cited by 113 · see citing works
Probiotics in Pediatrics. A Review and Practical Guide
Depoorter, L., & Vandenplas, Y. (2021) · Nutrients · doi:10.3390/nu13072176 · Cited by 112 · see citing works
Valverde-Molina, J., & García-Marcos, L. (2023) · Nutrients · doi:10.3390/nu15030486 · Cited by 92 · see citing works
Lung Microbiome in Asthma: Current Perspectives
Loverdos, K., Bellos, G., Kokolatou, L., Vasileiadis, I., Giamarellos‐Bourboulis, E. J., Pecchiari, M., Koulouris, N. G., Koutsoukou, A., & Rovina, N. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8111967 · Cited by 88 · see citing works
Microbial Dysbiosis Tunes the Immune Response Towards Allergic Disease Outcomes
Augustine, T., Kumar, M., Khodor, S. A., & van Panhuys, N. (2022) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-022-08939-9 · Cited by 75 · see citing works
Drago, L., CIOFFI, L. A., Giuliano, M. G., Pane, M., Amoruso, A., Schiavetti, I., Reid, G., Ciprandi, G., & PROPAM Study Group (2022) · Journal of Immunology Research · doi:10.1155/2022/3837418 · Cited by 68 · see citing works
Asthma in the Precision Medicine Era: Biologics and Probiotics
Chiu, C.-J., & Huang, M.-T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094528 · Cited by 60 · see citing works
Stricker, S., Hain, T., Chao, C., & Rudloff, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126791 · Cited by 60 · see citing works
Pulvirenti, G., Parisi, G. F., Giallongo, A., Papale, M. R., Manti, S., Savasta, S., Licari, A., Marseglia, G. L., & Leonardi, S. (2019) · Frontiers in Pediatrics · doi:10.3389/fped.2019.00393 · Cited by 52 · see citing works
Meirlaen, L., Levy, E. I., & Vandenplas, Y. (2021) · Nutrients · doi:10.3390/nu13030934 · Cited by 52 · see citing works
Accounting for the health risk of probiotics
Liu, X., Zhao, H., & Wong, A. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e27908 · Cited by 44 · see citing works
Ceccarelli, G., Statzu, M., Santinelli, L., Pinacchio, C., Bitossi, C., Cavallari, E. N., Vullo, V., Scagnolari, C., & d’Ettorre, G. (2019) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2019.1638907 · Cited by 44 · see citing works
The gut‐lung axis and asthma susceptibility in early life
Kahhaleh, F. G., Barrientos, G., & Conrad, M. L. (2024) · Acta Physiologica · doi:10.1111/apha.14092 · Cited by 37 · see citing works
Pediatric Obesity-Related Asthma: The Role of Nutrition and Nutrients in Prevention and Treatment
Calcaterra, V., Verduci, E., Ghezzi, M., Cena, H., Pascuzzi, M. C., Regalbuto, C., Lamberti, R., Rossi, V., Manuelli, M. C., Bosetti, A., et al. (2021) · Nutrients · doi:10.3390/nu13113708 · Cited by 41 · see citing works
Probiotics in Children with Asthma
Ciprandi, G., & Tosca, M. A. (2022) · Children · doi:10.3390/children9070978 · Cited by 34 · see citing works
Alsayed, A. R., Abed, A. I., Khader, H. A., Al-Shdifat, L., Hasoun, L., Al‐Rshaidat, M. M. D., Alkhatib, M., & Zihlif, M. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24044086 · Cited by 29 · see citing works
γδ T Lymphocytes in Asthma: a Complicated Picture
Zarobkiewicz, M., Wawryk-Gawda, E., Kowalska, W., Janiszewska, M., & Bojarska-Junak, A. (2021) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-021-00608-7 · Cited by 27 · see citing works
Impact of Probiotic Bacteria on Respiratory Allergy Disorders
Jakubczyk, D., & Górska, S. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.688137 · Cited by 28 · see citing works
Wawryk‐Gawda, E., Markut–Miotła, E., & Emeryk, A. (2021) · Allergologia et Immunopathologia · doi:10.15586/aei.v49i4.69 · Cited by 28 · see citing works
