Alpha tocopherol supplementation decreases serum C-reactive protein and monocyte interleukin-6 levels in normal volunteers and type 2 diabetic patients
Abstract
Type 2 diabetic subjects have an increased propensity to premature atherosclerosis. Alpha tocopherol (AT), a potent antioxidant, has several anti-atherogenic effects. There is scanty data on AT supplementation on inflammation in Type 2 diabetic subjects. The aim of the study was to test the effect of RRR-AT supplementation (1200 IU/d) on plasma C-reactive protein (CRP) and interleukin-6 (IL-6) release from activated monocyte in Type 2 diabetic patients with and without macrovascular complications compared to matched controls. The volunteers comprised Type 2 diabetic subjects with macrovascular disease (DM2-MV, n = 23), Type 2 diabetic subjects without macrovascular complications (DM2, n = 24), and matched controls (C, n = 25). Plasma high sensitive CRP (Hs-CRP) and Monocyte IL-6 were assayed at baseline, following 3 months of supplementation and following a 2 month washout phase. DM2-MV subjects have elevated HsCRP and monocyte IL-6 compared to controls. AT supplementation significantly lowered levels of C-reactive protein and monocyte interleukin-6 in all three groups. In conclusion, AT therapy decreases inflammation in diabetic patients and controls and could be an adjunctive therapy in the prevention of atherosclerosis.
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Increased consumption of dairy products has beneficial effects on plasma CRP and adiponectin concentrations in obese subjects.
“Increased consumption of dairy products has been shown to have beneficial effects on plasma CRP and adiponectin concentrations in obese subjects (683) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [683]
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Ziegler, M., Wallert, M., Lorkowski, S., & Peter, K. (2020) · Antioxidants · doi:10.3390/antiox9100935 · Cited by 64 · see citing works
Inflammation, Oxidative Stress and Metabolic Syndrome: Dietary Modulation
Fernández‐García, J. C., Cardona, F., & Tinahones, F. J. (2014) · Current Vascular Pharmacology · doi:10.2174/15701611113116660175 · Cited by 61 · see citing works
Accelerated atherosclerosis, dyslipidemia, and oxidative stress in end-stage renal disease
Mathur, S., Devaraj, S., & Jialal, I. (2002) · Current Opinion in Nephrology & Hypertension · doi:10.1097/00041552-200203000-00003 · Cited by 59 · see citing works
Self-citationVitamin E and Non-Communicable Diseases: A Review
Ciarcià, G., Bianchi, S., Tomasello, B., Acquaviva, R., Malfa, G. A., Николаевна, Н. И., Mantia, A. L., & Giacomo, C. D. (2022) · Biomedicines · doi:10.3390/biomedicines10102473 · Cited by 58 · see citing works
The Antioxidant Vitamins C and E
Packer, L. (2003) · AOCS Publishing eBooks · doi:10.4324/9780429270710 · Cited by 59 · see citing works
Choi, S. W., & Ho, C. K.-C. (2017) · Redox Report · doi:10.1080/13510002.2017.1324381 · Cited by 57 · see citing works
Al-Waili, N., Salom, K., Al-Ghamdi, A., Ansari, M. J., Al-Waili, A. N., & Al-Waili, T. N. (2013) · Journal of Medicinal Food · doi:10.1089/jmf.2012.0285 · Cited by 54 · see citing works
Role of C-reactive protein in the assessment of cardiovascular risk
Jialal, I., & Devaraj, S. (2003) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)03110-7 · Cited by 53 · see citing works
Self-citationSmith, K. S., Lee, C., Ridlington, J. W., Leonard, S. W., Devaraj, S., & Traber, M. G. (2003) · Lipids · doi:10.1007/s11745-003-1130-9 · Cited by 51 · see citing works
Self-citationDevaraj, S., Cabo-Chan, A. V., & Jialal, I. (2002) · Diabetes Care · doi:10.2337/diacare.25.3.524 · Cited by 51 · see citing works
Self-citationAge-related loss of associations between acute exercise-induced IL-6 and oxidative stress
Sacheck, J. M., Cannon, J. G., Hamada, K., Vannier, E. G., Blumberg, J. B., & Roubenoff, R. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00052.2005 · Cited by 48 · see citing works
- Authors
- Devaraj, S., & Jialal, I.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Jialal, Ishwarlal
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2000-10
- Volume
- 29
- Issue
- 8
- Pages
- 790-792
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W2085598380
- Cited by
- 227
- References
- 9
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 5 · 2020: 4 · 2019: 3 · 2018: 7 · 2017: 8 · 2016: 8 · 2015: 9 · 2014: 4 · 2013: 8 · 2012: 5
- FWCI
- 10.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- National Center for Complementary and Integrative Health (K-24AT00596, 1 RO1 AT00005-01, R01AT000005, K24AT000596)
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- alpha-tocopherol, vitamin E supplementation, type 2 diabetes, C-reactive protein, interleukin-6, monocytes, inflammation, macrovascular complications, atherosclerosis, antioxidant therapy
- MeSH terms
- Antioxidants, Arteriosclerosis, C-Reactive Protein, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Humans, Monocytes, Vitamin E, Interleukin-6, Case-Control Studies
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