Functional Properties of Spinach (Spinacia oleracea L.) Phytochemicals and Bioactives

Roberts, Joseph L.; Moreau, Régis

doi:10.1039/c6fo00051g

Cited by 284Phytochemicals and Antioxidant ActivitiesFood Science and Nutritional StudiesSeed and Plant Biochemistry

Functional Properties of Spinach (Spinacia oleracea L.) Phytochemicals and Bioactives

Roberts, Joseph L., Moreau, Régis·2016·Food & Function

DOI 10.1039/c6fo00051g

Open this paper in CoChat — free account

Abstract

Overwhelming evidence indicates that diets rich in fruits and vegetables are protective against common chronic diseases, such as cancer, obesity and cardiovascular disease. Leafy green vegetables, in particular, are recognized as having substantial health-promoting activities that are attributed to the functional properties of their nutrients and non-essential chemical compounds. Spinach (Spinacia oleracea L.) is widely regarded as a functional food due to its diverse nutritional composition, which includes vitamins and minerals, and to its phytochemicals and bioactives that promote health beyond basic nutrition. Spinach-derived phytochemicals and bioactives are able to (i) scavenge reactive oxygen species and prevent macromolecular oxidative damage, (ii) modulate expression and activity of genes involved in metabolism, proliferation, inflammation, and antioxidant defence, and (iii) curb food intake by inducing secretion of satiety hormones. These biological activities contribute to the anti-cancer, anti-obesity, hypoglycemic, and hypolipidemic properties of spinach. Despite these valuable attributes, spinach consumption remains low in comparison to other leafy green vegetables. This review examines the functional properties of spinach in cell culture, animals and humans with a focus on the molecular mechanisms by which spinach-derived non-essential phytochemicals and bioactives, such as glycolipids and thylakoids, impart their health benefits.

Integrity signals

Registry

Crossref · 10.1039/c6fo00051g

Cites

92 of 92 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Discrepancies in 20-hydroxyecdysone and phytochemical content may be attributed to different processing methods applied to spinach leaves.
“These discrepancies in 20HE and phytochemical content may be attributed to different processing methods applied to spinach leaves [149].”
From Ecdysterone and Turkesterone—Compounds with Prominent Potential in Sport and Healthy Nutrition (2024) · cites this paper as [149]
Spinacia oleracea has a wide variety of potential functionalities, mainly antioxidant, antimicrobial, anticancer, anti-obesity, hypoglycemic, and hypolipidemic.
“Due to the wide variety of bioactive and phytochemical compounds, S. oleracea has a wide variety of potential functionalities, mainly antioxidant, antimicrobial, anticancer, anti-obesity, hypoglycemic, and hypolipidemic [146,149,151].”
From Ecdysterone and Turkesterone—Compounds with Prominent Potential in Sport and Healthy Nutrition (2024) · cites this paper as [149]
The differences in 20-HE amounts may be due to different processing methods of the spinach leaves before analysis.
“These differences in 20-HE amounts may be due to different processing methods of the spinach leaves before analysis [29].”
From Phytoecdysteroids: Quantification in Selected Plant Species and Evaluation of Some Effects on Gastric Smooth Muscles (2024) · cites this paper as [29]

