Composition, Efficacy, and Safety of Spinach Extracts
Abstract
Spinach leaves, containing several active components, including flavonoids, exhibit antioxidative, antiproliferative, and antiinflammatory properties in biological systems. Spinach extracts have been demonstrated to exert numerous beneficial effects, such as chemo- and central nervous system protection and anticancer and antiaging functions. In this review article, we present a compilation of data generated in our laboratories and those of other investigators describing the chemical composition of spinach, its beneficial effects, relative safety information, and its recommended inclusion in the human diet. A powerful, water-soluble, natural antioxidant mixture (NAO), which specifically inhibits the lipoxygenase enzyme, was isolated from spinach leaves. The antioxidative activity of NAO has been compared to that of other known antioxidants and found to be superior in vitro and in vivo to that of green tea, N-acetylcysteine (NAC), butylated hydroxytoluene (BHT), and vitamin E. NAO has been tested for safety and is well tolerated in several species, such as mouse, rat, and rabbit. NAO has been found to be nonmutagenic and has shown promising anticarcinogenic effects in a few experimental models, such as skin and prostate cancer; it has not shown any target-organ toxicity or side effects. The current review provides epidemiological and preclinical data supporting the efficacy of extracts of spinach and the safety of its consumption.
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It is quite plausible that other non-ecdysteroid compounds are present in spinach with anabolic activity.
“It is quite plausible that other non-ecdysteroid compounds are present in spinach with anabolic activity [2].”
From Ecdysteroid Content and Therapeutic Activity in Elicited Spinach Accessions (2020) · cites this paper as [2]
Cites
Oxidants, antioxidants, and the degenerative diseases of aging.
Ames, B. N., Shigenaga, M. K., & Hagen, T. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7915 · Cited by 5,958 · see citing works
Antioxidant and Prooxidant Behavior of Flavonoids: Structure-Activity Relationships
Cao, G., Sofic, E., & Prior, R. L. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00351-6 · Cited by 2,415 · see citing works
Total Antioxidant Capacity of Fruits
Wang, H., Cao, G., & Prior, R. L. (1996) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf950579y · Cited by 1,686 · see citing works
Prior, R. L., Cao, G., Martín, A., Sofic, E., McEwen, J. J., O'Brien, C., Lischner, N., Ehlenfeldt, M. K., Kalt-Torres, W., Krewer, G. W., et al. (1998) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf980145d · Cited by 1,298 · see citing works
Polyphenolic Flavanols as Scavengers of Aqueous Phase Radicals and as Chain-Breaking Antioxidants
Salah, N., Miller, N. J., Paganga, G., Tijburg, L. B. M., Bolwell, G. P., & Rice-Evans, C. A. (1995) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1995.1473 · Cited by 1,276 · see citing works
Dietary Flavonoids: Intake, Health Effects and Bioavailability
Hollman, P. C. H., & Katan, M. (1999) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(99)00079-4 · Cited by 1,144 · see citing works
Joseph, J. A., Shukitt-Hale, B., Denisova, N. A., Bielinski, D., Martin, A., McEwen, J. J., & Bickford, P. C. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-18-08114.1999 · Cited by 980 · see citing works
Natural antioxidants in grapes and wines
Kanner, J., Frankel, E. N., Granit, R., German, B. J., & Kinsella, J. (1994) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00037a010 · Cited by 495 · see citing works
Carotenoids Affect Proliferation of Human Prostate Cancer Cells
Kotake‐Nara, E., Miyashita, K., Nagao, A., Kushiro, M., Zhang, H., & Sugawara, T. (2001) · Journal of Nutrition · doi:10.1093/jn/131.12.3303 · Cited by 465 · see citing works
Joseph, J. A., Shukitt‐Hale, B., Denisova, N. A., Prior, R. L., Cao, G., Martín, A., Taglialatela, G., & Bickford, P. C. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-19-08047.1998 · Cited by 432 · see citing works
Gil, M. I., Ferreres, F., & Tomás-Barberán, F. A. (1999) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf981200l · Cited by 399 · see citing works
Zhou, J., Gugger, E. T., Tanaka, T., Guo, Y., Blackburn, G. L., & Clinton, S. K. (1999) · Journal of Nutrition · doi:10.1093/jn/129.9.1628 · Cited by 339 · see citing works
A prospective study of carotenoid intake and risk of cataract extraction in US men
Brown, L., Rimm, E. B., Seddon, J. M., Giovannucci, E. L., Chasan‐Taber, L., Spiegelman, D. L., Willett, W. C., & Hankinson, S. E. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/70.4.517 · Cited by 339 · see citing works
Slattery, M. L., Benson, J. E., Curtin, K. P., Ma, K.-N., Schaeffer, D., & Potter, J. D. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.2.575 · Cited by 305 · see citing works
