Set, setting, and matrix
Abstract
The future use of psychedelics as an aid to therapeutic change is bound to come. The best source of information on how to use these extraordinary drugs is clearly a detailed description of the successes (and failures) of those researchers who have used these compounds to bring curative, creative and growth-potentiating experiences to their patients. A study of their work is recommended in order to identify those elements that lead to successful sessions. Two known essential elements are "set," which involves the personality and experiences of the patient, and "setting," which has to do with the environment of the session. A third element of importance is that of "matrix," which includes consideration of the environment (1) from which an individual comes, (2) in which the individual lives during the time of the sessions, and (3) to which the individual returns after successful therapy--the everyday living space; these three elements are discussed.
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Contextual factors, such as the environment in which the experience takes place (setting), the mindset of the individual (set), and the support available after the experience (integration and setting), have a huge impact on the effects of psychedelics.
“Contextual factors, such as the environment in which the experience takes place (setting), the mindset of the individual (set), and the support available after the experience (integration and setting), have a huge impact on the effects of psychedelics (85–88).”
From Potential therapeutic effects of an ayahuasca-inspired N,N-DMT and harmine formulation: a controlled trial in healthy subjects (2024) · cites this paper as [86]
Cites
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Serotonin and brain function: a tale of two receptors
Carhart-Harris, R., & Nutt, D. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117725915 · Cited by 739 · see citing works
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- Authors
- Eisner, B.
- Corresponding author
- Eisner, Betty
- Venue
- Journal of Psychoactive Drugs
- Publisher
- Informa UK Limited
- Published
- 1997-06-01
- Volume
- 29
- Issue
- 2
- Pages
- 213-216
- ISSN
- 0279-1072 (ISSN-L)
- 2159-9777
- OpenAlex
- W2153594880
- Cited by
- 135
- References
- 3
- Citations by year
- 2026: 23 · 2025: 24 · 2024: 23 · 2023: 18 · 2022: 13 · 2021: 7 · 2020: 5 · 2019: 5 · 2018: 4 · 2017: 4 · 2016: 1 · 2014: 2 · 2013: 1 · 2012: 2
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychoactive Drugs (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Social Sciences › Psychology › Social Psychology › Paranormal Experiences and Beliefs
- Keywords
- psychedelics, psychedelic therapy, therapeutic change, set and setting, matrix, patient personality, therapeutic environment, psychedelic-assisted psychotherapy
- MeSH terms
- Hallucinogens, Humans, Terminology as Topic, Psychotherapy, History, 20th Century
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