Prevalence of Childhood and Adult Obesity in the United States, 2011-2012
Ogden, C. L., Carroll, M. D., Kit, B. K., & Flegal, K. M. (2014) · JAMA · doi:10.1001/jama.2014.732 · Cited by 8,072 · see citing works
Prevalence of the Metabolic Syndrome Among US Adults: Findings From the Third National Health and Nutrition Examination Survey
Ford, E. S., Giles, W. H., & Dietz, W. H. (2002) · JAMA · doi:10.1001/jama.287.3.356 · Cited by 6,698 · see citing works
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.
Wade Harper, J. (1993) · Cell · doi:10.1016/0092-8674(93)90499-g · Cited by 5,651 · see citing works
Function and Activation of NF-kappaB in the Immune System
Baeuerle, P. A., & Henkel, T. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.001041 · Cited by 4,745 · see citing works
Plant Polyphenols as Dietary Antioxidants in Human Health and Disease
Pandey, K. B., & Rizvi, S. I. (2009) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.2.5.9498 · Cited by 4,727 · see citing works
Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships
Heim, K. E., Tagliaferro, A. R., & Bobilya, D. J. (2002) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(02)00208-5 · Cited by 4,261 · see citing works
Inflammatory Mechanisms in Obesity
Gregor, M. F., & Hotamisligil, G. S. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101322 · Cited by 3,754 · see citing works
Missing Pieces in the NF-κB Puzzle
Ghosh, S., & Karin, M. (2002) · Cell · doi:10.1016/s0092-8674(02)00703-1 · Cited by 3,638 · see citing works
Obesity and the Environment: Where Do We Go from Here?
Hill, J. O., Wyatt, H. R., Reed, G. W., & Peters, J. C. (2003) · Science · doi:10.1126/science.1079857 · Cited by 2,180 · see citing works
Atomic model of plant light-harvesting complex by electron crystallography
Kühlbrandt, W., Wang, D., & Fujiyoshi, Y. (1994) · Nature · doi:10.1038/367614a0 · Cited by 1,909 · see citing works
Endotoxin-tolerant Mice Have Mutations in Toll-like Receptor 4 ( Tlr4 )
Qureshi, S. T., Larivière, L., Leveque, G., Clermont, S., Moore, K. J., Gros, P., & Malo, D. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.4.615 · Cited by 1,525 · see citing works
Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4
Pålsson‐McDermott, E. M., & O'Neill, L. A. J. (2004) · Immunology · doi:10.1111/j.1365-2567.2004.01976.x · Cited by 1,254 · see citing works
Dietary polyphenols and their biological significance
Han, X., Shen, T., & Lou, H. (2007) · International Journal of Molecular Sciences · doi:10.3390/i8090950 · Cited by 1,081 · see citing works
Antioxidant and Antiproliferative Activities of Common Vegetables
Chu, Y.-F., Sun, J., Wu, X., & Liu, R. H. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf020665f · Cited by 937 · see citing works
Plant polyphenols in cancer and heart disease: implications as nutritional antioxidants
Duthie, G. G., Duthie, S. J., & Kyle, J. A. M. (2000) · Nutrition Research Reviews · doi:10.1079/095442200108729016 · Cited by 762 · see citing works
Prevalence and Trends of Metabolic Syndrome in the Adult U.S. Population, 1999–2010
Beltrán‐Sánchez, H., Harhay, M. O., Harhay, M. N., & McElligott, S. C. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.05.064 · Cited by 736 · see citing works
Deglycosylation by small intestinal epithelial cell ?-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans
N�meth, K., Plumb, G. W., Berrin, J., Juge, N., Jacob, R., Naim, H. Y., Williamson, G., Swallow, D. M., & Kroon, P. A. (2003) · European Journal of Nutrition · doi:10.1007/s00394-003-0397-3 · Cited by 680 · see citing works
Prevalence of Multiple Chronic Conditions Among US Adults: Estimates From the National Health Interview Survey, 2010
Ward, B. W., & Schiller, J. S. (2013) · Preventing Chronic Disease · doi:10.5888/pcd10.120203 · Cited by 578 · see citing works
(-)-Epigallocatechin-3-gallate blocks the induction of nitric oxide synthase by down-regulating lipopolysaccharide-induced activity of transcription factor nuclear factor-kappaB.
Lin, Y., & Lin, J. (1997) · PubMed · Cited by 539 · see citing works
Prevalence of Metabolic Syndrome in Patients with Psoriasis: A Population-Based Study in the United Kingdom
Langan, S., Seminara, N. M., Shin, D. B., Troxel, A. B., Kimmel, S. E., Mehta, N. N., Margolis, D. J., & Gelfand, J. M. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.365 · Cited by 523 · see citing works
Lignan contents of Dutch plant foods: a database including lariciresinol, pinoresinol, secoisolariciresinol and matairesinol
Milder, I. E. J., Arts, I. C. W., van de Putte, B., Venema, D. P., & Hollman, P. C. H. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20051371 · Cited by 503 · see citing works
Serum antioxidant capacity is increased by consumption of strawberries, spinach, red wine or vitamin C in elderly women
Cao, G., Russell, R. M., Lischner, N., & Prior, R. L. (1998) · The Journal of Nutrition · doi:10.1093/jn/128.12.2383 · Cited by 502 · see citing works
Phenolic acids in potatoes, vegetables, and some of their products
Mattila, P. H., & Hellström, J. (2006) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2006.05.007 · Cited by 490 · see citing works
Daily consumption of phenolics and total antioxidant capacity from fruit and vegetables in the American diet
Chun, O. K., Kim, D., Smith, N. L., Schroeder, D., Han, J. T., & Lee, C. Y. (2005) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.2176 · Cited by 487 · see citing works
(−)-Epigallocatechin-3-gallate Blocks the Induction of Nitric Oxide Synthase by Down-Regulating Lipopolysaccharide-Induced Activity of Transcription Factor Nuclear Factor-κB
Lin, Y., & Lin, J. (1997) · Molecular Pharmacology · doi:10.1124/mol.52.3.465 · Cited by 463 · see citing works
Phytoestrogen Content of Foods Consumed in Canada, Including Isoflavones, Lignans, and Coumestan
Thompson, L. U., Boucher, B. A., Liu, Z., Cotterchio, M., & Kreiger, N. (2006) · Nutrition and Cancer · doi:10.1207/s15327914nc5402_5 · Cited by 449 · see citing works
Long-Term Dietary Strawberry, Spinach, or Vitamin E Supplementation Retards the Onset of Age-Related Neuronal Signal-Transduction and Cognitive Behavioral Deficits
Joseph, J. A., Shukitt‐Hale, B., Denisova, N. A., Prior, R. L., Cao, G., Martín, A., Taglialatela, G., & Bickford, P. C. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-19-08047.1998 · Cited by 432 · see citing works
Consumption of vegetables reduces genetic damage in humans: first results of a human intervention trial with carotenoid-rich foods
Pool-Zobel, B. L. (1997) · Carcinogenesis · doi:10.1093/carcin/18.9.1847 · Cited by 417 · see citing works
Xanthophyll (lutein, zeaxanthin) content in fruits, vegetables and corn and egg products
Perry, A., Rasmussen, H., & Johnson, E. J. (2008) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2008.07.006 · Cited by 417 · see citing works
Effect of Postharvest Storage and Processing on the Antioxidant Constituents (Flavonoids and Vitamin C) of Fresh-Cut Spinach
Gil, M. I., Ferreres, F., & Tomás-Barberán, F. A. (1999) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf981200l · Cited by 399 · see citing works
Premenopausal Breast Cancer Risk and Intake of Vegetables, Fruits, and Related Nutrients
Freudenheim, J. L., Marshall, J. R., Vena, J. E., Laughlin, R., Brasure, J., Swanson, M. K., Nemoto, T., & Graham, S. (1996) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/88.6.340 · Cited by 346 · see citing works
Intestinal absorption, serum clearance, and interactions between lutein and beta-carotene when administered to human adults in separate or combined oral doses
Kostic, D., White, W., & Olson, J. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/62.3.604 · Cited by 313 · see citing works
Immunomodulatory and Anti-inflammatory Effect of p-Coumaric Acid, a Common Dietary Polyphenol on Experimental Inflammation in Rats
Pragasam, S. J., Venkatesan, V., & Rasool, M. (2012) · Inflammation · doi:10.1007/s10753-012-9532-8 · Cited by 290 · see citing works
Total phenolic contents and antioxidant properties of commonly consumed vegetables grown in Colorado
Zhou, K., & Yu, L. L. (2005) · LWT · doi:10.1016/j.lwt.2005.07.015 · Cited by 281 · see citing works
The non-provitamin A carotenoid, lutein, inhibits NF-κB-dependent gene expression through redox-based regulation of the phosphatidylinositol 3-kinase/PTEN/Akt and NF-κB-inducing kinase pathways: Role of H2O2 in NF-κB activation
Kim, J.-H., Na, H.-J., Kim, C.-K., Kim, J.-Y., Ha, K.-S., Lee, H., Chung, H.-T., Kwon, H. J., Kwon, Y.-G., & Kim, Y.-M. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.06.019 · Cited by 273 · see citing works
Fruits, Vegetables, and Colon Cancer Risk in a Pooled Analysis of 14 Cohort Studies
Koushik, A., Hunter, D. J., Spiegelman, D. L., Beeson, W. L., van den Brandt, P. A., Buring, J. E., Calle, E. E., Cho, E., Fraser, G. E., Freudenheim, J. L., et al. (2007) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djm155 · Cited by 270 · see citing works
The antioxidant activity of aqueous spinach extract: chemical identification of active fractions
Bergman, M., Varshavsky, L., Gottlieb, H. E., & Grossman, S. (2001) · Phytochemistry · doi:10.1016/s0031-9422(01)00137-6 · Cited by 240 · see citing works
Lutein, but not α-tocopherol, supplementation improves visual function in patients with age-related cataracts: a 2-y double-blind, placebo-controlled pilot study
Olmedilla‐Alonso, B., Granado, F., Blanco, I., & Vaquero, M. (2002) · Nutrition · doi:10.1016/s0899-9007(02)00861-4 · Cited by 237 · see citing works
The Potential Role of Dietary Xanthophylls in Cataract and Age-Related Macular Degeneration
Moeller, S. M., Jacques, P. F., & Blumberg, J. B. (2000) · Journal of the American College of Nutrition · doi:10.1080/07315724.2000.10718975 · Cited by 236 · see citing works
Antioxidant Capacity and Phenolic Content of Spinach As Affected by Genetics and Growing Season
Howard, L. R., Pandjaitan, N., Morelock, T. E., & Gil, M. I. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf020507o · Cited by 193 · see citing works
Nutritional composition of selected green leafy vegetables, herbs and carrots
Singh, G., Kawatra, A., & Sehgal, S. (2001) · Plant Foods for Human Nutrition · doi:10.1023/a:1011873119620 · Cited by 188 · see citing works
Effect of Organic and Conventional Cropping Systems on Ascorbic Acid, Vitamin C, Flavonoids, Nitrate, and Oxalate in 27 Varieties of Spinach (Spinacia oleracea L.)
Koh, E., Charoenprasert, S., & Mitchell, A. E. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf300051f · Cited by 181 · see citing works
Fruit and vegetable intake and esophageal cancer in a large prospective cohort study
Freedman, N. D., Park, Y., Subar, A. F., Hollenbeck, A. R., Leitzmann, M. F., Schatzkin, A. G., & Abnet, C. C. (2007) · International Journal of Cancer · doi:10.1002/ijc.22993 · Cited by 173 · see citing works
The role of phytochemicals in inhibition of cancer and inflammation: New directions and perspectives
Issa, A., Volate, S. R., & Wargovich, M. J. (2006) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2006.02.009 · Cited by 169 · see citing works
Antioxidant Capacity and Phenolic Content of Spinach As Affected by Genetics and Maturation
Pandjaitan, N., Howard, L. R., Morelock, T. E., & Gil, M. I. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf052077i · Cited by 147 · see citing works
Review article: the gastrointestinal tract: neuroendocrine regulation of satiety and food intake
Maljaars, J., Peters, H. P. F., & Masclee, A. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03550.x · Cited by 132 · see citing works
Green vegetables, red meat and colon cancer: chlorophyll prevents the cytotoxic and hyperproliferative effects of haem in rat colon
de Vogel, J. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh331 · Cited by 123 · see citing works
Antioxidant activity of carotenoid lutein in vitro and in vivo.
Sindhu, E. R., Preethi, K. C., & Kuttan, R. (2010) · PubMed · Cited by 119 · see citing works
High Prevalence of Abdominal, Intra-Abdominal and Subcutaneous Adiposity and Clustering of Risk Factors among Urban Asian Indians in North India
Bhardwaj, S., Misra, A., Misra, R., Goel, K., Bhatt, S. P., Rastogi, K., Vikram, N. K., & Gulati, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024362 · Cited by 118 · see citing works
Antioxidant Effects of Spinach (Spinacia oleracea L.) Supplementation in Hyperlipidemic Rats
Ko, S.-H., Park, J.-H., Kim, S.-Y., Lee, S. W., Chun, S.-S., & Park, E. (2014) · Preventive Nutrition and Food Science · doi:10.3746/pnf.2014.19.1.019 · Cited by 107 · see citing works