A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women
Chasan‐Taber, L., Willett, W. C., Seddon, J. M., Stampfer, M. J., ROSNER, B. A., Colditz, G. A., Speizer, F. E., & Hankinson, S. E. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/70.4.509 · Cited by 283 · see citing works
Tennant, R. W., French, J. E., & Spalding, J. W. (1995) · Environmental Health Perspectives · doi:10.1289/ehp.95103942 · Cited by 261 · see citing works
The antioxidant activity of aqueous spinach extract: chemical identification of active fractions
Bergman, M., Varshavsky, L., Gottlieb, H. E., & Grossman, S. (2001) · Phytochemistry · doi:10.1016/s0031-9422(01)00137-6 · Cited by 240 · see citing works
Self-citationThe Potential Role of Dietary Xanthophylls in Cataract and Age-Related Macular Degeneration
Moeller, S. M., Jacques, P. F., & Blumberg, J. B. (2000) · Journal of the American College of Nutrition · doi:10.1080/07315724.2000.10718975 · Cited by 236 · see citing works
Jefferson, W. N., Couse, J. F., Padilla‐Banks, E., Korach, K. S., & Newbold, R. R. (2002) · Biology of Reproduction · doi:10.1095/biolreprod67.4.1285 · Cited by 229 · see citing works
Dietary factors and gastric cancer in Korea: A case-control study
Kim, H. J., Chang, W. K., Kim, M. K., Lee, S. S., & Choi, B. Y. (2002) · International Journal of Cancer · doi:10.1002/ijc.10111 · Cited by 226 · see citing works
Diet and Its Preventive Role in Prostatic Disease
Denis, L., Morton, M. S., & Griffiths, K. (1999) · European Urology · doi:10.1159/000019912 · Cited by 223 · see citing works
Effects of dietary genistein exposure during development on male and female CD (Sprague-Dawley) rats
Delclos, K. B., Bucci, T. J., Lomax, L. G., Latendresse, J. R., Warbritton, A. R., Weis, C. C., & Newbold, R. R. (2001) · Reproductive Toxicology · doi:10.1016/s0890-6238(01)00177-0 · Cited by 208 · see citing works
Current Understanding of Sepsis
Wenzel, R. P., Pinsky, M. R., Ulevitch, R. J., & Young, L. D. (1996) · Clinical Infectious Diseases · doi:10.1093/clinids/22.3.407 · Cited by 130 · see citing works
LIPOXYGENASE CONTENT AND ANTIOXIDANT ACTIVITY OF SOME FRUITS AND VEGETABLES
Pinsky, A., Grossman, S., & Trop, M. (1971) · Journal of Food Science · doi:10.1111/j.1365-2621.1971.tb15131.x · Cited by 130 · see citing works
Self-citationPolyphenol Antioxidants in Citrus Juices: in vitro and in vivo Studies Relevant to Heart Disease
Vinson, J. A., Liang, X., Proch, J., Hontz, B. A., Dancel, J., & Sandone, N. (2002) · Advances in experimental medicine and biology · doi:10.1007/978-1-4757-5235-9_10 · Cited by 114 · see citing works
Eyeblink conditioning discriminates Alzheimerʼs patients from non-demented aged
Woodruff‐Pak, D. S., Finkbiner, R. G., & Sasse, D. K. (1990) · Neuroreport · doi:10.1097/00001756-199009000-00013 · Cited by 111 · see citing works
Ben-Shaul, V., Lomnitski, L., Nyska, A., Zurovsky, Y., Bergman, M., & Grossman, S. (2001) · Toxicology Letters · doi:10.1016/s0378-4274(01)00369-1 · Cited by 110 · see citing works
Self-citationJoseph, J. A., Denisova, N. A., Bielinski, D. F., Fisher, D. R., & Shukitt‐Hale, B. (2000) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00128-7 · Cited by 104 · see citing works
Edenharder, R., Keller, G., Platt, K. L., & Unger, K. K. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0013712 · Cited by 95 · see citing works
Vegetarian diet: panacea for modern lifestyle diseases?
Segasothy, M., & Phillips, P. A. (1999) · QJM · doi:10.1093/qjmed/92.9.531 · Cited by 89 · see citing works
Acylated flavonol glycosides from spinach leaves (Spinacia oleracea)
Ferreres, F., Castañer, M., & Tomás-Barberán, F. A. (1997) · Phytochemistry · doi:10.1016/s0031-9422(97)00244-6 · Cited by 75 · see citing works
Čulig, Z., Hobisch, A., Hittmair, A., Cronauer, M. V., Radmayr, C., Zhang, J., Bartsch, G. H., & Klocker, H. (1997) · The Prostate · doi:10.1002/(sici)1097-0045(19970701)32:2 · Cited by 74 · see citing works
Bergman, M., Perelman, A., Dubinsky, Z., & Grossman, S. (2003) · Phytochemistry · doi:10.1016/s0031-9422(02)00537-x · Cited by 73 · see citing works
Self-citationBertone, E. R., Hankinson, S. E., Newcomb, P. A., ROSNER, B. A., Willett, W. C., Stampfer, M. J., & Egan, K. M. (2001) · Cancer Causes & Control · doi:10.1023/a:1008985015927 · Cited by 71 · see citing works
Three highly oxygenated flavone glucuronides in leaves of Spinacia oleracea
Aritomi, M., & Kawasaki, T. (1984) · Phytochemistry · doi:10.1016/s0031-9422(00)84967-5 · Cited by 71 · see citing works
Longnecker, M. P., Newcomb, P. A., Mittendorf, R., Greenberg, E. R., & Willett, W. C. (1997) · PubMed · Cited by 71 · see citing works
Flavonol glycosides in leaves of Spinacia oleracea
Aritomi, M., Komori, T., & Kawasaki, T. (1985) · Phytochemistry · doi:10.1016/s0031-9422(00)94534-5 · Cited by 68 · see citing works