Exposure to Heavy Metals and Allergic Outcomes in Children: a Systematic Review and Meta-analysis
Wang, J., Yin, J., Hong, X., & Liu, R. (2022) · Biological Trace Element Research · doi:10.1007/s12011-021-03070-w · Cited by 29 · see citing works
Schmid, A. M., Razim, A., Wysmołek, M. E., Kerekes, D., Haunstetter, M., Kohl, P., Brazhnikov, G., Geissler, N., Thaler, M., Krčmářová, E., et al. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01329-4 · Cited by 27 · see citing works
The role of the early-life gut microbiome in childhood asthma
Boulund, U., Thorsen, J., Trivedi, U., Tranæs, K., Jiang, J., Shah, S. A., & Stokholm, J. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2457489 · Cited by 27 · see citing works
Efficacy of probiotics in the treatment of allergic diseases: a meta-analysis
Zhang, X., Fenglin, X., Zhao, Y., & Li, C. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1502390 · Cited by 23 · see citing works
Probiotics in the Prevention and Management of Human Diseases
Levy, E. I. (2021) · Elsevier eBooks · doi:10.1016/c2020-0-00028-9 · Cited by 21 · see citing works
Dangerous liaisons: Bacteria, antimicrobial therapies, and allergic diseases
Tramper‐Stranders, G. A., Ambrożej, D., Arcolacı, A., Atanasković‐Marković, M., Boccabella, C., Bonini, M., Karavelia, A., Mingomataj, E., O’Mahony, L., Sokołowska, M., et al. (2021) · Allergy · doi:10.1111/all.15046 · Cited by 24 · see citing works
Dietary Interventions and Nutritional Factors in the Prevention of Pediatric Asthma
Trambusti, I., Nuzzi, G., Costagliola, G., Verduci, E., D’Auria, E., Peroni, D. G., & Comberiati, P. (2020) · Frontiers in Pediatrics · doi:10.3389/fped.2020.00480 · Cited by 20 · see citing works
Searching for the one(s): Using Probiotics as Anthelmintic Treatments
Saracino, M. P., Vila, C. C., Baldi, P. C., & Maglio, D. H. G. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.714198 · Cited by 20 · see citing works
Primary Prevention of Pediatric Asthma through Nutritional Interventions
Nuzzi, G., Cicco, M. D., Trambusti, I., Agosti, M. A., Peroni, D. G., & Comberiati, P. (2022) · Nutrients · doi:10.3390/nu14040754 · Cited by 20 · see citing works
The Role of the Microbiome in the Pathogenesis and Treatment of Asthma
Logoń, K., Świrkosz, G., Nowak, M., Wrześniewska, M., Szczygieł, A., & Gomułka, K. (2023) · Biomedicines · doi:10.3390/biomedicines11061618 · Cited by 21 · see citing works
Grandinetti, R., Fainardi, V., Caffarelli, C., Capoferri, G., Lazzara, A., Tornesello, M., Meoli, A., Bergamini, B. M., Bertelli, L., Biserna, L., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11216558 · Cited by 19 · see citing works
Diet Modifications in Primary Prevention of Asthma. Where Do We Stand?
Sozańska, B., & Sikorska-Szaflik, H. (2021) · Nutrients · doi:10.3390/nu13010173 · Cited by 19 · see citing works
Using probiotics in paediatric populations
Schneider, R. E., & Sant’Anna, A. (2022) · Paediatrics & Child Health · doi:10.1093/pch/pxac087 · Cited by 18 · see citing works
Wassenaar, T. M., Juncos, V. A., & Zimmermann, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189700 · Cited by 16 · see citing works
Li, L., Sun, Q., Xiao, H., Zhang, Q.-N., Xu, S.-Y., Lai, L., Li, Z., & Li, C. (2022) · Journal of Immunology Research · doi:10.1155/2022/8447603 · Cited by 16 · see citing works
Smout, J., Valentin, C., Delbauve, S., Pauwels, J., Köhler, A., & Flamand, V. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1082648 · Cited by 16 · see citing works