Composition, Efficacy, and Safety of Spinach Extracts
Lomnitski, L., Bergman, M., Nyska, A., Ben-Shaul, V., & Grossman, S. (2003) · Nutrition and Cancer · doi:10.1207/s15327914nc4602_16 · Cited by 105 · see citing works
Isolation and Characterization of Structurally Novel Antimutagenic Flavonoids from Spinach ( Spinacia oleracea )
Edenharder, R., Keller, G., Platt, K. L., & Unger, K. K. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0013712 · Cited by 95 · see citing works
Mechanisms by which vegetable consumption reduces genetic damage in humans.
Pool-Zobel, B. L., Bub, A., Liegibel, U. M., Lishaut, S. T.-V., & Rechkemmer, G. (1998) · PubMed · Cited by 94 · see citing works
Relationship between Fresh-Packaged Spinach Leaves Exposed to Continuous Light or Dark and Bioactive Contents: Effects of Cultivar, Leaf Size, and Storage Duration
Lester, G. E., Makus, D. J., & Hodges, D. M. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf903596v · Cited by 89 · see citing works
β-Carotene and Lutein Inhibit Hydrogen Peroxide-Induced Activation of NF-κB and IL-8 Expression in Gastric Epithelial AGS Cells
Kim, Y., Seo, J. H., & Kim, H. (2011) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.57.216 · Cited by 84 · see citing works
Chloroplast membranes retard fat digestion and induce satiety: effect of biological membranes on pancreatic lipase/co-lipase
Albertsson, P., Köhnke, R., Emek, S. C., Mei, J., Rehfeld, J. F., Åkerlund, H., & Erlanson‐Albertsson, C. (2007) · Biochemical Journal · doi:10.1042/bj20061463 · Cited by 84 · see citing works
Hydrolysis of galactolipids by human pancreatic lipolytic enzymes and duodenal contents.
Andersson, L. I., Bratt, C., Arnoldsson, K. C., Herslöf, B. G., Olsson, N., Sternby, B., & Nilsson, Å. (1995) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41146-0 · Cited by 78 · see citing works
Flavonoid content and antioxidant capacity of spinach genotypes determined by high‐performance liquid chromatography/mass spectrometry
Cho, M. J., Howard, L. R., Prior, R. L., & Morelock, T. E. (2008) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.3206 · Cited by 77 · see citing works
Inhibitory effects of glycolipids fraction from spinach on mammalian DNA polymerase activity and human cancer cell proliferation
Kuriyama, I., Musumi, K., Yonezawa, Y., Takemura, M., Maeda, N., Iijima, H., Hada, T., Yoshida, H., & Mizushina, Y. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.02.007 · Cited by 76 · see citing works
Effects of glycolipids from spinach on mammalian DNA polymerases
Murakami, C., Kumagai, T., Hada, T., Kanekazu, U., Nakazawa, S., Kamisuki, S., Maeda, N., Xu, X., Yoshida, H., Sugawara, F., et al. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)01483-1 · Cited by 76 · see citing works
Body weight loss, reduced urge for palatable food and increased release of GLP-1 through daily supplementation with green-plant membranes for three months in overweight women
Montelius, C., Erlandsson, D., Vitija, E., Stenblom, E.-L., Egecioglu, E., & Erlanson‐Albertsson, C. (2014) · Appetite · doi:10.1016/j.appet.2014.06.101 · Cited by 72 · see citing works
Intake of carrots, spinach, and supplements containing vitamin A in relation to risk of breast cancer.
Longnecker, M. P., Newcomb, P. A., Mittendorf, R., Greenberg, E. R., & Willett, W. C. (1997) · PubMed · Cited by 71 · see citing works
Spinach and tomato consumption increases lymphocyte DNA resistance to oxidative stress but this is not related to cell carotenoid concentrations
Porrini, M., Riso, P., & Oriani, G. (2002) · European Journal of Nutrition · doi:10.1007/s003940200014 · Cited by 70 · see citing works
Thylakoids promote release of the satiety hormone cholecystokinin while reducing insulin in healthy humans
Köhnke, R., Lindbo, A., Larsson, T., Lindqvist, A., Rayner, M., Emek, S. C., Albertsson, P.-Å., Rehfeld, J. F., Landin‐Olsson, M., & Erlanson‐Albertsson, C. (2009) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520902803499 · Cited by 67 · see citing works
β-Carotene Does Not Change Markers of Enzymatic and Nonenzymatic Antioxidant Activity in Human Blood
Castenmiller, J. J. M., Lauridsen, S. T., Dragsted, L. O., Hof, K. H. V. H., Linssen, J. P. H., & West, C. E. (1999) · Journal of Nutrition · doi:10.1093/jn/129.12.2162 · Cited by 65 · see citing works
Impact of cooking methods on folates, ascorbic acid and lutein in green beans (Phaseolus vulgaris) and spinach (Spinacea oleracea)
Delchier, N., Reich, M., & Renard, C. M. G. C. (2012) · LWT · doi:10.1016/j.lwt.2012.06.017 · Cited by 64 · see citing works
Feed allowance and maternal backfat levels during gestation influence maternal cortisol levels, milk fat composition and offspring growth
Amdi, C., Giblin, L. M., Hennessy, A. A., Ryan, T., Stanton, C., Stickland, N. C., & Lawlor, P. G. (2013) · Journal of Nutritional Science · doi:10.1017/jns.2012.20 · Cited by 62 · see citing works
Thylakoids suppress appetite by increasing cholecystokinin resulting in lower food intake and body weight in high‐fat fed mice
Köhnke, R., Lindqvist, A., Göransson, N., Emek, S. C., Albertsson, P., Rehfeld, J. F., Hultgårdh‐Nilsson, A., & Erlanson‐Albertsson, C. (2009) · Phytotherapy Research · doi:10.1002/ptr.2855 · Cited by 61 · see citing works
Anti‐Tumor Effect of Orally Administered Spinach Glycolipid Fraction on Implanted Cancer Cells, Colon‐26, in Mice
Maeda, N., Kokai, Y., Ohtani, S., Sahara, H., Kumamoto‐Yonezawa, Y., Kuriyama, I., Hada, T., Sato, N., Yoshida, H., & Mizushina, Y. (2008) · Lipids · doi:10.1007/s11745-008-3202-5 · Cited by 60 · see citing works
Slowing Tumorigenic Progression in TRAMP Mice and Prostatic Carcinoma Cell Lines Using Natural Anti-Oxidant from Spinach, NAO--A Comparative Study of Three Anti-Oxidants
Nyska, A., Suttie, A. W., Bakshi, S., Lomnitski, L., Grossman, S., Bergman, M., Ben-Shaul, V., Crocket, P., Haseman, J. K., Moser, G. J., et al. (2003) · Toxicologic Pathology · doi:10.1080/01926230390173833 · Cited by 60 · see citing works
Eighteen-Month-Old Fischer 344 Rats Fed a Spinach-Enriched Diet Show Improved Delay Classical Eyeblink Conditioning and Reduced Expression of Tumor Necrosis Factor α (TNFα) and TNFβ in the Cerebellum
Cartford, M. C., Gemma, C., & Bickford, P. C. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-14-05813.2002 · Cited by 57 · see citing works
Genetic diversity of 38 spinach (Spinacia oleracea L.) germplasm accessions and 10 commercial hybrids assessed by TRAP markers
Hu, J., Mou, B., & Vick, B. A. (2007) · Genetic Resources and Crop Evolution · doi:10.1007/s10722-006-9175-4 · Cited by 52 · see citing works
Fatty Acids of Spinach Chloroplasts
Wolf, F. T., Coniglio, J. G., & Davis, J. T. (1962) · PLANT PHYSIOLOGY · doi:10.1104/pp.37.1.83 · Cited by 45 · see citing works
The Prophylactic Effects of Natural Water-Soluble Antioxidant from Spinach and Apocynin in a Rabbit Model of Lipopolysaccharide-Induced Endotoxemia
Lomnitski, L., Carbonatto, M., Ben-Shaul, V., Peano, S., Conz, A., Corradin, L., Maronpot, R. R., Grossman, S., & Nyska, A. (2000) · Toxicologic Pathology · doi:10.1177/019262330002800413 · Cited by 45 · see citing works
Effects of Apocynin and Natural Antioxidant from Spinach on Inducible Nitric Oxide Synthase and Cyclooxygenase‐2 Induction in Lipopolysaccharide‐Induced Hepatic Injury in Rat
Lomnitski, L., Foley, J. F., Grossman, S., Ben-Shaul, V., Maronpot, R. R., Moomaw, C. R., Carbonatto, M., & Nyska, A. (2000) · Pharmacology & Toxicology · doi:10.1111/j.0901-9928.2000.870104.x · Cited by 43 · see citing works
Supplementation by thylakoids to a high carbohydrate meal decreases feelings of hunger, elevates CCK levels and prevents postprandial hypoglycaemia in overweight women
Stenblom, E.-L., Montelius, C., Östbring, K., Håkansson, M., Nilsson, S., Rehfeld, J. F., & Erlanson‐Albertsson, C. (2013) · Appetite · doi:10.1016/j.appet.2013.04.022 · Cited by 41 · see citing works
The effect of lutein- and zeaxanthin-rich foods v. supplements on macular pigment level and serological markers of endothelial activation, inflammation and oxidation: pilot studies in healthy volunteers
Graydon, R., Hogg, R. E., Chakravarthy, U., Young, I. S., & Woodside, J. V. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114511005599 · Cited by 38 · see citing works
Acute Effects of a Spinach Extract Rich in Thylakoids on Satiety: A Randomized Controlled Crossover Trial
Rebello, C. J., Chu, J., Beyl, R., Edwall, D., Erlanson-Albertsson, C., & Greenway, F. L. (2015) · Journal of the American College of Nutrition · doi:10.1080/07315724.2014.1003999 · Cited by 37 · see citing works
Fruit and vegetable consumption and hypertriglyceridemia: Korean National Health and Nutrition Examination Surveys (KNHANES) 2007–2009
Yuan, C., Lee, H.-J., Shin, H. J., Stampfer, M. J., & Cho, E. (2015) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2015.77 · Cited by 33 · see citing works
Dietary thylakoids suppress blood glucose and modulate appetite-regulating hormones in pigs exposed to oral glucose tolerance test
Montelius, C., Szwiec, K., Kardas, M., Lozinska, L. M., Erlanson‐Albertsson, C., Pierzynowski, S. G., Rehfeld, J. F., & Weström, B. R. (2014) · Clinical Nutrition · doi:10.1016/j.clnu.2013.12.009 · Cited by 33 · see citing works
Mineral Contents of Organically and Conventionally Grown Spinach (Spinacea oleraceaL.) during Two Successive Seasons
Çıtak, S., & Sönmez, S. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf900660k · Cited by 32 · see citing works
Inhibitory effects of preventive and curative orally administered spinach glycoglycerolipid fraction on the tumor growth of sarcoma and colon in mouse graft models
Maeda, N., Kokai, Y., Ohtani, S., Hada, T., Yoshida, H., & Mizushina, Y. (2008) · Food Chemistry · doi:10.1016/j.foodchem.2008.05.059 · Cited by 31 · see citing works
Oral administration of monogalactosyl diacylglycerol from spinach inhibits colon tumor growth in mice
MAEDA, N., Kokai, Y., Hada, T., Yoshida, H., & Mizushina, Y. (2012) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2012.792 · Cited by 30 · see citing works
Effects of Green-Leafy Vegetable Intake on Postprandial Glycemic and Lipidemic Responses and ^|^alpha;-Tocopherol Concentration in Normal Weight and Obese Men
MARUYAMA, C., KIKUCHI, N., MASUYA, Y., HIROTA, S., ARAKI, R., & MARUYAMA, T. (2013) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.59.264 · Cited by 29 · see citing works
Chloroplast thylakoids reduce glucose uptake and decrease intestinal macromolecular permeability
Montelius, C., Gustafsson, K., Weström, B. R., Albertsson, P., Emek, S. C., Rayner, M., & Erlanson‐Albertsson, C. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511001267 · Cited by 29 · see citing works
Orally Fed Digalactosyldiacylglycerol Is Degraded during Absorption in Intact and Lymphatic Duct Cannulated Rats
Ohlsson, L., Blom, M., Bohlinder, K., Carlsson, A., & Nilsson, Å. (1998) · Journal of Nutrition · doi:10.1093/jn/128.2.239 · Cited by 28 · see citing works
Carotenoids : properties, effects and diseases
山口, 正. (2010) · Nova Science Publishers eBooks · Cited by 27 · see citing works
Digestion of plant monogalactosyldiacylglycerol and digalactosyldiacylglycerol in rat alimentary canal11Address correspondence to
Sugawara, T., & Miyazawa, T. (2000) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(99)00086-8 · Cited by 27 · see citing works
Antidiabetic activity of fruits and vegetables commonly consumed in Korea: Inhibitory potential against α-glucosidase and insulin-like action in vitro
Park, J.-H., Kim, R.-Y., & Park, E. (2012) · Food Science and Biotechnology · doi:10.1007/s10068-012-0155-5 · Cited by 20 · see citing works
Unique natural antioxidants (NAOs) and derived purified components inhibit cell cycle progression by downregulation of ppRb and E2F in human PC3 prostate cancer cells
Bakshi, S., Bergman, M., Dovrat, S., & Grossman, S. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.06.101 · Cited by 17 · see citing works
Assessment of antioxidant and antiproliferative properties of spinach plants grown under low oxygen availability
Fornaciari, S., Milano, F., Mussi, F., Sánchez, L. P., Forti, L., Buschini, A., & Arru, L. (2014) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.6756 · Cited by 13 · see citing works
Prevalence of low high-density lipoprotein cholesterol and hypertriglyceridaemia in patients treated with hypolipidaemic drugs
Laforest, L., Souchet, T., Moulin, P., Ritleng, C., Désaméricq, G., Jeunne, P. L., Schwalm, M.-S., & Ganse, E. H. V. (2009) · Archives of cardiovascular diseases · doi:10.1016/j.acvd.2008.06.021 · Cited by 10 · see citing works