β-Carotene Does Not Change Markers of Enzymatic and Nonenzymatic Antioxidant Activity in Human Blood
Castenmiller, J. J. M., Lauridsen, S. T., Dragsted, L. O., Hof, K. H. V. H., Linssen, J. P. H., & West, C. E. (1999) · Journal of Nutrition · doi:10.1093/jn/129.12.2162 · Cited by 65 · see citing works
Nyska, A., Suttie, A. W., Bakshi, S., Lomnitski, L., Grossman, S., Bergman, M., Ben-Shaul, V., Crocket, P., Haseman, J. K., Moser, G. J., et al. (2003) · Toxicologic Pathology · doi:10.1080/01926230390173833 · Cited by 60 · see citing works
Self-citationEdenharder, R., Leopold, C., & Kries, M. (1995) · Mutation Research/Genetic Toxicology · doi:10.1016/0165-1218(95)90101-9 · Cited by 59 · see citing works
Schleicher, R. L., Lamartiniere, C. A., Zheng, M., & Zhang, M. (1999) · Cancer Letters · doi:10.1016/s0304-3835(98)00322-x · Cited by 58 · see citing works
Cartford, M. C., Gemma, C., & Bickford, P. C. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-14-05813.2002 · Cited by 57 · see citing works
LIPOPOLYSACCHARIDE-INDUCED OXIDATIVE STRESS IN THE LIVER
Ben-Shaul, V., Sofer, Y., Bergman, M., Zurovsky, Y., & Grossman, S. (1999) · Shock · doi:10.1097/00024382-199910000-00007 · Cited by 52 · see citing works
Self-citationLomnitski, L., Carbonatto, M., Ben-Shaul, V., Peano, S., Conz, A., Corradin, L., Maronpot, R. R., Grossman, S., & Nyska, A. (2000) · Toxicologic Pathology · doi:10.1177/019262330002800413 · Cited by 45 · see citing works
Self-citationLomnitski, L., Foley, J. F., Grossman, S., Ben-Shaul, V., Maronpot, R. R., Moomaw, C. R., Carbonatto, M., & Nyska, A. (2000) · Pharmacology & Toxicology · doi:10.1111/j.0901-9928.2000.870104.x · Cited by 43 · see citing works
Self-citationAntioxidants attenuate endotoxin-induced acute renal failure in rats
Zurovsky, Y., & Gispaan, I. (1995) · American Journal of Kidney Diseases · doi:10.1016/0272-6386(95)90625-8 · Cited by 40 · see citing works
Zane, A., & Wender, S. H. (1961) · The Journal of Organic Chemistry · doi:10.1021/jo01069a531 · Cited by 39 · see citing works
Ren, H., Endo, H., & Hayashi, T. (2001) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/s1383-5718(01)00229-7 · Cited by 37 · see citing works
Food Sources of Phytoestrogens and Breast Cancer Risk in Mexican Women
Torres‐Sánchez, L., López‐Carrillo, L., López‐Cervantes, M., Rueda-Neria, C. M., & Wolff, M. S. (2000) · Nutrition and Cancer · doi:10.1207/s15327914nc372_3 · Cited by 36 · see citing works
Edenharder, R., Frangart, J., Hager, M., Hofmann, P., & Rauscher, R. (1998) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(98)00035-0 · Cited by 34 · see citing works
Nyska, A., Lomnitski, L., Spalding, J., Dunson, D., Goldsworthy, T., Ben-Shaul, V., Grossman, S., Bergman, M., & Boorman, G. (2001) · Toxicology Letters · doi:10.1016/s0378-4274(01)00345-9 · Cited by 31 · see citing works
Self-citationEffects of Water-Soluble Antioxidant from Spinach, NAO, on Doxorubicin-Induced Heart Injury
Breitbart, E., Lomnitski, L., Nyska, A., Malik, Z., Bergman, M., Sofer, Y., Haseman, J. K., & Grossman, S. (2001) · Human & Experimental Toxicology · doi:10.1191/096032701680350604 · Cited by 31 · see citing works
Self-citationScreening of Indian plants for biological activity--Part XI.
Aswal, B. S., Ds, B., Goel, A. K., Kar, K., & Bn, M. (1984) · PubMed · Cited by 31 · see citing works
Lomnitski, L., Nyska, A., Ben-Shaul, V., Maronpot, R. R., Haseman, J. K., Levin‐Harrus, T., Bergman, M., & Grossman, S. (2000) · Toxicologic Pathology · doi:10.1177/019262330002800412 · Cited by 30 · see citing works
Self-citationEffect of natural antioxidants and apocynin on LPS-induced endotoxemia in rabbit
Ben-Shaul, V., Lomnitskil, L., Nyska, A., Carbonatto, M., Peano, S., Zurovskyl, Y., Bergman, M., Eldridge, S. R., & Grossman, S. (2000) · Human & Experimental Toxicology · doi:10.1191/096032700666138364 · Cited by 29 · see citing works
Self-citationNowak, D., Pietras, T., Antczak, A. J., Kr�l, M., & Piasecka, G. (1993) · Antonie van Leeuwenhoek · doi:10.1007/bf00871734 · Cited by 27 · see citing works
Food allergy to spinach and mushroom
Herrera, I., Moneo, I., Caballero, M. L., Paz, S. D., Pimiento, A. P., & Rebollo, S. (2002) · Allergy · doi:10.1034/j.1398-9995.2002.1n3547.x · Cited by 24 · see citing works
Oral Allergy Syndrome Induced by Chestnut (Castanea sativa)
Antico, A. (1996) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)63404-7 · Cited by 21 · see citing works
de Rijk, E. P. C. T., Ravesloot, W. T. M., Hafmans, T. G. M., & van Esch, E. (2003) · Toxicologic Pathology · doi:10.1080/01926230390173798 · Cited by 21 · see citing works
Definition and Pathogenesis of Septic Shock
Vincent, J. (1996) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-80186-0_1 · Cited by 19 · see citing works
New approaches for estimating risk from exposure to diethylstilbestrol.