Relevance of gut microbiome research in food safety assessment
Garrido‐Romero, M., Pazos, F., Sánchez‐Martínez, E., Benito, C., Ruiz, J. Á. G., Borrego‐Yaniz, G., Bowes, C., Broll, H., Caminero, A., Caro, E., et al. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2410476 · Cited by 14 · see citing works
Kanj, A., & Skalski, J. H. (2024) · Journal of Fungi · doi:10.3390/jof10030192 · Cited by 15 · see citing works
Tong, X., Zhang, X., Wang, M., Wang, Z., Dong, F., Gong, E., Zuberbier, T., & Li, Y. (2024) · Clinical and Translational Allergy · doi:10.1002/clt2.12344 · Cited by 13 · see citing works
Treating asthma patients with probiotics: a systematic review and meta-analysis
Wang, Y., Xie, Q., & Yuan, J. (2023) · Nutrición Hospitalaria · doi:10.20960/nh.04360 · Cited by 13 · see citing works
Li, N., Gao, S., Tong, J., Yu, Y., Zhang, Q., & Xu, C. (2020) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2020.1796578 · Cited by 12 · see citing works
Satia, I., Cusack, R. P., Stevens, C., Schlatman, A., Wattie, J. N., Mian, F., Killian, K. J., O’Byrne, P. M., Bienenstock, J., Forsythe, P., et al. (2021) · Clinical & Experimental Allergy · doi:10.1111/cea.13976 · Cited by 12 · see citing works
Feleszko, W., Rossi, G. A., Krenke, R., Canonica, G. W., Gerven, L. V., & Kalyuzhin, O. V. (2020) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2020.1744436 · Cited by 12 · see citing works
Investigational Treatments in Phase I and II Clinical Trials: A Systematic Review in Asthma
Calzetta, L., Aiello, M., Frizzelli, A., Pistocchini, E., Ritondo, B. L., Rogliani, P., & Chetta, A. A. (2022) · Biomedicines · doi:10.3390/biomedicines10092330 · Cited by 10 · see citing works
Study on Intestinal Flora and Asthma: Knowledge Graph Analysis Based on CiteSpace (2001–2021)
Zheng, H., Dai, H., Yan, X., & Xiang, Q. (2023) · Journal of Asthma and Allergy · doi:10.2147/jaa.s402883 · Cited by 10 · see citing works
Milani, T., Sandy, C. M., Calazans, A. P. C. T., Silva, R. Q., da Fonseca, V. M. B., Martins, F. S., & Borges, M. D. C. (2022) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-022-10014-w · Cited by 9 · see citing works
The Changes in Bacterial Microbiome Associated with Immune Disorder in Allergic Respiratory Disease
Lyu, J., Kou, F., Men, X., Liu, Y., Tang, L., & Shu, W. (2022) · Microorganisms · doi:10.3390/microorganisms10102066 · Cited by 9 · see citing works
Lung microbiome: new insights into bronchiectasis’ outcome
Azoicai, A. N., Lupu, A., Alexoae, M. M., Stârcea, I. M., Mocanu, A., Lupu, V. V., Mitrofan, E. C., Nedelcu, A. H., Ţepordei, R. T., Munteanu, D., et al. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1405399 · Cited by 7 · see citing works
The Impact of the Human Milk Microbiota in the Prevention of Disease and Infant Health
Melekoğlu, E., Yılmaz, B., Çevik, A., Sürücü, Ş. G., Vurgeç, B. A., Gözüyeşil, E., Sharma, H., Boyan, N., & Özoğul, F. (2023) · Breastfeeding Medicine · doi:10.1089/bfm.2022.0292 · Cited by 8 · see citing works
Probiotics: current regulatory aspects of probiotics for use in different disease conditions
Pogačar, M. Š., Mičetić‐Turk, D., & Fijan, S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823733-5.00021-0 · Cited by 8 · see citing works
Theodosiou, A. A., Dorey, R. B., Laver, J. R., Cleary, D. W., Read, R. C., & Jones, C. E. (2021) · Journal of Infection · doi:10.1016/j.jinf.2021.03.012 · Cited by 8 · see citing works
Probiotics in asthma management: fiction or truth?