Flagged first, then by citations

Sorted by citations

Metabolomics Reveals Cu(OH) 2 Nanopesticide-Activated Anti-oxidative Pathways and Decreased Beneficial Antioxidants in Spinach Leaves
Zhao, L., Huang, Y., Adeleye, A. S., & Keller, A. A. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.7b02163 · Cited by 160 · see citing works
Beneficial Features of Biochar and Arbuscular Mycorrhiza for Improving Spinach Plant Growth, Root Morphological Traits, Physiological Properties, and Soil Enzymatic Activities
Jabborova, D., Annapurna, K., Paul, S., Kumar, S., Saad, H. A., Desouky, S. E., Ibrahim, M. F. M., & Elkelish, A. (2021) · Journal of Fungi · doi:10.3390/jof7070571 · Cited by 121 · see citing works
“It is rich in bioactive compounds that contribute to anticancer, antiobesity, hypoglycemic, and hypolipidemic properties [47].”
Background
Isolation and functionalities of bioactive peptides from fruits and vegetables: A reviews
Sosalagere, C., Kehinde, B. A., & Sharma, P. (2021) · Food Chemistry · doi:10.1016/j.foodchem.2021.130494 · Cited by 133 · see citing works
pH Alteration in Plant-Mediated Green Synthesis and Its Resultant Impact on Antimicrobial Properties of Silver Nanoparticles (AgNPs)
Miranda, A., Akpobolokemi, T., Chung, E., Ren, G., & Raimi‐Abraham, B. T. (2022) · Antibiotics · doi:10.3390/antibiotics11111592 · Cited by 108 · see citing works
Use of spinach powder as functional ingredient in the manufacture of UF-Soft cheese
El-Sayed, S. M. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e03278 · Cited by 99 · see citing works
Natural products from plants
Priya, S., & Satheeshkumar, P. K. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818593-3.00005-1 · Cited by 94 · see citing works
COVID-19, prevention and treatment with herbal medicine in the herbal markets of Salé Prefecture, North-Western Morocco
Chaachouay, N., Douira, A., & Zidane, L. (2021) · European Journal of Integrative Medicine · doi:10.1016/j.eujim.2021.101285 · Cited by 96 · see citing works
Optimization of supercritical carbon dioxide extraction of lutein and chlorophyll from spinach by-products using response surface methodology
Derrien, M., Aghabararnejad, M., Gosselin, A., Desjardins, Y., Angers, P., & Boumghar, Y. (2018) · LWT · doi:10.1016/j.lwt.2018.03.016 · Cited by 92 · see citing works
A Review of the Science of Colorful, Plant-Based Food and Practical Strategies for “Eating the Rainbow”
Minich, D. M. (2019) · Journal of Nutrition and Metabolism · doi:10.1155/2019/2125070 · Cited by 89 · see citing works
“Spinach contains phytochemicals that may help with its cardiovascular benefits [157], especially nitrates.”
Background
Plant-Based Diets and Phytochemicals in the Management of Diabetes Mellitus and Prevention of Its Complications: A Review
Ansari, P., Khan, J. T., Chowdhury, S., Reberio, A. D., Kumar, S., Seidel, V., Abdel‐Wahab, Y. H. A., & Flatt, P. R. (2024) · Nutrients · doi:10.3390/nu16213709 · Cited by 106 · see citing works
Update on the bioavailability and chemopreventative mechanisms of dietary chlorophyll derivatives
Hayes, M., & Ferruzzi, M. G. (2020) · Nutrition Research · doi:10.1016/j.nutres.2020.06.010 · Cited by 83 · see citing works
Effect of zinc nanoparticles seed priming and foliar application on the growth and physio-biochemical indices of spinach (Spinacia oleracea L.) under salt stress
Zafar, S., Perveen, S., Khan, M. K., Shaheen, M. R., Hussain, R., Sarwar, N., Rashid, S., Nafees, M., Farid, G., Alamri, S. A., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0263194 · Cited by 82 · see citing works
“) is a widely used leafy plant, its leaves and shoots serve the purpose of raw and boiled vegetables [25].”
Background
Retracted
Chlorophyll Supplementation in Early Life Prevents Diet‐Induced Obesity and Modulates Gut Microbiota in Mice
Li, Y., Cui, Y., Hu, X., Liao, X., & Zhang, Y. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201801219 · Cited by 82 · see citing works
Fruit and Vegetable-Based Beverages—Nutritional Properties and Health Benefits
Buțu, M., & Rodino, S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816689-5.00011-0 · Cited by 80 · see citing works
A review on the genetic resources, domestication and breeding history of spinach (Spinacia oleracea L.)
Ribera, A., Bai, Y., Wolters, A. A., van Treuren, R., & Kik, C. (2020) · Euphytica · doi:10.1007/s10681-020-02585-y · Cited by 80 · see citing works
Quinoa sprouts as potential vegetable source: Nutrient composition and functional contents of different quinoa sprout varieties
Le, L., Gong, X., An, Q., Xiang, D., Zou, L., Peng, L., Wu, X., Tan, M., Nie, Z., Wu, Q. H., et al. (2021) · Food Chemistry · doi:10.1016/j.foodchem.2021.129752 · Cited by 75 · see citing works
Beneficial effects of a chlorophyll-rich spinach extract supplementation on prevention of obesity and modulation of gut microbiota in high-fat diet-fed mice
Li, Y., Cui, Y., Lu, F. L., Wang, X. Q., Liao, X., Hu, X., & Zhang, Y. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103436 · Cited by 72 · see citing works
Food intake biomarkers for green leafy vegetables, bulb vegetables, and stem vegetables: a review
Brouwer-Brolsma, E. M., Brandl, B., Buso, M. E. C., Skurk, T., & Manach, C. (2020) · Genes & Nutrition · doi:10.1186/s12263-020-00667-z · Cited by 71 · see citing works
“Spinach has been considered since ancient times as a food with functional properties that supports health maintenance [52, 53].”
Background
Flavonoids in vegetables: improvement of dietary flavonoids by metabolic engineering to promote health
Tao, H., Li, L., He, Y., Zhang, X., Zhao, Y., Wang, Q., & Hong, G. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2131726 · Cited by 66 · see citing works
“…with high nutritional value (Panda et al. 2022) It is known as a natural antioxidant mixture due to being high in antioxidant phyto-constituents (Panda et al. 2022), and is well-known for its anti-allergic, antioxidant, hypolipidemic, and antimu-tagenic activities (Roberts and Moreau 2016).”
Background
Light‐Activated Biomedical Applications of Chlorophyll Derivatives
Pucci, C., Martinelli, C., Degl’Innocenti, A., Desii, A., Pasquale, D. D., & Ciofani, G. (2021) · Macromolecular Bioscience · doi:10.1002/mabi.202100181 · Cited by 64 · see citing works
Analytical approach, dissipation pattern and risk assessment of pesticide residue in green leafy vegetables: A comprehensive review.
Farha, W., el-Aty, A. M. A., Rahman, M. M., Jeong, J., Shin, H.-C., Wang, J., Shin, S.-S., & Shim, J. (2018) · Biomedical chromotography · doi:10.1002/bmc.4134 · Cited by 57 · see citing works
Vegetable Soups and Creams: Raw Materials, Processing, Health Benefits, and Innovation Trends
Fernández‐López, J., Botella-Martínez, C. M., Navarro, C., Sayas‐Barberá, E., Viuda‐Martos, M., Sánchez‐Zapata, E. J., & Pérez‐Álvarez, J. Á. (2020) · Plants · doi:10.3390/plants9121769 · Cited by 62 · see citing works
“Other structures mentioned in the literature are flavones and derivatives of patuletin, spinatoside, spinacetin, jaceidin, as well as lignans such as lariciresinol, secoisolariciresinol, and pinoresinol [54].”
Background
Evaluation of a Biochar-Based Slow-Release P Fertilizer to Improve Spinacia oleracea P Use, Yield, and Nutritional Quality
Sepúlveda-Cadavid, C., Romero, J. H., Torres, M., Becerra-Agudelo, E., & López, J. E. (2021) · Journal of Soil Science and Plant Nutrition · doi:10.1007/s42729-021-00583-0 · Cited by 56 · see citing works
Examining the role of AMF-Biochar in the regulation of spinach growth attributes, nutrients concentrations, and antioxidant enzymes in mitigating drought stress
Alotaibi, M. O., Ikram, M., Alotaibi, N. M., Hussain, G. S., Ghoneim, A. M., Younis, U., Naz, N., & Danish, S. (2023) · Plant Stress · doi:10.1016/j.stress.2023.100205 · Cited by 53 · see citing works
What Is the Current Direction of the Research on Carotenoids and Human Health? An Overview of Registered Clinical Trials
Martini, D., Negrini, L., Marino, M., Riso, P., Bo’, C. D., & Porrini, M. (2022) · Nutrients · doi:10.3390/nu14061191 · Cited by 51 · see citing works
“The main green vegetables studied included kale [46], broccoli [47–49], spinach [50], peas [51], and peppers [52].”
Background
Immune boosting functional components of natural foods and its health benefits
Stephen, J., Manoharan, D., & Radhakrishnan, M. (2023) · Food Production Processing and Nutrition · doi:10.1186/s43014-023-00178-5 · Cited by 54 · see citing works
“As spinach contains chlorophyll pigments, beta-carotene, iron, vitamin K, fibre, and vitamin A this can be used to treat cancer-causing impacts, diminish asthma, restrain bone defects, cures constipation, anaemia, and skin diseases (Roberts & Moreau 2016).”
Dietary phytonutrients in common green leafy vegetables and the significant role of processing techniques on spinach: a review
Sarma, U., & Bhavya, T. R. (2024) · Food Production Processing and Nutrition · doi:10.1186/s43014-023-00192-7 · Cited by 46 · see citing works
“Properties such as anti-cancer, anti-obesity, hypoglycemic, and hypolipi-demic effects of spinach are a result of these biological processes (Roberts and Moreau 2016).”
Background
Combined effects of ultrasound and aqueous chlorine dioxide treatments on nitrate content during storage and postharvest storage quality of spinach (Spinacia oleracea L.)
Mu, Y., Feng, Y., Wei, L., CuiHong, L., Cai, G., & Zhu, T. (2020) · Food Chemistry · doi:10.1016/j.foodchem.2020.127500 · Cited by 44 · see citing works
Plants of the genus Spinacia: From Bioactive Molecules to Food and Phytopharmacological Applications
Salehi, B., Tumer, T. B., Ozleyen, A., Peron, G., Dall’Acqua, S., Rajkovic, J., Naz, R., Nosheen, A., Mudau, F. N., Labanca, F., et al. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.03.028 · Cited by 44 · see citing works
Amaranthus tricolor (red amaranth), an indigenous source of nutrients, minerals, amino acids, phytochemicals, and assessment of its antibacterial activity
Jahan, F., Bhuiyan, M. N. H., Islam, M. J., Ahmed, S., Hasan, M. S., Bashera, M. A., Waliullah, M., Chowdhury, A. N., Islam, M. B., Saha, B. K., et al. (2022) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2022.100419 · Cited by 43 · see citing works
Enemies or Allies? Hormetic and Apparent Non-Dose-Dependent Effects of Natural Bioactive Antioxidants in the Treatment of Inflammation
Barreiro-Sisto, U., Fernández‐Fariña, S., Noya, A. M. G., Pedrido, R. M., & Maneiro, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031892 · Cited by 43 · see citing works
Novel biologically active principles from spinach, goji and quinoa
Fiorito, S., Preziuso, F., Epifano, F., Scotti, L., Bucciarelli, T., Taddeo, V. A., & Genovese, S. (2018) · Food Chemistry · doi:10.1016/j.foodchem.2018.10.018 · Cited by 43 · see citing works
Glycolipids from spinach suppress LPS-induced vascular inflammation through eNOS and NK-κB signaling
Ishii, M., Nakahara, T., Araho, D., Murakami, J., & Nishimura, M. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.04.052 · Cited by 42 · see citing works
Synergistic antimicrobial activity of plasma-activated water and propylparaben: Mechanism and applications for fresh produce sanitation
Liu, X., Li, Y., Wang, S., Huangfu, L., Zhang, M., & Xiang, Q. (2021) · LWT · doi:10.1016/j.lwt.2021.111447 · Cited by 40 · see citing works
In Vitro Bioaccessibility of Carotenoids and Chlorophylls in a Diverse Collection of Spinach Accessions and Commercial Cultivars
Hayes, M., Pottorff, M., Kay, C. D., Deynze, A. V., Osorio-Marin, J., Lila, M. A., Iorizzo, M., & Ferruzzi, M. G. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c00158 · Cited by 39 · see citing works