Cunha, G. R., Forsberg, J.-G., Golden, R., Haney, A. F., Iguchi, T., Newbold, R. R., Swan, S. H., & Welshons, W. V. (1999) · Environmental Health Perspectives · doi:10.1289/ehp.99107s4625 · Cited by 15 · see citing works
Glycerol-induced augmentation of sensitivity to endotoxin in rats
Zurovsky, Y., Eligal, Z., Grossman, S., Bergman, M., & Gafter, U. (1994) · Toxicon · doi:10.1016/0041-0101(94)90017-5 · Cited by 15 · see citing works
Self-citationTHE DETERMINATION OF FLAVONES OR QUERCETIN-LIKE SUBSTANCES IN CERTAIN NATURALLY OCCURRING PRODUCTS
Weatherby, L. S., & Cheng, A. L. S. (1943) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)72272-2 · Cited by 13 · see citing works
Mechanisms in adverse reactions to food. The mouth and pharynx.
Pastorello, E. A., Incorvaia, C., & Ortolani, C. (1995) · PubMed · Cited by 10 · see citing works
[Dietary carotene intake and lung cancer among men from Santiago].
García, J., Atalah, E., Urteaga, C., Fodor, M., & Chernilo, S. (1995) · PubMed · Cited by 5 · see citing works
Pastorello, E. A., Incorvaia, C., & Ortolani, C. (1995) · Allergy · doi:10.1111/j.1398-9995.1995.tb02720.x · Cited by 5 · see citing works
Increased sensitivity to bilateral nephrectomy in rat caused by endotoxemia
Zurovsky, Y., Eligal, Z., & Grossman, S. (1995) · Experimental and Toxicologic Pathology · doi:10.1016/s0940-2993(11)80347-7 · Cited by 4 · see citing works
Self-citationCross, D. (1991) · PubMed · Cited by 2 · see citing works
Occurrence of nitrates in vegetables and total dietary intakes [nitrate - nitrite - nitrosamine]
Santamaria, P. (1997) · Cited by 2 · see citing works
[Spinach powder-induced exogenous allergic alveolitis].
Schreiber, J., Müller, E., Becker, W. M., Zabel, P., Schlaak, M. S., & Amthor, M. (1998) · PubMed · Cited by 1 · see citing works
Flagged first, then by citations
1 of the 71 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Functional Properties of Spinach (Spinacia oleracea L.) Phytochemicals and Bioactives
Roberts, J. L., & Moreau, R. (2016) · Food & Function · doi:10.1039/c6fo00051g · Cited by 283 · see citing works
Antioxidant activity of the polysaccharide of the red microalga Porphyridium sp
Tannin-Spitz, T., Bergman, M., van Moppes, D., Grossman, S., & Arad, S. M. (2005) · Journal of Applied Phycology · doi:10.1007/s10811-005-0679-7 · Cited by 265 · see citing works
Self-citationTannin-Spitz, T., Grossman, S., Dovrat, S., Gottlieb, H. E., & Bergman, M. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.09.012 · Cited by 215 · see citing works
Self-citationRodríguez‐Fragoso, L., Martínez‐Arismendi, J. L., Orozco‐Bustos, D., Reyes-Esparza, J. A., Torres, E., & Burchiel, S. W. (2011) · Journal of Food Science · doi:10.1111/j.1750-3841.2011.02155.x · Cited by 179 · see citing works
Seed treatment with iron pyrite (FeS 2 ) nanoparticles increases the production of spinach
Srivastava, G. K., Das, C. K., Das, A., Singh, S. K., Roy, M., Kim, H., Sethy, N. K., Kumar, A., Sharma, R. K., Singh, S. K., et al. (2014) · RSC Advances · doi:10.1039/c4ra06861k · Cited by 157 · see citing works
Roy, M. K., Takenaka, M., Isobe, S., & Tsushida, T. (2006) · Food Chemistry · doi:10.1016/j.foodchem.2006.08.002 · Cited by 152 · see citing works
Antioxidant Capacity and Phenolic Content of Spinach As Affected by Genetics and Maturation
Pandjaitan, N., Howard, L. R., Morelock, T. E., & Gil, M. I. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf052077i · Cited by 147 · see citing works
Cucurbitacin glucosides: Antioxidant and free-radical scavenging activities
Tannin-Spitz, T., Bergman, M., & Grossman, S. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.09.075 · Cited by 133 · see citing works
Self-citationSustainable fire retardancy of textiles using bio-macromolecules
Basak, S., & Ali, S. W. (2016) · Polymer Degradation and Stability · doi:10.1016/j.polymdegradstab.2016.07.019 · Cited by 115 · see citing works
Antioxidant activity of 1,3-dicaffeoylquinic acid isolated from Inula viscosa
Danino, O., Gottlieb, H. E., Grossman, S., & Bergman, M. (2009) · Food Research International · doi:10.1016/j.foodres.2009.03.023 · Cited by 106 · see citing works
Self-citationPressurized Liquid Extraction of Flavonoids from Spinach
Howard, L. R., & Pandjaitan, N. (2008) · Journal of Food Science · doi:10.1111/j.1750-3841.2007.00658.x · Cited by 87 · see citing works
Cho, M. J., Howard, L. R., Prior, R. L., & Morelock, T. E. (2008) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.3206 · Cited by 77 · see citing works
Pereira, C., Días, M. I., Petropoulos, S. A., Plexida, S. G., Chrysargyris, A., Tzortzakis, N., Calhelha, R. C., Ivanov, M., Stojković, D. S., Sokóvić, M., et al. (2019) · Molecules · doi:10.3390/molecules24244494 · Cited by 71 · see citing works
Tam, N. N. C., Nyska, A., Maronpot, R. R., Kissling, G. E., Lomnitski, L., Suttie, A. W., Bakshi, S., Bergman, M., Grossman, S., & Ho, S. (2005) · The Prostate · doi:10.1002/pros.20313 · Cited by 56 · see citing works
Self-citationAlarcón-Flores, M. I., Romero‐González, R., Vidal, J. L. M., & Frenich, A. G. (2014) · Food Analytical Methods · doi:10.1007/s12161-014-9852-4 · Cited by 51 · see citing works
