Cited by 227Antioxidant Activity and Oxidative StressAdipokines, Inflammation, and Metabolic DiseasesExercise and Physiological Responses

Alpha tocopherol supplementation decreases serum C-reactive protein and monocyte interleukin-6 levels in normal volunteers and type 2 diabetic patients

Devaraj, Sridevi, Jialal, Ishwarlal·2000·Free Radical Biology and Medicine

Abstract

Type 2 diabetic subjects have an increased propensity to premature atherosclerosis. Alpha tocopherol (AT), a potent antioxidant, has several anti-atherogenic effects. There is scanty data on AT supplementation on inflammation in Type 2 diabetic subjects. The aim of the study was to test the effect of RRR-AT supplementation (1200 IU/d) on plasma C-reactive protein (CRP) and interleukin-6 (IL-6) release from activated monocyte in Type 2 diabetic patients with and without macrovascular complications compared to matched controls. The volunteers comprised Type 2 diabetic subjects with macrovascular disease (DM2-MV, n = 23), Type 2 diabetic subjects without macrovascular complications (DM2, n = 24), and matched controls (C, n = 25). Plasma high sensitive CRP (Hs-CRP) and Monocyte IL-6 were assayed at baseline, following 3 months of supplementation and following a 2 month washout phase. DM2-MV subjects have elevated HsCRP and monocyte IL-6 compared to controls. AT supplementation significantly lowered levels of C-reactive protein and monocyte interleukin-6 in all three groups. In conclusion, AT therapy decreases inflammation in diabetic patients and controls and could be an adjunctive therapy in the prevention of atherosclerosis.

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Crossref · 10.1016/s0891-5849(00)00420-2

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9 of 9 references verified0 citation errors · 0 not checkable

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  • Increased consumption of dairy products has beneficial effects on plasma CRP and adiponectin concentrations in obese subjects.

    “Increased consumption of dairy products has been shown to have beneficial effects on plasma CRP and adiponectin concentrations in obese subjects (683) .”

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Authors
Devaraj, S., & Jialal, I.
Affiliations
The University of Texas Southwestern Medical Center (US)
Corresponding author
Jialal, Ishwarlal
Venue
Free Radical Biology and Medicine
Publisher
Elsevier BV
Published
2000-10
Volume
29
Issue
8
Pages
790-792
ISSN
0891-5849 (ISSN-L)
OpenAlex
W2085598380
Cited by
227
References
9
Citations by year
2026: 3 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 5 · 2020: 4 · 2019: 3 · 2018: 7 · 2017: 8 · 2016: 8 · 2015: 9 · 2014: 4 · 2013: 8 · 2012: 5
FWCI
10.69
Type
journal article
Language
en
Open access
closed
Locations
  • Free Radical Biology and Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • American Heart Association
  • National Center for Complementary and Integrative Health (K-24AT00596, 1 RO1 AT00005-01, R01AT000005, K24AT000596)
Topics
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords
alpha-tocopherol, vitamin E supplementation, type 2 diabetes, C-reactive protein, interleukin-6, monocytes, inflammation, macrovascular complications, atherosclerosis, antioxidant therapy
MeSH terms
Antioxidants, Arteriosclerosis, C-Reactive Protein, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Humans, Monocytes, Vitamin E, Interleukin-6, Case-Control Studies

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