Biological transformation of chlorophyll-rich spinach (Spinacia oleracea L.) extracts under in vitro gastrointestinal digestion and colonic fermentation
Li, Y., Lu, F. L., Wang, X., Hu, X., Liao, X., & Zhang, Y. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109941 · Cited by 38 · see citing works
Spinach (Spinacia oleracea L.)
Ramaiyan, B., Kour, J., Nayik, G. A., Anand, N., & Alam, M. S. (2020) · Springer eBooks · doi:10.1007/978-981-15-7470-2_8 · Cited by 38 · see citing works
Spinach consumption ameliorates the gut microbiota and dislipaemia in rats with diet-induced non-alcoholic fatty liver disease (NAFLD).
Elvira-Torales, L. I., Periago, M., González-Barrio, R., Hidalgo, N., Navarro-González, I., Gómez-Gallego, C., Masuero, D., Soini, E., Vrhovšek, U., & García-Alonso, F. (2019) · Food & Function · doi:10.1039/c8fo01630e · Cited by 29 · see citing works
Spinacia oleracea Linn Considered as One of the Most Perfect Foods: A Pharmacological and Phytochemical Review
Gutiérrez, R. M. P., Velazquez, E. G., & Paredes-Carrera, S. P. (2019) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557519666190603090347 · Cited by 37 · see citing works
Antioxidant Capacity of Polar and Non-Polar Extracts of Four African Green Leafy Vegetables and Correlation with Polyphenol and Carotenoid Contents
Fioroni, N., Mouquet‐Rivier, C., Meudec, E., Cheynier, V., Boudard, F., Hémery, Y., & Laurent-Babot, C. (2023) · Antioxidants · doi:10.3390/antiox12091726 · Cited by 36 · see citing works
“Spinach is rich in vitamins (K, A, B9, C), minerals (magnesium, potassium, iron), and bioactive compounds (polyphenols, especially ﬂavonoid derivatives of patuletin or spinacetin, ﬂavones, and carotenoids) with antioxidant, anti-inﬂammatory, and anti-cancer properties [38].”
Background
Spinach
Murcia, M. A., Jiménez‐Monreal, A. M., Gonzalez, J., & Martínez‐Tomé, M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-812780-3.00011-8 · Cited by 35 · see citing works
Ethnobotanical and ethnopharmacological study of medicinal plants used in the treatment of anemia in the region of Haouz-Rehamna (Morocco)
Benkhnigue, O., Chaachouay, N., Khamar, H., Azzouzi, F. E., Douira, A., & Zidane, L. (2022) · Journal of Pharmacy & Pharmacognosy Research · doi:10.56499/jppres21.1196_10.2.279 · Cited by 32 · see citing works
“…activities (e.g., antioxidant, anti-inflammatory, anticonvulsant, neuroprotective, antiviral, immunostimulant, hepatoprotective, laxative) (Sendl et al., 1992; Shojaii and Abdollahi Fard, 2012; Roberts and Moreau, 2016; Fredotovic et al., 2017; Farkhondeha and Samarghandian, 2018; Li et al., 2020).”
BackgroundInfluential
Role of dietary iron revisited: in metabolism, ferroptosis and pathophysiology of cancer.
Pandrangi, S. L., Chittineedi, P., Chikati, R., Lingareddy, J. R., Nagoor, M., & Ponnada, S. K. (2022) · PubMed Central · Cited by 32 · see citing works
Ecdysterone and Turkesterone—Compounds with Prominent Potential in Sport and Healthy Nutrition
Todorova, V., Ivanova, S., Chakarov, D., Kraev, K., & Ivanov, K. (2024) · Nutrients · doi:10.3390/nu16091382 · Cited by 31 · see citing works
“Due to the wide variety of bioactive and phytochemical compounds, S. oleracea has a wide variety of potential functionalities, mainly antioxidant, antimicrobial, anticancer, anti-obesity, hypoglycemic, and hypolipidemic [146,149,151].”
BackgroundInfluential
Dietary spinach reshapes the gut microbiome in an Apc-mutant genetic background: mechanistic insights from integrated multi-omics
Chen, Y., Li, J., Menon, R., Jayaraman, A., Lee, K., Huang, Y., Dashwood, W. M., Zhang, K., Sun, D., & Dashwood, R. H. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1972756 · Cited by 31 · see citing works
Replacement of meat by spinach on physicochemical and nutritional properties of chicken burgers
de Carvalho, F. A. L., Pateiro, M., Domínguez, R., Barba‐Orellana, S., Mattar, J. R., Brnčić, S. R., Barba, F. J., & Lorenzo, J. M. (2019) · Journal of Food Processing and Preservation · doi:10.1111/jfpp.13935 · Cited by 31 · see citing works
Ameliorative Effect of Spinach on Non-Alcoholic Fatty Liver Disease Induced in Rats by a High-Fat Diet
Elvira-Torales, L. I., Martín‐Pozuelo, G., González‐Barrio, R., NAVARRO-GONZÁLEZ, I., Pallarés, F. J., Santaella, M., García‐Alonso, J., Sevilla, A., & Periago, M. J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071662 · Cited by 30 · see citing works
“8 mg of gallic acid equivalents/day/person, due to the low daily intake [4].”
Background
Modulation of growth and biochemical responses in spinach (Spinacia oleracea L.) through foliar application of some amino acids under drought conditions
Kausar, A., Zahra, N., Tahir, H., Hafeez, M. B., Abbas, W., & Raza, A. (2023) · South African Journal of Botany · doi:10.1016/j.sajb.2023.05.018 · Cited by 28 · see citing works
Extraction, Identification, and Potential Health Benefits of Spinach Flavonoids: A Review
Singh, J., Jayaprakasha, G. K., & Patil, B. S. (2018) · ACS symposium series · doi:10.1021/bk-2018-1286.ch006 · Cited by 28 · see citing works
Preharvest UV-C treatment improves the quality of spinach primary production and postharvest storage
Martínez‐Sánchez, A., Lozano-Pastor, P., Artés‐Hernández, F., Artés, F., & Aguayo, E. (2019) · Postharvest Biology and Technology · doi:10.1016/j.postharvbio.2019.05.021 · Cited by 27 · see citing works
Spinach consumption and nonalcoholic fatty liver disease among adults: a case–control study
Mokhtari, E., Farhadnejad, H., Salehi‐Sahlabadi, A., Najibi, N., Azadi, M., Teymoori, F., & Mirmiran, P. (2021) · BMC Gastroenterology · doi:10.1186/s12876-021-01784-8 · Cited by 27 · see citing works
“Plenty of interventional and experimental studies, have investigated spinach’s antioxidant and anti-inflammatory properties [16, 17].”
Background
The Cardioprotective Role of Nitrate-Rich Vegetables
Olas, B. (2024) · Foods · doi:10.3390/foods13050691 · Cited by 26 · see citing works
“It is known to have various antioxidant, hypoglycemic, lipid-lowering, anti-obesity, antiproliferative, and anti-inflammatory properties [95,97].”
BackgroundInfluential
Tecticornia sp. (Samphire)—A Promising Underutilized Australian Indigenous Edible Halophyte
Srivarathan, S., Phan, A. D. T., Hong, H. T., Chua, E. T., Wright, O. R. L., Sultanbawa, Y. F., & Netzel, M. E. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.607799 · Cited by 26 · see citing works
Administration of hydro-alcoholic extract of spinach improves oxidative stress and inflammation in high-fat diet-induced NAFLD rats
Amirinejad, A., Totmaj, A. S., Mardali, F., Hekmatdoost, A., Emamat, H., Safa, M., & Shidfar, F. (2021) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-021-03396-x · Cited by 26 · see citing works
Inducing fungal resistance of spinach treated with preharvest hormetic doses of UV-C
Martínez‐Sánchez, A., Guirao-Martínez, J., Martínez, J. A., Lozano-Pastor, P., & Aguayo, E. (2019) · LWT · doi:10.1016/j.lwt.2019.108302 · Cited by 26 · see citing works
Glucopyranoside flavonoids isolated from leaves of Spinacia oleracea (spinach) inhibit the formation of advanced glycation end products (AGEs) and aldose reductase activity (RLAR)
Gutiérrez, R. M. P., & Velazquez, E. G. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110299 · Cited by 25 · see citing works
Physiological and Phytochemical Responses of Spinach Baby Leaves Grown in a PFAL System with LEDs and Saline Nutrient Solution
Bantis, F., Fotelli, M. N., Ilić, Z. S., & Κουκουνάρας, Α. (2020) · Agriculture · doi:10.3390/agriculture10110574 · Cited by 25 · see citing works
“However, spinach consumption is relatively low compared to other leafy vegetables [5].”
Background
Musa paradisiaca inflorescence induces human colon cancer cell death by modulating cascades of transcriptional events
Arun, K. B., Madhavan, A., Reshmitha, T. R., Thomas, S., & Nisha, P. (2017) · Food & Function · doi:10.1039/c7fo01454f · Cited by 25 · see citing works
Analysis of widely targeted metabolites of quinoa sprouts (Chenopodium quinoa Willd.) under saline-alkali stress provides new insights into nutritional value
Qian, G., Wang, M., Zhou, J., Wang, X., Zhang, Y., Liu, Y., Zhu, P., Han, L., Liu, C., Liu, C., et al. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.138575 · Cited by 24 · see citing works
Advances and Promises of Nutritional Influences on Natural Bone Repair
Roberts, J. L., & Drissi, H. (2019) · Journal of Orthopaedic Research® · doi:10.1002/jor.24527 · Cited by 24 · see citing works
“Although bioactive compounds in isolation can have wide‐reaching health benefits through antioxidant and anti‐inflammatory actions, they are known to act additively and synergistically to elicit a more pronounced biological effect when consumed together.(105,106) A recent study demonstrated that grape seed phenolic ex…”
Background
Impact of Harvest Month and Drying Process on the Nutritional and Bioactive Properties of Wild Palmaria palmata from Atlantic Canada
Lafeuille, B., Tamigneaux, É., Berger, K., Provencher, V., & Beaulieu, L. (2023) · Marine Drugs · doi:10.3390/md21070392 · Cited by 23 · see citing works
Prospective study of total and various types of vegetables and the risk of metabolic syndrome among children and adolescents
Hosseinpour‐Niazi, S., Bakhshi, B., Betru, E., Mirmiran, P., Darand, M., & Azizi, F. (2019) · World Journal of Diabetes · doi:10.4239/wjd.v10.i6.362 · Cited by 23 · see citing works
Plant-based Diets and Phytochemicals in the Management of Diabetes Mellitus and Prevention of its Complications: A Review
Ansari, P., Khan, J. T., Choudhary, S., Reberio, A. D., Kumar, S., Seidel, V., Abdel-Wahab, Y. H. A., & Flatt, P. R. (2024) · doi:10.20944/preprints202408.1739.v1 · Cited by 89 · see citing works
Allelopathic effects of tree peony extracts on bok choy, spinach and tatsoi
Guo, Y., He, S., Zhang, S., Shi, L., & Jia, W. (2025) · Scientific Reports · doi:10.1038/s41598-025-11422-y · Cited by 22 · see citing works
Modulatory functions of bioactive fruits, vegetables and spices in adipogenesis and angiogenesis
Sarkar, P. A., & Thirumurugan, K. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2018.12.036 · Cited by 22 · see citing works
Health-Promoting Nutrients and Potential Bioaccessibility of Breads Enriched with Fresh Kale and Spinach
Czarnowska‐Kujawska, M., Starowicz, M., Barišić, V., & Kujawski, W. M. (2022) · Foods · doi:10.3390/foods11213414 · Cited by 22 · see citing works
“, patuletin, spinatoside), phenolic acids (ferulic and p-coumaric acids), and lignans [13].”
Background
Circadian-based approach for improving physiological, phytochemical and chloroplast proteome in Spinacia oleracea under salinity stress and light emitting diodes
Vajjiravel, P., Nagarajan, D., Pugazhenthi, V., Suresh, A., Sivalingam, M. K., Venkat, A., Mahapatra, P. P., Razi, K., Murad, M. A., Bae, D. W., et al. (2024) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2024.108350 · Cited by 22 · see citing works
Nutritional and Bioactive Constituents of Antioxidant and Antimicrobial Properties in Spinacia oleracea: A Review
Faujan, N. H., Zubairi, S. I., & Ahmad Baker, A. A. (2023) · Sains Malaysiana · doi:10.17576/jsm-2023-5209-08 · Cited by 21 · see citing works
The effects of hydroalcoholic extract of spinach on prevention and treatment of some metabolic and histologic features in a rat model of nonalcoholic fatty liver disease
Amirinejad, A., Hekmatdoost, A., Ebrahimi, A., Ranjbaran, F., & Shidfar, F. (2019) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.10215 · Cited by 21 · see citing works
Industrial freezing effects on the content and bioaccessibility of spinach ( Spinacia oleracea L.) polyphenols
Kamiloğlu, S. (2020) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.10458 · Cited by 21 · see citing works