(CONTAM), E. P. O. C. I. T. F. C. (2010) · EFSA Journal · doi:10.2903/j.efsa.2010.1935 · Cited by 51 · see citing works
Campanholi, K. D. S. S., Braga, G., da Silva, J. B., da Rocha, N. L., de Francisco, L. M. B., de Oliveira, É. L., Bruschi, M. L., de Castro‐Hoshino, L. V., Sato, F., Hioka, N., et al. (2018) · Langmuir · doi:10.1021/acs.langmuir.8b00658 · Cited by 44 · see citing works
Plants of the genus Spinacia: From Bioactive Molecules to Food and Phytopharmacological Applications
Salehi, B., Tumer, T. B., Ozleyen, A., Peron, G., Dall’Acqua, S., Rajkovic, J., Naz, R., Nosheen, A., Mudau, F. N., Labanca, F., et al. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.03.028 · Cited by 44 · see citing works
Fruit/Vegetable-Drug Interactions: Effects on Drug Metabolizing Enzymes and Drug Transporters
Rodríguez‐Fragoso, L., & Reyes-Esparz, J. (2013) · InTech eBooks · doi:10.5772/48283 · Cited by 49 · see citing works
Panda, V., & Shinde, P. (2017) · Appetite · doi:10.1016/j.appet.2017.02.030 · Cited by 36 · see citing works
Cancer oxidative stress and dietary antioxidants
Preedy, V. R. (2014) · doi:10.1016/b978-0-12-405205-5.01001-1 · Cited by 35 · see citing works
Rahman, M. H., Jha, M. K., & Suk, K. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612822666151204001234 · Cited by 36 · see citing works
Ecdysterone and Turkesterone—Compounds with Prominent Potential in Sport and Healthy Nutrition
Todorova, V., Ivanova, S., Chakarov, D., Kraev, K., & Ivanov, K. (2024) · Nutrients · doi:10.3390/nu16091382 · Cited by 31 · see citing works
“Spinach is source of beneficial phytonutrient constituents, such as phenolic compounds (flavonoids, phenolic stilbenes, and lignans) and , zeaxanthin, and β -carotene) [146,149,153].”
BackgroundHypoglycemic effect of Basella rubra in streptozotocin induced diabetic albino rats
Nirmala, A., Saroja, S., Vasanthi, H. R., & Lalitha, G. (2009) · Journal of Pharmacognosy and Phytotherapy · doi:10.5897/jpp.9000029 · Cited by 31 · see citing works
Anti-Inflammatory and Neuroactive Properties of Selected Fruit Extracts
Heim, K. C., Angers, P., Léonhart, S., & Ritz, B. W. (2012) · Journal of Medicinal Food · doi:10.1089/jmf.2011.0265 · Cited by 29 · see citing works
Green and Sustainable Textile Materials Using Natural Resources
Pandit, P., Gayatri, T. N., & Maiti, S. (2018) · doi:10.1002/9781119407089.ch9 · Cited by 29 · see citing works
Enhancing oral delivery of plant-derived vesicles for colitis
Liu, Y., Ahumada, A. L., Bayraktar, E., Schwartz, P., Chowdhury, M. A., Shi, S., Sebastian, M. M., Khant, H. A., de Val, N., Bayram, N. N., et al. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.03.056 · Cited by 27 · see citing works
Koli, P. (2017) · Environmental Progress & Sustainable Energy · doi:10.1002/ep.12829 · Cited by 27 · see citing works
Rheological and physicochemical properties of vegetable juices and concentrates: A review
Salehi, F. (2021) · Journal of Food Processing and Preservation · doi:10.1111/jfpp.15326 · Cited by 27 · see citing works
Hait-Darshan, R., Grossman, S., Bergman, M., Deutsch, M., & Zurgil, N. (2008) · Food Research International · doi:10.1016/j.foodres.2008.11.006 · Cited by 27 · see citing works
Self-citationInternalization of Salmonella in Leafy Greens and Impact on Acid Tolerance
Grivokostopoulos, N. C., Makariti, I. P., Hilaj, N., Apostolidou, Z. A., & Skandamis, P. N. (2022) · Applied and Environmental Microbiology · doi:10.1128/aem.02249-21 · Cited by 26 · see citing works
Arru, L., Mussi, F., Forti, L., & Buschini, A. (2021) · Foods · doi:10.3390/foods10020382 · Cited by 22 · see citing works
Vajjiravel, P., Nagarajan, D., Pugazhenthi, V., Suresh, A., Sivalingam, M. K., Venkat, A., Mahapatra, P. P., Razi, K., Murad, M. A., Bae, D. W., et al. (2024) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2024.108350 · Cited by 22 · see citing works
Panda, V., Kinjal, M., Sudhamani, S., Nandave, M., & Ojha, S. K. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/2359389 · Cited by 23 · see citing works
Krutz, N. L., Winget, J. M., Ryan, C. A., Wimalasena, R. L., Maurer‐Stroh, S., Dearman, R. J., Kimber, I., & Gerberick, G. F. (2019) · Toxicological Sciences · doi:10.1093/toxsci/kfz078 · Cited by 22 · see citing works
Faujan, N. H., Zubairi, S. I., & Ahmad Baker, A. A. (2023) · Sains Malaysiana · doi:10.17576/jsm-2023-5209-08 · Cited by 21 · see citing works
Variation in Antioxidant Activity, Total Phenolics, and Nitrate in Spinach
Yosefi, Z., Tabaraki, R., Gharneh, H. A. A., & Mehrabi, A. A. (2010) · International Journal of Vegetable Science · doi:10.1080/19315260903577278 · Cited by 21 · see citing works
LEAF VEGETABLES AS SOURCE OF PHYTOCHEMICALS
Dūma, M., Alsiņa, I., Zeipiņa, S., Lepse, L., & Dubova, L. (2014) · Cited by 21 · see citing works
Mechanisms of intestinal pharmacokinetic natural product-drug interactions
Oyanna, V. O., & Clarke, J. D. (2024) · Drug Metabolism Reviews · doi:10.1080/03602532.2024.2386597 · Cited by 20 · see citing works
CNS depressive role of aqueous extract of Spinacia oleracea L. leaves in adult male albino rats.