Ciprandi, G., Tosca, M. A., & Drago, L. (2023) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2023.2189103 · Cited by 8 · see citing works
Forouhandeh, H., Soofiyani, S. R., Hosseini, K., Beirami, S. M., Ahangari, H., Moammer, Y., Ebrahimzadeh, S., Nejad, M. K., Farjami, A., Khodaiefar, F., et al. (2023) · Recent Advances in Inflammation & Allergy Drug Discovery · doi:10.2174/0127722708246899230928080651 · Cited by 7 · see citing works
The lung microbiome in neonates
Permall, D. L., Pasha, A. B., Chen, X.-Q., & Lu, H. (2019) · The Turkish Journal of Pediatrics · doi:10.24953/turkjped.2019.06.001 · Cited by 7 · see citing works
Research advance in correlation between childhood asthma and gut microbiota
Ma, Y., Zheng, H., Tian, H., Cui, J., & Liu, L. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1649180 · Cited by 5 · see citing works
Wan, W., Qiu, Y., Huang, X., Ren, Y., Peng, A., & Yang, C. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1190765 · Cited by 5 · see citing works
Depoorter, L., & Vandenplas, Y. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85170-1.00014-2 · Cited by 5 · see citing works
Fukumori, C., Casaro, M. B., Thomas, A. M., Mendes, E., Ribeiro, W. R., Crisma, A. R., Murata, G. M., Bizzarro, B., Dias‐Neto, E., Setúbal, J. C., et al. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103496 · Cited by 5 · see citing works
Adjibade, M., Vigneron, L., Delvert, R., Adel‐Patient, K., Divaret‐Chauveau, A., Annesi‐Maesano, I., Heude, B., Charles, M.-A. A., & de Lauzon‐Guillain, B. (2024) · Maternal and Child Nutrition · doi:10.1111/mcn.13673 · Cited by 4 · see citing works
Venter, C., Beltran, J., Bracchiglione, J., Sáenz, F., Riera, P., Solà, I., Akdis, C., Arasi, S., Canani, R. B., Fleischer, D. M., et al. (2026) · Allergy · doi:10.1111/all.70429 · Cited by 3 · see citing works
Matterne, U., Tischer, C., Wang, J., Knüttel, H., Genuneit, J., Perkin, M. R., & Apfelbacher, C. (2021) · F1000Research · doi:10.12688/f1000research.51490.2 · Cited by 2 · see citing works
Probiotics in the prevention and management of allergic diseases (asthma and allergic rhinitis)
Meirlaen, L., Levy, E. I., & Vandenplas, Y. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823733-5.00027-1 · Cited by 3 · see citing works
Management of asthma using probiotics
Garg, A. P., Ateeq, A., Bisht, N., & Patil, B. (2024) · doi:10.37349/eaa.2024.00026 · Cited by 3 · see citing works
Probiotics in Allergic Rhinitis Management: Is There a Positioning for Them?
Ciprandi, G., & Tosca, M. A. (2022) · Allergies · doi:10.3390/allergies2030011 · Cited by 5 · see citing works
Dezfouli, K. A., Darban, M., Hemati, M., Zahir, M., Soltani‐Kermanshahi, M., Abdolshahi, A., Sadr, H., & Bagheri, B. (2025) · Drug Research · doi:10.1055/a-2564-2569 · Cited by 2 · see citing works
Fecal microbiota transplantation in allergic diseases
Önata, E. T., & Özdemır, Ö. (2024) · World Journal of Methodology · doi:10.5662/wjm.v15.i2.101430 · Cited by 1 · see citing works
Obesity-related asthma in children: mechanisms, clinical challenges, and management strategies
Xu, L., Pan, Z., Yang, Q., Shen, W., Yu, Q., & Hao, C. (2026) · Allergy medicine. · doi:10.1016/j.allmed.2026.100095 · Cited by 1 · see citing works
Rodrigues, P. B., Valentin, C., Woenande, E., Delbauve, S., Vermijlen, D., Köhler, A., Flamand, V., & Everard, A. (2026) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2026.110301 · Cited by 1 · see citing works
Rafiei, Z., Azadi, H., Dehghan, P., Panahiyan, P., Maleki, P., & Zarezadeh, M. (2026) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10738-5 · Cited by 1 · see citing works
Probiotic Bacteria in Microbiome against Allergy
Fard, N. A., Mazhary, Z., & Javanshir, N. (2020) · Biochemistry · doi:10.5772/intechopen.93385 · Cited by 1 · see citing works
Microbiome Therapeutics in Respiratory Illnesses
Shariff, M., & Aditi (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819265-8.00002-4 · Cited by 1 · see citing works
Biotics in atopic diseases: state of the art and future perspectives
D’Auria, E., Acunzo, M., Salvatore, S., Grazi, R., Agosti, M. A., Vandenplas, Y., & Zuccotti, G. (2022) · Minerva Pediatrics · doi:10.23736/s2724-5276.22.07010-0 · Cited by 1 · see citing works
Progress on probiotics as add-on therapy for allergic rhinitis
Ciprandi, G., del Giudice, M. M., & Drago, L. (2024) · Revue française d'allergologie · doi:10.1016/j.reval.2023.103766 · Cited by 1 · see citing works