Dietary intakes of green leafy vegetables and incidence of cardiovascular diseases
Ojagbemi, A., Okekunle, A. P., Olowoyo, P., Akpa, O. M., Akinyemi, R., Ovbiagele, B. I., & Owolabi, M. O. (2021) · Cardiovascular journal of South Africa/Cardiovascular journal of Southern Africa · doi:10.5830/cvja-2021-017 · Cited by 21 · see citing works
“protect against several diseases.(29,59) The fibre component of GLV is also known for its cholesterol-lowering effects.”
Background
Antioxidant potential of extruded snacks enriched with hyper-protein quinoa flour and vegetable extracts
Roa-Acosta, D. F., Bravo, J., Solanilla‐Duque, J. F., GALINDEZ, J. Z. Z., & Jordan Alexis Martínez, C. R. U. Z. (2022) · Food Science and Technology · doi:10.1590/fst.74621 · Cited by 21 · see citing works
The current status of old traditional medicine introduced from Persia to China
Shi, J., Yang, Y., Zhou, X., Zhao, L., Li, X., Yusuf, A., Hossseini, M. M. Z., Sefidkon, F., & Hu, X. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.953352 · Cited by 21 · see citing works
Profiling of Nutritionally Vital Bioactive Compounds in Emerging Green Leafy Vegetables: A Comparative Study
Saini, R. K., Song, M., Yu, J.-W., Lee, J., Ahn, H.-Y., Keum, Y., & Lee, J. (2022) · Foods · doi:10.3390/foods11233867 · Cited by 21 · see citing works
“These GLVs are a rich source of carotenoids [13–15], polyphenols, and several other bioactive compounds [16,17].”
Background
Strategic Successive Harvesting of Rocket and Spinach Baby Leaves Enhanced Their Quality and Production Efficiency
Bantis, F., Kaponas, C., Charalambous, C., & Κουκουνάρας, Α. (2021) · Agriculture · doi:10.3390/agriculture11050465 · Cited by 21 · see citing works
“) is another important leafy vegetable with high nutritional content, as it is classified third in antioxidant capacity among vegetables [4].”
Background
Efficient Extraction and Sensitive HPLC-MS/MS Quantification of Selected Ecdysteroids in Plants
Fang, X., Szołtysik, R., Tang, J., & Bajkacz, S. (2022) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2022.104580 · Cited by 20 · see citing works
Mechanisms of intestinal pharmacokinetic natural product-drug interactions
Oyanna, V. O., & Clarke, J. D. (2024) · Drug Metabolism Reviews · doi:10.1080/03602532.2024.2386597 · Cited by 20 · see citing works
“Although its origin is debated to be from iran, china, or Nepal, production statistics indicate china is the world’s largest producer (Roberts and Moreau 2016). like other botan-icals, spinach contains many constituents, such as amino acids, minerals, thylakoids, glycolipids, and poly-phenols…”
Effect of Compost Extract Addition to Different Types of Fertilizers on Quality at Harvest and Shelf Life of Spinach
Giménez, A., Gómez, P. A., Bustamante, M. A., Pérez-Murcia, M. D., Martínez‐Sabater, E., Ros, M., Pascual, J. A., Egea‐Gilabert, C., & Fernández, J. A. (2021) · Agronomy · doi:10.3390/agronomy11040632 · Cited by 20 · see citing works
“Spinach is a green leafy vegetable considered a functional food because it is rich in mineral elements, vitamins, phytochemicals and bioactive compounds [1].”
Background
Red to Blue Light Ratio and Iron Nutrition Influence Growth, Metabolic Response, and Mineral Nutrients of Spinach Grown Indoors
Vaštakaitė‐Kairienė, V., Brazaitytė, A., Miliauskienė, J., & Runkle, E. S. (2022) · Sustainability · doi:10.3390/su141912564 · Cited by 20 · see citing works
Ecdysteroid Content and Therapeutic Activity in Elicited Spinach Accessions
Gorelick, J., Iraqi, R. H., & Bernstein, N. (2020) · Plants · doi:10.3390/plants9060727 · Cited by 19 · see citing works
“The recognized nutritional benefits of spinach are well known, rich in many vitamins and minerals [1].”
Background
The Generation of Nitric Oxide from Aldehyde Dehydrogenase-2: The Role of Dietary Nitrates and Their Implication in Cardiovascular Disease Management
Maiuolo, J., Oppedisano, F., Carresi, C., Gliozzi, M., Musolino, V., Macrì, R., Scarano, F., Coppoletta, A., Cardamone, A., Bosco, F., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415454 · Cited by 19 · see citing works
Cultural Practices and Mechanical Weed Control for the Management of a Low-Diversity Weed Community in Spinach
Gazoulis, I., Kanatas, P. J., & Antonopoulos, N. (2021) · Diversity · doi:10.3390/d13120616 · Cited by 19 · see citing works
Spinach Methanolic Extract Attenuates the Retinal Degeneration in Diabetic Rats
Bautista‐Pérez, R., Cano-Martı́nez, A., Velazquez, E. G., Rosas, M., Gutiérrez, R. M. P., Jiménez-Gómez, F., & Flores‐Estrada, J. (2021) · Antioxidants · doi:10.3390/antiox10050717 · Cited by 18 · see citing works
“mice, and adenocarcinoma of the transgenic mouse prostate [9,10].”
Background
Foliar Application of Protein Hydrolysates on Baby-Leaf Spinach Grown at Different N Levels
Bonasia, A., Conversa, G., Lazzizera, C., & Elia, A. (2021) · Agronomy · doi:10.3390/agronomy12010036 · Cited by 18 · see citing works
“Spinach leaves are an accessible source of natural antioxidants having protective properties for human health [1,2], but they also represent a source of anti-nutritional compounds such as nitrate and oxalate [3].”
Background
Effect of Green Synthesized Iron Oxide Nanoparticles Using Spinach Extract on Triton X-100-Induced Atherosclerosis in Rats
Abert, H. O., Aduwamai, U. H., & Adamu, S. S. (2022) · Biochemistry Research International · doi:10.1155/2022/9311227 · Cited by 18 · see citing works
“It curbs food intake by inducing the secretion of satiety hormones [13].”
Background
Enhancing spinach (Spinacia oleracea L.) resilience in pesticide-contaminated soil: Role of pesticide-tolerant Ciceribacter azotifigens and Serratia marcescens in root architecture, leaf gas exchange attributes and antioxidant response restoration
Shahid, M., & Singh, U. B. (2024) · Chemosphere · doi:10.1016/j.chemosphere.2024.142487 · Cited by 18 · see citing works
Phytochemical Analysis of Flower extracts of Different Cassia Species by Using Gas Chromatography-Mass Spectrometry
Socrates, S. H., & Mohan, S. (2018) · International Journal of Biological Chemistry · doi:10.3923/ijbc.2019.1.11 · Cited by 16 · see citing works
Effects of biofertilizers on the growth, leaf physiological indices and chlorophyll fluorescence response of spinach seedlings
Zhang, B., Zhang, H., Lu, D., Cheng, L., & Li, J. (2023) · PLoS ONE · doi:10.1371/journal.pone.0294349 · Cited by 17 · see citing works
“…oleracea L .) is a big-leaf variety, which belonged to the spinach genus Che-nopodiaceae (annual herbaceous plant), as an important leafy green vegetable its leaves and shoots that contain large quantities of bioactive compounds, minerals, and vitamins like A, B, and C and nutrients [1, 2].”
Background
Influence of simulated food and oral processing on carotenoid and chlorophyll in vitro bioaccessibility among six spinach genotypes
Hayes, M., Corbin, S., Nunn, C., Pottorff, M., Kay, C. D., Lila, M. A., Iorizzo, M., & Ferruzzi, M. G. (2021) · Food & Function · doi:10.1039/d1fo00600b · Cited by 17 · see citing works
Spinach (Spinacia oleracea) microgreen prevents the formation of advanced glycation end products in model systems and breads
Zhou, Q., Liang, W., Wan, J., & Wang, M. (2023) · Current Research in Food Science · doi:10.1016/j.crfs.2023.100490 · Cited by 16 · see citing works
Exogenous curcumin mitigates As stress in spinach plants: A biochemical and metabolomics investigation
Zhang, L., Zengin, G., Ozfidan‐Konakci, C., Yıldıztugay, E., Arikan, B., Ekim, R., Koyukan, B., Elbasan, F., & Lucini, L. (2024) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2024.108713 · Cited by 16 · see citing works
Uptake of vegetable and soft drink affected transformation and bioaccessibility of lead in gastrointestinal track exposed to lead-contaminated soil particles
Fan, J., Zhao, L., Kan, J., Qiu, H., Xu, X., & Cao, X. (2020) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.110411 · Cited by 16 · see citing works
Effect of crop maturity stages and lactic acid fermentation on nutrient absorption properties, and bioaccessibility of Fe, Zn and Ca in Spinacia oleracea L
Ismail, T., Akhtar, S., Qamar, M., Esatbeyoglu, T., Sestili, P., Saeed, W., & Lazarte, C. E. (2024) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2024.106427 · Cited by 15 · see citing works
Nutritional, Biochemical, and Functional Properties of Spinach Leaf-Enriched Dough: A Healthier Alternative to Conventional Pasta
Iacobellis, I., Lisi, A. D., Vacca, M., Apa, C. A., Celano, G., Mancini, L., Minervini, F., Calasso, M. P., & Angelis, M. D. (2024) · Foods · doi:10.3390/foods13223608 · Cited by 15 · see citing works
“…confirmed by the scavenging activity assay (Figure 3C), which showed the highest value for uncooked PSP25 and the lowest for CP, consistent with previous studies highlighting the significant potential of spinach to prevent oxidative stress-related issues as the result of the considerable…”
Impacts of Commonly Used Edible Plants on the Modulation of Platelet Function
Albadawi, D. A. I., Ravishankar, D., Vallance, T. M., Patel, K., Osborn, H. M. I., & Vaiyapuri, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020605 · Cited by 15 · see citing works
“Spinacia oleracea (spinach) leaves have many beneficial effects on human health including antioxidant, anti-cancer, anti-inflammatory, hypolipidemic and hypoglycaemic effects [94].”
Background
New insights into molecular mechanisms of "Cold or Hot" nature of food: When East meets West.
Zhou, Y., & Xu, B. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110361 · Cited by 13 · see citing works
Inhibitory impact of MgO nanoparticles on oxidative stress and other physiological attributes of spinach plant grown under field condition
Gautam, A., Sharma, P., Ashokhan, S., Yaacob, J. S., Kumar, V., & Guleria, P. (2023) · Physiology and Molecular Biology of Plants · doi:10.1007/s12298-023-01391-9 · Cited by 14 · see citing works
“Spinacia oleracea (spinach) is a nutrient-enriched annual green leafy vegetable consumed in cooked and raw forms (Morelock and Correll 2008; Roberts and Moreau 2016).”
An investigation on glutathione derived from spinach and red cabbage leaves and their effects of adding to meat patties
Al-Temimi, A. A., Al-Hilifi, S. A., & AL-Mossawi, A.-E.-B. H. J. (2023) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2023.103632 · Cited by 13 · see citing works
“…health advantages, including protection against cancer and obesity, protection against damage caused by macromolecular oxidation, and protection against agerelated macular degeneration (Roberts and Moreau, 2016; Verma et al., 2018b; Verma et al., 2020; Gutierrez et al., 2019; Sarkar et al., 2022b).”
BackgroundInfluential
Alpha-cadinol as a potential ACE-inhibitory volatile compound identified from Phaseolus vulgaris L. through in vitro and in silico analysis
Tripathi, J., Gupta, S., & Gautam, S. (2022) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2022.2057359 · Cited by 13 · see citing works
“…garlic are very commonly consumed vegetables across the globe, and already have well characterised biological activities such as anti-cancerous, anti-inflammatory, anti-viral and anti-microbial activities (Aguiar et al., 2021; Guimar~aes et al., 2019; Roberts & Moreau, 2016; Bayan et al., 2014).”
Background
Lemon Juice Formulations Modulate In Vitro Digestive Recovery of Spinach Phytochemicals
Vujčić, V., Šola, I., & Rusak, G. (2022) · Food Technology and Biotechnology · doi:10.17113/ftb.60.03.22.7104 · Cited by 13 · see citing works
“According to the literature, both spinach and lemon juice are good sources of antioxidants (2,11,14,32,45).”
BackgroundInfluential