Das, S., & Guha, D. (2008) · PubMed · Cited by 20 · see citing works
Ecdysteroid Content and Therapeutic Activity in Elicited Spinach Accessions
Gorelick, J., Iraqi, R. H., & Bernstein, N. (2020) · Plants · doi:10.3390/plants9060727 · Cited by 19 · see citing works
Mamta, Misra, K., Dhillon, G. S., Brar, S. K., & Verma, M. (2013) · Springer eBooks · doi:10.1007/978-1-4614-8005-1_6 · Cited by 19 · see citing works
Adhikary, S., Choudhary, D., Ahmad, N., Kumar, S., Dev, K., Mittapelly, N., Pandey, G., Mishra, P. R., Maurya, R., & Trivedi, R. (2017) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000000809 · Cited by 17 · see citing works
Bakshi, S., Bergman, M., Dovrat, S., & Grossman, S. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.06.101 · Cited by 17 · see citing works
Self-citationYadav, Y. C., Pathak, K., & Pathak, D. (2019) · Current Drug Therapy · doi:10.2174/1574885514666190126141424 · Cited by 15 · see citing works
St‐Pierre, A., Blondeau, D., Boivin, M., Beaupré, V., Boucher, N., & Desgagné‐Penix, I. (2019) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.12936 · Cited by 15 · see citing works
Koli, P., & Sharma, U. (2021) · Advanced Energy and Sustainability Research · doi:10.1002/aesr.202100079 · Cited by 15 · see citing works
Lomnitski, L., Grossman, S., Padilla‐Banks, E., Jefferson, W. N., Nyska, A., & Newbold, R. R. (2003) · Journal of Nutrition · doi:10.1093/jn/133.11.3584 · Cited by 15 · see citing works
Self-citationFornaciari, S., Milano, F., Mussi, F., Sánchez, L. P., Forti, L., Buschini, A., & Arru, L. (2014) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.6756 · Cited by 13 · see citing works
Shere, P. D., Sahni, P., Devkatte, A. N., & Pawar, V. N. (2020) · Nutrition & Food Science · doi:10.1108/nfs-10-2019-0318 · Cited by 12 · see citing works
Recent Advances in Phytochemicals in Fruits and Vegetables
Shahidi, F., Ambigaipalan, P., & Chandrasekara, A. (2017) · Wiley eBooks · doi:10.1002/9781119158042.ch71 · Cited by 12 · see citing works
Adaptogenic Properties of a Phytoecdysteroid-Rich Extract from the Leaves of Spinacia oleracea L.