1. Probiotics in Prevention of the Atopic March: Myth or Reality?
Atanasković‐Marković, M. (2019) · The Central European Journal of Paediatrics · doi:10.5457/p2005-114.226 · Cited by 1 · see citing works
Probiotics: present and future
Никитина, Е. А., Орлова, С. В., & Orlova, A. A. (2021) · Medical alphabet · doi:10.33667/2078-5631-2021-21-101-114 · Cited by 1 · see citing works
Immunity, microbiome and probiotics in viral infections
Rosenson, R. I. (2021) · Terapevt (General Physician) · doi:10.33920/med-12-2108-07
The changes of microbiota associated with immunological disturbances in allergic respiratory diseasePreprint
Lyu, J., Kou, F., Men, X., Liu, Y., Tang, L., & Wen, S. (2022) · doi:10.22541/au.164905942.28613699/v1
Probióticos: una mirada al mecanismo de acción y aplicaciones clínicas en Pediatría
Camacho, J. H., Castañeda-Gutiérrez, L. D., Mongui-Gutierrez, D., Martin-Ramirez, A., Orozco, A. M. E., Chiquiza, J. S. C., Hueras, L. V., Valencia, J. F. C., Martínez, J. S. A., Burgos, C. A. G., et al. (2022) · Salud Uninorte · doi:10.14482/sun.38.3.618.92
L’utilisation des probiotiques dans la population pédiatrique
Schneider, R. E., & Sant’Anna, A. (2022) · Paediatrics & Child Health · doi:10.1093/pch/pxac086
Stephensen, C. B., & Kenyon, N. J. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821848-8.00182-7
Advent of Pharmabiotics as a Promising Therapeutic Tool for Human Health and Diseases Management
Mulay, V., Satav, D., Fernandes, A., Pisalwar, P., & Ahmed, S. (2023) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815079609123010008
Schabussová, I., Schmid, A. M., Razim, A., Wysmołek, M. E., Kerekes, D., Haunstetter, M., Kohl, P., Brazhnikov, G., Geissler, N., Thaler, M., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-2756710/v1
Çocuklarda Profilaktik ve Terapötik Probiyotik Kullanımı
Önata, E. T., & Özdemır, Ö. (2024) · JOURNAL OF BIOTECHNOLOGY AND STRATEGIC HEALTH RESEARCH · doi:10.34084/bshr.1465778
Allergen immunotherapy as a form of preventing the development of allergies: A literature review
Zalewska, A., Drobik, M., Michałek, M., Kozieł, M., Hariasz, W., Gądek, K., & Lichodij, A. (2026) · Annales Academiae Medicae Silesiensis · doi:10.18794/aams/211787
Microbiome and Diseases: Allergy
Amar, Y., Faihs, V., Hils, M., Köberle, M., & Biedermann, T. (2026) · Springer eBooks · doi:10.1007/978-3-032-26410-7_12
Wang, H., Hu, Q., Li, J., Chen, K., Qi, X., Zhang, R., Wang, X., Wang, Y., & Li, Y. (2026) · Pediatric Research · doi:10.1038/s41390-026-05452-z
- Authors
- Wei, X., Jiang, P., Liu, J., Sun, R., & Zhu, L.
- Affiliations
- Tianjin First Center Hospital (CN)
- Corresponding author
- Zhu, Liqin
- Venue
- Journal of Asthma
- Publisher
- Informa UK Limited
- Published
- 2019-01-18
- Volume
- 57
- Issue
- 2
- Pages
- 167-178
- ISSN
- 0277-0903 (ISSN-L)
- 1532-4303
- OpenAlex
- W2909358526
- Cited by
- 91
- References
- 53
- Citations by year
- 2026: 7 · 2025: 4 · 2024: 11 · 2023: 14 · 2022: 20 · 2021: 23 · 2020: 5 · 2019: 7
- FWCI
- 1.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Asthma (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Keywords
- probiotics, asthma prevention, infants, wheezing, atopy, probiotic supplementation, infant health
- MeSH terms
- Asthma, Humans, Hypersensitivity, Infant, Respiratory Sounds, Incidence, Randomized Controlled Trials as Topic, Dietary Supplements, Probiotics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review