The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
The Potential Role of Dietary Xanthophylls in Cataract and Age-Related Macular Degeneration
Abstract
The carotenoid xanthophylls, lutein and zeaxanthin, accumulate in the eye lens and macular region of the retina. Lutein and zeaxanthin concentrations in the macula are greater than those found in plasma and other tissues. A relationship between macular pigment optical density, a marker of lutein and zeaxanthin concentration in the macula, and lens optical density, an antecedent of cataractous changes, has been suggested. The xanthophylls may act to protect the eye from ultraviolet phototoxicity via quenching reactive oxygen species and/or other mechanisms. Some observational studies have shown that generous intakes of lutein and zeaxanthin, particularly from certain xanthophyll-rich foods like spinach, broccoli and eggs, are associated with a significant reduction in the risk for cataract (up to 20%) and for age-related macular degeneration (up to 40%). While the pathophysiology of cataract and age-related macular degeneration is complex and contains both environmental and genetic components, research studies suggest dietary factors including antioxidant vitamins and xanthophylls may contribute to a reduction in the risk of these degenerative eye diseases. Further research is necessary to confirm these observations.
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Citations
Cites
Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration
Seddon, J. M. (1994) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1994.03520180037032 · Cited by 993
Antioxidant status and neovascular age-related macular degeneration
(1993) · Archives of Ophthalmology · doi:10.1001/archopht.1993.01090010108035 · Cited by 304
Dietary fat and age-related maculopathy
Mares-Perlman, J. A. (1995) · Archives of Ophthalmology · doi:10.1001/archopht.1995.01100060069034 · Cited by 298
VandenLangenberg, G. M., Mares-Perlman, J. A., Klein, R., Klein, B. E. K., Brady, W. E., & Palta, M. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009625 · Cited by 234 · cited 1×
“[33] followed subjects from the Beaver Dam cohort who were free of late stage AMD at baseline for five years and found no significant association between specific macular lesions and lutein and zeaxanthin intake either 10 years before study enrollment or at baseline.”
Background
Cited by
B IOLOGIC M ECHANISMS OF THE P ROTECTIVE R OLE OF L UTEIN AND Z EAXANTHIN IN THE E YE
Krinsky, N. I., Landrum, J. T., & Bone, R. A. (2003) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.23.011702.073307 · Cited by 779
(2007) · doi:10.1007/978-3-540-37885-3 · Cited by 476
Environmental and cultural stimulants in the production of carotenoids from microorganisms
Bhosale, P. (2004) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-003-1441-1 · Cited by 341
Functional Properties of Spinach (Spinacia oleracea L.) Phytochemicals and Bioactives
Roberts, J. L., & Moreau, R. (2016) · Food & Function · doi:10.1039/c6fo00051g · Cited by 283
Composition, Efficacy, and Safety of Spinach Extracts
Lomnitski, L., Bergman, M., Nyska, A., Ben-Shaul, V., & Grossman, S. (2003) · Nutrition and Cancer · doi:10.1207/s15327914nc4602_16 · Cited by 105
Metadata
- Authors
- Moeller, S. M., Jacques, P. F., & Blumberg, J. B.
- Venue
- Journal of the American College of Nutrition
- Publisher
- Informa UK Limited
- Published
- 2000-10
- Volume
- 19
- Issue
- sup5
- Pages
- 522S-527S
- ISSN
- 0731-5724 (ISSN-L)
- 1541-1087
- OpenAlex
- W2137858596
- Cited by
- 235
- References
- 4
- FWCI
- 7.93
- Type
- journal article
- Language
- en
- Open access
- closed
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- Moeller, S. M., Jacques, P. F., & Blumberg, J. B. (2000). The Potential Role of Dietary Xanthophylls in Cataract and Age-Related Macular Degeneration. Journal of the American College of Nutrition. https://doi.org/10.1080/07315724.2000.10718975
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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