Sidorova, Y. S., Shipelin, V. A., Petrov, N. A., Zorin, S. N., & Mazo, V. K. (2021) · Plants · doi:10.3390/plants10122555 · Cited by 11 · see citing works
Panda, V., Shinde, P., & Dande, P. (2020) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2018.1502323 · Cited by 10 · see citing works
Belić, M., Zdravković-Korać, S., Janošević, D. A., Savić, J., Todorović, S., Banjac, N., & Milojević, J. (2020) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-020-01878-3 · Cited by 10 · see citing works
Spinacia oleracea modulates radiation-induced biochemical changes in mice testis
Sisodia, R., Yadav, R., Sharma, K., & Bhatia, A. (2008) · Indian Journal of Pharmaceutical Sciences · doi:10.4103/0250-474x.42980 · Cited by 10 · see citing works
Effect of Spinach Extract on RANKL-Mediated Osteoclast Differentiation
Kim, D.-G., Kim, M.-H., Kang, M., & Shin, J. H. (2015) · Journal of the Korean Society of Food Science and Nutrition · doi:10.3746/jkfn.2015.44.4.532 · Cited by 9 · see citing works
Trivedi, R., Adhikary, S., Kothari, P., Ahmad, N., Mittapelly, N., Pandey, G., Shukla, M. K., Kumar, S., Dev, K., Choudhary, D., et al. (2020) · Clinical Phytoscience · doi:10.1186/s40816-020-00190-z · Cited by 9 · see citing works
Beaupré, V., Boucher, N., & Desgagné‐Penix, I. (2020) · Biomedicines · doi:10.3390/biomedicines8070219 · Cited by 9 · see citing works
Liu, M., Liu, W., Zhang, W., Niu, J., & Yao, J. (2022) · BioMed Research International · doi:10.1155/2022/2228632 · Cited by 9 · see citing works
Piletz, J. E., Mao, Y., Roy, D., Qizilbash, B. M., Nkamssi, E., Weir, E., Graham, J., Emmanuel, M., Iqbal, S., Brue, K., et al. (2021) · Nutrients · doi:10.3390/nu13020488 · Cited by 8 · see citing works
Cho, H.-J., Choi, S.-A., Kim, C. G., Jung, T.-S., Hong, J.-H., Rhee, M. H., Park, H.-J., & Park, H.-J. (2011) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2011.19.2.218 · Cited by 8 · see citing works
Somatic Embryogenesis in Spinach—A Review
Zdravković-Korać, S., Belić, M., Ćalić, D., & Milojević, J. (2023) · Horticulturae · doi:10.3390/horticulturae9091048 · Cited by 7 · see citing works
Energy effective drying modes of soy-vegetable compositions
Петрова, Ж. О., & Слободянюк, К. С. (2017) · Ukrainian Journal of Food Science · doi:10.24263/2310-1008-2017-5-1-15 · Cited by 6 · see citing works
Al-Subhi, F. M. M. (2020) · Alexandria Science Exchange Journal · doi:10.21608/asejaiqjsae.2020.94865 · Cited by 6 · see citing works
Milano, F., Mussi, F., Fornaciari, S., Altunoz, M., Forti, L., Arru, L., & Buschini, A. (2019) · Biomolecules · doi:10.3390/biom9020053 · Cited by 6 · see citing works
Khuda‐Bukhsh, A. R., Saha, S. K., Das, S., & Saha, S. S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819547-5.00018-3 · Cited by 6 · see citing works
Spinacia Oleracea: Exploring the Therapeutic Potential in Persian Medicine and Modern Pharmacology
Akbari, F., Mollaei, M., Argani, P., Daneshfard, B., & Derakhshan, A. R. (2024) · Current Drug Discovery Technologies · doi:10.2174/0115701638275971240201060710 · Cited by 5 · see citing works
Cho, H., Choi, S.-A., Kim, C.-G., Hong, J. H., Park, H., & Park, H.-J. (2011) · Journal of Medicinal Food · doi:10.1089/jmf.2010.1411 · Cited by 5 · see citing works
Matsuda, H., Ooi, S., Otokozawa, R., Kumazaki, K., Udagawa, E., Asakura, M., Suzuki, D., & Shirai, T. (2017) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2017.1409070 · Cited by 5 · see citing works
Mohanty, S., & Pattnaik, A. K. (2024) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/0113862073285538240417051928 · Cited by 4 · see citing works
Lidiková, J., Musilová, J., Tomáš, J., Kavalcová, P., Lenková, M., & Tóthová, K. (2015) · Potravinarstvo Slovak Journal of Food Sciences · doi:10.5219/519 · Cited by 4 · see citing works
Farjah, G. H., Pour, M. M., Ansari, M. H. K., Karimipour, M., & Pourheidar, B. (2018) · Europe PMC (PubMed Central) · doi:10.30466/vrf.2018.30825 · Cited by 4 · see citing works
Khan, M. N. E. A., Masabni, J. G., & Niu, G. (2025) · Sustainability · doi:10.3390/su17093925 · Cited by 4 · see citing works
Biofunctional Properties of RuBisCO Extract From Spinacia oleracea L.
Marinaccio, L., Gentile, G., Flamminii, F., Zengin, G., Cerretani, L., Minetti, S., Cichelli, A., Mollica, A., & Stefanucci, A. (2026) · Journal of Food Biochemistry · doi:10.1155/jfbc/6645393 · Cited by 3 · see citing works
Соколова, Д. В., & Solovieva, A. E. (2023) · VEGETABLE CROPS OF RUSSIA · doi:10.18619/2072-9146-2023-4-23-29 · Cited by 3 · see citing works
Freshness and spoilage indicators of spinach for waste valorization: a review
Işık, B. Ş., & Altay, F. (2025) · Bioresource Technology Reports · doi:10.1016/j.biteb.2025.102171 · Cited by 3 · see citing works
Sensory acceptability and quality of flavored yogurt enriched with Spinacia oleracea extract
Nejad, J. H., Sani, A. M., & Hojjatoleslamy, M. (2014) · Nutrition & Food Science · doi:10.1108/nfs-02-2013-0023 · Cited by 3 · see citing works
Morphological, biochemical, and nutritional value of prickly and smooth fruit spinach
Abolghasemi, R., Haghighi, M., & Etemadi, N. (2022) · Acta agriculturae Slovenica · doi:10.14720/aas.2022.118.2.1557 · Cited by 2 · see citing works
Green Leafy Vegetables in Cancer Prevention
Mutanen, M. L., Niku, M., & Oikarinen, S. I. (2010) · Springer eBooks · doi:10.1007/978-90-481-9800-9_2 · Cited by 2 · see citing works
Gatade, A. A., Ranveer, R. C., & Sahoo, A. K. (2013) · International Journal of Pharma and Bio Sciences · Cited by 2 · see citing works
OPTIMAL POSTHARVEST STORAGE PARAMETERS AND SHELF LIFE OF BABY SPINACH (SPINACIA OLERACEA L.)