Spinach (Spinacia oleracea L.)
Ramaiyan, B., Kour, J., Nayik, G. A., Anand, N., & Alam, M. S. (2020) · Springer eBooks · doi:10.1007/978-981-15-7470-2_8 · Cited by 38 · see citing works
A REVIEW ON THE PHARMACOLOGICAL PROPERTIES OF PHYTOCONSTITUENTS AND BIOACTIVES PRESENT IN SPINACH (Spinacea oleracea)
Kesarwani, N., Giriyam, R., Babu, V. N. K., Khurana, N., Sharma, N., Vyas, M., & Reema (2021) · PLANT CELL BIOTECHNOLOGY AND MOLECULAR BIOLOGY · Cited by 1 · see citing works
A REVIEW ON MEDICINAL USES OF SPINACIA OLERACEA
Pasumarthy, S. M., Poojitha, S., MANEESH, C., Mydhili, A., Lakshmi, G. M., & Nikitha, C. (2025) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.17483977 · Cited by 1 · see citing works
Nutritional and health beneficial properties of spinach (Spinacia oleracea L): A comprehensive review
Balasubramaniam, A. K., Saste, G., Kureshi, A. A., Mulay, V. P., & Hingorani, L. (2025) · Pharmacological Research - Natural Products · doi:10.1016/j.prenap.2025.100368 · Cited by 9 · see citing works
Plants of the genus Spinacia: From Bioactive Molecules to Food and Phytopharmacological Applications
Salehi, B., Tumer, T. B., Ozleyen, A., Peron, G., Dall’Acqua, S., Rajkovic, J., Naz, R., Nosheen, A., Mudau, F. N., Labanca, F., et al. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.03.028 · Cited by 44 · see citing works