Viškelis, J., Rubinskienė, M., Urbonavičienė, D., Bobinaitė, R., & Viškelis, P. (2015) · International Scientific Conference Rural Development · doi:10.15544/rd.2015.024 · Cited by 2 · see citing works
Molecular Approaches Toward Targeted Cancer Therapy with Some Food Plant Products
Khuda‐Bukhsh, A. R., Saha, S. K., & Das, S. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405205-5.00008-8 · Cited by 2 · see citing works
Spinach (Spinacia oleracea L.)
Gupta, U. S. (2011) · Science Publishers eBooks · doi:10.1201/b10736-25 · Cited by 2 · see citing works
Rea, K., Inarejos-García, A. M., Bermell, S. G., Garcia-Bou, R., Olusoga, Y., & Deaton, J. G. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312689 · Cited by 1 · see citing works
Há evidências científicas na medicina antienvelhecimento?
Gorzoni, M. L., & Pires, S. L. (2010) · Anais Brasileiros de Dermatologia · doi:10.1590/s0365-05962010000100008 · Cited by 1 · see citing works
Effects of different stirrer modes on the physicochemical properties of vegetables during cooking
Ning, M., Zhang, F., Deng, Q., Chen, Y., Chen, J., & Wang, Z. (2023) · International Journal of Food Science & Technology · doi:10.1111/ijfs.16308 · Cited by 1 · see citing works
Khatun, S., & Khatun, M. K. (2023) · GSC Advanced Research and Reviews · doi:10.30574/gscarr.2023.16.3.0362 · Cited by 1 · see citing works
Nivedha, R. M., Prasanna, R., Khatun, M., Varsha, D., Bhardwaj, A., LAL, S. K., Basu, S., Rej, S., Singh, A. K., & Shivay, Y. S. (2025) · Biocatalysis and Agricultural Biotechnology · doi:10.1016/j.bcab.2025.103844 · Cited by 1 · see citing works
Fan, D. (2010) · Library and Archives Canada (Government of Canada) · Cited by 1 · see citing works
Nutritional And Biochemical Evaluation Of Vitamin K Enriched Dietary Sources
Muhammad, Y. (2013) · HEC National Digital Library · Cited by 1 · see citing works
Plant extract reduces tobacco smoke harmful effects on alveolar macrophage immune responses
Bissonnette, É. Y., Proulx, L.-I., Spahr, A., Janelle, M. F., & Dupuis, S. (2006) · Toxicological & Environmental Chemistry Reviews · doi:10.1080/02772240600901692
Keikhaei, F., Naghsh, N., & Modaresi, M. (2014) · مجله دانشگاه علوم پزشکی اراک
Mohana, S. D., Sudhakar, Y., Ravindra, K., Rami, P., & Memorial, R. (2012)
Basella rubra Linn : A Dyeing study for Silk
Deshmukh, A. S. (2015) · Biolife · doi:10.17812/blj.2015.3322
El-Kady, R. I., Salama, R., & Etman, A. (2005) · Journal of Animal and Poultry Production · doi:10.21608/jappmu.2005.237962
Sharma, S., & Rani, S. (2022) · International Journal of Pharmaceutical Sciences Review and Research · doi:10.47583/ijpsrr.2022.v77i02.025
PROXIMATE ANALYSIS OF SPINACH (Spinacia oleracea): NUTRITIONAL AND BUSINESS IMPLICATIONS
Sudharani, P., Kishan, K. P. C., & Shakhya, S. (2024) · EPRA International Journal of Research & Development (IJRD) · doi:10.36713/epra15662
Jayanthi, M., Sakthi Uma, J., Prabha, V. V., & Sushma, J. (2024) · European Journal of Nutrition & Food Safety · doi:10.9734/ejnfs/2024/v16i61449
Selected traditional green vegetables products of south west Nigeria
Akinwande, B. A., Oyedokun, J., Quadri, J. A., Alawode, O. W., & Olatunde, S. J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-27384-1.00007-3
- Authors
- Lomnitski, L., Bergman, M., Nyska, A., Ben-Shaul, V., & Grossman, S.
- Affiliations
- Bar-Ilan University (IL)
- ORCID
- Nyska, Abraham
- Venue
- Nutrition and Cancer
- Publisher
- Informa UK Limited
- Published
- 2003-07
- Volume
- 46
- Issue
- 2
- Pages
- 222-231
- ISSN
- 0163-5581 (ISSN-L)
- 1532-7914
- OpenAlex
- W2028545626
- Cited by
- 105
- References
- 71
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 10 · 2023: 6 · 2022: 4 · 2021: 6 · 2020: 6 · 2019: 6 · 2018: 4 · 2017: 8 · 2016: 3 · 2015: 4 · 2014: 9 · 2013: 4 · 2012: 2
- FWCI
- 0.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutrition and Cancer (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Nursing › Nutrition and Dietetics › Food Science and Nutritional Studies
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- spinach, spinach extract, lipoxygenase inhibition, flavonoids, antioxidant activity, anticarcinogenic activity, skin cancer, prostate cancer, food safety, dietary phytochemicals, anti-aging
- MeSH terms
- Animals, Anti-Inflammatory Agents, Antineoplastic Agents, Antioxidants, Estrogens, Food Hypersensitivity, Health Promotion, Humans, Plant Extracts, Antimutagenic Agents, Spinacia oleracea
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