Authors: Roberts, J. L., & Moreau, R.
Affiliations: University of Nebraska–Lincoln (US)
Corresponding author: Roberts, Joseph L.
ORCID: Roberts, Joseph L.
Moreau, Régis
Venue: Food & Function
Publisher: Royal Society of Chemistry (RSC)
Published: 2016
Volume: 7
Issue: 8
Pages: 3337-3353
ISSN: 2042-6496 (ISSN-L)
2042-650X
DOI: 10.1039/c6fo00051g
OpenAlex: W2471377492
Cited by: 283
References: 92
Citations by year: 2026: 20 · 2025: 44 · 2024: 40 · 2023: 38 · 2022: 36 · 2021: 39 · 2020: 31 · 2019: 24 · 2018: 7 · 2017: 4
FWCI: 1.08
Type: journal article
Language: en
Open access: closed
Locations: Food & Function (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Health Sciences › Nursing › Nutrition and Dietetics › Food Science and Nutritional Studies
Life Sciences › Agricultural and Biological Sciences › Food Science › Seed and Plant Biochemistry
Keywords: spinach, phytochemicals, bioactive compounds, functional foods, leafy vegetables, reactive oxygen species scavenging, oxidative damage, gene expression modulation, satiety hormones, food intake regulation, anticancer activity, anti-obesity, hypoglycemic activity, hypolipidemic activity, glycolipids, thylakoids, antioxidant defense, inflammation
MeSH terms: Animals, Anti-Inflammatory Agents, Anticholesteremic Agents, Antineoplastic Agents, Antioxidants, Cells, Cultured, Glycolipids, Humans, Hypoglycemic Agents, Randomized Controlled Trials as Topic, Reactive Oxygen Species, Oxidative Stress, Spinacia oleracea, Anti-Obesity Agents, Thylakoids, Cell Proliferation, Functional Food, Phytochemicals

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Functional Properties of Spinach (Spinacia oleracea L.) Phytochemicals and Bioactives

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks